John Clifford Cambier
Title | Electronic Research Admin |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | ADM AVCRC COMIRB |
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Phone | 303/724-8663 |
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Research DP3DK110845 (MICHELS, AARON W)Aug 1, 2016 - Jul 31, 2020 NIH Insulin Specific T and B cells in Type 1 Diabetes Role: Co-Principal Investigator |
| R01AI124487 (CAMBIER, JOHN C)Mar 1, 2016 - Feb 28, 2021 NIH Autoimmunity risk alleles compromising B cell anergy Role: Principal Investigator |
| R21AI124488 (CAMBIER, JOHN C)Feb 16, 2016 - Jul 31, 2018 NIH Perturbation of B cell anergy in T1D Role: Principal Investigator |
| R01DK096492 (CAMBIER, JOHN C)Aug 20, 2012 - Dec 31, 2017 NIH B Cells and Type 1 Diabetes Role: Principal Investigator |
| R21AI099346 (CAMBIER, JOHN C.)Aug 1, 2012 - Jul 31, 2015 NIH Mouse modeling of a human STING gene variant for infectious disease Role: Principal Investigator |
| S10RR027331 (CAMBIER, JOHN C.)Dec 10, 2009 - Dec 9, 2011 NIH iCyt Reflection High Speed Cell Sorter Role: Principal Investigator |
| R01AI077597 (CAMBIER, JOHN C.)Dec 1, 2009 - Nov 30, 2015 NIH Infectious Agents and B Cell Anergy Role: Principal Investigator |
| R21AI078207 (CAMBIER, JOHN C.)Jul 1, 2009 - Jun 30, 2012 NIH B Cell Development in Aging Role: Principal Investigator |
| T32AI074491 (CAMBIER, JOHN C;PELANDA, ROBERTA)Jul 1, 2007 - Jun 30, 2024 NIH Molecular Mechanisms of Immune Tolerance Role: Principal Investigator |
| R21AI069894 (CAMBIER, JOHN C.)Aug 15, 2006 - Jul 31, 2009 NIH Characterization of anergic human B cells Role: Principal Investigator |
| R13AG029058 (CAMBIER, JOHN C.)Aug 15, 2006 - Aug 31, 2007 NIH Aging Research in Immunology: Satellite to 2006 European Congress of Immunology Role: Principal Investigator |
| R01AI062739 (CAMBIER, JOHN C.)Jun 1, 2005 - Sep 30, 2011 NIH NKIP signaling and functions Role: Principal Investigator |
| R13AI066860 (CAMBIER, JOHN C.)Jun 1, 2005 - May 31, 2006 NIH FASEB Conference-Immunoreceptors Role: Principal Investigator |
| R13CA096580 (CAMBIER, JOHN C.)Aug 1, 2002 - Jul 31, 2003 NIH Conference Proposal: IMMUNORECEPTORS Role: Principal Investigator |
| R01AI039773 (CAMBIER, JOHN C.)Jan 1, 1997 - Dec 31, 2002 NIH IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION Role: Principal Investigator |
| R01AI036676 (CAMBIER, JOHN C.)Jun 1, 1995 - Jan 31, 2006 NIH HIV GP120 Desensitization of T Cell Receptor Function Role: Principal Investigator |
| R21AI036676 (CAMBIER, JOHN C.)Jun 1, 1995 - Sep 29, 2002 NIH HIV GP120 Desensitization of TCell Receptor Function Role: Principal Investigator |
| R56AI074444 (CAMBIER, JOHN C.)May 1, 1993 - Sep 29, 2009 NIH Inhibitory receptors and their mode of action Role: Principal Investigator |
| R01DK047121 (CAMBIER, JOHN C.)May 1, 1993 - Nov 30, 2005 NIH INHIBITORY RECEPTORS AND THEIR MODE OF ACTION Role: Principal Investigator |
| P01AI029903 (CAMBIER, JOHN C.)Apr 1, 1990 - Mar 31, 1995 NIH MOLECULAR BASIS OF HIV INDUCED IMMUNE SUPPRESSION Role: Principal Investigator |
| P01AI022295 (MARRACK, PHILIPPA C.)Jul 1, 1985 - Jul 31, 2014 NIH Antigen Recognition by Lymphocytes Role: Co-Principal Investigator |
| R01AG013983 (CAMBIER, JOHN C.)Dec 1, 1984 - Aug 31, 2011 NIH B Cells and Autoimmunity Role: Principal Investigator |
| R01AI021768 (CAMBIER, JOHN C.)Dec 1, 1984 - May 31, 1996 NIH SIGNAL TRANSDUCTION IN B CELL ACTIVATION Role: Principal Investigator |
| R01AI020519 (CAMBIER, JOHN C.)May 1, 1983 - Feb 28, 2009 NIH Molecular Biology of B Cell Tolerance and Activation Role: Principal Investigator |
Bibliographic
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Stensland ZC, Cambier JC, Smith MJ. Therapeutic Targeting of Autoreactive B Cells: Why, How, and When? Biomedicines. 2021 Jan 16; 9(1). PMID: 33467130.
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Crute BW, Sheraden R, Ott VL, Harley ITW, Getahun A, Cambier JC. Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors. Front Immunol. 2020; 11:592329. PMID: 33193438.
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Smith MJ, Cambier JC, Gottlieb PA. Endotypes in T1D: B lymphocytes and early onset. Curr Opin Endocrinol Diabetes Obes. 2020 08; 27(4):225-230. PMID: 32618634.
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Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A. Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020; 11:238. PMID: 32153571.
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Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019 05 16; 5. PMID: 31094704.
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Franks SE, Getahun A, Cambier JC. A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation. J Immunol. 2019 06 15; 202(12):3381-3393. PMID: 31076529.
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Getahun A, Cambier JC. Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease. Annu Rev Cell Dev Biol. 2019 10 06; 35:337-356. PMID: 30883216.
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Leon MA, Wemlinger SM, Larson NR, Ruffalo JK, Sestak JO, Middaugh CR, Cambier JC, Berkland C. Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells. Mol Pharm. 2019 04 01; 16(4):1563-1572. PMID: 30681867.
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Tu MM, Lee FYF, Jones RT, Kimball AK, Saravia E, Graziano RF, Coleman B, Menard K, Yan J, Michaud E, Chang H, Abdel-Hafiz HA, Rozhok AI, Duex JE, Agarwal N, Chauca-Diaz A, Johnson LK, Ng TL, Cambier JC, Clambey ET, Costello JC, Korman AJ, Theodorescu D. Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. Sci Adv. 2019 02; 5(2):eaav2437. PMID: 30801016.
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Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728334.
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Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, Cambier JC, Melamed D. The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development. Front Immunol. 2018; 9:2715. PMID: 30524445.
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Walker MM, Crute BW, Cambier JC, Getahun A. B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses. J Immunol. 2018 11 01; 201(9):2641-2653. PMID: 30282750.
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Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC. Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice. Diabetologia. 2018 12; 61(12):2621-2632. PMID: 30255377.
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Franks SE, Cambier JC. Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy. Front Immunol. 2018; 9:665. PMID: 29681901.
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Kogut I, McCarthy SM, Pavlova M, Astling DP, Chen X, Jakimenko A, Jones KL, Getahun A, Cambier JC, Pasmooij AMG, Jonkman MF, Roop DR, Bilousova G. High-efficiency RNA-based reprogramming of human primary fibroblasts. Nat Commun. 2018 02 21; 9(1):745. PMID: 29467427.
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Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznicka M, Cambier J, Witzenrath M, Schumann RR, Suttorp N, Opitz B. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infect Immun. 2018 03; 86(3). PMID: 29263110.
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Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC. Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles. Diabetes. 2018 04; 67(4):697-703. PMID: 29343548.
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Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B. The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. PLoS Pathog. 2018 01; 14(1):e1006829. PMID: 29298342.
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Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2018 05; 89:82-89. PMID: 29233566.
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Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018 01; 24(1):50-61. PMID: 29176737.
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Smith MJ, Simmons KM, Cambier JC. B cells in type 1 diabetes mellitus and diabetic kidney disease. Nat Rev Nephrol. 2017 Oct 17; 13(11):712-720. PMID: 29038537.
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Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 04 03; 214(4):931-941. PMID: 28341640.
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Smith MJ, Packard TA, O'Neill SK, Hinman RM, Rihanek M, Gottlieb PA, Cambier JC. Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function. J Vis Exp. 2017 02 16; (120). PMID: 28287549.
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Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight. 2016 12 08; 1(20):e88242. PMID: 27942583.
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Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. J Clin Med. 2016 Nov 08; 5(11). PMID: 27834793.
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Franks SE, Getahun A, Hogarth PM, Cambier JC. Targeting B cells in treatment of autoimmunity. Curr Opin Immunol. 2016 12; 43:39-45. PMID: 27718447.
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Noges LE, White J, Cambier JC, Kappler JW, Marrack P. Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines. J Immunol. 2016 08 15; 197(4):1221-30. PMID: 27357147.
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Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 05 02; 213(5):751-69. PMID: 27114609.
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Cambier J. Preview of Immunological Reviews for 2016. Immunol Rev. 2016 Jan; 269(1):5-6. PMID: 26683140.
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Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 01; 196(1):217-31. PMID: 26582947.
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Getahun A, Cambier JC. Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling. Immunol Rev. 2015 Nov; 268(1):66-73. PMID: 26497513.
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Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 01; 195(11):5461-5471. PMID: 26500350.
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Akerlund J, Getahun A, Cambier JC. B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens. J Autoimmun. 2015 Aug; 62:45-54. PMID: 26152931.
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Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E39-48. PMID: 25535377.
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White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT. Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production. Cell. 2014 Dec 18; 159(7):1549-62. PMID: 25525874.
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Smith MJ, Packard TA, O'Neill SK, Henry Dunand CJ, Huang M, Fitzgerald-Miller L, Stowell D, Hinman RM, Wilson PC, Gottlieb PA, Cambier JC. Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients. Diabetes. 2015 May; 64(5):1703-12. PMID: 25524915.
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Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356.
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Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, M?ller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. J Immunol. 2014 Jul 15; 193(2):909-920. PMID: 24929000.
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Hinman RM, Smith MJ, Cambier JC. B cells and type 1 diabetes ...in mice and men. Immunol Lett. 2014 Aug; 160(2):128-32. PMID: 24472603.
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Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15; 192(4):1641-50. PMID: 24442438.
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Hinman RM, Cambier JC. Role of B lymphocytes in the pathogenesis of type 1 diabetes. Curr Diab Rep. 2014; 14(11):543. PMID: 25189436.
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Packard TA, Cambier JC. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation. F1000Prime Rep. 2013 Oct 01; 5:40. PMID: 24167721.
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Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C. Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep. 2013 Oct; 14(10):900-6. PMID: 24008845.
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Bounab Y, Getahun A, Cambier JC, Da?ron M. Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol. 2013 Jun; 25(3):313-20. PMID: 23684445.
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Cambier JC. Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways. J Clin Invest. 2013 May; 123(5):1928-31. PMID: 23619359.
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Slansky JE, Cohen JJ, Cambier JC. Integrated immunology in Colorado. Immunol Res. 2013 Mar; 55(1-3):1-2. PMID: 22975788.
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Packard TA, Li QZ, Cosgrove GP, Bowler RP, Cambier JC. COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype. Immunol Res. 2013 Mar; 55(1-3):48-57. PMID: 22941590.
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Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15; 190(6):2835-43. PMID: 23378430.
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Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108.
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Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC. Retention of anergy and inhibition of antibody responses during acute ? herpesvirus 68 infection. J Immunol. 2012 Sep 15; 189(6):2965-74. PMID: 22904300.
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Jin L, Cambier JC. SMIP-016 in action: CD37 as a death receptor. Cancer Cell. 2012 May 15; 21(5):597-598. PMID: 22624709.
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Kogut I, Scholz JL, Cancro MP, Cambier JC. B cell maintenance and function in aging. Semin Immunol. 2012 Oct; 24(5):342-9. PMID: 22560930.
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Khalil AM, Cambier JC, Shlomchik MJ. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 2012 Jun 01; 336(6085):1178-81. PMID: 22555432.
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Waterman PM, Marschner S, Brandl E, Cambier JC. The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling. Immunol Lett. 2012 Mar 30; 143(1):122-30. PMID: 22370159.
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O'Brien RL, Chain JL, Aydintug MK, Bohrer-Kunter D, Huang Y, Hardy IR, Cambier JC, Lahmers K, Nuhsbaum T, Davidson R, Sun D, Born WK. a? TCR? T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking ?d T cells. Invest Ophthalmol Vis Sci. 2012 Jan 25; 53(1):301-8. PMID: 22199243.
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Xu LG, Jin L, Zhang BC, Akerlund LJ, Shu HB, Cambier JC. VISA is required for B cell expression of TLR7. J Immunol. 2012 Jan 01; 188(1):248-58. PMID: 22105994.
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O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity. 2011 Nov 23; 35(5):746-56. PMID: 22078222.
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Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601. PMID: 21813776.
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Grubeck-Loebenstein B, Cambier J. Immune senescence. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):509-11. PMID: 21782404.
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Yarkoni Y, Cambier JC. Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude. Mol Immunol. 2011 Sep; 48(15-16):1851-8. PMID: 21663969.
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Lukin K, Fields S, Guerrettaz L, Straign D, Rodriguez V, Zandi S, M?nsson R, Cambier JC, Sigvardsson M, Hagman J. A dose-dependent role for EBF1 in repressing non-B-cell-specific genes. Eur J Immunol. 2011 Jun; 41(6):1787-93. PMID: 21469119.
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Van Den Broeck A, Cambier J. B cells talk to their progenitors. Blood. 2011 Mar 17; 117(11):2985-6. PMID: 21415272.
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Jin L, Xu LG, Yang IV, Davidson EJ, Schwartz DA, Wurfel MM, Cambier JC. Identification and characterization of a loss-of-function human MPYS variant. Genes Immun. 2011 Jun; 12(4):263-9. PMID: 21248775.
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Dhirapong A, Lleo A, Yang GX, Tsuneyama K, Dunn R, Kehry M, Packard TA, Cambier JC, Liu FT, Lindor K, Coppel RL, Ansari AA, Gershwin ME. B cell depletion therapy exacerbates murine primary biliary cirrhosis. Hepatology. 2011 Feb; 53(2):527-35. PMID: 21274873.
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Jin L, Lenz LL, Cambier JC. Cellular reactive oxygen species inhibit MPYS induction of IFN?. PLoS One. 2010 Dec 10; 5(12):e15142. PMID: 21170271.
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Chan MA, Gigliotti NM, Matangkasombut P, Gauld SB, Cambier JC, Rosenwasser LJ. CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage. Clin Immunol. 2010 Dec; 137(3):330-6. PMID: 20805040.
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Waterman PM, Cambier JC. The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms. FEBS Lett. 2010 Dec 15; 584(24):4878-82. PMID: 20875413.
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Yarkoni Y, Getahun A, Cambier JC. Molecular underpinning of B-cell anergy. Immunol Rev. 2010 Sep; 237(1):249-63. PMID: 20727040.
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Cady CT, Powell MS, Harbeck RJ, Giclas PC, Murphy JR, Katial RK, Weber RW, Hogarth PM, Johnson S, Bonvini E, Koenig S, Cambier JC. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. Immunol Lett. 2010 May 04; 130(1-2):57-65. PMID: 20004689.
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Getahun A, O'Neill SK, Cambier JC. Establishing anergy as a bona fide in vivo mechanism of B cell tolerance. J Immunol. 2009 Nov 01; 183(9):5439-41. PMID: 19843930.
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Cambier JC, Getahun A. B cell activation versus anergy; the antigen receptor as a molecular switch. Immunol Lett. 2010 Jan 18; 128(1):6-7. PMID: 19808046.
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O'Neill SK, Liu E, Cambier JC. Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2009 Aug; 16(4):293-8. PMID: 19502979.
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Jackson L, Cady CT, Cambier JC. TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23. J Immunol. 2009 Aug 15; 183(4):2585-92. PMID: 19635918.
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O'Neill SK, Veselits ML, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre ML, Cambier JC, Clark MR. Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6262-7. PMID: 19332776.
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Decot?-Ricardo D, Chagas KK, Rocha JD, Redner P, Lopes UG, Cambier JC, Barros de Arruda L, Pe?anha LM. Modulation of in vitro murine B-lymphocyte response by curcumin. Phytomedicine. 2009 Oct; 16(10):982-8. PMID: 19303754.
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Crowley JE, Stadanlick JE, Cambier JC, Cancro MP. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood. 2009 Feb 12; 113(7):1464-73. PMID: 18791164.
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Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, Cohen PL, Eisenberg RA. B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol. 2008 Sep 01; 181(5):2961-72. PMID: 18713966.
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Guerrettaz LM, Johnson SA, Cambier JC. Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11898-902. PMID: 18697924.
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Cady CT, Rice JS, Ott VL, Cambier JC. Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors. Immunol Rev. 2008 Aug; 224:44-57. PMID: 18759919.
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Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol. 2008 Aug; 28(16):5014-26. PMID: 18559423.
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Jin L, Stolpa JC, Young RM, Pugh-Bernard AE, Refaeli Y, Cambier JC. MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death. Immunol Lett. 2008 Mar 15; 116(2):184-94. PMID: 18194817.
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Rider DA, Havenith CE, de Ridder R, Schuurman J, Favre C, Cooper JC, Walker S, Baadsgaard O, Marschner S, vandeWinkel JG, Cambier J, Parren PW, Alexander DR. A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity. Cancer Res. 2007 Oct 15; 67(20):9945-53. PMID: 17942927.
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Conrad FJ, Rice JS, Cambier JC. Multiple paths to loss of anergy and gain of autoimmunity. Autoimmunity. 2007 Sep; 40(6):418-24. PMID: 17729035.
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Lyubchenko T, Dal Porto JM, Holers VM, Cambier JC. Cutting edge: Complement (C3d)-linked antigens break B cell anergy. J Immunol. 2007 Sep 01; 179(5):2695-9. PMID: 17709481.
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Cambier JC, Gauld SB, Merrell KT, Vilen BJ. B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol. 2007 Aug; 7(8):633-43. PMID: 17641666.
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Velez MG, Kane M, Liu S, Gauld SB, Cambier JC, Torres RM, Pelanda R. Ig allotypic inclusion does not prevent B cell development or response. J Immunol. 2007 Jul 15; 179(2):1049-57. PMID: 17617597.
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Brauweiler A, Merrell K, Gauld SB, Cambier JC. Cutting Edge: Acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness. J Immunol. 2007 Mar 15; 178(6):3353-7. PMID: 17339427.
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Mills DM, Stolpa JC, Cambier JC. Modulation of MHC class II signal transduction by CD19. Adv Exp Med Biol. 2007; 596:139-48. PMID: 17338182.
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Merrell KT, Benschop RJ, Gauld SB, Aviszus K, Decote-Ricardo D, Wysocki LJ, Cambier JC. Identification of anergic B cells within a wild-type repertoire. Immunity. 2006 Dec; 25(6):953-62. PMID: 17174121.
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Pugh-Bernard AE, Cambier JC. B cell receptor signaling in human systemic lupus erythematosus. Curr Opin Rheumatol. 2006 Sep; 18(5):451-5. PMID: 16896281.
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Powell MS, Barnes NC, Bradford TM, Musgrave IF, Wines BD, Cambier JC, Hogarth PM. Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding. J Immunol. 2006 Jun 15; 176(12):7489-94. PMID: 16751395.
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Gauld SB, Merrell KT, Cambier JC. Silencing of autoreactive B cells by anergy: a fresh perspective. Curr Opin Immunol. 2006 Jun; 18(3):292-7. PMID: 16616480.
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Gauld SB, Benschop RJ, Merrell KT, Cambier JC. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat Immunol. 2005 Nov; 6(11):1160-7. PMID: 16200069.
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Cambier J. Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling. Immunol Rev. 2005 Jun; 205:5-6. PMID: 15882340.
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Lyubchenko T, dal Porto J, Cambier JC, Holers VM. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway. J Immunol. 2005 Mar 15; 174(6):3264-72. PMID: 15749857.
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Gauld SB, Cambier JC. Src-family kinases in B-cell development and signaling. Oncogene. 2004 Oct 18; 23(48):8001-6. PMID: 15489917.
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Isnardi I, Lesourne R, Bruhns P, Fridman WH, Cambier JC, Da?ron M. Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap. J Biol Chem. 2004 Dec 10; 279(50):51931-8. PMID: 15456754.
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Dal Porto JM, Burke K, Cambier JC. Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck. Immunity. 2004 Sep; 21(3):443-53. PMID: 15357954.
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Dal Porto JM, Gauld SB, Merrell KT, Mills D, Pugh-Bernard AE, Cambier J. B cell antigen receptor signaling 101. Mol Immunol. 2004 Jul; 41(6-7):599-613. PMID: 15219998.
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Jordan MB, Mills DM, Kappler J, Marrack P, Cambier JC. Promotion of B cell immune responses via an alum-induced myeloid cell population. Science. 2004 Jun 18; 304(5678):1808-10. PMID: 15205534.
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Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther. 2004; 6(4):131-9. PMID: 15225355.
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Brauweiler AM, Cambier JC. Autonomous SHIP-dependent FcgammaR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death. Immunol Lett. 2004 Mar 29; 92(1-2):75-81. PMID: 15081530.
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Mills DM, Stolpa JC, Cambier JC. Cognate B cell signaling via MHC class II: differential regulation of B cell antigen receptor and MHC class II/Ig-alpha beta signaling by CD22. J Immunol. 2004 Jan 01; 172(1):195-201. PMID: 14688326.
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Mills DM, Cambier JC. B lymphocyte activation during cognate interactions with CD4+ T lymphocytes: molecular dynamics and immunologic consequences. Semin Immunol. 2003 Dec; 15(6):325-9. PMID: 15001171.
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Ott VL, Cambier JC, Kappler J, Marrack P, Swanson BJ. Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol. 2003 Oct; 4(10):974-81. PMID: 12949532.
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Nakamura K, Yube K, Miyatake A, Cambier JC, Hirashima M. Involvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation. Mol Immunol. 2003 May; 39(15):909-21. PMID: 12695117.
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Brauweiler AM, Cambier JC. Fc gamma RIIB activation leads to inhibition of signalling by independently ligated receptors. Biochem Soc Trans. 2003 Feb; 31(Pt 1):281-5. PMID: 12546702.
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Chumley MJ, Dal Porto JM, Cambier JC. The unique antigen receptor signaling phenotype of B-1 cells is influenced by locale but induced by antigen. J Immunol. 2002 Aug 15; 169(4):1735-43. PMID: 12165494.
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Marschner S, H?nig T, Cambier JC, Finkel TH. Ligation of human CD4 interferes with antigen-induced activation of primary T cells. Immunol Lett. 2002 Jun 03; 82(1-2):131-9. PMID: 12008044.
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Gauld SB, Dal Porto JM, Cambier JC. B cell antigen receptor signaling: roles in cell development and disease. Science. 2002 May 31; 296(5573):1641-2. PMID: 12040177.
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Johnson SA, Rozzo SJ, Cambier JC. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol. 2002 May 15; 168(10):5014-23. PMID: 11994453.
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Ott VL, Cambier JC. Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling. Semin Immunol. 2002 Feb; 14(1):1-6. PMID: 11884225.
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Bannish G, Fuentes-Panan? EM, Cambier JC, Pear WS, Monroe JG. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med. 2001 Dec 03; 194(11):1583-96. PMID: 11733573.
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Jensen WA, Marschner S, Ott VL, Cambier JC. FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization. Biochem Soc Trans. 2001 Nov; 29(Pt 6):840-6. PMID: 11709085.
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Brauweiler A, Tamir I, Marschner S, Helgason CD, Cambier JC. Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells. J Immunol. 2001 Jul 01; 167(1):204-11. PMID: 11418650.
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Lang P, Stolpa JC, Freiberg BA, Crawford F, Kappler J, Kupfer A, Cambier JC. TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science. 2001 Feb 23; 291(5508):1537-40. PMID: 11222857.
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Benschop RJ, Aviszus K, Zhang X, Manser T, Cambier JC, Wysocki LJ. Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity. 2001 Jan; 14(1):33-43. PMID: 11163228.
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Fong DC, Brauweiler A, Minskoff SA, Bruhns P, Tamir I, Mellman I, Daeron M, Cambier JC. Mutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling. J Immunol. 2000 Oct 15; 165(8):4453-62. PMID: 11035084.
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Giallourakis C, Kashiwada M, Pan PY, Danial N, Jiang H, Cambier J, Coggeshall KM, Rothman P. Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase. J Biol Chem. 2000 Sep 22; 275(38):29275-82. PMID: 10875931.
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Ott VL, Cambier JC. Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention? J Allergy Clin Immunol. 2000 Sep; 106(3):429-40. PMID: 10984360.
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Buhl AM, Nemazee D, Cambier JC, Rickert R, Hertz M. B-cell antigen receptor competence regulates B-lymphocyte selection and survival. Immunol Rev. 2000 Aug; 176:141-53. PMID: 11043774.
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Kepley CL, Cambier JC, Morel PA, Lujan D, Ortega E, Wilson BS, Oliver JM. Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. J Allergy Clin Immunol. 2000 Aug; 106(2):337-48. PMID: 10932079.
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Brauweiler AM, Tamir I, Cambier JC. Bilevel control of B-cell activation by the inositol 5-phosphatase SHIP. Immunol Rev. 2000 Aug; 176:69-74. PMID: 11043768.
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Tamir I, Dal Porto JM, Cambier JC. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr Opin Immunol. 2000 Jun; 12(3):307-15. PMID: 10781410.
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Chumley MJ, Dal Porto JM, Kawaguchi S, Cambier JC, Nemazee D, Hardy RR. A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro. J Immunol. 2000 May 01; 164(9):4586-93. PMID: 10779761.
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Brauweiler A, Tamir I, Dal Porto J, Benschop RJ, Helgason CD, Humphries RK, Freed JH, Cambier JC. Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med. 2000 May 01; 191(9):1545-54. PMID: 10790429.
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Tamir I, Stolpa JC, Helgason CD, Nakamura K, Bruhns P, Daeron M, Cambier JC. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity. 2000 Mar; 12(3):347-58. PMID: 10755621.
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Nakamura K, Brauweiler A, Cambier JC. Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions. J Immunol. 2000 Jan 15; 164(2):631-8. PMID: 10623804.
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Benschop RJ, Melamed D, Nemazee D, Cambier JC. Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. J Exp Med. 1999 Sep 20; 190(6):749-56. PMID: 10499913.
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Famiglietti SJ, Nakamura K, Cambier JC. Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis. Immunol Lett. 1999 May 03; 68(1):35-40. PMID: 10397153.
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Buhl AM, Cambier JC. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J Immunol. 1999 Apr 15; 162(8):4438-46. PMID: 10201980.
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Benschop RJ, Cambier JC. B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol. 1999 Apr; 11(2):143-51. PMID: 10322153.
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Vilen BJ, Nakamura T, Cambier JC. Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity. 1999 Feb; 10(2):239-48. PMID: 10072076.
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Fong DC, Cambier JC. Inhibitory receptors and their modes of action. Cold Spring Harb Symp Quant Biol. 1999; 64:329-34. PMID: 11232303.
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Cambier JC, Fong D, Tamir I. The unexpected complexity of Fc gamma RIIB signal transduction. Curr Top Microbiol Immunol. 1999; 244:43-55. PMID: 10453648.
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Witter DJ, Famiglietti SJ, Cambier JC, Castelhano AL. Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP. Bioorg Med Chem Lett. 1998 Nov 17; 8(22):3137-42. PMID: 9873691.
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Rozdzial MM, Pleiman CM, Cambier JC, Finkel TH. pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton. J Immunol. 1998 Nov 15; 161(10):5491-9. PMID: 9820525.
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Kouskoff V, Famiglietti S, Lacaud G, Lang P, Rider JE, Kay BK, Cambier JC, Nemazee D. Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J Exp Med. 1998 Oct 19; 188(8):1453-64. PMID: 9782122.
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Venkataraman C, Chelvarajan RL, Cambier JC, Bondada S. Interleukin-4 overcomes the negative influence of cyclic AMP accumulation on antigen receptor stimulated B lymphocytes. Mol Immunol. 1998 Oct; 35(14-15):997-1014. PMID: 9881695.
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Venkataraman C, Lu PJ, Buhl AM, Chen CS, Cambier JC, Bondada S. CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase. Eur J Immunol. 1998 10; 28(10):3003-16. PMID: 9808169.
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Tamir I, Cambier JC. Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene. 1998 Sep 17; 17(11 Reviews):1353-64. PMID: 9779983.
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Nakamura K, Cambier JC. B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation. J Immunol. 1998 Jul 15; 161(2):684-91. PMID: 9670943.
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Pao LI, Famiglietti SJ, Cambier JC. Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction. J Immunol. 1998 Apr 01; 160(7):3305-14. PMID: 9531288.
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Malbec O, Fong DC, Turner M, Tybulewicz VL, Cambier JC, Fridman WH, Da?ron M. Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol. 1998 Feb 15; 160(4):1647-58. PMID: 9469421.
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Melamed D, Benschop RJ, Cambier JC, Nemazee D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell. 1998 Jan 23; 92(2):173-82. PMID: 9458042.
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Buhl AM, Cambier JC. Co-receptor and accessory regulation of B-cell antigen receptor signal transduction. Immunol Rev. 1997 Dec; 160:127-38. PMID: 9476671.
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Buhl AM, Pleiman CM, Rickert RC, Cambier JC. Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med. 1997 Dec 01; 186(11):1897-910. PMID: 9382888.
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Drake JR, Webster P, Cambier JC, Mellman I. Delivery of B cell receptor-internalized antigen to endosomes and class II vesicles. J Exp Med. 1997 Oct 20; 186(8):1299-306. PMID: 9334369.
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V?ly F, Olivero S, Olcese L, Moretta A, Damen JE, Liu L, Krystal G, Cambier JC, Da?ron M, Vivier E. Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. Eur J Immunol. 1997 Aug; 27(8):1994-2000. PMID: 9295037.
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Hippen KL, Buhl AM, D'Ambrosio D, Nakamura K, Persin C, Cambier JC. Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation. Immunity. 1997 Jul; 7(1):49-58. PMID: 9252119.
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Vilen BJ, Famiglietti SJ, Carbone AM, Kay BK, Cambier JC. B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. J Immunol. 1997 Jul 01; 159(1):231-43. PMID: 9200459.
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Cambier JC. Inhibitory receptors abound? Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):5993-5. PMID: 9177155.
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Cambier JC. Positive and negative signal co-operativity in the immune system: the BCR, Fc gamma RIIB, CR2 paradigm. Biochem Soc Trans. 1997 May; 25(2):441-5. PMID: 9191132.
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Pao LI, Cambier JC. Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells. J Immunol. 1997 Mar 15; 158(6):2663-9. PMID: 9058799.
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Jensen WA, Pleiman CM, Beaufils P, Wegener AM, Malissen B, Cambier JC. Qualitatively distinct signaling through T cell antigen receptor subunits. Eur J Immunol. 1997 Mar; 27(3):707-16. PMID: 9079813.
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Pao LI, Bedzyk WD, Persin C, Cambier JC. Molecular targets of CD45 in B cell antigen receptor signal transduction. J Immunol. 1997 Feb 01; 158(3):1116-24. PMID: 9013950.
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Fong DC, Malbec O, Arock M, Cambier JC, Fridman WH, Da?ron M. Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol Lett. 1996 Dec; 54(2-3):83-91. PMID: 9052859.
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D'Ambrosio D, Fong DC, Cambier JC. The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling. Immunol Lett. 1996 Dec; 54(2-3):77-82. PMID: 9052858.
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D'Ambrosio D, Hippen KL, Cambier JC. Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor. Eur J Immunol. 1996 Aug; 26(8):1960-5. PMID: 8765045.
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Makida R, Hofer MF, Takase K, Cambier JC, Leung DY. Bacterial superantigens induce V beta-specific T cell receptor internalization. Mol Immunol. 1996 Jul; 33(10):891-900. PMID: 8845021.
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Olcese L, Lang P, V?ly F, Cambiaggi A, Marguet D, Bl?ry M, Hippen KL, Biassoni R, Moretta A, Moretta L, Cambier JC, Vivier E. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol. 1996 Jun 15; 156(12):4531-4. PMID: 8648092.
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Kurosaki T, Johnson SA, Pao L, Sada K, Yamamura H, Cambier JC. Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med. 1995 Dec 01; 182(6):1815-23. PMID: 7500027.
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Valentine MA, Czernik AJ, Rachie N, Hidaka H, Fisher CL, Cambier JC, Bomsztyk K. Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes. J Exp Med. 1995 Dec 01; 182(6):1943-9. PMID: 7500040.
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Johnson SA, Pleiman CM, Pao L, Schneringer J, Hippen K, Cambier JC. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J Immunol. 1995 Nov 15; 155(10):4596-603. PMID: 7594458.
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Campbell KS, Bedzyk WD, Cambier JC. Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate. Mol Immunol. 1995 Nov; 32(16):1283-94. PMID: 8559152.
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Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol. 1995 Oct 01; 155(7):3281-5. PMID: 7561018.
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Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med. 1995 Jun 01; 181(6):2077-84. PMID: 7539038.
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Davila DR, Davis DP, Campbell K, Cambier JC, Zigmond LA, Burchiel SW. Role of alterations in Ca(2+)-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J Toxicol Environ Health. 1995 Jun; 45(2):101-26. PMID: 7783249.
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D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science. 1995 Apr 14; 268(5208):293-7. PMID: 7716523.
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Cambier JC. New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL) Immunol Today. 1995 Feb; 16(2):110. PMID: 7888063.
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Cambier JC, Johnson SA. Differential binding activity of ARH1/TAM motifs. Immunol Lett. 1995 Jan; 44(2-3):77-80. PMID: 7797258.
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Goldman F, Jensen WA, Johnson GL, Heasley L, Cambier JC. gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J Immunol. 1994 Oct 01; 153(7):2905-17. PMID: 7522245.
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Pleiman CM, D'Ambrosio D, Cambier JC. The B-cell antigen receptor complex: structure and signal transduction. Immunol Today. 1994 Sep; 15(9):393-9. PMID: 7945780.
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Pleiman CM, Abrams C, Gauen LT, Bedzyk W, Jongstra J, Shaw AS, Cambier JC. Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4268-72. PMID: 8183901.
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Clark MR, Johnson SA, Cambier JC. Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J. 1994 Apr 15; 13(8):1911-9. PMID: 8168489.
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Kawauchi K, Lazarus AH, Rapoport MJ, Harwood A, Cambier JC, Delovitch TL. Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor. J Immunol. 1994 Apr 01; 152(7):3306-16. PMID: 7511643.
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Pleiman CM, Hertz WM, Cambier JC. Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science. 1994 Mar 18; 263(5153):1609-12. PMID: 8128248.
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Pleiman CM, Chien NC, Cambier JC. Point mutations define a mIgM transmembrane region motif that determines intersubunit signal transduction in the antigen receptor. J Immunol. 1994 Mar 15; 152(6):2837-44. PMID: 8144885.
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Andr? P, Cambier JC, Wade TK, Raetz T, Wade WF. Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules. J Exp Med. 1994 Feb 01; 179(2):763-8. PMID: 8294884.
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Cambier JC, Jensen WA. The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors. Curr Opin Genet Dev. 1994 Feb; 4(1):55-63. PMID: 8193541.
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Cambier JC, Pleiman CM, Clark MR. Signal transduction by the B cell antigen receptor and its coreceptors. Annu Rev Immunol. 1994; 12:457-86. PMID: 8011288.
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Grupp SA, Campbell K, Mitchell RN, Cambier JC, Abbas AK. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem. 1993 Dec 05; 268(34):25776-9. PMID: 8245014.
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Wade WF, Davoust J, Salamero J, Andr? P, Watts TH, Cambier JC. Structural compartmentalization of MHC class II signaling function. Immunol Today. 1993 Nov; 14(11):539-46. PMID: 8274197.
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Harwood AE, Cambier JC. B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1. J Immunol. 1993 Nov 01; 151(9):4513-22. PMID: 8409414.
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Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. Mol Cell Biol. 1993 Sep; 13(9):5877-87. PMID: 8395016.
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Juan M, Vilella R, Mila J, Yag?e J, Miralles A, Campbell KS, Friedrich RJ, Cambier J, Vives J, De Fougerolles AR, et al. CDw50 and ICAM-3: two names for the same molecule. Eur J Immunol. 1993 Jul; 23(7):1508-12. PMID: 8325327.
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Friedrich RJ, Campbell KS, Cambier JC. The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene. J Immunol. 1993 Apr 01; 150(7):2814-22. PMID: 8454858.
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Cambier JC, Bedzyk W, Campbell K, Chien N, Friedrich J, Harwood A, Jensen W, Pleiman C, Clark MR. The B-cell antigen receptor: structure and function of primary, secondary, tertiary and quaternary components. Immunol Rev. 1993 Apr; 132:85-106. PMID: 8349299.
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Clark MR, Friedrich RJ, Campbell KS, Cambier JC. Human pre-B and B cell membrane mu-chains are noncovalently associated with a disulfide-linked complex containing a product of the B29 gene. J Immunol. 1992 Nov 01; 149(9):2857-63. PMID: 1401917.
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Clark MR, Campbell KS, Kazlauskas A, Johnson SA, Hertz M, Potter TA, Pleiman C, Cambier JC. The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science. 1992 Oct 02; 258(5079):123-6. PMID: 1439759.
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Cambier JC, Campbell KS. Membrane immunoglobulin and its accomplices: new lessons from an old receptor. FASEB J. 1992 Oct; 6(13):3207-17. PMID: 1397843.
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Cambier JC. Signal transduction by T- and B-cell antigen receptors: converging structures and concepts. Curr Opin Immunol. 1992 Jun; 4(3):257-64. PMID: 1418703.
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Kansas GS, Cambier JC, Tedder TF. CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes. Eur J Immunol. 1992 Jan; 22(1):147-52. PMID: 1730248.
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Wysocki LJ, Creadon G, Lehmann KR, Cambier JC. B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro. Immunology. 1992 Jan; 75(1):116-21. PMID: 1537587.
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Campbell KS, Hager EJ, Cambier JC. Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J Immunol. 1991 Sep 01; 147(5):1575-80. PMID: 1880417.
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Blackman MA, Finkel TH, Kappler J, Cambier J, Marrack P. Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6682-6. PMID: 1907374.
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Hauschildt S, L?ckhoff A, Langhorne J, Wiesm?ller KH, Jung G, Bessler W, Cambier JC. Increase in the intracellular free calcium concentration is not an obligatory early event in lipopeptide-induced B-cell activation. Immunology. 1991 Jul; 73(3):366-8. PMID: 1879881.
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Justement LB, Campbell KS, Chien NC, Cambier JC. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science. 1991 Jun 28; 252(5014):1839-42. PMID: 1648262.
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Reth M, Hombach J, Wienands J, Campbell KS, Chien N, Justement LB, Cambier JC. The B-cell antigen receptor complex. Immunol Today. 1991 Jun; 12(6):196-201. PMID: 1878135.
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Campbell KS, Hager EJ, Friedrich RJ, Cambier JC. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3982-6. PMID: 2023945.
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Cambier JC, Morrison DC, Chien MM, Lehmann KR. Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking. J Immunol. 1991 Apr 01; 146(7):2075-82. PMID: 1848577.
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Fisher CL, Ghysdael J, Cambier JC. Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1. J Immunol. 1991 Mar 15; 146(6):1743-9. PMID: 1900874.
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Finkel TH, Kubo RT, Cambier JC. T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor. Immunol Today. 1991 Feb; 12(2):79-85. PMID: 1829360.
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Cambier JC. Capturing antigen receptor components. Curr Biol. 1991 Feb; 1(1):25-7. PMID: 15336198.
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Rijkers GT, Griffioen AW, Zegers BJ, Cambier JC. Ligation of membrane immunoglobulin leads to inactivation of the signal-transducing ability of membrane immunoglobulin, CD19, CD21, and B-cell gp95. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8766-70. PMID: 1701054.
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Cambier JC, Fisher CL, Pickles H, Morrison DC. Dual molecular mechanisms mediate ligand-induced membrane Ig desensitization. J Immunol. 1990 Jul 01; 145(1):13-9. PMID: 2113552.
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Chien MM, Cambier JC. Divalent cation regulation of phosphoinositide metabolism. Naturally occurring B lymphoblasts contain a Mg2(+)-regulated phosphatidylinositol-specific phospholipase C. J Biol Chem. 1990 Jun 05; 265(16):9201-7. PMID: 2160965.
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Gallagher RB, Cambier JC. Signal transmission pathways and lymphocyte function. Immunol Today. 1990 Jun; 11(6):187-9. PMID: 2162179.
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Justement LB, Wienands J, Hombach J, Reth M, Cambier JC. Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells. J Immunol. 1990 May 01; 144(9):3272-80. PMID: 2109774.
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Cambier JC, Campbell KS. Signal transduction by B lymphocyte receptors: structure-function relationships of membrane immunoglobulins and associated molecules. Semin Immunol. 1990 Mar; 2(2):139-49. PMID: 1966612.
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Campbell KS, Cambier JC. B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J. 1990 Feb; 9(2):441-8. PMID: 2154371.
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Cross D, Cambier JC. Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression. J Immunol. 1990 Jan 15; 144(2):432-9. PMID: 1688578.
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Finkel TH, Cambier JC, Kubo RT, Born WK, Marrack P, Kappler JW. The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell. 1989 Sep 22; 58(6):1047-54. PMID: 2673539.
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Cambier JC. Transmembrane signaling in T lymphocyte dependent B lymphocyte activation. Semin Immunol. 1989 Sep; 1(1):43-54. PMID: 15630958.
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Cambier JC, Lehmann KR. Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J Exp Med. 1989 Sep 01; 170(3):877-86. PMID: 2788709.
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Wade WF, Chen ZZ, Maki R, McKercher S, Palmer E, Cambier JC, Freed JH. Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6297-301. PMID: 2503831.
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Klemsz MJ, Justement LB, Palmer E, Cambier JC. Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands. J Immunol. 1989 Aug 01; 143(3):1032-9. PMID: 2787345.
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Justement LB, Kreiger J, Cambier JC. Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig. J Immunol. 1989 Aug 01; 143(3):881-9. PMID: 2663989.
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Finkel TH, Marrack P, Kappler JW, Kubo RT, Cambier JC. Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance. J Immunol. 1989 May 01; 142(9):3006-12. PMID: 2523422.
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Marrack P, Blackman M, Burgert HG, McCormack JM, Cambier J, Finkel TH, Kappler J. T-cell repertoire and thymus. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:105-10. PMID: 2639749.
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Chien MM, Cambier JC. Measurement of phosphoinositide hydrolysis in isolated cell membrane preparations. Methods Enzymol. 1989; 168:338-47. PMID: 2542728.
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Cambier J. Lymphocyte subsets and activation. Curr Opin Immunol. 1988 Dec; 1(2):220-7. PMID: 2978539.
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Caldwell KK, Newell MK, Cambier JC, Prasad KN, Masserano JM, Schlegel W, Cooper DM. Evaluation of methods for the isolation of plasma membranes displaying guanosine 5'-triphosphate-dependence for the regulation of adenylate cyclase activity: potential application to the study of other guanosine 5'-triphosphate-dependent transduction systems. Anal Biochem. 1988 Nov 15; 175(1):177-90. PMID: 3245566.
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Cambier J, Chen ZZ, Pasternak J, Ransom J, Sandoval V, Pickles H. Ligand-induced desensitization of B-cell membrane immunoglobulin-mediated Ca2+ mobilization and protein kinase C translocation. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6493-7. PMID: 3045817.
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Ransom JT, Chen M, Sandoval VM, Pasternak JA, Digiusto D, Cambier JC. Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis. J Immunol. 1988 May 01; 140(9):3150-5. PMID: 2834453.
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Cambier JC, Julius MH. Early changes in quiescent B cell physiology subsequent to cognate and bystander interaction with helper T cells. Scand J Immunol. 1988 Jan; 27(1):59-71. PMID: 2963373.
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Ransom JT, Cambier JC. The dynamics and relationship of K+ efflux and Ca++ influx in B lymphocytes after antigen-receptor cross-linking. Soc Gen Physiol Ser. 1988; 43:241-51. PMID: 3269025.
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Finkel TH, McDuffie M, Kappler JW, Marrack P, Cambier JC. Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature. 1987 Nov 12-18; 330(6144):179-81. PMID: 3499573.
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Harris LK, Cambier JC. B lymphocyte activation. Transmembrane signal transduction by membrane immunoglobulin in isolated cell membranes. J Immunol. 1987 Aug 01; 139(3):963-70. PMID: 3036948.
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Cambier JC, Newell MK, Justement LB, McGuire JC, Leach KL, Chen ZZ. Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature. 1987 Jun 18-24; 327(6123):629-32. PMID: 3037375.
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Chen ZZ, McGuire JC, Leach KL, Cambier JC. Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction. J Immunol. 1987 Apr 01; 138(7):2345-52. PMID: 3494063.
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Julius MH, Paige CJ, Leanderson T, Cambier JC. Neither interleukin 2 nor gamma interferon directly promote growth or differentiation of mouse B cells. Scand J Immunol. 1987 Feb; 25(2):195-202. PMID: 3103206.
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Cambier JC, Justement LB, Newell MK, Chen ZZ, Harris LK, Sandoval VM, Klemsz MJ, Ransom JT. Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation. Immunol Rev. 1987 Feb; 95:37-57. PMID: 2437013.
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Cambier JC, Ransom JT, Harris LK, Coggeshall KM, Chen ZZ, Newell MK, Justement LB. Coupling of B cell surface Ig, Ia and BSF1 receptors to intracellular "second messengers". Adv Exp Med Biol. 1987; 213:195-205. PMID: 2820209.
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Cambier JC, Ransom JT. Molecular mechanisms of transmembrane signaling in B lymphocytes. Annu Rev Immunol. 1987; 5:175-99. PMID: 2439102.
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Cambier JC, Chen ZZ, Ransom JT, Coggeshall KM, Klemsz MJ, Harris LK, Sandoval VM, Newell MK. Differential transmembrane signaling in B lymphocyte activation. Ann N Y Acad Sci. 1987; 494:52-64. PMID: 3037967.
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Ransom JT, DiGiusto DL, Cambier J. Flow cytometric analysis of intracellular calcium mobilization. Methods Enzymol. 1987; 141:53-63. PMID: 3496517.
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Justement L, Chen Z, Harris L, Ransom J, Sandoval V, Smith C, Rennick D, Roehm N, Cambier J. BSF1 induces membrane protein phosphorylation but not phosphoinositide metabolism, Ca2+ mobilization, protein kinase C translocation, or membrane depolarization in resting murine B lymphocytes. J Immunol. 1986 Dec 01; 137(11):3664-70. PMID: 3023486.
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Ransom JT, Harris LK, Cambier JC. Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes. J Immunol. 1986 Jul 15; 137(2):708-14. PMID: 3014002.
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Cambier JC, Heusser CH, Julius MH. Abortive activation of B lymphocytes by monoclonal anti-immunoglobulin antibodies. J Immunol. 1986 May 01; 136(9):3140-6. PMID: 3485681.
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Carotenuto P, Pontesilli O, Cambier JC, Hayward AR. Desferoxamine blocks IL 2 receptor expression on human T lymphocytes. J Immunol. 1986 Apr 01; 136(7):2342-7. PMID: 3005409.
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Chen ZZ, Coggeshall KM, Cambier JC. Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J Immunol. 1986 Mar 15; 136(6):2300-4. PMID: 3005408.
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Leclercq L, Cambier JC, Mishal Z, Julius MH, Theze J. Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis, and progression through cell cycle. J Immunol. 1986 Jan; 136(2):539-45. PMID: 2416811.
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Ransom JT, Cambier JC. B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression. J Immunol. 1986 Jan; 136(1):66-72. PMID: 3079612.
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Ransom JT, DiGiusto DL, Cambier JC. Single cell analysis of calcium mobilization in anti-immunoglobulin-stimulated B lymphocytes. J Immunol. 1986 Jan; 136(1):54-7. PMID: 2415629.
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Jakoi ER, Cambier J, Saslow S. Transepithelial transport of maternal antibody: purification of IgG receptor from newborn rat intestine. J Immunol. 1985 Nov; 135(5):3360-4. PMID: 2931482.
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Butler JE, Cambier JC, Klobasa F. Identification and characterization of a hapten-modifiable TEPC 15 cross-reactive idiotype in swine. Mol Immunol. 1985 Oct; 22(10):1159-68. PMID: 2417108.
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Cambier JC, Monroe JG, Mark Coggeshall K, Ransom JT. The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin. Immunol Today. 1985 Jul; 6(7):218-22. PMID: 25290184.
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Monroe JG, Cambier JC, Mody EA, Pisetsky DS. Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. Clin Immunol Immunopathol. 1985 Jan; 34(1):124-9. PMID: 3871181.
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Coggeshall KM, Cambier JC. B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg. J Immunol. 1985 Jan; 134(1):101-7. PMID: 2981089.
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Coggeshall KM, Cambier JC. B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis. J Immunol. 1984 Dec; 133(6):3382-6. PMID: 6092473.
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Roehm N, Herron L, Cambier J, DiGuisto D, Haskins K, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell. 1984 Sep; 38(2):577-84. PMID: 6331891.
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Roehm NW, Leibson HJ, Zlotnik A, Kappler J, Marrack P, Cambier JC. Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med. 1984 Sep 01; 160(3):679-94. PMID: 6432933.
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Cambier JC, Monroe JG. B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies. J Immunol. 1984 Aug; 133(2):576-81. PMID: 6610706.
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Havran WL, DiGiusto DL, Cambier JC. mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10-fold on most splenic B cells. J Immunol. 1984 Apr; 132(4):1712-6. PMID: 6421926.
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Monroe JG, Niedel JE, Cambier JC. B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. J Immunol. 1984 Mar; 132(3):1472-8. PMID: 6229582.
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Monroe JG, Cambier JC. B cell activation. II. Receptor cross-linking by thymus-independent and thymus-dependent antigens induces a rapid decrease in the plasma membrane potential of antigen-binding B lymphocytes. J Immunol. 1983 Dec; 131(6):2641-4. PMID: 6196393.
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Monroe JG, Cambier JC. B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled. J Exp Med. 1983 Nov 01; 158(5):1589-99. PMID: 6415207.
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Monroe JG, Cambier JC. Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle. J Immunol Methods. 1983 Sep 30; 63(1):45-56. PMID: 6604756.
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Monroe JG, Cambier JC. B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes. J Exp Med. 1983 Jun 01; 157(6):2073-86. PMID: 6602204.
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Elkins K, Cambier JC. Constitutive production of a factor supporting B lymphocyte differentiation by a T cell hybridoma. J Immunol. 1983 Mar; 130(3):1247-51. PMID: 6337214.
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Monroe JG, Havran WL, Cambier JC. B lymphocyte activation: entry into cell cycle is accompanied by decreased expression of IgD but not IgM. Eur J Immunol. 1983 Mar; 13(3):208-13. PMID: 6601015.
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Monroe JG, Cambier JC. Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. J Immunol. 1983 Feb; 130(2):626-31. PMID: 6600247.
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Elkins K, Cambier J. Nonspecific lymphokines derived from monoclonal T cell lines in primary B cell immune responses. Lymphokine Res. 1983; 2(4):119-25. PMID: 6332247.
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Cambier JC, Monroe JG. Flow cytometry as an analytic and preparative tool for studies of neuroendocrine function. Methods Enzymol. 1983; 103:227-45. PMID: 6199646.
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Cambier JC, Monroe JG, Neale MJ. Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells. J Exp Med. 1982 Dec 01; 156(6):1635-49. PMID: 6184434.
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Monroe JG, Havran WL, Cambier JC. Enrichment of viable lymphocytes in defined cycle phases by sorting on the basis of pulse width of axial light extinction. Cytometry. 1982 Jul; 3(1):24-7. PMID: 6180872.
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Cambier JC, Neale MJ. Isolated phosphorylcholine binding lymphocytes. I. Use of a cleavable crosslinking reagent for solid-phase adsorbent isolation of functional antigen binding cells. J Immunol Methods. 1982 Jun 11; 51(2):209-21. PMID: 6809832.
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Monroe JG, Cambier JC. Cell cycle dependence for expression of membrane associated IgD, IgM and Ia antigen on mitogen-stimulated murine B-lymphocytes. Ann N Y Acad Sci. 1982; 399:238-54. PMID: 6984607.
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Cambier JC, Havran WL, Fern?ndez de Albornoz T, Corley RB. Identification of a brain theta-positive, secretory cell from hematopoietic tissues. J Immunol. 1981 Oct; 127(4):1685-91. PMID: 7196931.
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Cambier JC, Corley RB. The effect of second signals on the induction of B cell tolerance: failure of helper T cells to block tolerance induction. Eur J Immunol. 1981 Jul; 11(7):550-6. PMID: 6169534.
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Cambier JC, Neale MJ. Induction of clonally restricted thymus-dependent antibody responses in vitro using phosphorylcholine derivatized sheep erythrocytes. J Immunol Methods. 1980; 38(3-4):231-8. PMID: 7003017.
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Kettman JR, Cambier JC, Uhr JW, Ligler F, Vitetta ES. The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells. Immunol Rev. 1979; 43:69-95. PMID: 83290.
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Dehen H, Willer JC, Prier S, Boureau F, Cambier J. Congenital insensitivity to pain and the "morphine-like" analgesic system. Pain. 1978 Dec; 5(4):351-358. PMID: 84372.
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Ligler FS, Cambier JC, Vitetta ES, Kettman JR, Uhr JW. Inactivation of antigen-responsive clones with antisera specific for IgM or IgD. J Immunol. 1978 Apr; 120(4):1139-42. PMID: 305934.
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Cambier JC, Ligler FS, Uhr JW, Kettman JR, Vitetta ES. Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD. Proc Natl Acad Sci U S A. 1978 Jan; 75(1):432-5. PMID: 305047.
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Vitetta ES, Cambier JC, Ligler FS, Kettman JR, Uhr JW. B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells. J Exp Med. 1977 Dec 01; 146(6):1804-8. PMID: 303688.
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Cambier JC, Uhr JW, Kettman JR, Vitetta ES. B cell tolerance. I. Analysis of hapten-specific unresponsiveness induced in vitro in adult and neonatal murine spleen cell populations. J Immunol. 1977 Dec; 119(6):2054-9. PMID: 72117.
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Cambier JC, Vitetta ES, Kettman JR, Wetzel GM, Uhr JW. B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells. J Exp Med. 1977 Jul 01; 146(1):107-17. PMID: 68987.
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Cambier JC, Vitetta ES, Uhr JW, Kettman JR. B-cell tolerance. II. Trinitrophenyl human gamma globulin-induced tolerance in adult and neonatal murine B cells responsive to thymus-dependent and independent forms of the same hapten. J Exp Med. 1977 Mar 01; 145(3):778-83. PMID: 95788.
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Vitetta ES, Cambier J, Forman J, Kettman JR, Yuan D, Uhr JW. Immunoglobulin receptors on murine B lymphocytes. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:185-91. PMID: 302188.
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Cambier JC, Kettman JR, Vitetta ES, Uhr JW. Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance. J Exp Med. 1976 Jul 01; 144(1):293-7. PMID: 1084409.
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Cambier JC, Butler JE. Two immunochemically and physicochemically distinct secretory components from rat exocrine secretion. J Immunol. 1976 Apr; 116(4):994-9. PMID: 815439.
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1994 | 10 | 1995 | 10 | 1996 | 5 | 1997 | 11 | 1998 | 10 | 1999 | 7 | 2000 | 11 | 2001 | 5 | 2002 | 5 | 2003 | 4 | 2004 | 8 | 2005 | 3 | 2006 | 4 | 2007 | 8 | 2008 | 5 | 2009 | 7 | 2010 | 5 | 2011 | 8 | 2012 | 7 | 2013 | 7 | 2014 | 8 | 2015 | 4 | 2016 | 6 | 2017 | 5 | 2018 | 8 | 2019 | 6 | 2020 | 3 | 2021 | 1 |
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