JamesMillerJames York E Miller39.74515960000000-104.8406280000000059Miller, JamesLung cancerChempreventionPremalignancyYork E303/399-8020Professor-Clinicalprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:descriptiondescriptionDivisionvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson26542061Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA, Franklin WACancer prevention research (Philadelphia, Pa.)Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA, Franklin WA. Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2016 Jan; 9(1):96-104.Cancer Prev Res (Phila)2015-11-05T00:00:002015Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma.9329980Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YEThe Journal of clinical investigationFranklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE. Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. J Clin Invest. 1997 Oct 15; 100(8):2133-7.J Clin Invest1997-10-15T00:00:001997Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.9559343Cook RM, Franklin WA, Moore MD, Johnson BE, Miller YEGenes, chromosomes & cancerCook RM, Franklin WA, Moore MD, Johnson BE, Miller YE. Mutational inactivation of aminoacylase-I in a small cell lung cancer cell line. Genes Chromosomes Cancer. 1998 Apr; 21(4):320-5.Genes Chromosomes Cancer1998-04-01T00:00:001998Mutational inactivation of aminoacylase-I in a small cell lung cancer cell line.8117451Geraci MW, Miller YE, Escobedo-Morse A, Kane MAAmerican journal of respiratory cell and molecular biologyGeraci MW, Miller YE, Escobedo-Morse A, Kane MA. Novel bombesin-like peptide binding proteins from lung. Am J Respir Cell Mol Biol. 1994 Mar; 10(3):331-8.Am J Respir Cell Mol Biol1994-03-01T00:00:001994Novel bombesin-like peptide binding proteins from lung.10815878Keith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Kennedy TC, Prindiville S, Franklin WAClinical cancer research : an official journal of the American Association for Cancer ResearchKeith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Kennedy TC, Prindiville S, Franklin WA. Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res. 2000 May; 6(5):1616-25.Clin Cancer Res2000-05-01T00:00:002000Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer.8598132Cohen AJ, Gilman LB, Moore M, Franklin WA, Miller YEChestCohen AJ, Gilman LB, Moore M, Franklin WA, Miller YE. Inactivation of neutral endopeptidase in lung cancer. Chest. 1996 Mar; 109(3 Suppl):12S-13S.Chest1996-03-01T00:00:001996Inactivation of neutral endopeptidase in lung cancer.11830527Keith RL, Miller YE, Hoshikawa Y, Moore MD, Gesell TL, Gao B, Malkinson AM, Golpon HA, Nemenoff RA, Geraci MWCancer researchKeith RL, Miller YE, Hoshikawa Y, Moore MD, Gesell TL, Gao B, Malkinson AM, Golpon HA, Nemenoff RA, Geraci MW. Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Cancer Res. 2002 Feb 01; 62(3):734-40.Cancer Res2002-02-01T00:00:002002Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer.AshleighMorganAshleigh Morgan39.74515960000000-104.8406280000000012328Morgan, AshleighInstructor9829752Bunn PA, Helfrich BA, Brenner DG, Chan DC, Dykes DJ, Cohen AJ, Miller YEClinical cancer research : an official journal of the American Association for Cancer ResearchBunn PA, Helfrich BA, Brenner DG, Chan DC, Dykes DJ, Cohen AJ, Miller YE. Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo. Clin Cancer Res. 1998 Nov; 4(11):2849-58.Clin Cancer Res1998-11-01T00:00:001998Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo.14578133Prindiville SA, Byers T, Hirsch FR, Franklin WA, Miller YE, Vu KO, Wolf HJ, Bar?n AE, Shroyer KR, Zeng C, Kennedy TC, Bunn PACancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyPrindiville SA, Byers T, Hirsch FR, Franklin WA, Miller YE, Vu KO, Wolf HJ, Bar?n AE, Shroyer KR, Zeng C, Kennedy TC, Bunn PA. Sputum cytological atypia as a predictor of incident lung cancer in a cohort of heavy smokers with airflow obstruction. Cancer Epidemiol Biomarkers Prev. 2003 Oct; 12(10):987-93.Cancer Epidemiol Biomarkers Prev2003-10-01T00:00:002003Sputum cytological atypia as a predictor of incident lung cancer in a cohort of heavy smokers with airflow obstruction.5Other Faculty1Professor3Asst Professor2Assoc Professor4Instructor15350627Varella-Garcia M, Kittelson J, Schulte AP, Vu KO, Wolf HJ, Zeng C, Hirsch FR, Byers T, Kennedy T, Miller YE, Keith RL, Franklin WACancer detection and preventionVarella-Garcia M, Kittelson J, Schulte AP, Vu KO, Wolf HJ, Zeng C, Hirsch FR, Byers T, Kennedy T, Miller YE, Keith RL, Franklin WA. Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer. Cancer Detect Prev. 2004; 28(4):244-51.Cancer Detect Prev2004-01-01T00:00:002004Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer.15777969Merrick DT, Haney J, Petrunich S, Sugita M, Miller YE, Keith RL, Kennedy TC, Franklin WALung cancer (Amsterdam, Netherlands)Merrick DT, Haney J, Petrunich S, Sugita M, Miller YE, Keith RL, Kennedy TC, Franklin WA. Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis. Lung Cancer. 2005 Apr; 48(1):31-45.Lung Cancer2005-04-01T00:00:002005Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis.17600274Varella-Garcia M, Chen L, Powell RL, Hirsch FR, Kennedy TC, Keith R, Miller YE, Mitchell JD, Franklin WAAmerican journal of respiratory and critical care medicineVarella-Garcia M, Chen L, Powell RL, Hirsch FR, Kennedy TC, Keith R, Miller YE, Mitchell JD, Franklin WA. Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer. Am J Respir Crit Care Med. 2007 Sep 01; 176(5):505-12.Am J Respir Crit Care Med2007-06-28T00:00:002007Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer.17989344Jonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL, Bjornsson J, McWilliams A, Lam S, Hirsch FR, Franklin WAAmerican journal of respiratory and critical care medicineJonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL, Bjornsson J, McWilliams A, Lam S, Hirsch FR, Franklin WA. Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer. Am J Respir Crit Care Med. 2008 Feb 01; 177(3):342-7.Am J Respir Crit Care Med2007-11-07T00:00:002007Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer.19096306Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar AJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerEdell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A. Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. J Thorac Oncol. 2009 Jan; 4(1):49-54.J Thorac Oncol2009-01-01T00:00:002009Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial.10424594Girod CE, Shin DH, Geraci MW, Warren HB, Dobbs LG, Gao B, Rainer JS, Bauer AK, Ikegami M, Shannon JM, Miller YEChestGirod CE, Shin DH, Geraci MW, Warren HB, Dobbs LG, Gao B, Rainer JS, Bauer AK, Ikegami M, Shannon JM, Miller YE. Surfactant protein C promoter-driven expression of T1-alpha induces lung inflammation. Chest. 1999 Jul; 116(1 Suppl):61S.Chest1999-07-01T00:00:001999Surfactant protein C promoter-driven expression of T1-alpha induces lung inflammation.21170350Ostroff RM, Bigbee WL, Franklin W, Gold L, Mehan M, Miller YE, Pass HI, Rom WN, Siegfried JM, Stewart A, Walker JJ, Weissfeld JL, Williams S, Zichi D, Brody ENPloS oneOstroff RM, Bigbee WL, Franklin W, Gold L, Mehan M, Miller YE, Pass HI, Rom WN, Siegfried JM, Stewart A, Walker JJ, Weissfeld JL, Williams S, Zichi D, Brody EN. Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. PLoS One. 2010 Dec 07; 5(12):e15003.PLoS One2010-12-07T00:00:002010Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.21303977Rafnar T, Sulem P, Besenbacher S, Gudbjartsson DF, Zanon C, Gudmundsson J, Stacey SN, Kostic JP, Thorgeirsson TE, Thorleifsson G, Bjarnason H, Skuladottir H, Gudbjartsson T, Isaksson HJ, Isla D, Murillo L, Garc?a-Prats MD, Panadero A, Aben KK, Vermeulen SH, van der Heijden HF, Feser WJ, Miller YE, Bunn PA, Kong A, Wolf HJ, Franklin WA, Mayordomo JI, Kiemeney LA, Jonsson S, Thorsteinsdottir U, Stefansson KCancer researchRafnar T, Sulem P, Besenbacher S, Gudbjartsson DF, Zanon C, Gudmundsson J, Stacey SN, Kostic JP, Thorgeirsson TE, Thorleifsson G, Bjarnason H, Skuladottir H, Gudbjartsson T, Isaksson HJ, Isla D, Murillo L, Garc?a-Prats MD, Panadero A, Aben KK, Vermeulen SH, van der Heijden HF, Feser WJ, Miller YE, Bunn PA, Kong A, Wolf HJ, Franklin WA, Mayordomo JI, Kiemeney LA, Jonsson S, Thorsteinsdottir U, Stefansson K. Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. Cancer Res. 2011 Feb 15; 71(4):1356-61.Cancer Res2011-02-08T00:00:002011Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk.21636546Keith RL, Blatchford PJ, Kittelson J, Minna JD, Kelly K, Massion PP, Franklin WA, Mao J, Wilson DO, Merrick DT, Hirsch FR, Kennedy TC, Bunn PA, Geraci MW, Miller YECancer prevention research (Philadelphia, Pa.)Keith RL, Blatchford PJ, Kittelson J, Minna JD, Kelly K, Massion PP, Franklin WA, Mao J, Wilson DO, Merrick DT, Hirsch FR, Kennedy TC, Bunn PA, Geraci MW, Miller YE. Oral iloprost improves endobronchial dysplasia in former smokers. Cancer Prev Res (Phila). 2011 Jun; 4(6):793-802.Cancer Prev Res (Phila)2011-06-01T00:00:002011Oral iloprost improves endobronchial dysplasia in former smokers.22003147Coldren CD, Miller YEAmerican journal of respiratory and critical care medicineColdren CD, Miller YE. Progressive endobronchial premalignancy: marked by original CIN. Am J Respir Crit Care Med. 2011 Oct 15; 184(8):869-70.Am J Respir Crit Care Med2011-10-15T00:00:002011Progressive endobronchial premalignancy: marked by original CIN.12409588Garg K, Keith RL, Byers T, Kelly K, Kerzner AL, Lynch DA, Miller YERadiologyGarg K, Keith RL, Byers T, Kelly K, Kerzner AL, Lynch DA, Miller YE. Randomized controlled trial with low-dose spiral CT for lung cancer screening: feasibility study and preliminary results. Radiology. 2002 Nov; 225(2):506-10.Radiology2002-11-01T00:00:002002Randomized controlled trial with low-dose spiral CT for lung cancer screening: feasibility study and preliminary results.22929969Peled N, Hakim M, Bunn PA, Miller YE, Kennedy TC, Mattei J, Mitchell JD, Hirsch FR, Haick HJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerPeled N, Hakim M, Bunn PA, Miller YE, Kennedy TC, Mattei J, Mitchell JD, Hirsch FR, Haick H. Non-invasive breath analysis of pulmonary nodules. J Thorac Oncol. 2012 Oct; 7(10):1528-33.J Thorac Oncol2012-10-01T00:00:002012Non-invasive breath analysis of pulmonary nodules.23689750Keith RL, Miller YENature reviews. Clinical oncologyKeith RL, Miller YE. Lung cancer chemoprevention: current status and future prospects. Nat Rev Clin Oncol. 2013 Jun; 10(6):334-43.Nat Rev Clin Oncol2013-05-21T00:00:002013Lung cancer chemoprevention: current status and future prospects.8631021Cohen AJ, Bunn PA, Franklin W, Magill-Solc C, Hartmann C, Helfrich B, Gilman L, Folkvord J, Helm K, Miller YECancer researchCohen AJ, Bunn PA, Franklin W, Magill-Solc C, Hartmann C, Helfrich B, Gilman L, Folkvord J, Helm K, Miller YE. Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux. Cancer Res. 1996 Feb 15; 56(4):831-9.Cancer Res1996-02-15T00:00:001996Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux.11562389Hirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA, Kennedy TCJournal of the National Cancer InstituteHirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA, Kennedy TC. Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study. J Natl Cancer Inst. 2001 Sep 19; 93(18):1385-91.J Natl Cancer Inst2001-09-19T00:00:002001Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study.15182282Fessler MB, Cool CD, Miller YE, Schwarz MI, Brown KKRespirology (Carlton, Vic.)Fessler MB, Cool CD, Miller YE, Schwarz MI, Brown KK. Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly. Respirology. 2004 Jun; 9(2):274-7.Respirology2004-06-01T00:00:002004Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly.15313935Keith RL, Miller YE, Hudish TM, Girod CE, Sotto-Santiago S, Franklin WA, Nemenoff RA, March TH, Nana-Sinkam SP, Geraci MWCancer researchKeith RL, Miller YE, Hudish TM, Girod CE, Sotto-Santiago S, Franklin WA, Nemenoff RA, March TH, Nana-Sinkam SP, Geraci MW. Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Cancer Res. 2004 Aug 15; 64(16):5897-904.Cancer Res2004-08-15T00:00:002004Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice.18006932Miller YE, Blatchford P, Hyun DS, Keith RL, Kennedy TC, Wolf H, Byers T, Bunn PA, Lewis MT, Franklin WA, Hirsch FR, Kittelson JCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyMiller YE, Blatchford P, Hyun DS, Keith RL, Kennedy TC, Wolf H, Byers T, Bunn PA, Lewis MT, Franklin WA, Hirsch FR, Kittelson J. Bronchial epithelial Ki-67 index is related to histology, smoking, and gender, but not lung cancer or chronic obstructive pulmonary disease. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2425-31.Cancer Epidemiol Biomarkers Prev2007-11-01T00:00:002007Bronchial epithelial Ki-67 index is related to histology, smoking, and gender, but not lung cancer or chronic obstructive pulmonary disease.18199720Byers T, Wolf HJ, Franklin WA, Braudrick S, Merrick DT, Shroyer KR, Hirsch FR, Zeng C, Bar?n AE, Bunn PA, Miller YE, Kennedy TCCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyByers T, Wolf HJ, Franklin WA, Braudrick S, Merrick DT, Shroyer KR, Hirsch FR, Zeng C, Bar?n AE, Bunn PA, Miller YE, Kennedy TC. Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity. Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):158-62.Cancer Epidemiol Biomarkers Prev2008-01-01T00:00:002008Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity.19547694Massion PP, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR, Miller YE, Franklin WA, Varella-Garcia MPloS oneMassion PP, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR, Miller YE, Franklin WA, Varella-Garcia M. Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS One. 2009 Jun 09; 4(6):e5611.PLoS One2009-06-09T00:00:002009Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer.20332298Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin X, Hirsch FR, Kennedy TC, Keith RL, Bar?n AE, Belinsky SA, Miller YE, Byers T, Franklin WACancer prevention research (Philadelphia, Pa.)Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin X, Hirsch FR, Kennedy TC, Keith RL, Bar?n AE, Belinsky SA, Miller YE, Byers T, Franklin WA. The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence. Cancer Prev Res (Phila). 2010 Apr; 3(4):447-53.Cancer Prev Res (Phila)2010-03-23T00:00:002010The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence.20647338Karoor V, Le M, Merrick D, Dempsey EC, Miller YECancer prevention research (Philadelphia, Pa.)Karoor V, Le M, Merrick D, Dempsey EC, Miller YE. Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors. Cancer Prev Res (Phila). 2010 Sep; 3(9):1141-7.Cancer Prev Res (Phila)2010-07-20T00:00:002010Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors.19401528Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Lewis M, Jackson MK, Hirsch FR, Bunn PA, Miller YECancer prevention research (Philadelphia, Pa.)Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Lewis M, Jackson MK, Hirsch FR, Bunn PA, Miller YE. A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer. Cancer Prev Res (Phila). 2009 May; 2(5):440-9.Cancer Prev Res (Phila)2009-04-28T00:00:002009A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer.22700853Karoor V, Le M, Merrick D, Fagan KA, Dempsey EC, Miller YECancer prevention research (Philadelphia, Pa.)Karoor V, Le M, Merrick D, Fagan KA, Dempsey EC, Miller YE. Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism. Cancer Prev Res (Phila). 2012 Aug; 5(8):1061-71.Cancer Prev Res (Phila)2012-06-14T00:00:002012Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism.23268837Mascaux C, Feser WJ, Lewis MT, Bar?n AE, Coldren CD, Merrick DT, Kennedy TC, Eckelberger JI, Rozeboom LM, Franklin WA, Minna JD, Bunn PA, Miller YE, Keith RL, Hirsch FRCancer prevention research (Philadelphia, Pa.)Mascaux C, Feser WJ, Lewis MT, Bar?n AE, Coldren CD, Merrick DT, Kennedy TC, Eckelberger JI, Rozeboom LM, Franklin WA, Minna JD, Bunn PA, Miller YE, Keith RL, Hirsch FR. Endobronchial miRNAs as biomarkers in lung cancer chemoprevention. Cancer Prev Res (Phila). 2013 Feb; 6(2):100-8.Cancer Prev Res (Phila)2012-12-26T00:00:002012Endobronchial miRNAs as biomarkers in lung cancer chemoprevention.29211494Ghosh M, Miller YE, Nakachi I, Kwon JB, Bar?n AE, Brantley AE, Merrick DT, Franklin WA, Keith RL, Vandivier RWAmerican journal of respiratory and critical care medicineGhosh M, Miller YE, Nakachi I, Kwon JB, Bar?n AE, Brantley AE, Merrick DT, Franklin WA, Keith RL, Vandivier RW. Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 04 01; 197(7):885-896.Am J Respir Crit Care Med2018-04-01T00:00:002018Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease.12700 East 19th Avenue2RC2Research 212700 East 19th AvenueAurora80045-2560COMarkSteeleMark P Steele39.74515960000000-104.8406280000000013969Steele, MarkProfessorD002278Disorders25450.970666Carcinoma in SituD012907Activities & Behaviors43015560.560565SmokingD008175Disorders42122160.395565Lung Neoplasms29997230Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RACancer researchMerrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018 09 01; 78(17):4971-4983.Cancer Res2018-07-11T00:00:002018Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.AnnCartwrightAnn Marie Cartwright39.74515960000000-104.8406280000000014977Cartwright, AnnInstructor30766097Krefft SD, Rose CS, Nawaz S, Miller YEFederal practitioner : for the health care professionals of the VA, DoD, and PHSKrefft SD, Rose CS, Nawaz S, Miller YE. Deployment-Related Lung Disorders. Fed Pract. 2015 Sep; 32(Suppl 10):24S-31S.Fed Pract2015-09-01T00:00:002015Deployment-Related Lung Disorders.D001980Anatomy1152530.868804BronchiD002273Chemicals & Drugs581100.936116CarcinogensONC GENERAL OPERATIONSPUL GENERAL OPERATIONSPULM&SLEEPMED31308004Keith RL, Blatchford PJ, Merrick DT, Bunn PA, Bagwell B, Dwyer-Nield LD, Jackson MK, Geraci MW, Miller YECancer prevention research (Philadelphia, Pa.)Keith RL, Blatchford PJ, Merrick DT, Bunn PA, Bagwell B, Dwyer-Nield LD, Jackson MK, Geraci MW, Miller YE. A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers. Cancer Prev Res (Phila). 2019 10; 12(10):721-730.Cancer Prev Res (Phila)2019-07-15T00:00:002019A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers.SOM-RAD General OperationsCSPH-Bio Info General OpsSOM-MEDSOM-PathologySOM-PEDSUniversity of Colorado Denver - Anschutz Medical CampusVijayalakshmiKaroorVijayalakshmi Karoor39.74515960000000-104.840628000000001716Karoor, VijayalakshmiAsst ProfessorDavidCamidgeDavid Ross Camidge39.74273230000000-104.839191400000002375Camidge, DavidProfessorChristopherEvansChristopher M Evans39.74515960000000-104.840628000000004099Evans, ChristopherProfessorDavidLynchDavid Lynch39.74403510000000-104.836059400000004424Lynch, DavidAffiliate - NJH2.993440.00266984326research areas2.179860.015818924coauthor of128.2476.5355260similar to1158selected publicationsJamesFiniganJames H. Finigan39.74515960000000-104.840628000000005084Finigan, JamesAffiliate - NJHStevenAbmanSteven H Abman39.74403510000000-104.83605940000000518Abman, StevenProfessorDanielMerrickDaniel T Merrick39.74389450000000-104.83943520000000910Merrick, DanielAssociate ProfessorAnnaBaronAnna E Baron39.74528180000000-104.83757270000000743Baron, AnnaProfessorPaulBunnPaul A Bunn39.74389450000000-104.8394352000000097Bunn, PaulProfessorRobertKeithRobert Leonard Keith39.74528180000000-104.83757270000000988Keith, RobertProfessor32287288Warsavage T, Xing F, Bar?n AE, Feser WJ, Hirsch E, Miller YE, Malkoski S, Wolf HJ, Wilson DO, Ghosh DPloS oneWarsavage T, Xing F, Bar?n AE, Feser WJ, Hirsch E, Miller YE, Malkoski S, Wolf HJ, Wilson DO, Ghosh D. Quantifying the incremental value of deep learning: Application to lung nodule detection. PLoS One. 2020; 15(4):e0231468.PLoS One2020-04-14T00:00:002020Quantifying the incremental value of deep learning: Application to lung nodule detection.06/1972Harvard CollegeCambridge, MAHarvard College, Biochemical SciencesABBiochemical Sciences06/1976Duke University SOMDurham, NCDuke University SOM, MedicineMDMedicine07/1978Barnes Hospital, Washington UniversitySt. Louis, MOBarnes Hospital, Washington University, Internal MedicineInternal Medicine07/1979University of ColoradoDenver, COUniversity of Colorado, Internal MedicineInternal Medicine07/1982University of ColoradoDenver, COUniversity of Colorado, Pulmonary/Critical Care MedicinePulmonary/Critical Care Medicine07/1982Eleanor Roosevelt Institute for Cancer ResearchDenver, COEleanor Roosevelt Institute for Cancer Research, GeneticsGeneticsCo-InvestigatorPIDetermine toxicity and compliance for inhaled iloprost for chemoprevention of lung cancer in former smokers.PIDevelop a predictive biomarker for iloprost chemoprevention of lung cancer.Authorship 2289826Authorship 2289839Authorship 2289846Authorship 2289852Authorship 2289863Authorship 2289874Authorship 22898813Authorship 22898912Authorship 22899013Authorship 2289912Authorship 22899213Authorship 2289934Authorship 2289946Authorship 2289958Authorship 2289962Authorship 22899715Authorship 22899823Authorship 2289996Authorship 2290005Authorship 22900113Authorship 22900210Authorship 22900311Authorship 22900412Authorship 2290054Authorship 2290061Authorship 2290072Authorship 22900811Authorship 2290091Authorship 2290103Authorship 2290117Authorship 2290125Authorship 22901310Authorship 2290142Authorship 2290153Authorship 2290165Authorship 2290177Authorship 2290182Authorship 2290193Authorship 2290202Authorship 22902111Authorship 2290225Authorship 2290237Authorship 2290245Authorship 2290255Authorship 22902616Authorship 2290274Authorship 2290288Authorship 2290297Authorship 2290305Authorship 22903110Authorship 2290322Authorship 2290335Authorship 2290345Authorship 2290352Authorship 2290368Authorship 2290376Authorship 2290386Authorship 22903912023-08-31NIHGHOSH, MOUMITA ;MILLER, YORK E2017-09-01(PQ1) Progenitor cell malfunction, mutations and changes in microenvironment: A dynamic risk spectrum for cancer evolutionR01CA2198932021-10-31V FoundationMiller, York2017-10-01Precision Chemoprevention of Lung CancerV Foundation Translational Research Award2020-12-31NCIMiller, York2014-08-26A Phase I Trial of Inhaled Iloprost for the Prevention of Lung Cancer in Former SmokersHHSN2612012000351-0-26100004-122296774Egloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JMRespiratory researchEgloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JM. Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study. Respir Res. 2012 Feb 01; 13:9.Respir Res2012-02-01T00:00:002012Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study.18945870Miller YEAmerican journal of respiratory and critical care medicineMiller YE. Minimizing unintended consequences of detecting lung nodules by computed tomography. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):891-2.Am J Respir Crit Care Med2008-11-01T00:00:002008Minimizing unintended consequences of detecting lung nodules by computed tomography.18635814Minowada G, Miller YEAmerican journal of respiratory cell and molecular biologyMinowada G, Miller YE. Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol. 2009 Jan; 40(1):31-7.Am J Respir Cell Mol Biol2008-07-17T00:00:002008Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis.9515845Lam S, Kennedy T, Unger M, Miller YE, Gelmont D, Rusch V, Gipe B, Howard D, LeRiche JC, Coldman A, Gazdar AFChestLam S, Kennedy T, Unger M, Miller YE, Gelmont D, Rusch V, Gipe B, Howard D, LeRiche JC, Coldman A, Gazdar AF. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest. 1998 Mar; 113(3):696-702.Chest1998-03-01T00:00:001998Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.25590604Vachani A, Pass HI, Rom WN, Midthun DE, Edell ES, Laviolette M, Li XJ, Fong PY, Hunsucker SW, Hayward C, Mazzone PJ, Madtes DK, Miller YE, Walker MG, Shi J, Kearney P, Fang KC, Massion PPJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerVachani A, Pass HI, Rom WN, Midthun DE, Edell ES, Laviolette M, Li XJ, Fong PY, Hunsucker SW, Hayward C, Mazzone PJ, Madtes DK, Miller YE, Walker MG, Shi J, Kearney P, Fang KC, Massion PP. Validation of a multiprotein plasma classifier to identify benign lung nodules. J Thorac Oncol. 2015 Apr; 10(4):629-37.J Thorac Oncol2015-04-01T00:00:002015Validation of a multiprotein plasma classifier to identify benign lung nodules.19738076Kim WY, Jin Q, Oh SH, Kim ES, Yang YJ, Lee DH, Feng L, Behrens C, Prudkin L, Miller YE, Lee JJ, Lippman SM, Hong WK, Wistuba II, Lee HYCancer researchKim WY, Jin Q, Oh SH, Kim ES, Yang YJ, Lee DH, Feng L, Behrens C, Prudkin L, Miller YE, Lee JJ, Lippman SM, Hong WK, Wistuba II, Lee HY. Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development. Cancer Res. 2009 Sep 15; 69(18):7439-48.Cancer Res2009-09-08T00:00:002009Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development.9859901Scher H, Miller YE, Aguayo SM, Johnson KJ, Miller JE, McCray PBPediatric pulmonologyScher H, Miller YE, Aguayo SM, Johnson KJ, Miller JE, McCray PB. Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis. Pediatr Pulmonol. 1998 Nov; 26(5):326-31.Pediatr Pulmonol1998-11-01T00:00:001998Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis.9817713Cohen AJ, King TE, Gilman LB, Magill-Solc C, Miller YEAmerican journal of respiratory and critical care medicineCohen AJ, King TE, Gilman LB, Magill-Solc C, Miller YE. High expression of neutral endopeptidase in idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 1):1593-9.Am J Respir Crit Care Med1998-11-01T00:00:001998High expression of neutral endopeptidase in idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells.9554745Gallione CJ, Klaus DJ, Yeh EY, Stenzel TT, Xue Y, Anthony KB, McAllister KA, Baldwin MA, Berg JN, Lux A, Smith JD, Vary CP, Craigen WJ, Westermann CJ, Warner ML, Miller YE, Jackson CE, Guttmacher AE, Marchuk DAHuman mutationGallione CJ, Klaus DJ, Yeh EY, Stenzel TT, Xue Y, Anthony KB, McAllister KA, Baldwin MA, Berg JN, Lux A, Smith JD, Vary CP, Craigen WJ, Westermann CJ, Warner ML, Miller YE, Jackson CE, Guttmacher AE, Marchuk DA. Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles. Hum Mutat. 1998; 11(4):286-94.Hum Mutat1998-01-01T00:00:001998Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles.8598142Girod CE, Shin DH, Hershenson MB, Solway J, Redlich CA, Gilman LB, Miller YEChestGirod CE, Shin DH, Hershenson MB, Solway J, Redlich CA, Gilman LB, Miller YE. 2A3 and 3F9. Novel lung epithelial antigens with early upregulation in hyperoxic and radiation lung injury models. Chest. 1996 Mar; 109(3 Suppl):33S.Chest1996-03-01T00:00:0019962A3 and 3F9. Novel lung epithelial antigens with early upregulation in hyperoxic and radiation lung injury models.8294396Lindberg FP, Lublin DM, Telen MJ, Veile RA, Miller YE, Donis-Keller H, Brown EJThe Journal of biological chemistryLindberg FP, Lublin DM, Telen MJ, Veile RA, Miller YE, Donis-Keller H, Brown EJ. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J Biol Chem. 1994 Jan 21; 269(3):1567-70.J Biol Chem1994-01-21T00:00:001994Rh-related antigen CD47 is the signal-transducer integrin-associated protein.8394326Cook RM, Burke BJ, Buchhagen DL, Minna JD, Miller YEThe Journal of biological chemistryCook RM, Burke BJ, Buchhagen DL, Minna JD, Miller YE. Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J Biol Chem. 1993 Aug 15; 268(23):17010-7.J Biol Chem1993-08-15T00:00:001993Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer.1406819Aguayo SM, Miller YE, Waldron JA, Bogin RM, Sunday ME, Staton GW, Beam WR, King TEThe New England journal of medicineAguayo SM, Miller YE, Waldron JA, Bogin RM, Sunday ME, Staton GW, Beam WR, King TE. Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Engl J Med. 1992 Oct 29; 327(18):1285-8.N Engl J Med1992-10-29T00:00:001992Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease.1563004Aguayo SM, King TE, Kane MA, Sherritt KM, Silvers W, Nett LM, Petty TL, Miller YECancer researchAguayo SM, King TE, Kane MA, Sherritt KM, Silvers W, Nett LM, Petty TL, Miller YE. Urinary levels of bombesin-like peptides in asymptomatic cigarette smokers: a potential risk marker for smoking-related diseases. Cancer Res. 1992 May 01; 52(9 Suppl):2727s-2731s.Cancer Res1992-05-01T00:00:001992Urinary levels of bombesin-like peptides in asymptomatic cigarette smokers: a potential risk marker for smoking-related diseases.2394833Aguayo SM, King TE, Waldron JA, Sherritt KM, Kane MA, Miller YEThe Journal of clinical investigationAguayo SM, King TE, Waldron JA, Sherritt KM, Kane MA, Miller YE. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma. J Clin Invest. 1990 Sep; 86(3):838-44.J Clin Invest1990-09-01T00:00:001990Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma.2794048Aguayo SM, Kane MA, King TE, Schwarz MI, Grauer L, Miller YEThe Journal of clinical investigationAguayo SM, Kane MA, King TE, Schwarz MI, Grauer L, Miller YE. Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers. J Clin Invest. 1989 Oct; 84(4):1105-13.J Clin Invest1989-10-01T00:00:001989Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers.2542383Miller YE, Minna JD, Gazdar AFThe Journal of clinical investigationMiller YE, Minna JD, Gazdar AF. Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p. J Clin Invest. 1989 Jun; 83(6):2120-4.J Clin Invest1989-06-01T00:00:001989Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p.true1Asst ProfessorAsst Professortrue1ProfessorProfessortrue1Professor-ClinicalProfessor-Clinicaltrue1InstructorInstructortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Affiliate - NJHAffiliate - NJHtrue1InstructorInstructortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Affiliate - NJHAffiliate - NJHtrue1ProfessorProfessor24346345Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MWCancer prevention research (Philadelphia, Pa.)Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MW. Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions. Cancer Prev Res (Phila). 2014 Feb; 7(2):255-65.Cancer Prev Res (Phila)2013-12-17T00:00:002013Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.25114662Mehan MR, Williams SA, Siegfried JM, Bigbee WL, Weissfeld JL, Wilson DO, Pass HI, Rom WN, Muley T, Meister M, Franklin W, Miller YE, Brody EN, Ostroff RMClinical proteomicsMehan MR, Williams SA, Siegfried JM, Bigbee WL, Weissfeld JL, Wilson DO, Pass HI, Rom WN, Muley T, Meister M, Franklin W, Miller YE, Brody EN, Ostroff RM. Validation of a blood protein signature for non-small cell lung cancer. Clin Proteomics. 2014; 11(1):32.Clin Proteomics2014-08-01T00:00:002014Validation of a blood protein signature for non-small cell lung cancer.