XianzhongMengXianzhong Meng39.74515960000000-104.84062800000000455Meng, Xianzhong303/724-6303Professorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 829446Authorship 84047225439778Bennett DT, Reece TB, Foley LS, Sjoberg A, Meng X, Fullerton DA, Weyant MJThe Journal of thoracic and cardiovascular surgeryBennett DT, Reece TB, Foley LS, Sjoberg A, Meng X, Fullerton DA, Weyant MJ. C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of?transcription 3. J Thorac Cardiovasc Surg. 2015 Jan; 149(1):369-75.J Thorac Cardiovasc Surg2014-09-18T00:00:002014C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of?transcription 3.25442996Deng XS, Meng X, Zeng Q, Fullerton D, Mitchell M, Jaggers JThe Annals of thoracic surgeryDeng XS, Meng X, Zeng Q, Fullerton D, Mitchell M, Jaggers J. Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation. Ann Thorac Surg. 2015 Jan; 99(1):62-71.Ann Thorac Surg2014-10-22T00:00:002014Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation.Authorship 911292Authorship 1213895Authorship 1220812Authorship 122184825454921Freeman KA, Fullerton DA, Foley LS, Bell MT, Cleveland JC, Weyant MJ, Mares J, Meng X, Puskas F, Reece TBThe Journal of thoracic and cardiovascular surgeryFreeman KA, Fullerton DA, Foley LS, Bell MT, Cleveland JC, Weyant MJ, Mares J, Meng X, Puskas F, Reece TB. Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor. J Thorac Cardiovasc Surg. 2015 Feb; 149(2):578-84; discussion 584-6.J Thorac Cardiovasc Surg2014-10-15T00:00:002014Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor.Authorship 122577625412776Song R, Fullerton DA, Ao L, Zheng D, Zhao KS, Meng XJournal of molecular medicine (Berlin, Germany)Song R, Fullerton DA, Ao L, Zheng D, Zhao KS, Meng X. BMP-2 and TGF-?1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells. J Mol Med (Berl). 2015 Apr; 93(4):403-12.J Mol Med (Berl)2014-11-22T00:00:002014BMP-2 and TGF-?1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells.Authorship 122890825798067Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng XInternational journal of biological sciencesZhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X. Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-?B and ERK1/2 pathways. Int J Biol Sci. 2015; 11(4):482-93.Int J Biol Sci2015-03-20T00:00:002015Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-?B and ERK1/2 pathways.Authorship 123157725823011Zhai Y, Ao L, Cleveland JC, Zeng Q, Reece TB, Fullerton DA, Meng XPloS oneZhai Y, Ao L, Cleveland JC, Zeng Q, Reece TB, Fullerton DA, Meng X. Toll-like receptor 4 mediates the inflammatory responses and matrix protein remodeling in remote non-ischemic myocardium in a mouse model of myocardial ischemia and reperfusion. PLoS One. 2015; 10(3):e0121853.PLoS One2015-03-30T00:00:002015Toll-like receptor 4 mediates the inflammatory responses and matrix protein remodeling in remote non-ischemic myocardium in a mouse model of myocardial ischemia and reperfusion.Authorship 123441925655994Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC, Fullerton DA, Meng X, Herson PS, Reece TBThe Journal of surgical researchFreeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC, Fullerton DA, Meng X, Herson PS, Reece TB. Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. J Surg Res. 2015 May 01; 195(1):21-8.J Surg Res2014-12-23T00:00:002014Alpha-2 agonist attenuates ischemic injury in spinal cord neurons.Authorship 941365Authorship 944418Authorship 947637Authorship 127050925865765Foley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC, Weyant MJ, Meng X, Puskas F, Reece TBThe Annals of thoracic surgeryFoley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC, Weyant MJ, Meng X, Puskas F, Reece TB. Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression. Ann Thorac Surg. 2015 Jul; 100(1):41-6; discussion 46.Ann Thorac Surg2015-04-09T00:00:002015Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression.Authorship 128554826122822Yao Q, Song R, Ao L, Zhan Q, Cleveland JC, Yu X, Fullerton DA, Meng XBiochimica et biophysica actaYao Q, Song R, Ao L, Zhan Q, Cleveland JC, Yu X, Fullerton DA, Meng X. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta. 2015 Sep; 1852(9):1940-9.Biochim Biophys Acta2015-06-27T00:00:002015Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway.Authorship 963291Authorship 964671Authorship 969524Authorship 99386Authorship 131883525990696Venardos N, Bennett D, Weyant MJ, Reece TB, Meng X, Fullerton DAThe Journal of surgical researchVenardos N, Bennett D, Weyant MJ, Reece TB, Meng X, Fullerton DA. Matrix Gla protein regulates calcification of the aortic valve. 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J Endotoxin Res. 2002; 8(1):59-67.J Endotoxin Res2002-01-01T00:00:002002IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia.ErlindaTheErlinda The39.74528180000000-104.8375727000000012232The, ErlindaAffiliate12124212Raeburn CD, Dinarello CA, Zimmerman MA, Calkins CM, Pomerantz BJ, McIntyre RC, Harken AH, Meng XAmerican journal of physiology. Heart and circulatory physiologyRaeburn CD, Dinarello CA, Zimmerman MA, Calkins CM, Pomerantz BJ, McIntyre RC, Harken AH, Meng X. Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H650-7.Am J Physiol Heart Circ Physiol2002-08-01T00:00:002002Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction.Authorship 155428828052863Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng XAmerican journal of physiology. Cell physiologyZhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C407-C417.Am J Physiol Cell Physiol2017-01-04T00:00:002017Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway.Authorship 155842628079228Ao L, Zhai Y, Jin C, Cleveland JC, Fullerton DA, Meng XMolecular medicine (Cambridge, Mass.)Ao L, Zhai Y, Jin C, Cleveland JC, Fullerton DA, Meng X. Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and TLR4. Mol Med. 2017 Jan; 23:863-872.Mol Med2016-12-19T00:00:002016Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and TLR4.Authorship 157156728137840Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng XProceedings of the National Academy of Sciences of the United States of AmericaZeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1631-1636.Proc Natl Acad Sci U S A2017-01-30T00:00:002017Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice.28152512Hui H, Zhai Y, Ao L, Cleveland JC, Liu H, Fullerton DA, Meng XOncotargetHui H, Zhai Y, Ao L, Cleveland JC, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget. 2017 Feb 28; 8(9):15663-15676.Oncotarget2017-02-28T00:00:002017Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice.5Other Faculty1Professor3Asst Professor2Assoc Professor4InstructorAuthorship 15801113Authorship 159719728237874Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng XCytokineLi J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X. 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J Mol Med (Berl). 2017 07; 95(7):739-751.J Mol Med (Berl)2017-03-22T00:00:002017Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9.28362018Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng XMolecular medicine (Cambridge, Mass.)Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng X. IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells. Mol Med. 2017 05; 23:83-91.Mol Med2017-03-27T00:00:002017IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells.28356268Yao Q, Song R, Ao L, Cleveland JC, Fullerton DA, Meng XAmerican journal of physiology. Cell physiologyYao Q, Song R, Ao L, Cleveland JC, Fullerton DA, Meng X. Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. 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An epigenetic regulatory loop controls pro-osteogenic activation by TGF-?1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. 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Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med. 2006 Aug; 3(8):e277.PLoS Med2006-08-01T00:00:002006Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.28438736Song R, Fullerton DA, Ao L, Zhao KS, Reece TB, Cleveland JC, Meng XJournal of the American Heart AssociationSong R, Fullerton DA, Ao L, Zhao KS, Reece TB, Cleveland JC, Meng X. Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves. 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Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue. Cytokine. 2010 Jul; 51(1):60-6.Cytokine2010-05-15T00:00:002010Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue.21162749Li J, Jin C, Cleveland JC, Ao L, Xu D, Fullerton DA, Meng XCardiovascular diabetologyLi J, Jin C, Cleveland JC, Ao L, Xu D, Fullerton DA, Meng X. Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin. 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Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522.Proc Natl Acad Sci U S A2019-02-28T00:00:002019Interleukin-37 monomer is the active form for reducing innate immunity.D051197Chemicals & Drugs1073350.790202Toll-Like Receptor 4CEDC-BioengineeringPUL GENERAL OPERATIONSD001024Disorders673150.716421Aortic Valve StenosisSOM-OTO General OperationsChemical & Biological EnginSOM-MEDSOM-PEDSSOM-SRGCritical CareCT ClinicalGI ClinicalInfectious DiseaseRS PLAS ClinicalCardiologyUniversity of Colorado BoulderUniversity of Colorado Denver - Anschutz Medical CampusRachelMcMahanRachel H. McMahan39.74515960000000-104.840628000000001637McMahan, RachelAssoc Professor-ResearchDavidFullertonDavid A Fullerton39.74403280000000-104.840810400000001929Fullerton, DavidProfessorCharlesDinarelloCharles A Dinarello39.74528180000000-104.8375727000000023Dinarello, CharlesDistinguished ProfessorT.ReeceT. Brett Reece39.74403280000000-104.840810400000002473Reece, T.ProfessorShi-LongLuShi-Long Lu39.74515960000000-104.840628000000003097Lu, Shi-LongProfessorJosephClevelandJoseph C Cleveland39.74403280000000-104.84081040000000302Cleveland, JosephProfessorYuhuanLuoYuhuan Luo39.74515960000000-104.840628000000004144Luo, YuhuanResearch Instructor11.80260.00723089401research areas9.77310.016571834coauthor of307.36519.723860similar to11108selected publicationsKristiAnsethKristi S Anseth40.00830860000000-105.24906720000000856Anseth, KristiDistinguished ProfessorJohnCarrollJohn D Carroll39.74515960000000-104.84062800000000563Carroll, JohnProfessorAuthorship 119409Authorship 120332Authorship 120354Authorship 130237Authorship 213089531861929Song R, Zhai Y, Ao L, Fullerton DA, Meng XInternational journal of molecular sciencesSong R, Zhai Y, Ao L, Fullerton DA, Meng X. MicroRNA-204 Deficiency in Human Aortic Valves Elevates Valvular Osteogenic Activity. 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Int J Biol Sci. 2020; 16(15):3062-3074.Int J Biol Sci2020-10-03T00:00:002020Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level.Authorship 2307446Authorship 2313585Authorship 231324533272595Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJThe Journal of surgical researchGergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins Inhibit Toll-Like Receptor 4-Mediated Growth of Human Esophageal Adenocarcinoma Cells. J Surg Res. 2021 04; 260:436-447.J Surg Res2020-11-30T00:00:002020Statins Inhibit Toll-Like Receptor 4-Mediated Growth of Human Esophageal Adenocarcinoma Cells.33189669Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DAThe Annals of thoracic surgeryJarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. 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ACS Biomater Sci Eng. 2016 Aug 08; 2(8):1403-1410.ACS Biomater Sci Eng2016-07-15T00:00:002016Biomimetic Nerve Guidance Conduit Containing Intraluminal Microchannels with Aligned Nanofibers Markedly Facilitates in Nerve Regeneration.2025-06-30NIHMENG, XIANZHONG2021-01-01Downregulation of Inflamm-aging for Protection Against Organ Damage in SepsisI01BX005163Principal InvestigatorAuthorship 101208824030400Bell MT, Puskas F, Agoston VA, Cleveland JC, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TBCirculationBell MT, Puskas F, Agoston VA, Cleveland JC, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation. 2013 Sep 10; 128(11 Suppl 1):S152-6.Circulation2013-09-10T00:00:002013Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury.Authorship 238327733774002Gergen AK, Jarrett MJ, Li A, Cheng L, Tilva KR, Madsen HJ, Meng X, Fullerton DA, Weyant MJThe Annals of thoracic surgeryGergen AK, Jarrett MJ, Li A, Cheng L, Tilva KR, Madsen HJ, Meng X, Fullerton DA, Weyant MJ. Expression of Adhesion Molecules in a Gastroduodenal Reflux Murine Model. Ann Thorac Surg. 2022 03; 113(3):926-933.Ann Thorac Surg2021-03-25T00:00:002021Expression of Adhesion Molecules in a Gastroduodenal Reflux Murine Model.Authorship 239782633901456Venardos N, Gergen AK, Jarrett M, Weyant MJ, Reece TB, Meng X, Fullerton DAThe Annals of thoracic surgeryVenardos N, Gergen AK, Jarrett M, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin Induces Calcification of the Aortic Valve Through Extracellular Signal-regulated Kinase 1/2 and ?-catenin Signaling. Ann Thorac Surg. 2022 03; 113(3):824-835.Ann Thorac Surg2021-04-23T00:00:002021Warfarin Induces Calcification of the Aortic Valve Through Extracellular Signal-regulated Kinase 1/2 and ?-catenin Signaling.Authorship 24556110Authorship 249239434417174Zhao P, Yao Q, Zhang PJ, The E, Zhai Y, Ao L, Jarrett MJ, Dinarello CA, Fullerton DA, Meng XScience advancesZhao P, Yao Q, Zhang PJ, The E, Zhai Y, Ao L, Jarrett MJ, Dinarello CA, Fullerton DA, Meng X. Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip. Sci Adv. 2021 08; 7(34).Sci Adv2021-08-20T00:00:002021Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip.34534678Gergen AK, Jarrett MJ, Li A, Meng X, Pratap A, Fullerton DA, Weyant MJSeminars in thoracic and cardiovascular surgeryGergen AK, Jarrett MJ, Li A, Meng X, Pratap A, Fullerton DA, Weyant MJ. Toll-like Receptor 4 Mediates Reflux-Induced Inflammation in a Murine Reflux Model. Semin Thorac Cardiovasc Surg. 2022; 34(4):1324-1335.Semin Thorac Cardiovasc Surg2021-09-15T00:00:002021Toll-like Receptor 4 Mediates Reflux-Induced Inflammation in a Murine Reflux Model.Authorship 255516535001242Gergen AK, Madsen HJ, Li A, Cheng L, Meng X, Fullerton DA, Pratap A, Weyant MJDigestive diseases and sciencesGergen AK, Madsen HJ, Li A, Cheng L, Meng X, Fullerton DA, Pratap A, Weyant MJ. Simvastatin Inhibits Histologic Changes Associated with Gastroduodenal Reflux in a Murine Model. Dig Dis Sci. 2022 Oct; 67(10):4732-4741.Dig Dis Sci2022-01-10T00:00:002022Simvastatin Inhibits Histologic Changes Associated with Gastroduodenal Reflux in a Murine Model.Authorship 255916935062861Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng XMolecular medicine (Cambridge, Mass.)Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng X. Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity. Mol Med. 2022 01 21; 28(1):5.Mol Med2022-01-21T00:00:002022Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity.Authorship 199793Authorship 259920935411432Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng XInflammation research : official journal of the European Histamine Research Society ... [et al.]Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng X. Monocytes augment inflammatory responses in human aortic valve interstitial cells via ?2-integrin/ICAM-1-mediated signaling. Inflamm Res. 2022 Jun; 71(5-6):681-694.Inflamm Res2022-04-11T00:00:002022Monocytes augment inflammatory responses in human aortic valve interstitial cells via ?2-integrin/ICAM-1-mediated signaling.Authorship 260041635493479Zhai Y, Ao L, Yao Q, The E, Fullerton DA, Meng XFrontiers in immunologyZhai Y, Ao L, Yao Q, The E, Fullerton DA, Meng X. Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury. Front Immunol. 2022; 13:891570.Front Immunol2022-04-14T00:00:002022Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury.Authorship 222205Authorship 23335Authorship 274960836037361The E, de Graaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng XProceedings of the National Academy of Sciences of the United States of AmericaThe E, de Graaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2202577119.Proc Natl Acad Sci U S A2022-08-29T00:00:002022Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3.Authorship 277241236822134Deng XS, Meng X, Fullerton D, Stone M, Iguidbashian J, Jaggers JThe Journal of surgical researchDeng XS, Meng X, Fullerton D, Stone M, Iguidbashian J, Jaggers J. Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells. J Surg Res. 2023 06; 286:118-126.J Surg Res2023-02-21T00:00:002023Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells.Authorship 262978KristynMastersKristyn Simcha Masters28341Masters, KristynProfessortrue1Distinguished ProfessorDistinguished Professortrue1ProfessorProfessortrue1Assoc Professor-ResearchAssoc Professor-Researchtrue1ProfessorProfessortrue1ProfessorProfessortrue1Research InstructorResearch InstructorAuthorship 288167837564205The E, Zhai Y, Yao Q, Ao L, Li S, Fullerton DA, Dinarello CA, Meng XInternational journal of biological sciencesThe E, Zhai Y, Yao Q, Ao L, Li S, Fullerton DA, Dinarello CA, Meng X. Recombinant IL-37 Exerts an Anti-inflammatory Effect on Human Aortic Valve Interstitial Cells through Extracellular and Intracellular Actions. Int J Biol Sci. 2023; 19(12):3908-3919.Int J Biol Sci2023-07-31T00:00:002023Recombinant IL-37 Exerts an Anti-inflammatory Effect on Human Aortic Valve Interstitial Cells through Extracellular and Intracellular Actions.true1Asst ProfessorAsst Professortrue1ProfessorProfessorAuthorship 305632true1Senior InstructorSenior Instructortrue1AffiliateAffiliateAuthorship 297113638094127Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Meng XFrontiers in cardiovascular medicineZhai Y, Yao Q, The E, Ao L, Fullerton DA, Meng X. Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity. 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PLoS One. 2014; 9(5):e95400.PLoS One2014-05-08T00:00:002014Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-?B interaction.Authorship 485292Authorship 502114Authorship 518654Authorship 519809Authorship 111471624746950Venardos N, Nadlonek NA, Zhan Q, Weyant MJ, Reece TB, Meng X, Fullerton DAThe Journal of surgical researchVenardos N, Nadlonek NA, Zhan Q, Weyant MJ, Reece TB, Meng X, Fullerton DA. Aortic valve calcification is mediated by a differential response of aortic valve interstitial cells to inflammation. J Surg Res. 2014 Jul; 190(1):1-8.J Surg Res2014-03-22T00:00:002014Aortic valve calcification is mediated by a differential response of aortic valve interstitial cells to inflammation.Authorship 53502Authorship 547807Authorship 59864Authorship 610531Authorship 640695Authorship 113543724918749Jin C, Cleveland JC, Ao L, Li J, Zeng Q, Fullerton DA, Meng XMolecular medicine (Cambridge, Mass.)Jin C, Cleveland JC, Ao L, Li J, Zeng Q, Fullerton DA, Meng X. Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4. Mol Med. 2014 Jun 09; 20:280-9.Mol Med2014-06-09T00:00:002014Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4.Authorship 652678Authorship 113916624928671Bennett DT, Deng XS, Yu JA, Bell MT, Mauchley DC, Meng X, Reece TB, Fullerton DA, Weyant MJThe Annals of thoracic surgeryBennett DT, Deng XS, Yu JA, Bell MT, Mauchley DC, Meng X, Reece TB, Fullerton DA, Weyant MJ. Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells. Ann Thorac Surg. 2014 Aug; 98(2):439-45; discussion 445-6.Ann Thorac Surg2014-06-10T00:00:002014Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells.Authorship 114545724875140Song R, Ao L, Zhao KS, Zheng D, Venardos N, Fullerton DA, Meng XInflammation research : official journal of the European Histamine Research Society ... [et al.]Song R, Ao L, Zhao KS, Zheng D, Venardos N, Fullerton DA, Meng X. Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway. Inflamm Res. 2014 Sep; 63(9):703-10.Inflamm Res2014-05-30T00:00:002014Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway.Authorship 671802Authorship 701213Authorship 115629625101972Wang D, Zeng Q, Song R, Ao L, Fullerton DA, Meng XBiochimica et biophysica actaWang D, Zeng Q, Song R, Ao L, Fullerton DA, Meng X. Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-?B pathway in BMP-2 expression. Biochim Biophys Acta. 2014 Nov; 1843(11):2744-53.Biochim Biophys Acta2014-08-04T00:00:002014Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-?B pathway in BMP-2 expression.Authorship 718848Authorship 739458Authorship 749596Authorship 776806Authorship 78084Authorship 800452Authorship 806466