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Connection

Theodore Randolph to Protein Stability

This is a "connection" page, showing publications Theodore Randolph has written about Protein Stability.

 
Connection Strength
  
 
 
1.571
  
  1. Daniels AL, Calderon CP, Randolph TW. Machine learning and statistical analyses for extracting and characterizing "fingerprints" of antibody aggregation at container interfaces from flow microscopy images. Biotechnol Bioeng. 2020 11; 117(11):3322-3335.
    View in: PubMed
    Score: 0.164
  2. Snell JR, Monticello CR, Her C, Ross EL, Frazer-Abel AA, Carpenter JF, Randolph TW. DEHP Nanodroplets Leached From Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum. J Pharm Sci. 2020 01; 109(1):429-442.
    View in: PubMed
    Score: 0.152
  3. Mehta SB, Carpenter JF, Randolph TW. Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces. J Pharm Sci. 2016 08; 105(8):2338-48.
    View in: PubMed
    Score: 0.124
  4. Cordes AA, Carpenter JF, Randolph TW. Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses. J Pharm Sci. 2012 Jul; 101(7):2307-15.
    View in: PubMed
    Score: 0.092
  5. Cordes AA, Platt CW, Carpenter JF, Randolph TW. Selective domain stabilization as a strategy to reduce fusion protein aggregation. J Pharm Sci. 2012 Apr; 101(4):1400-9.
    View in: PubMed
    Score: 0.091
  6. Salinas BA, Sathish HA, Shah AU, Carpenter JF, Randolph TW. Buffer-dependent fragmentation of a humanized full-length monoclonal antibody. J Pharm Sci. 2010 Jul; 99(7):2962-74.
    View in: PubMed
    Score: 0.081
  7. Hoehne M, Samuel F, Dong A, Wurth C, Mahler HC, Carpenter JF, Randolph TW. Adsorption of monoclonal antibodies to glass microparticles. J Pharm Sci. 2011 Jan; 100(1):123-32.
    View in: PubMed
    Score: 0.081
  8. Fast JL, Cordes AA, Carpenter JF, Randolph TW. Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability. Biochemistry. 2009 Dec 15; 48(49):11724-36.
    View in: PubMed
    Score: 0.078
  9. Thirumangalathu R, Krishnan S, Ricci MS, Brems DN, Randolph TW, Carpenter JF. Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution. J Pharm Sci. 2009 Sep; 98(9):3167-81.
    View in: PubMed
    Score: 0.077
  10. Bee JS, Chiu D, Sawicki S, Stevenson JL, Chatterjee K, Freund E, Carpenter JF, Randolph TW. Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies. J Pharm Sci. 2009 Sep; 98(9):3218-38.
    View in: PubMed
    Score: 0.077
  11. Bee JS, Stevenson JL, Mehta B, Svitel J, Pollastrini J, Platz R, Freund E, Carpenter JF, Randolph TW. Response of a concentrated monoclonal antibody formulation to high shear. Biotechnol Bioeng. 2009 Aug 01; 103(5):936-43.
    View in: PubMed
    Score: 0.076
  12. Gandhi AV, Randolph TW, Carpenter JF. Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions. J Pharm Sci. 2019 06; 108(6):1973-1983.
    View in: PubMed
    Score: 0.037
  13. Qi W, Orgel S, Francon A, Randolph TW, Carpenter JF. Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations. J Pharm Sci. 2018 08; 107(8):2070-2078.
    View in: PubMed
    Score: 0.035
  14. Nejadnik MR, Randolph TW, Volkin DB, Sch?neich C, Carpenter JF, Crommelin DJA, Jiskoot W. Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. J Pharm Sci. 2018 08; 107(8):2013-2019.
    View in: PubMed
    Score: 0.035
  15. Pardeshi NN, Zhou C, Randolph TW, Carpenter JF. Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses. J Pharm Sci. 2018 07; 107(7):1852-1857.
    View in: PubMed
    Score: 0.035
  16. Zhou C, Qi W, Lewis EN, Randolph TW, Carpenter JF. Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20. J Pharm Sci. 2016 08; 105(8):2302-9.
    View in: PubMed
    Score: 0.031
  17. Mehta SB, Lewus R, Bee JS, Randolph TW, Carpenter JF. Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation. J Pharm Sci. 2015 Apr; 104(4):1282-90.
    View in: PubMed
    Score: 0.028
  18. Mehta SB, Bee JS, Randolph TW, Carpenter JF. Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation. Biochemistry. 2014 May 27; 53(20):3367-77.
    View in: PubMed
    Score: 0.027
  19. Liu L, Braun LJ, Wang W, Randolph TW, Carpenter JF. Freezing-induced perturbation of tertiary structure of a monoclonal antibody. J Pharm Sci. 2014 Jul; 103(7):1979-1986.
    View in: PubMed
    Score: 0.027
  20. Barnard JG, Kahn D, Cetlin D, Randolph TW, Carpenter JF. Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions. J Pharm Sci. 2014 Mar; 103(3):890-9.
    View in: PubMed
    Score: 0.026
  21. Liu L, Qi W, Schwartz DK, Randolph TW, Carpenter JF. The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study. J Pharm Sci. 2013 Aug; 102(8):2460-70.
    View in: PubMed
    Score: 0.025
  22. Chou DK, Krishnamurthy R, Manning MC, Randolph TW, Carpenter JF. Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation. J Pharm Sci. 2013 Feb; 102(2):660-73.
    View in: PubMed
    Score: 0.024
  23. Chou DK, Krishnamurthy R, Manning MC, Randolph TW, Carpenter JF. Physical stability of albinterferon-a(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation. J Pharm Sci. 2012 Aug; 101(8):2702-19.
    View in: PubMed
    Score: 0.023
  24. Liu L, Randolph TW, Carpenter JF. Particles shed from syringe filters and their effects on agitation-induced protein aggregation. J Pharm Sci. 2012 Aug; 101(8):2952-9.
    View in: PubMed
    Score: 0.023
  25. Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Sch?neich C, Winter G, Friess W, Crommelin DJ, Carpenter JF. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci. 2012 Mar; 101(3):946-54.
    View in: PubMed
    Score: 0.023
  26. Bee JS, Randolph TW, Carpenter JF, Bishop SM, Dimitrova MN. Effects of surfaces and leachables on the stability of biopharmaceuticals. J Pharm Sci. 2011 Oct; 100(10):4158-70.
    View in: PubMed
    Score: 0.022
  27. Carpenter JF, Randolph TW, Jiskoot W, Crommelin DJ, Middaugh CR, Winter G. Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. J Pharm Sci. 2010 May; 99(5):2200-8.
    View in: PubMed
    Score: 0.020
  28. Vessely C, Estey T, Randolph TW, Henderson I, Cooper J, Nayar R, Braun LJ, Carpenter JF. Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. J Pharm Sci. 2009 Sep; 98(9):2970-93.
    View in: PubMed
    Score: 0.019
  29. Estey T, Vessely C, Randolph TW, Henderson I, Braun LJ, Nayar R, Carpenter JF. Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry. J Pharm Sci. 2009 Sep; 98(9):2994-3012.
    View in: PubMed
    Score: 0.019
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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