MarioSantiagoMario L Santiago39.74528180000000-104.837572700000003386Santiago, MarioLOur laboratory studies the interplay between the innate and adaptive immune response against retroviruses to conceptually advance vaccine and cure strategies against HIV/AIDS. We are specifically interested in “restriction factors” – host proteins that could directly inhibit retroviruses but we discovered also play critical roles in shaping adaptive immune responses. These factors could be regulated by Type I interferons, thus highlighting possibilities for clinical translation.303/724-4946Associate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 812218Authorship 828855Authorship 846036Authorship 846611Authorship 1195288Authorship 119529525539593Gibbert K, Francois S, Sigmund AM, Harper MS, Barrett BS, Kirchning CJ, Lu M, Santiago ML, Dittmer URetrovirologyGibbert K, Francois S, Sigmund AM, Harper MS, Barrett BS, Kirchning CJ, Lu M, Santiago ML, Dittmer U. Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3. Retrovirology. 2014 Dec 24; 11:126.Retrovirology2014-12-24T00:00:002014Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.25589647Halemano K, Barrett BS, Heilman KJ, Morrison TE, Santiago MLJournal of virologyHalemano K, Barrett BS, Heilman KJ, Morrison TE, Santiago ML. Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response. J Virol. 2015 Apr; 89(7):4011-4.J Virol2015-01-14T00:00:002015Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.Authorship 860696Authorship 873177Authorship 885978Authorship 12492110Authorship 124922Authorship 12492325994147Guo K, Halemano K, Schmitt K, Katuwal M, Wang Y, Harper MS, Heilman KJ, Kuwata T, Stephens EB, Santiago MLImmunogeneticsGuo K, Halemano K, Schmitt K, Katuwal M, Wang Y, Harper MS, Heilman KJ, Kuwata T, Stephens EB, Santiago ML. Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques. Immunogenetics. 2015 Jul; 67(7):355-70.Immunogenetics2015-05-21T00:00:002015Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques.Chiu Y-L, Witkowska E, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC. 2006. Proc Natl Acad Sci USAChiu Y-L, Witkowska E, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC. 2006. . High molecular mass APOBEC3G complexes restrict Alu retrotransposition. Proc Natl Acad Sci USA. 2006; 42(103):15588-15593.2006-01-01T00:00:002006High molecular mass APOBEC3G complexes restrict Alu retrotranspositionSantiago ML, Hafalla JC, Kurtis JD, Aligui GL, Wiest PM, Olveda RM, Olds GR, Dunne DW, Ramirez BLInt Arch Allergy Immunol Santiago ML, Hafalla JC, Kurtis JD, Aligui GL, Wiest PM, Olveda RM, Olds GR, Dunne DW, Ramirez BL. Identification of the Schistosoma japonicum 22.6-kDa antigen as a major target of the human IgE response: similarity of IgE-binding epitopes to allergen peptides. Int Arch Allergy Immunol. 1998; 2(117):94-104.1998-01-01T00:00:001998Identification of the Schistosoma japonicum 22.6-kDa antigen as a major target of the human IgE response: similarity of IgE-binding epitopes to allergen peptidesAuthorship 949356Authorship 132187426489798Wang Y, Schmitt K, Guo K, Santiago ML, Stephens EBThe Journal of general virologyWang Y, Schmitt K, Guo K, Santiago ML, Stephens EB. Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer. J Gen Virol. 2016 Jan; 97(1):1-17.J Gen Virol2015-10-20T00:00:002015Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer.Authorship 1321961126529416Harper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasenkrug KJ, Dittmer U, Wilson CC, Santiago MLPLoS pathogensHarper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasenkrug KJ, Dittmer U, Wilson CC, Santiago ML. Interferon-a Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms. PLoS Pathog. 2015; 11(11):e1005254.PLoS Pathog2015-11-03T00:00:002015Interferon-a Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.Authorship 136253826762145Dillon SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, Wilson CCRetrovirologyDillon SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, Wilson CC. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. 2016 Jan 14; 13:5.Retrovirology2016-01-14T00:00:002016Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection.Authorship 137243826846717Li SX, Barrett BS, Guo K, Kassiotis G, Hasenkrug KJ, Dittmer U, Gibbert K, Santiago MLScientific reportsLi SX, Barrett BS, Guo K, Kassiotis G, Hasenkrug KJ, Dittmer U, Gibbert K, Santiago ML. Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection. Sci Rep. 2016 Feb 05; 6:20425.Sci Rep2016-02-05T00:00:002016Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.Authorship 137505426957198Li SX, Barrett BS, Guo K, Santiago MLCurrent HIV researchLi SX, Barrett BS, Guo K, Santiago ML. Tetherin/BST-2: Restriction Factor or Immunomodulator? Curr HIV Res. 2016; 14(3):235-46.Curr HIV Res2016-01-01T00:00:002016Tetherin/BST-2: Restriction Factor or Immunomodulator?Authorship 1405162127099312Lavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, M?ller JA, M?nch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer UJournal of virologyLavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, M?ller JA, M?nch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer U. Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo. J Virol. 2016 07 01; 90(13):6001-6013.J Virol2016-06-10T00:00:002016Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.9233677Hafalla JC, Santiago ML, Pasay MC, Ramirez BL, Gozar MM, Saul A, Kaslow DCMolecular and biochemical parasitologyHafalla JC, Santiago ML, Pasay MC, Ramirez BL, Gozar MM, Saul A, Kaslow DC. Minimal variation in the Pfs28 ookinete antigen from Philippine field isolates of Plasmodium falciparum. Mol Biochem Parasitol. 1997 Jul; 87(1):97-9.Mol Biochem Parasitol1997-07-01T00:00:001997Minimal variation in the Pfs28 ookinete antigen from Philippine field isolates of Plasmodium falciparum.10029318Hafalla JC, Alamares JG, Acosta LP, Dunne DW, Ramirez BL, Santiago MLMolecular and biochemical parasitologyHafalla JC, Alamares JG, Acosta LP, Dunne DW, Ramirez BL, Santiago ML. Molecular identification of a 21.7 kDa schistosoma japonicum antigen as a target of the human IgE response. Mol Biochem Parasitol. 1999 Jan 05; 98(1):157-61.Mol Biochem Parasitol1999-01-05T00:00:001999Molecular identification of a 21.7 kDa schistosoma japonicum antigen as a target of the human IgE response.10583866Hernandez MG, Hafalla JC, Acosta LP, Aligui FF, Aligui GD, Ramirez BL, Dunne DW, Santiago MLParasite immunologyHernandez MG, Hafalla JC, Acosta LP, Aligui FF, Aligui GD, Ramirez BL, Dunne DW, Santiago ML. Paramyosin is a major target of the human IgA response against Schistosoma japonicum. Parasite Immunol. 1999 Dec; 21(12):641-7.Parasite Immunol1999-12-01T00:00:001999Paramyosin is a major target of the human IgA response against Schistosoma japonicum.Authorship 147340427584592Wang Y, Wang Z, Pramanik A, Santiago ML, Qiu J, Stephens EBVirologyWang Y, Wang Z, Pramanik A, Santiago ML, Qiu J, Stephens EB. A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction. Virology. 2016 11; 498:149-163.Virology2016-08-30T00:00:002016A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction.Authorship 147926Dillon SM, Santiago ML, Wilson CCHIV-1 pathogenesis in the gutDillon SM, Santiago ML, Wilson CC. Encyclopedia of AIDS (eds. Hope TJ, Stevenson M, Richman D). HIV-1 pathogenesis in the gut. 2016; 1-8.2016-06-06T00:00:002016Encyclopedia of AIDS (eds. Hope TJ, Stevenson M, Richman D)11405934Sharp PM, Bailes E, Chaudhuri RR, Rodenburg CM, Santiago MO, Hahn BHPhilosophical transactions of the Royal Society of London. Series B, Biological sciencesSharp PM, Bailes E, Chaudhuri RR, Rodenburg CM, Santiago MO, Hahn BH. The origins of acquired immune deficiency syndrome viruses: where and when? Philos Trans R Soc Lond B Biol Sci. 2001 Jun 29; 356(1410):867-76.Philos Trans R Soc Lond B Biol Sci2001-06-29T00:00:002001The origins of acquired immune deficiency syndrome viruses: where and when?11511008Torres EP, Ramirez BL, Salazar F, Pasay MC, Alamares JG, Santiago ML, Hafalla JCParasitology researchTorres EP, Ramirez BL, Salazar F, Pasay MC, Alamares JG, Santiago ML, Hafalla JC. Detection of bancroftian filariasis in human blood samples from Sorsogon province, the Philippines by polymerase chain reaction. Parasitol Res. 2001 Aug; 87(8):677-9.Parasitol Res2001-08-01T00:00:002001Detection of bancroftian filariasis in human blood samples from Sorsogon province, the Philippines by polymerase chain reaction.Authorship 152544627880772Rubtsova K, Rubtsov AV, Halemano K, Li SX, Kappler JW, Santiago ML, Marrack PPloS oneRubtsova K, Rubtsov AV, Halemano K, Li SX, Kappler JW, Santiago ML, Marrack P. T Cell Production of IFN? in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses. PLoS One. 2016; 11(11):e0166322.PLoS One2016-11-23T00:00:002016T Cell Production of IFN? in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses.Authorship 153713528002063Dillon SM, Kibbie J, Lee EJ, Guo K, Santiago ML, Austin GL, Gianella S, Landay AL, Donovan AM, Frank DN, McCARTER MD, Wilson CCAIDS (London, England)Dillon SM, Kibbie J, Lee EJ, Guo K, Santiago ML, Austin GL, Gianella S, Landay AL, Donovan AM, Frank DN, McCARTER MD, Wilson CC. Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation. AIDS. 2017 02 20; 31(4):511-521.AIDS2017-02-20T00:00:002017Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation.Authorship 1574991228241075Yoder AC, Guo K, Dillon SM, Phang T, Lee EJ, Harper MS, Helm K, Kappes JC, Ochsenbauer C, McCarter MD, Wilson CC, Santiago MLPLoS pathogensYoder AC, Guo K, Dillon SM, Phang T, Lee EJ, Harper MS, Helm K, Kappes JC, Ochsenbauer C, McCarter MD, Wilson CC, Santiago ML. The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria. PLoS Pathog. 2017 02; 13(2):e1006226.PLoS Pathog2017-02-27T00:00:002017The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria.5Other Faculty14717118Santiago ML, Bibollet-Ruche F, Gross-Camp N, Majewski AC, Masozera M, Munanura I, Kaplin BA, Sharp PM, Shaw GM, Hahn BHAIDS research and human retrovirusesSantiago ML, Bibollet-Ruche F, Gross-Camp N, Majewski AC, Masozera M, Munanura I, Kaplin BA, Sharp PM, Shaw GM, Hahn BH. Noninvasive detection of Simian immunodeficiency virus infection in a wild-living L'Hoest's monkey (Cercopithecus Ihoesti). AIDS Res Hum Retroviruses. 2003 Dec; 19(12):1163-6.AIDS Res Hum Retroviruses2003-12-01T00:00:002003Noninvasive detection of Simian immunodeficiency virus infection in a wild-living L'Hoest's monkey (Cercopithecus Ihoesti).1Professor3Asst Professor2Assoc ProfessorAuthorship 160616428341640Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JCThe Journal of experimental medicineGetahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 04 03; 214(4):931-941.J Exp Med2017-03-24T00:00:002017Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.Surg Onc Clinical16160179Santiago ML, Range F, Keele BF, Li Y, Bailes E, Bibollet-Ruche F, Fruteau C, No? R, Peeters M, Brookfield JF, Shaw GM, Sharp PM, Hahn BHJournal of virologySantiago ML, Range F, Keele BF, Li Y, Bailes E, Bibollet-Ruche F, Fruteau C, No? R, Peeters M, Brookfield JF, Shaw GM, Sharp PM, Hahn BH. Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Ta? Forest, C?te d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2. J Virol. 2005 Oct; 79(19):12515-27.J Virol2005-10-01T00:00:002005Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Ta? Forest, C?te d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2.Authorship 161827828415995Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago MLRetrovirologyBarrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML. Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction. Retrovirology. 2017 04 17; 14(1):25.Retrovirology2017-04-17T00:00:002017Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.2011-02-28NIHSANTIAGO, MARIO LUIS2009-09-22Apobec3 and the Neutralizing Antibody Response Against Pathogenic RetrovirusesR56AI0841232015-05-31NIHSANTIAGO, MARIO LUIS2010-06-01Innate Restriction Factor Modulation of Retrovirus-specific Humoral ImmunityR01AI0907952021-05-31NIHSANTIAGO, MARIO LUIS2015-12-01APOBEC3/Rfv3 and Immunoglobulin Somatic HypermutationR01AI1166032016-03-31NIHSANTIAGO, MARIO LUIS2015-04-16HIV-Associated Interferon Effector Mechanisms in the GALTR56AI1162712016-07-31NIHSANTIAGO, MARIO LUIS2014-08-25Immunological impact of Tetherin retrovirus restrictionR21AI112418Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator16728595Keele BF, Van Heuverswyn F, Li Y, Bailes E, Takehisa J, Santiago ML, Bibollet-Ruche F, Chen Y, Wain LV, Liegeois F, Loul S, Ngole EM, Bienvenue Y, Delaporte E, Brookfield JF, Sharp PM, Shaw GM, Peeters M, Hahn BHScience (New York, N.Y.)Keele BF, Van Heuverswyn F, Li Y, Bailes E, Takehisa J, Santiago ML, Bibollet-Ruche F, Chen Y, Wain LV, Liegeois F, Loul S, Ngole EM, Bienvenue Y, Delaporte E, Brookfield JF, Sharp PM, Shaw GM, Peeters M, Hahn BH. Chimpanzee reservoirs of pandemic and nonpandemic HIV-1. Science. 2006 Jul 28; 313(5786):523-6.Science2006-05-25T00:00:002006Chimpanzee reservoirs of pandemic and nonpandemic HIV-1.LornaAllenLorna L Allen39.74528180000000-104.8375727000000012802Allen, LornaAsst ProfessorAuthorship 164375928615202Miller SM, Miles B, Guo K, Folkvord J, Meditz AL, McCarter MD, Levy DN, MaWhinney S, Santiago ML, Connick EJournal of virologyMiller SM, Miles B, Guo K, Folkvord J, Meditz AL, McCarter MD, Levy DN, MaWhinney S, Santiago ML, Connick E. Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1. J Virol. 2017 09 01; 91(17).J Virol2017-08-10T00:00:002017Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1.18604273Liu W, Worobey M, Li Y, Keele BF, Bibollet-Ruche F, Guo Y, Goepfert PA, Santiago ML, Ndjango JB, Neel C, Clifford SL, Sanz C, Kamenya S, Wilson ML, Pusey AE, Gross-Camp N, Boesch C, Smith V, Zamma K, Huffman MA, Mitani JC, Watts DP, Peeters M, Shaw GM, Switzer WM, Sharp PM, Hahn BHPLoS pathogensLiu W, Worobey M, Li Y, Keele BF, Bibollet-Ruche F, Guo Y, Goepfert PA, Santiago ML, Ndjango JB, Neel C, Clifford SL, Sanz C, Kamenya S, Wilson ML, Pusey AE, Gross-Camp N, Boesch C, Smith V, Zamma K, Huffman MA, Mitani JC, Watts DP, Peeters M, Shaw GM, Switzer WM, Sharp PM, Hahn BH. Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees. PLoS Pathog. 2008 Jul 04; 4(7):e1000097.PLoS Pathog2008-07-04T00:00:002008Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees.Authorship 164422828698284Schroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RMThe Journal of experimental medicineSchroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RM. Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies. J Exp Med. 2017 Aug 07; 214(8):2283-2302.J Exp Med2017-07-11T00:00:002017Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies.19748647Decker JM, Zammit KP, Easlick JL, Santiago ML, Bonenberger D, Hahn BH, Kutsch O, Bibollet-Ruche FVirologyDecker JM, Zammit KP, Easlick JL, Santiago ML, Bonenberger D, Hahn BH, Kutsch O, Bibollet-Ruche F. Effective activation alleviates the replication block of CCR5-tropic HIV-1 in chimpanzee CD4+ lymphocytes. Virology. 2009 Nov 10; 394(1):109-18.Virology2009-09-12T00:00:002009Effective activation alleviates the replication block of CCR5-tropic HIV-1 in chimpanzee CD4+ lymphocytes.20624919Lassen KG, Wissing S, Lobritz MA, Santiago M, Greene WCThe Journal of biological chemistryLassen KG, Wissing S, Lobritz MA, Santiago M, Greene WC. Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif. J Biol Chem. 2010 Sep 17; 285(38):29326-35.J Biol Chem2010-07-12T00:00:002010Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif.20702647Kolokithas A, Rosenke K, Malik F, Hendrick D, Swanson L, Santiago ML, Portis JL, Hasenkrug KJ, Evans LHJournal of virologyKolokithas A, Rosenke K, Malik F, Hendrick D, Swanson L, Santiago ML, Portis JL, Hasenkrug KJ, Evans LH. The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3. J Virol. 2010 Oct; 84(20):10933-6.J Virol2010-08-11T00:00:002010The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.2022-04-30NIHSANTIAGO, MARIO LUIS2017-05-01Role of Type I IFNs in Mucosal HIV-1 Immunity and PathogenesisR01AI134220Principal Investigator21111238Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WCCellDoitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801.Cell2010-11-24T00:00:002010Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue.21868050Schmitt K, Guo K, Algaier M, Ruiz A, Cheng F, Qiu J, Wissing S, Santiago ML, Stephens EBVirologySchmitt K, Guo K, Algaier M, Ruiz A, Cheng F, Qiu J, Wissing S, Santiago ML, Stephens EB. Differential virus restriction patterns of rhesus macaque and human APOBEC3A: implications for lentivirus evolution. Virology. 2011 Oct 10; 419(1):24-42.Virology2011-08-25T00:00:002011Differential virus restriction patterns of rhesus macaque and human APOBEC3A: implications for lentivirus evolution.22961660Halemano K, Harper MS, Guo K, Li SX, Heilman KJ, Barrett BS, Santiago MLImmunologic researchHalemano K, Harper MS, Guo K, Li SX, Heilman KJ, Barrett BS, Santiago ML. Humoral immunity in the Friend retrovirus infection model. Immunol Res. 2013 Mar; 55(1-3):249-60.Immunol Res2013-03-01T00:00:002013Humoral immunity in the Friend retrovirus infection model.23055550Fischer W, Apetrei C, Santiago ML, Li Y, Gautam R, Pandrea I, Shaw GM, Hahn BH, Letvin NL, Nabel GJ, Korber BTJournal of virologyFischer W, Apetrei C, Santiago ML, Li Y, Gautam R, Pandrea I, Shaw GM, Hahn BH, Letvin NL, Nabel GJ, Korber BT. Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages. J Virol. 2012 Dec; 86(24):13217-31.J Virol2012-10-10T00:00:002012Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages.23533681Halemano K, Barrett BS, Li SX, Harper MS, Smith DS, Heilman KJ, Santiago MLPloS oneHalemano K, Barrett BS, Li SX, Harper MS, Smith DS, Heilman KJ, Santiago ML. Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice. PLoS One. 2013; 8(3):e60500.PLoS One2013-03-22T00:00:002013Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.15103367Worobey M, Santiago ML, Keele BF, Ndjango JB, Joy JB, Labama BL, Dhed'A BD, Rambaut A, Sharp PM, Shaw GM, Hahn BHNatureWorobey M, Santiago ML, Keele BF, Ndjango JB, Joy JB, Labama BL, Dhed'A BD, Rambaut A, Sharp PM, Shaw GM, Hahn BH. Origin of AIDS: contaminated polio vaccine theory refuted. Nature. 2004 Apr 22; 428(6985):820.Nature2004-04-22T00:00:002004Origin of AIDS: contaminated polio vaccine theory refuted.13001 East 17th Place2SOMSchool of Medicine13001 East 17th PlaceAurora80045-2570CO15823605Gomez LM, Pacyniak E, Flick M, Hout DR, Gomez ML, Nerrienet E, Ayouba A, Santiago ML, Hahn BH, Stephens EBVirologyGomez LM, Pacyniak E, Flick M, Hout DR, Gomez ML, Nerrienet E, Ayouba A, Santiago ML, Hahn BH, Stephens EB. Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains. Virology. 2005 Apr 25; 335(1):46-60.Virology2005-04-25T00:00:002005Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains.9665504Santiago ML, Santiago EG, Hafalla JC, Manalo MA, Orantia L, Cajimat MN, Martin C, Cuaresma C, Dominguez CE, Borromeo ME, De Groot AS, Flanigan TP, Carpenter CC, Mayer KH, Ramirez BLJournal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology AssociationSantiago ML, Santiago EG, Hafalla JC, Manalo MA, Orantia L, Cajimat MN, Martin C, Cuaresma C, Dominguez CE, Borromeo ME, De Groot AS, Flanigan TP, Carpenter CC, Mayer KH, Ramirez BL. Molecular epidemiology of HIV-1 infection in the Philippines, 1985 to 1997: transmission of subtypes B and E and potential emergence of subtypes C and F. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jul 01; 18(3):260-9.J Acquir Immune Defic Syndr Hum Retrovirol1998-07-01T00:00:001998Molecular epidemiology of HIV-1 infection in the Philippines, 1985 to 1997: transmission of subtypes B and E and potential emergence of subtypes C and F.11799233Santiago ML, Rodenburg CM, Kamenya S, Bibollet-Ruche F, Gao F, Bailes E, Meleth S, Soong SJ, Kilby JM, Moldoveanu Z, Fahey B, Muller MN, Ayouba A, Nerrienet E, McClure HM, Heeney JL, Pusey AE, Collins DA, Boesch C, Wrangham RW, Goodall J, Sharp PM, Shaw GM, Hahn BHScience (New York, N.Y.)Santiago ML, Rodenburg CM, Kamenya S, Bibollet-Ruche F, Gao F, Bailes E, Meleth S, Soong SJ, Kilby JM, Moldoveanu Z, Fahey B, Muller MN, Ayouba A, Nerrienet E, McClure HM, Heeney JL, Pusey AE, Collins DA, Boesch C, Wrangham RW, Goodall J, Sharp PM, Shaw GM, Hahn BH. SIVcpz in wild chimpanzees. Science. 2002 Jan 18; 295(5554):465.Science2002-01-18T00:00:002002SIVcpz in wild chimpanzees.12525656Ling B, Santiago ML, Meleth S, Gormus B, McClure HM, Apetrei C, Hahn BH, Marx PAJournal of virologyLing B, Santiago ML, Meleth S, Gormus B, McClure HM, Apetrei C, Hahn BH, Marx PA. Noninvasive detection of new simian immunodeficiency virus lineages in captive sooty mangabeys: ability to amplify virion RNA from fecal samples correlates with viral load in plasma. J Virol. 2003 Feb; 77(3):2214-26.J Virol2003-02-01T00:00:002003Noninvasive detection of new simian immunodeficiency virus lineages in captive sooty mangabeys: ability to amplify virion RNA from fecal samples correlates with viral load in plasma.12525658Santiago ML, Bibollet-Ruche F, Bailes E, Kamenya S, Muller MN, Lukasik M, Pusey AE, Collins DA, Wrangham RW, Goodall J, Shaw GM, Sharp PM, Hahn BHJournal of virologySantiago ML, Bibollet-Ruche F, Bailes E, Kamenya S, Muller MN, Lukasik M, Pusey AE, Collins DA, Wrangham RW, Goodall J, Shaw GM, Sharp PM, Hahn BH. Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzee. J Virol. 2003 Feb; 77(3):2233-42.J Virol2003-02-01T00:00:002003Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzee.12805455Santiago ML, Lukasik M, Kamenya S, Li Y, Bibollet-Ruche F, Bailes E, Muller MN, Emery M, Goldenberg DA, Lwanga JS, Ayouba A, Nerrienet E, McClure HM, Heeney JL, Watts DP, Pusey AE, Collins DA, Wrangham RW, Goodall J, Brookfield JF, Sharp PM, Shaw GM, Hahn BHJournal of virologySantiago ML, Lukasik M, Kamenya S, Li Y, Bibollet-Ruche F, Bailes E, Muller MN, Emery M, Goldenberg DA, Lwanga JS, Ayouba A, Nerrienet E, McClure HM, Heeney JL, Watts DP, Pusey AE, Collins DA, Wrangham RW, Goodall J, Brookfield JF, Sharp PM, Shaw GM, Hahn BH. Foci of endemic simian immunodeficiency virus infection in wild-living eastern chimpanzees (Pan troglodytes schweinfurthii). J Virol. 2003 Jul; 77(13):7545-62.J Virol2003-07-01T00:00:002003Foci of endemic simian immunodeficiency virus infection in wild-living eastern chimpanzees (Pan troglodytes schweinfurthii).15194762Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, M?ller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, M?nch JJournal of virologyKirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, M?ller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, M?nch J. Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol. 2004 Jul; 78(13):6864-74.J Virol2004-07-01T00:00:002004Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.15613358Nerrienet E, Santiago ML, Foupouapouognigni Y, Bailes E, Mundy NI, Njinku B, Kfutwah A, Muller-Trutwin MC, Barre-Sinoussi F, Shaw GM, Sharp PM, Hahn BH, Ayouba AJournal of virologyNerrienet E, Santiago ML, Foupouapouognigni Y, Bailes E, Mundy NI, Njinku B, Kfutwah A, Muller-Trutwin MC, Barre-Sinoussi F, Shaw GM, Sharp PM, Hahn BH, Ayouba A. Simian immunodeficiency virus infection in wild-caught chimpanzees from cameroon. J Virol. 2005 Jan; 79(2):1312-9.J Virol2005-01-01T00:00:002005Simian immunodeficiency virus infection in wild-caught chimpanzees from cameroon.16777597Schindler M, M?nch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, M?ller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff FCellSchindler M, M?nch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, M?ller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 2006 Jun 16; 125(6):1055-67.Cell2006-06-16T00:00:002006Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.17494082Takehisa J, Kraus MH, Decker JM, Li Y, Keele BF, Bibollet-Ruche F, Zammit KP, Weng Z, Santiago ML, Kamenya S, Wilson ML, Pusey AE, Bailes E, Sharp PM, Shaw GM, Hahn BHJournal of virologyTakehisa J, Kraus MH, Decker JM, Li Y, Keele BF, Bibollet-Ruche F, Zammit KP, Weng Z, Santiago ML, Kamenya S, Wilson ML, Pusey AE, Bailes E, Sharp PM, Shaw GM, Hahn BH. Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees. J Virol. 2007 Jul; 81(14):7463-75.J Virol2007-05-09T00:00:002007Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees.20566830Santiago ML, Benitez RL, Montano M, Hasenkrug KJ, Greene WCJournal of immunology (Baltimore, Md. : 1950)Santiago ML, Benitez RL, Montano M, Hasenkrug KJ, Greene WC. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J Immunol. 2010 Jul 15; 185(2):1114-23.J Immunol2010-06-21T00:00:002010Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.18772436Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WCScience (New York, N.Y.)Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WC. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science. 2008 Sep 05; 321(5894):1343-6.Science2008-09-05T00:00:002008Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.20980520Santiago ML, Smith DS, Barrett BS, Montano M, Benitez RL, Pelanda R, Hasenkrug KJ, Greene WCJournal of virologySantiago ML, Smith DS, Barrett BS, Montano M, Benitez RL, Pelanda R, Hasenkrug KJ, Greene WC. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011 Jan; 85(1):189-99.J Virol2010-10-27T00:00:002010Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.21998583Smith DS, Guo K, Barrett BS, Heilman KJ, Evans LH, Hasenkrug KJ, Greene WC, Santiago MLPLoS pathogensSmith DS, Guo K, Barrett BS, Heilman KJ, Evans LH, Hasenkrug KJ, Greene WC, Santiago ML. Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response. PLoS Pathog. 2011 Oct; 7(10):e1002284.PLoS Pathog2011-10-06T00:00:002011Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.22457621Barrett BS, Smith DS, Li SX, Guo K, Hasenkrug KJ, Santiago MLPLoS pathogensBarrett BS, Smith DS, Li SX, Guo K, Hasenkrug KJ, Santiago ML. A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo. PLoS Pathog. 2012; 8(3):e1002596.PLoS Pathog2012-03-22T00:00:002012A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.23315078Harper MS, Barrett BS, Smith DS, Li SX, Gibbert K, Dittmer U, Hasenkrug KJ, Santiago MLJournal of immunology (Baltimore, Md. : 1950)Harper MS, Barrett BS, Smith DS, Li SX, Gibbert K, Dittmer U, Hasenkrug KJ, Santiago ML. IFN-a treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3. J Immunol. 2013 Feb 15; 190(4):1583-90.J Immunol2013-01-11T00:00:002013IFN-a treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.23648232Schmitt K, Guo K, Katuwal M, Wilson D, Prochnow C, Bransteitter R, Chen XS, Santiago ML, Stephens EBVirologySchmitt K, Guo K, Katuwal M, Wilson D, Prochnow C, Bransteitter R, Chen XS, Santiago ML, Stephens EB. Lentivirus restriction by diverse primate APOBEC3A proteins. Virology. 2013 Jul 20; 442(1):82-96.Virology2013-05-04T00:00:002013Lentivirus restriction by diverse primate APOBEC3A proteins.Authorship 178096629367246Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon DJournal of virologyWestrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D. Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. J Virol. 2018 04 01; 92(7).J Virol2018-03-14T00:00:002018Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.Authorship 1791781529610295Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu LProceedings of the National Academy of Sciences of the United States of AmericaChen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.Proc Natl Acad Sci U S A2018-04-02T00:00:002018SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways.29762170Dillon SM, Guo K, Austin GL, Gianella S, Engen PA, Mutlu EA, Losurdo J, Swanson G, Chakradeo P, Keshavarzian A, Landay AL, Santiago ML, Wilson CCAIDS (London, England)Dillon SM, Guo K, Austin GL, Gianella S, Engen PA, Mutlu EA, Losurdo J, Swanson G, Chakradeo P, Keshavarzian A, Landay AL, Santiago ML, Wilson CC. A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis. AIDS. 2018 07 31; 32(12):1599-1611.AIDS2018-07-31T00:00:002018A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis.Authorship 18113112D012192Disorders15460.957163Retroviridae InfectionsD015497Living Beings1537830.646943HIV-1D057134Chemicals & Drugs1032290.84293Antibodies, NeutralizingAuthorship 97516923725696Li SX, Barrett BS, Harper MS, Heilman KJ, Halemano K, Steele AK, Guo K, Silverman RH, Santiago MLVirologyLi SX, Barrett BS, Harper MS, Heilman KJ, Halemano K, Steele AK, Guo K, Silverman RH, Santiago ML. Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection. Virology. 2013 Aug 15; 443(1):134-42.Virology2013-05-29T00:00:002013Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.Authorship 193167730595553Uchil PD, Pi R, Haugh KA, Ladinsky MS, Ventura JD, Barrett BS, Santiago ML, Bjorkman PJ, Kassiotis G, Sewald X, Mothes WCell host & microbeUchil PD, Pi R, Haugh KA, Ladinsky MS, Ventura JD, Barrett BS, Santiago ML, Bjorkman PJ, Kassiotis G, Sewald X, Mothes W. A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus. Cell Host Microbe. 2019 01 09; 25(1):87-100.e10.Cell Host Microbe2018-12-27T00:00:002018A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.D003564Chemicals & Drugs30580.950007Cytidine DeaminaseAuthorship 199338730984202Castleman MJ, Dillon SM, Purba CM, Cogswell AC, Kibbie JJ, McCarter MD, Santiago ML, Barker E, Wilson CCFrontiers in immunologyCastleman MJ, Dillon SM, Purba CM, Cogswell AC, Kibbie JJ, McCarter MD, Santiago ML, Barker E, Wilson CC. Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFN? Production From Human Colonic ILC3s via Multiple Mechanisms. Front Immunol. 2019; 10:649.Front Immunol2019-03-29T00:00:002019Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFN? Production From Human Colonic ILC3s via Multiple Mechanisms.Authorship 200568731087035Dittmer U, Sutter K, Kassiotis G, Zelinskyy G, B?nki Z, Stoiber H, Santiago ML, Hasenkrug KJFEMS microbiology reviewsDittmer U, Sutter K, Kassiotis G, Zelinskyy G, B?nki Z, Stoiber H, Santiago ML, Hasenkrug KJ. Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity. FEMS Microbiol Rev. 2019 09 01; 43(5):435-456.FEMS Microbiol Rev2019-09-01T00:00:002019Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.D005622Living Beings8300.956706Friend murine leukemia virusAuthorship 204484331341068Hasenkrug KJ, Lavender KJ, Santiago ML, Sutter K, Dittmer UmSphereHasenkrug KJ, Lavender KJ, Santiago ML, Sutter K, Dittmer U. Different Biological Activities of Specific Interferon Alpha Subtypes. mSphere. 2019 07 24; 4(4).mSphere2019-07-24T00:00:002019Different Biological Activities of Specific Interferon Alpha Subtypes.SOM-MEDSOM-PEDSSOM-SRGIDInfectious DiseaseUniversity of Colorado Denver - Anschutz Medical CampusAdrianaWeinbergAdriana Weinberg39.74528180000000-104.837572700000001328Weinberg, AdrianaProfessorMartinMcCarterMartin D. McCarter39.74403280000000-104.840810400000001544McCarter, MartinProfessorCharlesDinarelloCharles A Dinarello39.74528180000000-104.8375727000000023Dinarello, CharlesDistinguished ProfessorStephanieDillonStephanie M Dillon39.74528180000000-104.837572700000002389Dillon, StephanieAssoc Professor-ResearchKristineErlandsonKristine M. Erlandson39.74528180000000-104.837572700000002990Erlandson, KristineAssociate ProfessorKejunGuoKejun Guo39.74528180000000-104.837572700000003183Guo, KejunAsst Professor-ResearchCaraWilsonCara Chandler Wilson39.74528180000000-104.83757270000000367Wilson, CaraProfessor6.721150.0081543385research areas3.150950.037569647coauthor of71.368712.269560similar to1196selected publicationsSuzhaoLiSuzhao Li39.74528180000000-104.837572700000003691Li, SuzhaoAssoc Professor-ResearchConniePriceConnie Price39.74528180000000-104.837572700000004797Price, ConnieAffiliate - DHHAJuanitaLovatoJuanita Lovato39.74528180000000-104.837572700000005074Lovato, JuanitaAffiliate - DHHAAuthorship 210315831608062Dickow J, Francois S, Kaiserling RL, Malyshkina A, Drexler I, Westendorf AM, Lang KS, Santiago ML, Dittmer U, Sutter KFrontiers in immunologyDickow J, Francois S, Kaiserling RL, Malyshkina A, Drexler I, Westendorf AM, Lang KS, Santiago ML, Dittmer U, Sutter K. Diverse Immunomodulatory Effects of Individual IFNa Subtypes on Virus-Specific CD8+ T Cell Responses. Front Immunol. 2019; 10:2255.Front Immunol2019-09-24T00:00:002019Diverse Immunomodulatory Effects of Individual IFNa Subtypes on Virus-Specific CD8+ T Cell Responses.Authorship 214837431935222Ickler J, Francois S, Widera M, Santiago ML, Dittmer U, Sutter KPloS oneIckler J, Francois S, Widera M, Santiago ML, Dittmer U, Sutter K. HIV infection does not alter interferon a/? receptor 2 expression on mucosal immune cells. PLoS One. 2020; 15(1):e0218905.PLoS One2020-01-14T00:00:002020HIV infection does not alter interferon a/? receptor 2 expression on mucosal immune cells.2024-12-31NIHSANTIAGO, MARIO LUIS;WILSON, CARA C.2020-01-07Gut Cytotoxic CD4 T cells in HIV-1 PathogenesisR01AI145428Co-Principal InvestigatorAuthorship 216304632051266Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EMJournal of virologyMiller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease. J Virol. 2020 04 16; 94(9).J Virol2020-04-16T00:00:002020Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease.Authorship 226120532849530Agazio A, Cimons J, Shotts KM, Guo K, Santiago ML, Pelanda R, Torres RMFrontiers in immunologyAgazio A, Cimons J, Shotts KM, Guo K, Santiago ML, Pelanda R, Torres RM. Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1. Front Immunol. 2020; 11:1565.Front Immunol2020-07-22T00:00:002020Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1.Authorship 2288991533064743Guo K, Shen G, Kibbie J, Gonzalez T, Dillon SM, Smith HA, Cooper EH, Lavender K, Hasenkrug KJ, Sutter K, Dittmer U, Kroehl M, Kechris K, Wilson CC, Santiago MLPLoS pathogensGuo K, Shen G, Kibbie J, Gonzalez T, Dillon SM, Smith HA, Cooper EH, Lavender K, Hasenkrug KJ, Sutter K, Dittmer U, Kroehl M, Kechris K, Wilson CC, Santiago ML. Qualitative Differences Between the IFNa subtypes and IFN? Influence Chronic Mucosal HIV-1 Pathogenesis. PLoS Pathog. 2020 10; 16(10):e1008986.PLoS Pathog2020-10-16T00:00:002020Qualitative Differences Between the IFNa subtypes and IFN? Influence Chronic Mucosal HIV-1 Pathogenesis.Authorship 236386433654719Dillon SM, Guo K, Castleman MJ, Santiago ML, Wilson CCBio-protocolDillon SM, Guo K, Castleman MJ, Santiago ML, Wilson CC. Quantifying HIV-1-Mediated Gut CD4+ T Cell Deathin the Lamina Propria Aggregate Culture (LPAC) Model. Bio Protoc. 2020 Jan 20; 10(2):e3486.Bio Protoc2020-01-20T00:00:002020Quantifying HIV-1-Mediated Gut CD4+ T Cell Deathin the Lamina Propria Aggregate Culture (LPAC) Model.Authorship 2379238Authorship 238273433758840Guo K, Barrett BS, Mickens KL, Vladar EK, Morrison JH, Hasenkrug KJ, Poeschla EM, Santiago MLbioRxiv : the preprint server for biologyGuo K, Barrett BS, Mickens KL, Vladar EK, Morrison JH, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon Resistance of Emerging SARS-CoV-2 Variants. bioRxiv. 2021 Dec 10.bioRxiv2021-12-10T00:00:002021Interferon Resistance of Emerging SARS-CoV-2 Variants.33821272Hasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith B, Meade-White K, Shupert WL, Hawman DW, Feldmann HbioRxiv : the preprint server for biologyHasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith B, Meade-White K, Shupert WL, Hawman DW, Feldmann H. Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques. bioRxiv. 2021 Apr 04.bioRxiv2021-04-04T00:00:002021Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques.Authorship 175031Authorship 241916434117105Castleman MJ, Dillon SM, Thompson TA, Santiago ML, McCarter MD, Barker E, Wilson CCJournal of immunology (Baltimore, Md. : 1950)Castleman MJ, Dillon SM, Thompson TA, Santiago ML, McCarter MD, Barker E, Wilson CC. Gut Bacteria Induce Granzyme B Expression in Human Colonic ILC3s In Vitro in an IL-15-Dependent Manner. J Immunol. 2021 06 15; 206(12):3043-3052.J Immunol2021-06-11T00:00:002021Gut Bacteria Induce Granzyme B Expression in Human Colonic ILC3s In Vitro in an IL-15-Dependent Manner.Authorship 244944434311582Hasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith BJ, Meade-White K, Shupert WL, Hawman DW, Feldmann HmBioHasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith BJ, Meade-White K, Shupert WL, Hawman DW, Feldmann H. Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques. mBio. 2021 08 31; 12(4):e0150321.mBio2021-07-27T00:00:002021Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques.Authorship 2536391334893529Barrett B, Nguyen DH, Xu J, Guo K, Shetty S, Jones ST, Mickens KL, Shepard C, Roers A, Behrendt R, Wu L, Kim B, Santiago MLJournal of immunology (Baltimore, Md. : 1950)Barrett B, Nguyen DH, Xu J, Guo K, Shetty S, Jones ST, Mickens KL, Shepard C, Roers A, Behrendt R, Wu L, Kim B, Santiago ML. SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. J Immunol. 2022 01 15; 208(2):444-453.J Immunol2021-12-10T00:00:002021SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.Authorship 255375934996045Windsor WJ, Knight V, Merkel PA, Lamb MM, Tucker HR, Carson K, Howard KM, Yates JL, Santiago ML, McCarthy MK, Morrison TE, Kedl RM, Frazer-Abel A, Guo K, Andersen G, Huey L, Barrett BS, Col?n-Franco JM, Lee WT, Chu MCThe American journal of tropical medicine and hygieneWindsor WJ, Knight V, Merkel PA, Lamb MM, Tucker HR, Carson K, Howard KM, Yates JL, Santiago ML, McCarthy MK, Morrison TE, Kedl RM, Frazer-Abel A, Guo K, Andersen G, Huey L, Barrett BS, Col?n-Franco JM, Lee WT, Chu MC. COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method. Am J Trop Med Hyg. 2022 01 07; 106(2):562-565.Am J Trop Med Hyg2022-01-07T00:00:002022COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method.Authorship 25759419Authorship 25794112Authorship 2573481835217532Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JMProceedings of the National Academy of Sciences of the United States of AmericaGalbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Specialized interferon action in COVID-19. Proc Natl Acad Sci U S A. 2022 03 15; 119(11).Proc Natl Acad Sci U S A2022-03-15T00:00:002022Specialized interferon action in COVID-19.35169807Olson D, Calvimontes DM, Lamb MM, Guzman G, Barrios E, Chacon A, Rojop N, Arias K, Gomez M, Bolanos GA, Monzon J, Chard AN, Iwamoto C, Duca LM, Vuong N, Fineman M, Lesteberg K, Beckham D, Santiago ML, Quicke K, Ebel G, Gutierrez EZ, Azziz-Baumgartner E, Hayden FG, Mansour H, Edwards K, Newman LS, Asturias EJmedRxiv : the preprint server for health sciencesOlson D, Calvimontes DM, Lamb MM, Guzman G, Barrios E, Chacon A, Rojop N, Arias K, Gomez M, Bolanos GA, Monzon J, Chard AN, Iwamoto C, Duca LM, Vuong N, Fineman M, Lesteberg K, Beckham D, Santiago ML, Quicke K, Ebel G, Gutierrez EZ, Azziz-Baumgartner E, Hayden FG, Mansour H, Edwards K, Newman LS, Asturias EJ. Clinical and Economic Impact of COVID-19 on Plantation Workers: Preliminary Results from the Guatemala Agricultural Workers and Respiratory Illness Impact (AGRI) Study. medRxiv. 2022 Feb 08.medRxiv2022-02-08T00:00:002022Clinical and Economic Impact of COVID-19 on Plantation Workers: Preliminary Results from the Guatemala Agricultural Workers and Respiratory Illness Impact (AGRI) Study.35258402Dillon SM, Mickens KL, Thompson TA, Cooper EH, Nesladek S, Christians AJ, Castleman M, Guo K, Wood C, Frank DN, Kechris K, Santiago ML, Wilson CCGut microbesDillon SM, Mickens KL, Thompson TA, Cooper EH, Nesladek S, Christians AJ, Castleman M, Guo K, Wood C, Frank DN, Kechris K, Santiago ML, Wilson CC. Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection. Gut Microbes. 2022 Jan-Dec; 14(1):2045852.Gut Microbes2022-01-01T00:00:002022Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection.Authorship 199421Authorship 211346Authorship 263332235671565Warren CJ, Santiago ML, Pyeon DAnnual review of virologyWarren CJ, Santiago ML, Pyeon D. APOBEC3: Friend or Foe in Human Papillomavirus Infection and Oncogenesis? Annu Rev Virol. 2022 09 29; 9(1):375-395.Annu Rev Virol2022-06-07T00:00:002022APOBEC3: Friend or Foe in Human Papillomavirus Infection and Oncogenesis?Authorship 218112Authorship 264955835867811Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago MLProceedings of the National Academy of Sciences of the United States of AmericaGuo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2203760119.Proc Natl Acad Sci U S A2022-07-22T00:00:002022Interferon resistance of emerging SARS-CoV-2 variants.Authorship 22638Authorship 2656552235891324Iwamoto C, Lesteberg KE, Lamb MM, Calvimontes DM, Guo K, Barrett BS, Mickens KL, Duca LM, Monzon J, Chard AN, Guzman G, Barrios E, Rojop N, Arias K, Gomez M, Paiz C, Bolanos GA, Edwards KM, Zielinski Gutierrez E, Azziz-Baumgartner E, Asturias EJ, Santiago ML, Beckham JD, Olson DVaccinesIwamoto C, Lesteberg KE, Lamb MM, Calvimontes DM, Guo K, Barrett BS, Mickens KL, Duca LM, Monzon J, Chard AN, Guzman G, Barrios E, Rojop N, Arias K, Gomez M, Paiz C, Bolanos GA, Edwards KM, Zielinski Gutierrez E, Azziz-Baumgartner E, Asturias EJ, Santiago ML, Beckham JD, Olson D. High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021. Vaccines (Basel). 2022 Jul 21; 10(7).Vaccines (Basel)2022-07-21T00:00:002022High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021.35938870Jones ST, Guo K, Cooper EH, Dillon SM, Wood C, Nguyen DH, Shen G, Barrett BS, Frank DN, Kroehl M, Janoff EN, Kechris K, Wilson CC, Santiago MLJournal of virologyJones ST, Guo K, Cooper EH, Dillon SM, Wood C, Nguyen DH, Shen G, Barrett BS, Frank DN, Kroehl M, Janoff EN, Kechris K, Wilson CC, Santiago ML. Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection. J Virol. 2022 09 14; 96(17):e0097622.J Virol2022-08-08T00:00:002022Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection.Authorship 245596Authorship 27654819Authorship 2750967Authorship 2727601436502430Olson D, Calvimontes DM, Lamb MM, Guzman G, Barrios E, Chacon A, Rojop N, Arias K, Gomez M, Bolanos GA, Monzon J, Chard AN, Iwamoto C, Duca LM, Vuong N, Fineman M, Lesteberg K, Beckham D, Santiago ML, Quicke K, Ebel G, Gutierrez EZ, Azziz-Baumgartner E, Hayden FG, Mansour H, Edwards K, Newman LS, Asturias EJEmerging infectious diseasesOlson D, Calvimontes DM, Lamb MM, Guzman G, Barrios E, Chacon A, Rojop N, Arias K, Gomez M, Bolanos GA, Monzon J, Chard AN, Iwamoto C, Duca LM, Vuong N, Fineman M, Lesteberg K, Beckham D, Santiago ML, Quicke K, Ebel G, Gutierrez EZ, Azziz-Baumgartner E, Hayden FG, Mansour H, Edwards K, Newman LS, Asturias EJ. Clinical and Economic Impact of COVID-19 on Agricultural Workers, Guatemala1. Emerg Infect Dis. 2022; 28(13):277-287.Emerg Infect Dis2022-01-01T00:00:002022Clinical and Economic Impact of COVID-19 on Agricultural Workers, Guatemala1.36458014Sertznig H, Roesmann F, Wilhelm A, Heininger D, Bleekmann B, Elsner C, Santiago M, Schuhenn J, Karakoese Z, Benatzy Y, Snodgrass R, Esser S, Sutter K, Dittmer U, Widera MFrontiers in immunologySertznig H, Roesmann F, Wilhelm A, Heininger D, Bleekmann B, Elsner C, Santiago M, Schuhenn J, Karakoese Z, Benatzy Y, Snodgrass R, Esser S, Sutter K, Dittmer U, Widera M. SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps. Front Immunol. 2022; 13:935800.Front Immunol2022-11-15T00:00:002022SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.Authorship 265438true1Distinguished ProfessorDistinguished Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Asst Professor-ResearchAsst Professor-Researchtrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Assoc Professor-ResearchAssoc Professor-Researchtrue1Assoc Professor-ResearchAssoc Professor-Researchtrue1Asst ProfessorAsst ProfessorAuthorship 282971Authorship 28632Authorship 2913951537745311Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen L, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EBbioRxiv : the preprint server for biologyPasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen L, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB. Regulation of human interferon signaling by transposon exonization. bioRxiv. 2023 Sep 15.bioRxiv2023-09-15T00:00:002023Regulation of human interferon signaling by transposon exonization.true1ProfessorProfessorAuthorship 287895AndresHenao MartinezAndres F. Henao Martinez39.74528180000000-104.837572700000008322Henao Martinez, Andres0000-0001-7363-8652Associate ProfessorAuthorship 2943911037883584Malyshkina A, Bayer W, Podschwadt P, Otto L, Karakoese Z, Sutter K, Bruderek K, Wang B, Lavender KJ, Santiago ML, Leipe PM, Elsner C, Esser S, Brandau S, Gunzer M, Dittmer UPLoS pathogensMalyshkina A, Bayer W, Podschwadt P, Otto L, Karakoese Z, Sutter K, Bruderek K, Wang B, Lavender KJ, Santiago ML, Leipe PM, Elsner C, Esser S, Brandau S, Gunzer M, Dittmer U. Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles. PLoS Pathog. 2023 Oct; 19(10):e1011725.PLoS Pathog2023-10-26T00:00:002023Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles.true1ProfessorProfessortrue1Affiliate - DHHAAffiliate - DHHAtrue1Affiliate - DHHAAffiliate - DHHAAuthorship 1064917Authorship 1064923Authorship 38626824495380Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CCRetrovirologySteele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo. Retrovirology. 2014 Feb 04; 11:14.Retrovirology2014-02-04T00:00:002014Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo.24335304Cavrois M, Neidleman J, Santiago ML, Derdeyn CA, Hunter E, Greene WCJournal of virologyCavrois M, Neidleman J, Santiago ML, Derdeyn CA, Hunter E, Greene WC. Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol. 2014 Feb; 88(4):2083-94.J Virol2013-12-11T00:00:002013Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains.Authorship 397424Authorship 40043Authorship 402712Authorship 467198Authorship 109678724821801Halemano K, Guo K, Heilman KJ, Barrett BS, Smith DS, Hasenkrug KJ, Santiago MLProceedings of the National Academy of Sciences of the United States of AmericaHalemano K, Guo K, Heilman KJ, Barrett BS, Smith DS, Hasenkrug KJ, Santiago ML. Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7759-64.Proc Natl Acad Sci U S A2014-05-12T00:00:002014Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.Authorship 110250924872193Li SX, Barrett BS, Heilman KJ, Messer RJ, Liberatore RA, Bieniasz PD, Kassiotis G, Hasenkrug KJ, Santiago MLJournal of immunology (Baltimore, Md. : 1950)Li SX, Barrett BS, Heilman KJ, Messer RJ, Liberatore RA, Bieniasz PD, Kassiotis G, Hasenkrug KJ, Santiago ML. Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo. J Immunol. 2014 Jul 01; 193(1):306-16.J Immunol2014-05-28T00:00:002014Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.Authorship 502991Authorship 510166Authorship 5391Authorship 572064Authorship 615588Authorship 616677Authorship 622418EricPoeschlaEric M Poeschla39.74528180000000-104.837572700000009025Poeschla, EricProfessorAuthorship 705491Authorship 116150625262471Katuwal M, Wang Y, Schmitt K, Guo K, Halemano K, Santiago ML, Stephens EBVirologyKatuwal M, Wang Y, Schmitt K, Guo K, Halemano K, Santiago ML, Stephens EB. Cellular HIV-1 inhibition by truncated old world primate APOBEC3A proteins lacking a complete deaminase domain. Virology. 2014 Nov; 468-470:532-544.Virology2014-09-28T00:00:002014Cellular HIV-1 inhibition by truncated old world primate APOBEC3A proteins lacking a complete deaminase domain.Authorship 116536725303118Barrett BS, Guo K, Harper MS, Li SX, Heilman KJ, Davidson NO, Santiago MLVirologyBarrett BS, Guo K, Harper MS, Li SX, Heilman KJ, Davidson NO, Santiago ML. Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo. Virology. 2014 Nov; 468-470:601-608.Virology2014-10-07T00:00:002014Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.Authorship 116941Authorship 116942Santiago ML, Greene WCThe role of the APOBEC3 family of cytidine deaminases in innate immunity, G to A hypermutation, and evolution of retroviruses. In: The Origin and Evolution of Viruses, E. Domingo, C. Parish, J.L. Holland (eds.). Santiago ML, Greene WC. The role of the APOBEC3 family of cytidine deaminases in innate immunity, G to A hypermutation, and evolution of retroviruses. In: The Origin and Evolution of Viruses, E. Domingo, C. Parish, J.L. Holland (eds.). 2007.2007-01-01T00:00:002007The role of the APOBEC3 family of cytidine deaminases in innate immunity, G to A hypermutation, and evolution of retroviruses. In: The Origin and Evolution of Viruses, E. Domingo, C. Parish, J.L. Holland (eds.)Bailes E, Chaudhuri RR, Santiago ML, Bibollet-Ruche F, Hahn BH and Sharp PMThe evolution of primate lentiviruses and the origin of AIDS. In The Molecular Epidemiology of Human Viruses, T. Leitner (ed.) p. 65-95. Kluwer Academic Publishers, Boston, MA.Bailes E, Chaudhuri RR, Santiago ML, Bibollet-Ruche F, Hahn BH and Sharp PM. The evolution of primate lentiviruses and the origin of AIDS. In The Molecular Epidemiology of Human Viruses, T. Leitner (ed.) p. 65-95. Kluwer Academic Publishers, Boston, MA. 2002.2002-01-01T00:00:002002The evolution of primate lentiviruses and the origin of AIDS. In The Molecular Epidemiology of Human Viruses, T. Leitner (ed.) p. 65-95. Kluwer Academic Publishers, Boston, MAAuthorship 116945825355878Warren CJ, Xu T, Guo K, Griffin LM, Westrich JA, Lee D, Lambert PF, Santiago ML, Pyeon DJournal of virologyWarren CJ, Xu T, Guo K, Griffin LM, Westrich JA, Lee D, Lambert PF, Santiago ML, Pyeon D. APOBEC3A functions as a restriction factor of human papillomavirus. J Virol. 2015 Jan; 89(1):688-702.J Virol2014-10-29T00:00:002014APOBEC3A functions as a restriction factor of human papillomavirus.Authorship 116946725362178Connick E, Folkvord JM, Lind KT, Rakasz EG, Miles B, Wilson NA, Santiago ML, Schmitt K, Stephens EB, Kim HO, Wagstaff R, Li S, Abdelaal HM, Kemp N, Watkins DI, MaWhinney S, Skinner PJJournal of immunology (Baltimore, Md. : 1950)Connick E, Folkvord JM, Lind KT, Rakasz EG, Miles B, Wilson NA, Santiago ML, Schmitt K, Stephens EB, Kim HO, Wagstaff R, Li S, Abdelaal HM, Kemp N, Watkins DI, MaWhinney S, Skinner PJ. Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL. J Immunol. 2014 Dec 01; 193(11):5613-25.J Immunol2014-10-31T00:00:002014Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL.Authorship 780581Authorship 786192Authorship 80289Authorship 805961