 Connection
Dennis Roop to Mice, Transgenic
This is a "connection" page, showing publications Dennis Roop has written about Mice, Transgenic.
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Connection Strength |
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2.043 |
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Chen J, Roop DR. Genetically engineered mouse models for skin research: taking the next step. J Dermatol Sci. 2008 Oct; 52(1):1-12.
Score: 0.206
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Bickenbach JR, Longley MA, Bundman DS, Dominey AM, Bowden PE, Rothnagel JA, Roop DR. A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis. Differentiation. 1996 Dec; 61(2):129-39.
Score: 0.093
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Greenhalgh DA, Wang XJ, Roop DR. Multistage skin carcinogenesis in transgenic mice. Proc Assoc Am Physicians. 1995 Jul; 107(2):258-75.
Score: 0.084
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Greenhalgh DA, Wang XJ, Rothnagel JA, Eckhardt JN, Quintanilla MI, Barber JL, Bundman DS, Longley MA, Schlegel R, Roop DR. Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas. Cell Growth Differ. 1994 Jun; 5(6):667-75.
Score: 0.078
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Rothnagel JA, Greenhalgh DA, Wang XJ, Sellheyer K, Bickenbach JR, Dominey AM, Roop DR. Transgenic models of skin diseases. Arch Dermatol. 1993 Nov; 129(11):1430-6.
Score: 0.075
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Honeycutt KA, Waikel RL, Koster MI, Wang XJ, Roop DR. The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog. 2010 Apr; 49(4):315-9.
Score: 0.059
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Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res. 2009 Sep 15; 69(18):7207-15.
Score: 0.056
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Koster MI, Marinari B, Payne AS, Kantaputra PN, Costanzo A, Roop DR. DeltaNp63 knockdown mice: A mouse model for AEC syndrome. Am J Med Genet A. 2009 Sep; 149A(9):1942-7.
Score: 0.056
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Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60.
Score: 0.047
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Koster MI, Lu SL, White LD, Wang XJ, Roop DR. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Cancer Res. 2006 Apr 15; 66(8):3981-6.
Score: 0.045
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Chen J, Roop DR. Mouse models in preclinical studies for pachyonychia congenita. J Investig Dermatol Symp Proc. 2005 Oct; 10(1):37-46.
Score: 0.043
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Koster MI, Roop DR. Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle. 2004 Apr; 3(4):411-3.
Score: 0.039
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Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 2004 Jan 15; 18(2):126-31.
Score: 0.038
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Arin MJ, Roop DR. Inducible mouse models for inherited skin diseases: implications for skin gene therapy. Cells Tissues Organs. 2004; 177(3):160-8.
Score: 0.038
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Koster MI, Huntzinger KA, Roop DR. Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. J Investig Dermatol Symp Proc. 2002 Dec; 7(1):41-5.
Score: 0.035
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Cao T, Tsai SY, O'Malley BW, Wang XJ, Roop DR. The epidermis as a bioreactor: topically regulated cutaneous delivery into the circulation. Hum Gene Ther. 2002 Jun 10; 13(9):1075-80.
Score: 0.034
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Zhou Z, Wang D, Wang XJ, Roop DR. In utero activation of K5.CrePR1 induces gene deletion. Genesis. 2002 Feb; 32(2):191-2.
Score: 0.033
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Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet. 2001 Jun; 28(2):165-8.
Score: 0.032
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Arin MJ, Longley MA, Wang XJ, Roop DR. Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders. J Cell Biol. 2001 Feb 05; 152(3):645-9.
Score: 0.031
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Cao T, Longley MA, Wang XJ, Roop DR. An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy. J Cell Biol. 2001 Feb 05; 152(3):651-6.
Score: 0.031
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Cao T, Wang XJ, Roop DR. Regulated cutaneous gene delivery: the skin as a bioreactor. Hum Gene Ther. 2000 Nov 01; 11(16):2297-300.
Score: 0.031
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Suga Y, Jarnik M, Attar PS, Longley MA, Bundman D, Steven AC, Koch PJ, Roop DR. Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. J Cell Biol. 2000 Oct 16; 151(2):401-12.
Score: 0.030
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Wang XJ, Greenhalgh DA, Donehower LA, Roop DR. Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. Mol Carcinog. 2000 Oct; 29(2):67-75.
Score: 0.030
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Wang XJ, Greenhalgh DA, Roop DR. Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Mol Carcinog. 2000 Mar; 27(3):200-9.
Score: 0.029
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Wang XJ, Liefer KM, Greenhalgh DA, Roop DR. 12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation. Mol Carcinog. 1999 Dec; 26(4):305-11.
Score: 0.029
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Wojcik SM, Imakado S, Seki T, Longley MA, Petherbridge L, Bundman DS, Bickenbach JR, Rothnagel JA, Roop DR. Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle. Differentiation. 1999 Oct; 65(2):97-112.
Score: 0.028
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Rothnagel JA, Seki T, Ogo M, Longley MA, Wojcik SM, Bundman DS, Bickenbach JR, Roop DR. The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis. Differentiation. 1999 Oct; 65(2):119-30.
Score: 0.028
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Waikel RL, Wang XJ, Roop DR. Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis. Oncogene. 1999 Aug 26; 18(34):4870-8.
Score: 0.028
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Wang XJ, Liefer KM, Tsai S, O'Malley BW, Roop DR. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8483-8.
Score: 0.028
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DiSepio D, Bickenbach JR, Longley MA, Bundman DS, Rothnagel JA, Roop DR. Characterization of loricrin regulation in vitro and in transgenic mice. Differentiation. 1999 May; 64(4):225-35.
Score: 0.027
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Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Medina D, Brinkley BR, Roop DR. Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis. Oncogene. 1998 Jul 09; 17(1):35-45.
Score: 0.026
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Rodr?guez-Villanueva J, Greenhalgh D, Wang XJ, Bundman D, Cho S, Delehedde M, Roop D, McDonnell TJ. Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene. 1998 Feb 19; 16(7):853-63.
Score: 0.025
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Attar PS, Wertz PW, McArthur M, Imakado S, Bickenbach JR, Roop DR. Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function. Mol Endocrinol. 1997 Jun; 11(6):792-800.
Score: 0.024
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Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. 2017 08 31; 36(35):4997-5005.
Score: 0.024
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Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR. Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2386-91.
Score: 0.024
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Greenhalgh DA, Wang XJ, Donehower LA, Roop DR. Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer Res. 1996 Oct 01; 56(19):4413-23.
Score: 0.023
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Greenhalgh DA, Wang XJ, Roop DR. Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox. J Investig Dermatol Symp Proc. 1996 Apr; 1(2):162-76.
Score: 0.022
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Rothnagel JA, Roop DR. Hair follicle companion layer: reacquainting an old friend. J Invest Dermatol. 1995 May; 104(5 Suppl):42S-43S.
Score: 0.021
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Greenhalgh DA, Wang XJ, Eckhardt JN, Roop DR. 12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy. Cell Growth Differ. 1995 May; 6(5):579-86.
Score: 0.021
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Wang XJ, Greenhalgh DA, Lu XR, Bickenbach JR, Roop DR. TGF alpha and v-fos cooperation in transgenic mouse epidermis induces aberrant keratinocyte differentiation and stable, autonomous papillomas. Oncogene. 1995 Jan 19; 10(2):279-89.
Score: 0.020
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Rothnagel JA, Longley MA, Holder RA, Bundman DS, Seki T, Bickenbach JR, Roop DR. Genetic disorders of keratin: are scarring alopecias a sub-set? J Dermatol Sci. 1994 Jul; 7 Suppl:S164-9.
Score: 0.020
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Wang XJ, Greenhalgh DA, Eckhardt JN, Rothnagel JA, Roop DR. Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression. Mol Carcinog. 1994 May; 10(1):15-22.
Score: 0.019
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Sch?fer M, Willrodt AH, Kurinna S, Link AS, Farwanah H, Geusau A, Gruber F, Sorg O, Huebner AJ, Roop DR, Sandhoff K, Saurat JH, Tschachler E, Schneider MR, Langbein L, Bloch W, Beer HD, Werner S. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med. 2014 04; 6(4):442-57.
Score: 0.019
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Greenhalgh DA, Wang XJ, Dominey AM, Rothnagel JA, Roop DR. Development of transgenic mouse models of skin carcinogenesis: potential applications. Prog Clin Biol Res. 1994; 387:75-94.
Score: 0.019
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Greenhalgh DA, Roop DR. Dissecting molecular carcinogenesis: development of transgenic mouse models by epidermal gene targeting. Adv Cancer Res. 1994; 64:247-96.
Score: 0.019
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Greenhalgh DA, Quintanilla MI, Orengo CC, Barber JL, Eckhardt JN, Rothnagel JA, Roop DR. Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Res. 1993 Nov 01; 53(21):5071-5.
Score: 0.019
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White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ. Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Oct; 123(10):4390-404.
Score: 0.019
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Greenhalgh DA, Rothnagel JA, Wang XJ, Quintanilla MI, Orengo CC, Gagne TA, Bundman DS, Longley MA, Fisher C, Roop DR. Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia. Oncogene. 1993 Aug; 8(8):2145-57.
Score: 0.018
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Sellheyer K, Bickenbach JR, Rothnagel JA, Bundman D, Longley MA, Krieg T, Roche NS, Roberts AB, Roop DR. Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5237-41.
Score: 0.018
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Greenhalgh DA, Rothnagel JA, Quintanilla MI, Orengo CC, Gagne TA, Bundman DS, Longley MA, Roop DR. Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene. Mol Carcinog. 1993; 7(2):99-110.
Score: 0.018
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Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Hilsenbeck SG, Roop DR, Leavitt AD, Li Y. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene. 2011 Oct 27; 30(43):4399-409.
Score: 0.016
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Rosenthal DS, Steinert PM, Chung S, Huff CA, Johnson J, Yuspa SH, Roop DR. A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes. Cell Growth Differ. 1991 Feb; 2(2):107-13.
Score: 0.016
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Rothnagel JA, Longley MA, Bundman D, Greenhalgh DA, Dominey AM, Roop DR. Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders. J Invest Dermatol. 1990 Nov; 95(5 Suppl):59S-61S.
Score: 0.015
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Kim S, Choi IF, Quante JR, Zhang L, Roop DR, Koster MI. p63 directly induces expression of Alox12, a regulator of epidermal barrier formation. Exp Dermatol. 2009 Dec; 18(12):1016-21.
Score: 0.014
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Iwai N, Zhou Z, Roop DR, Behringer RR. Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium. Stem Cells. 2008 May; 26(5):1298-306.
Score: 0.013
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Lee S, Chari NS, Kim HW, Wang X, Roop DR, Cho SH, DiGiovanni J, McDonnell TJ. Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis. Mol Carcinog. 2007 Dec; 46(12):949-57.
Score: 0.012
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Shah VR, Koster MI, Roop DR, Spencer DM, Wei L, Li Q, Schwartz RJ, Chang J. Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis. 2007 Apr; 45(4):194-9.
Score: 0.012
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Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop DR, Koch PJ. An unexpected role for keratin 10 end domains in susceptibility to skin cancer. J Cell Sci. 2006 Dec 15; 119(Pt 24):5067-76.
Score: 0.012
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Geng S, Mezentsev A, Kalachikov S, Raith K, Roop DR, Panteleyev AA. Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function. J Cell Sci. 2006 Dec 01; 119(Pt 23):4901-12.
Score: 0.012
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Honeycutt KA, Chen Z, Koster MI, Miers M, Nuchtern J, Hicks J, Roop DR, Shohet JM. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene. 2006 Jul 06; 25(29):4027-32.
Score: 0.011
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Matsumoto T, Kiguchi K, Jiang J, Carbajal S, Ruffino L, Beltr?n L, Wang XJ, Roop DR, DiGiovanni J. Development of transgenic mice that inducibly express an active form of c-Src in the epidermis. Mol Carcinog. 2004 Aug; 40(4):189-200.
Score: 0.010
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Sil AK, Maeda S, Sano Y, Roop DR, Karin M. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4.
Score: 0.010
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Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, Toftgard R, McDonnell TJ. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem. 2004 Jan 09; 279(2):1197-205.
Score: 0.009
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Cao T, He W, Roop DR, Wang XJ. K14-GLp65 transactivator induces transgene expression in embryonic epidermis. Genesis. 2002 Feb; 32(2):189-90.
Score: 0.008
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Klug DB, Carter C, Crouch E, Roop D, Conti CJ, Richie ER. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11822-7.
Score: 0.007
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Borkowski TA, Letterio JJ, Mackall CL, Saitoh A, Wang XJ, Roop DR, Gress RE, Udey MC. A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice. J Clin Invest. 1997 Aug 01; 100(3):575-81.
Score: 0.006
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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