Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.
 Back to Details

Connection

Sean Colgan to Intestinal Mucosa

This is a "connection" page, showing publications Sean Colgan has written about Intestinal Mucosa.

 
Connection Strength
  
 
 
20.794
  
  1. Ornelas A, Countess JA, Kim JY, Cohen RH, Gomez BD, Roer RL, Minhajuddin F, Yenugudhati Vijaya Sai K, Zhou L, Dunn JLM, Chandler C, Reigan P, Cartwright IM, Hall CHT, Bhagavatula G, Onyiah JC, Dowdell AS, Colgan SP. Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa. Proc Natl Acad Sci U S A. 2026 Apr 14; 123(15):e2527863123.
    View in: PubMed
    Score: 0.638
  2. Fagundes RR, Colgan SP. Feeding microbes to feed the Gut: inulin reprograms intestinal epithelial metabolism and proliferation through HIF1a. Gut Microbes. 2026 Dec 31; 18(1):2644684.
    View in: PubMed
    Score: 0.635
  3. Bhagavatula G, Schaepe C, Colgan S. Measuring Intestinal Barrier Permeability by Detecting Flux of Fluorescent Tracers Across Human Colonoid Monolayers. J Vis Exp. 2025 10 17; (224).
    View in: PubMed
    Score: 0.617
  4. Ornelas A, Countess JA, Kim JY, Colgan SP. Modifying microbially derived short chain fatty acids to promote health. J Physiol. 2026 01; 604(1):116-128.
    View in: PubMed
    Score: 0.602
  5. Wang T, Wang RX, Colgan SP. Physiologic hypoxia in the intestinal mucosa: a central role for short-chain fatty acids. Am J Physiol Cell Physiol. 2024 10 01; 327(4):C1087-C1093.
    View in: PubMed
    Score: 0.570
  6. Cartwright IM, Zhou L, Koch SD, Welch N, Zakharov D, Callahan R, Steiner CA, Gerich ME, Onyiah JC, Colgan SP. Chlorination of epithelial tight junction proteins by neutrophil myeloperoxidase promotes barrier dysfunction and mucosal inflammation. JCI Insight. 2024 06 11; 9(14).
    View in: PubMed
    Score: 0.562
  7. Steiner CA, Cartwright IM, Taylor CT, Colgan SP. Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis. Am J Physiol Cell Physiol. 2022 09 01; 323(3):C866-C878.
    View in: PubMed
    Score: 0.494
  8. Cartwright IM, Dowdell AS, Hanson C, Kostelecky RE, Welch N, Steiner CA, Colgan SP. Contact-dependent, polarized acidification response during neutrophil-epithelial interactions. J Leukoc Biol. 2022 12; 112(6):1543-1553.
    View in: PubMed
    Score: 0.489
  9. Ornelas A, Dowdell AS, Lee JS, Colgan SP. Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function. Cells. 2022 03 10; 11(6).
    View in: PubMed
    Score: 0.481
  10. Cartwright IM, Colgan SP. In vitro Monitoring of Extracellular pH in Real-Time. J Vis Exp. 2021 06 03; (172).
    View in: PubMed
    Score: 0.456
  11. Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell. 2020 09 15; 31(20):2249-2258.
    View in: PubMed
    Score: 0.430
  12. Hall CHT, Lee JS, Murphy EM, Gerich ME, Dran R, Glover LE, Abdulla ZI, Skelton MR, Colgan SP. Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. Gastroenterology. 2020 09; 159(3):984-998.e1.
    View in: PubMed
    Score: 0.424
  13. Wang RX, Lee JS, Campbell EL, Colgan SP. Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11648-11657.
    View in: PubMed
    Score: 0.424
  14. Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2020 03; 13(2):230-244.
    View in: PubMed
    Score: 0.411
  15. Onyiah JC, Schaefer REM, Colgan SP. A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression. J Innate Immun. 2018; 10(3):228-238.
    View in: PubMed
    Score: 0.370
  16. Lee JS, Wang RX, Alexeev EE, Lanis JM, Battista KD, Glover LE, Colgan SP. Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function. J Biol Chem. 2018 04 20; 293(16):6039-6051.
    View in: PubMed
    Score: 0.364
  17. Alexeev EE, Lanis JM, Kao DJ, Campbell EL, Kelly CJ, Battista KD, Gerich ME, Jenkins BR, Walk ST, Kominsky DJ, Colgan SP. Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol. 2018 05; 188(5):1183-1194.
    View in: PubMed
    Score: 0.363
  18. Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, Wang RX, Onyiah JC, Kominsky DJ, Colgan SP. Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2. J Immunol. 2017 10 15; 199(8):2976-2984.
    View in: PubMed
    Score: 0.352
  19. Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2018 03; 11(2):357-368.
    View in: PubMed
    Score: 0.350
  20. Colgan SP, Campbell EL. Oxygen metabolism and innate immune responses in the gut. J Appl Physiol (1985). 2017 Nov 01; 123(5):1321-1327.
    View in: PubMed
    Score: 0.348
  21. Lanis JM, Kao DJ, Alexeev EE, Colgan SP. Tissue metabolism and the inflammatory bowel diseases. J Mol Med (Berl). 2017 Sep; 95(9):905-913.
    View in: PubMed
    Score: 0.345
  22. Wang RX, Colgan SP. Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses. Mol Aspects Med. 2017 Dec; 58:93-101.
    View in: PubMed
    Score: 0.339
  23. Lanis JM, Alexeev EE, Curtis VF, Kitzenberg DA, Kao DJ, Battista KD, Gerich ME, Glover LE, Kominsky DJ, Colgan SP. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol. 2017 09; 10(5):1133-1144.
    View in: PubMed
    Score: 0.337
  24. Chun C, Zheng L, Colgan SP. Tissue metabolism and host-microbial interactions in the intestinal mucosa. Free Radic Biol Med. 2017 04; 105:86-92.
    View in: PubMed
    Score: 0.330
  25. Campbell EL, Kao DJ, Colgan SP. Neutrophils and the inflammatory tissue microenvironment in the mucosa. Immunol Rev. 2016 09; 273(1):112-20.
    View in: PubMed
    Score: 0.328
  26. Glover LE, Lee JS, Colgan SP. Oxygen metabolism and barrier regulation in the intestinal mucosa. J Clin Invest. 2016 10 03; 126(10):3680-3688.
    View in: PubMed
    Score: 0.326
  27. Onyiah JC, Colgan SP. Cytokine responses and epithelial function in the intestinal mucosa. Cell Mol Life Sci. 2016 11; 73(22):4203-4212.
    View in: PubMed
    Score: 0.323
  28. Zheng L, Kelly CJ, Colgan SP. Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. Am J Physiol Cell Physiol. 2015 Sep 15; 309(6):C350-60.
    View in: PubMed
    Score: 0.303
  29. Campbell EL, Colgan SP. Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa. J Leukoc Biol. 2015 Oct; 98(4):517-22.
    View in: PubMed
    Score: 0.295
  30. Colgan SP, Curtis VF, Campbell EL. The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis. 2013 Sep; 19(10):2238-44.
    View in: PubMed
    Score: 0.266
  31. Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, McNamee EN, Eltzschig HK, Kominsky DJ, Colgan SP. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 2014 Jan; 7(1):114-23.
    View in: PubMed
    Score: 0.261
  32. Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP. Fundamental role for HIF-1a in constitutive expression of human ß defensin-1. Mucosal Immunol. 2013 Nov; 6(6):1110-8.
    View in: PubMed
    Score: 0.257
  33. Colgan SP, Ehrentraut SF, Glover LE, Kominsky DJ, Campbell EL. Contributions of neutrophils to resolution of mucosal inflammation. Immunol Res. 2013 Mar; 55(1-3):75-82.
    View in: PubMed
    Score: 0.257
  34. Colgan SP, Fennimore B, Ehrentraut SF. Adenosine and gastrointestinal inflammation. J Mol Med (Berl). 2013 Feb; 91(2):157-64.
    View in: PubMed
    Score: 0.255
  35. Keely S, Kelly CJ, Weissmueller T, Burgess A, Wagner BD, Robertson CE, Harris JK, Colgan SP. Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome. Gut Microbes. 2012 May-Jun; 3(3):250-60.
    View in: PubMed
    Score: 0.243
  36. Glover LE, Colgan SP. Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology. 2011 May; 140(6):1748-55.
    View in: PubMed
    Score: 0.227
  37. Kominsky DJ, Keely S, MacManus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP. An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol. 2011 Jun 01; 186(11):6505-14.
    View in: PubMed
    Score: 0.226
  38. Glover LE, Irizarry K, Scully M, Campbell EL, Bowers BE, Aherne CM, Kominsky DJ, MacManus CF, Colgan SP. IFN-? attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1ß. J Immunol. 2011 Feb 01; 186(3):1790-8.
    View in: PubMed
    Score: 0.222
  39. Campbell EL, MacManus CF, Kominsky DJ, Keely S, Glover LE, Bowers BE, Scully M, Bruyninckx WJ, Colgan SP. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14298-303.
    View in: PubMed
    Score: 0.215
  40. Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol. 2010 May; 7(5):281-7.
    View in: PubMed
    Score: 0.210
  41. Keely S, Glover LE, Weissmueller T, MacManus CF, Fillon S, Fennimore B, Colgan SP. Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia. Mol Biol Cell. 2010 Feb 15; 21(4):538-46.
    View in: PubMed
    Score: 0.206
  42. Louis NA, Robinson AM, MacManus CF, Karhausen J, Scully M, Colgan SP. Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol. 2008 Mar 15; 180(6):4246-55.
    View in: PubMed
    Score: 0.182
  43. Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology. 2008 Jan; 134(1):145-55.
    View in: PubMed
    Score: 0.180
  44. Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med (Berl). 2007 Dec; 85(12):1295-300.
    View in: PubMed
    Score: 0.178
  45. Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, Colgan SP. Selective induction of mucin-3 by hypoxia in intestinal epithelia. J Cell Biochem. 2006 Dec 15; 99(6):1616-27.
    View in: PubMed
    Score: 0.167
  46. Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 2006 Nov; 20(13):2242-50.
    View in: PubMed
    Score: 0.166
  47. Kim JY, Colgan SP, Cartwright IM. Neutrophil-derived reactive oxygen species and bystander tissue damage in inflammatory bowel disease. Free Radic Biol Med. 2026 Aug 01; 251:428-439.
    View in: PubMed
    Score: 0.160
  48. Ibla JC, Khoury J, Kong T, Robinson A, Colgan SP. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C282-9.
    View in: PubMed
    Score: 0.159
  49. Cohen RH, Colgan SP, Cartwright IM. Pleiotropic Mucosal Innate Immune Memory in the Gastrointestinal Tract. Int J Mol Sci. 2025 Oct 16; 26(20).
    View in: PubMed
    Score: 0.154
  50. Bhagavatula G, Worledge CS, Schaepe C, Murphy EM, Neuhart RM, Lee JS, Cartwright I, Colgan SP, Hall CHT. Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine Colitis. Cell Mol Gastroenterol Hepatol. 2025; 19(11):101557.
    View in: PubMed
    Score: 0.151
  51. Lee JS, Kao DJ, Worledge CS, Villamaria ZF, Wang RX, Welch NM, Kostelecky RE, Colgan SP. E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult. Gut Microbes. 2025 Dec; 17(1):2490211.
    View in: PubMed
    Score: 0.149
  52. Blumberg RS, Pitman RS, Taylor CT, Colgan SP. Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J Interferon Cytokine Res. 2005 Apr; 25(4):209-19.
    View in: PubMed
    Score: 0.149
  53. Ornelas A, Welch N, Countess JA, Zhou L, Wang RX, Dowdell AS, Colgan SP. Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers. Gut Microbes. 2023 12; 15(2):2267706.
    View in: PubMed
    Score: 0.134
  54. Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS. Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest. 2003 Sep; 112(5):745-54.
    View in: PubMed
    Score: 0.133
  55. Karhausen J, Ibla JC, Colgan SP. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):77-87.
    View in: PubMed
    Score: 0.128
  56. Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, Hansen KR, Thompson LF, Colgan SP. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest. 2002 Oct; 110(7):993-1002.
    View in: PubMed
    Score: 0.125
  57. Dowdell AS, Cartwright IM, Kitzenberg DA, Kostelecky RE, Mahjoob O, Saeedi BJ, Welch N, Glover LE, Colgan SP. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022 09 27; 40(13):111409.
    View in: PubMed
    Score: 0.125
  58. Lawrence DW, Comerford KM, Colgan SP. Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switch. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1235-45.
    View in: PubMed
    Score: 0.122
  59. Colgan SP, Comerford KM, Lawrence DW. Epithelial cell-neutrophil interactions in the alimentary tract: a complex dialog in mucosal surveillance and inflammation. ScientificWorldJournal. 2002 Jan 09; 2:76-88.
    View in: PubMed
    Score: 0.119
  60. Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 05 18; 118(20).
    View in: PubMed
    Score: 0.114
  61. Furuta GT, Turner JR, Taylor CT, Hershberg RM, Comerford K, Narravula S, Podolsky DK, Colgan SP. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med. 2001 May 07; 193(9):1027-34.
    View in: PubMed
    Score: 0.113
  62. Lee JS, Wang RX, Alexeev EE, Colgan SP. Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic. Gut Microbes. 2021 Jan-Dec; 13(1):1-20.
    View in: PubMed
    Score: 0.111
  63. Wang RX, Henen MA, Lee JS, Vögeli B, Colgan SP. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021 Jan-Dec; 13(1):1938380.
    View in: PubMed
    Score: 0.111
  64. Furuta GT, Dzus AL, Taylor CT, Colgan SP. Parallel induction of epithelial surface-associated chemokine and proteoglycan by cellular hypoxia: implications for neutrophil activation. J Leukoc Biol. 2000 Aug; 68(2):251-9.
    View in: PubMed
    Score: 0.108
  65. Colgan SP, Hershberg RM, Furuta GT, Blumberg RS. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13938-43.
    View in: PubMed
    Score: 0.103
  66. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999 Jun 15; 69(1):7-11.
    View in: PubMed
    Score: 0.099
  67. Friedman GB, Taylor CT, Parkos CA, Colgan SP. Epithelial permeability induced by neutrophil transmigration is potentiated by hypoxia: role of intracellular cAMP. J Cell Physiol. 1998 Jul; 176(1):76-84.
    View in: PubMed
    Score: 0.093
  68. Taylor CT, Dzus AL, Colgan SP. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterology. 1998 Apr; 114(4):657-68.
    View in: PubMed
    Score: 0.091
  69. Colgan SP. Nitric oxide and intestinal epithelia: just say NO. Gastroenterology. 1998 Mar; 114(3):601-3.
    View in: PubMed
    Score: 0.091
  70. Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 10; 85(10).
    View in: PubMed
    Score: 0.088
  71. Colgan SP, Morales VM, Madara JL, Polischuk JE, Balk SP, Blumberg RS. IFN-gamma modulates CD1d surface expression on intestinal epithelia. Am J Physiol. 1996 Jul; 271(1 Pt 1):C276-83.
    View in: PubMed
    Score: 0.081
  72. Colgan SP. Targeting hypoxia in inflammatory bowel disease. J Investig Med. 2016 Feb; 64(2):364-8.
    View in: PubMed
    Score: 0.078
  73. Colgan SP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Frendl G, Madara JL. Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem. 1995 May 05; 270(18):10531-9.
    View in: PubMed
    Score: 0.075
  74. Saeedi BJ, Kao DJ, Kitzenberg DA, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell. 2015 Jun 15; 26(12):2252-62.
    View in: PubMed
    Score: 0.075
  75. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38.
    View in: PubMed
    Score: 0.074
  76. Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless A, Kelly CJ, Kominsky DJ, Colgan SP. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J. 2015 Jan; 29(1):208-15.
    View in: PubMed
    Score: 0.072
  77. Colgan SP, Resnick MB, Parkos CA, Delp-Archer C, McGuirk D, Bacarra AE, Weller PF, Madara JL. IL-4 directly modulates function of a model human intestinal epithelium. J Immunol. 1994 Sep 01; 153(5):2122-9.
    View in: PubMed
    Score: 0.071
  78. Colgan SP, Parkos CA, Matthews JB, D'Andrea L, Awtrey CS, Lichtman AH, Delp-Archer C, Madara JL. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J Physiol. 1994 Aug; 267(2 Pt 1):C402-10.
    View in: PubMed
    Score: 0.071
  79. Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, MacManus CF, Müller W, Colgan SP, Bruder D. IFN-?-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 01; 192(3):1267-76.
    View in: PubMed
    Score: 0.068
  80. Colgan SP, Serhan CN, Parkos CA, Delp-Archer C, Madara JL. Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest. 1993 Jul; 92(1):75-82.
    View in: PubMed
    Score: 0.066
  81. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93.
    View in: PubMed
    Score: 0.062
  82. Colgan SP, Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol. 2012; 74:153-75.
    View in: PubMed
    Score: 0.059
  83. MacManus CF, Campbell EL, Keely S, Burgess A, Kominsky DJ, Colgan SP. Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization. FASEB J. 2011 Jun; 25(6):1856-64.
    View in: PubMed
    Score: 0.056
  84. Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 2010 Jul; 139(1):259-69.e3.
    View in: PubMed
    Score: 0.052
  85. Frick JS, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol. 2009 Apr 15; 182(8):4957-64.
    View in: PubMed
    Score: 0.049
  86. Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, Brayden DJ. Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers. J Control Release. 2009 Apr 02; 135(1):35-43.
    View in: PubMed
    Score: 0.048
  87. Zheng W, Kuhlicke J, Jäckel K, Eltzschig HK, Singh A, Sjöblom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J. 2009 Jan; 23(1):204-13.
    View in: PubMed
    Score: 0.047
  88. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42.
    View in: PubMed
    Score: 0.041
  89. Yang Y, Atkins CL, Fan Y, Hou L, Zhao J, Gao J, Wen Y, Moreno NF, Huang X, Bishehsari F, Czopik AK, Colgan SP, Purnak T, Summa KC, Cong Y, Jacobsen EA, Ju C. Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis. Proc Natl Acad Sci U S A. 2026 May 12; 123(19):e2525334123.
    View in: PubMed
    Score: 0.040
  90. Callahan RC, Curry JC, Bhagavatula G, Staley AW, Schaefer RE, Minhajuddin F, Zhou L, Neuhart RM, Atif SM, Orlicky DJ, Cartwright IM, Gerich ME, Steiner CA, Theiss AL, Hall CH, Colgan SP, Onyiah JC. Epithelial HO-1 regulates iron availability and promotes colonic tumorigenesis in a context-dependent manner. JCI Insight. 2026 Feb 09; 11(3).
    View in: PubMed
    Score: 0.039
  91. Canny G, Cario E, Lennartsson A, Gullberg U, Brennan C, Levy O, Colgan SP. Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G557-67.
    View in: PubMed
    Score: 0.039
  92. Canny G, Colgan SP. Events at the host-microbial interface of the gastrointestinal tract. I. Adaptation to a microbial world: role of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G593-7.
    View in: PubMed
    Score: 0.037
  93. Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest. 2004 Oct; 114(8):1098-106.
    View in: PubMed
    Score: 0.036
  94. Kaser A, Nieuwenhuis EE, Strober W, Fuss I, Colgan S, Blumberg RS. CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 3:S719-22.
    View in: PubMed
    Score: 0.035
  95. Alula KM, Dowdell AS, LeBere B, Lee JS, Levens CL, Kuhn KA, Kaipparettu BA, Thompson WE, Blumberg RS, Colgan SP, Theiss AL. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome. 2023 11 17; 11(1):256.
    View in: PubMed
    Score: 0.034
  96. van de Wal Y, Corazza N, Allez M, Mayer LF, Iijima H, Ryan M, Cornwall S, Kaiserlian D, Hershberg R, Koezuka Y, Colgan SP, Blumberg RS. Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology. 2003 May; 124(5):1420-31.
    View in: PubMed
    Score: 0.033
  97. Brand S, Sakaguchi T, Gu X, Colgan SP, Reinecker HC. Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. Gastroenterology. 2002 Jan; 122(1):166-77.
    View in: PubMed
    Score: 0.030
  98. Lee SY, Madan A, Furuta GT, Colgan SP, Sibley E. Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. Mol Genet Metab. 2002 Jan; 75(1):65-9.
    View in: PubMed
    Score: 0.030
  99. Narravula S, Colgan SP. Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. J Immunol. 2001 Jun 15; 166(12):7543-8.
    View in: PubMed
    Score: 0.029
  100. Somnay-Wadgaonkar K, Nusrat A, Kim HS, Canchis WP, Balk SP, Colgan SP, Blumberg RS. Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol. 1999 Mar; 11(3):383-92.
    View in: PubMed
    Score: 0.024
  101. Taylor CT, Lisco SJ, Awtrey CS, Colgan SP. Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors. J Pharmacol Exp Ther. 1998 Feb; 284(2):568-75.
    View in: PubMed
    Score: 0.023
  102. McCormick BA, Parkos CA, Colgan SP, Carnes DK, Madara JL. Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium. J Immunol. 1998 Jan 01; 160(1):455-66.
    View in: PubMed
    Score: 0.022
  103. Neudecker V, Colgan SP, Eltzschig HK. Novel therapeutic concepts for inflammatory bowel disease-from bench to bedside. J Mol Med (Berl). 2017 09; 95(9):899-903.
    View in: PubMed
    Score: 0.022
  104. Christ AD, Colgan SP, Balk SP, Blumberg RS. Human intestinal epithelial cell lines produce factor(s) that inhibit CD3-mediated T-lymphocyte proliferation. Immunol Lett. 1997 Aug; 58(3):159-65.
    View in: PubMed
    Score: 0.022
  105. Hofman P, D'Andrea L, Carnes D, Colgan SP, Madara JL. Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils. Am J Physiol. 1996 Jul; 271(1 Pt 1):C312-20.
    View in: PubMed
    Score: 0.020
  106. Parkos CA, Colgan SP, Liang TW, Nusrat A, Bacarra AE, Carnes DK, Madara JL. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol. 1996 Feb; 132(3):437-50.
    View in: PubMed
    Score: 0.020
  107. Parkos CA, Colgan SP, Bacarra AE, Nusrat A, Delp-Archer C, Carlson S, Su DH, Madara JL. Intestinal epithelia (T84) possess basolateral ligands for CD11b/CD18-mediated neutrophil adherence. Am J Physiol. 1995 Feb; 268(2 Pt 1):C472-9.
    View in: PubMed
    Score: 0.018
  108. Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis. Gut. 2015 Aug; 64(8):1236-47.
    View in: PubMed
    Score: 0.018
  109. Parkos CA, Colgan SP, Madara JL. Interactions of neutrophils with epithelial cells: lessons from the intestine. J Am Soc Nephrol. 1994 Aug; 5(2):138-52.
    View in: PubMed
    Score: 0.018
  110. Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL. Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition. J Clin Invest. 1994 Aug; 94(2):788-96.
    View in: PubMed
    Score: 0.018
  111. Balk SP, Burke S, Polischuk JE, Frantz ME, Yang L, Porcelli S, Colgan SP, Blumberg RS. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994 Jul 08; 265(5169):259-62.
    View in: PubMed
    Score: 0.018
  112. Resnick MB, Colgan SP, Patapoff TW, Mrsny RJ, Awtrey CS, Delp-Archer C, Weller PF, Madara JL. Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP. J Immunol. 1993 Nov 15; 151(10):5716-23.
    View in: PubMed
    Score: 0.017
  113. Madara JL, Parkos C, Colgan S, MacLeod RJ, Nash S, Matthews J, Delp C, Lencer W. Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. J Clin Invest. 1992 Jun; 89(6):1938-44.
    View in: PubMed
    Score: 0.015
  114. Madara JL, Parkos C, Colgan S, Nusrat A, Atisook K, Kaoutzani P. The movement of solutes and cells across tight junctions. Ann N Y Acad Sci. 1992; 664:47-60.
    View in: PubMed
    Score: 0.015
  115. Lencer WI, Barrett K, Colgan S, Cohen MB, Duggan CP, Kotelchuck M, Rhoads JM. Research agenda for pediatric gastroenterology, hepatology and nutrition: secretion and diarrhea. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S246-9.
    View in: PubMed
    Score: 0.007
  116. Kim HS, Colgan SP, Pitman R, Hershberg RM, Blumberg RS. Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis. Mol Immunol. 2000 Oct; 37(14):861-8.
    View in: PubMed
    Score: 0.007
  117. Parkos CA, Colgan SP, Diamond MS, Nusrat A, Liang TW, Springer TA, Madara JL. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils. Mol Med. 1996 Jul; 2(4):489-505.
    View in: PubMed
    Score: 0.005
  118. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol. 1993 Nov; 123(4):895-907.
    View in: PubMed
    Score: 0.004
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Copyright © 2026 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)