ChadPearsonChad G. Pearson39.74528180000000-104.837572700000002153Pearson, ChadG.303/724-5742Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1194461025533842Galati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CGThe Journal of cell biologyGalati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CG. DisAp-dependent striated fiber elongation is required to organize ciliary arrays. J Cell Biol. 2014 Dec 22; 207(6):705-15.J Cell Biol2014-12-22T00:00:002014DisAp-dependent striated fiber elongation is required to organize ciliary arrays.MeredithBettertonMeredith D Betterton40.00825400000000-105.268079500000009526Betterton, MeredithProfessorAuthorship 896821Authorship 132068826412126Dahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH, Pearson CGCurrent biology : CBDahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH, Pearson CG. A Short CEP135 Splice Isoform Controls Centriole Duplication. Curr Biol. 2015 Oct 05; 25(19):2591-6.Curr Biol2015-09-24T00:00:002015A Short CEP135 Splice Isoform Controls Centriole Duplication.MarisaRuehleMarisa Demaree Ruehle39.74528180000000-104.8375727000000010777Ruehle, MarisaInstructorAuthorship 1366523Authorship 136892526700722Galati DF, Abuin DS, Tauber GA, Pham AT, Pearson CGBiology openGalati DF, Abuin DS, Tauber GA, Pham AT, Pearson CG. Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays. Biol Open. 2015 Dec 23; 5(1):20-31.Biol Open2015-12-23T00:00:002015Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays.26793300Bayless BA, Galati DF, Pearson CGCiliaBayless BA, Galati DF, Pearson CG. Tetrahymena basal bodies. Cilia. 2015; 5:1.Cilia2016-01-19T00:00:002016Tetrahymena basal bodies.Authorship 139998626929450Garcia G, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner JThe Journal of cell biologyGarcia G, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J. Assembly, molecular organization, and membrane-binding properties of development-specific septins. J Cell Biol. 2016 Feb 29; 212(5):515-29.J Cell Biol2016-02-29T00:00:002016Assembly, molecular organization, and membrane-binding properties of development-specific septins.Authorship 142596327270699Ruehle MD, Orias E, Pearson CGGeneticsRuehle MD, Orias E, Pearson CG. Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools. Genetics. 2016 06; 203(2):649-65.Genetics2016-06-01T00:00:002016Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools.Authorship 144182427226318Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel BDevelopment (Cambridge, England)Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016 07 01; 143(13):2292-304.Development2016-05-25T00:00:002016miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling.Authorship 146025427251062Meehl JB, Bayless BA, Giddings TH, Pearson CG, Winey MMolecular biology of the cellMeehl JB, Bayless BA, Giddings TH, Pearson CG, Winey M. Tetrahymena Poc1 ensures proper intertriplet microtubule linkages to maintain basal body integrity. Mol Biol Cell. 2016 08 01; 27(15):2394-403.Mol Biol Cell2016-06-01T00:00:002016Tetrahymena Poc1 ensures proper intertriplet microtubule linkages to maintain basal body integrity.11553724Kosco KA, Pearson CG, Maddox PS, Wang PJ, Adams IR, Salmon ED, Bloom K, Huffaker TCMolecular biology of the cellKosco KA, Pearson CG, Maddox PS, Wang PJ, Adams IR, Salmon ED, Bloom K, Huffaker TC. Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol Biol Cell. 2001 Sep; 12(9):2870-80.Mol Biol Cell2001-09-01T00:00:002001Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast.Authorship 151520320461132Gardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJCellular and molecular bioengineeringGardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJ. Model Convolution: A Computational Approach to Digital Image Interpretation. Cell Mol Bioeng. 2010 Jun; 3(2):163-170.Cell Mol Bioeng2010-02-06T00:00:002010Model Convolution: A Computational Approach to Digital Image Interpretation.Authorship 152044627807131Bayless BA, Galati DF, Junker AD, Backer CB, Gaertig J, Pearson CGThe Journal of cell biologyBayless BA, Galati DF, Junker AD, Backer CB, Gaertig J, Pearson CG. Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces. J Cell Biol. 2016 Nov 21; 215(4):457-466.J Cell Biol2016-11-02T00:00:002016Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces.Authorship 153186327875681Galati DF, Mitchell BJ, Pearson CGDevelopmental cellGalati DF, Mitchell BJ, Pearson CG. Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life. Dev Cell. 2016 11 21; 39(4):387-389.Dev Cell2016-11-21T00:00:002016Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life.Authorship 153728627541566Wall KP, Pagratis M, Armstrong G, Balsbaugh JL, Verbeke E, Pearson CG, Hough LEACS chemical biologyWall KP, Pagratis M, Armstrong G, Balsbaugh JL, Verbeke E, Pearson CG, Hough LE. Molecular Determinants of Tubulin's C-Terminal Tail Conformational Ensemble. ACS Chem Biol. 2016 11 18; 11(11):2981-2990.ACS Chem Biol2016-09-28T00:00:002016Molecular Determinants of Tubulin's C-Terminal Tail Conformational Ensemble.12925780Yoder TJ, Pearson CG, Bloom K, Davis TNMolecular biology of the cellYoder TJ, Pearson CG, Bloom K, Davis TN. The Saccharomyces cerevisiae spindle pole body is a dynamic structure. Mol Biol Cell. 2003 Aug; 14(8):3494-505.Mol Biol Cell2003-05-03T00:00:002003The Saccharomyces cerevisiae spindle pole body is a dynamic structure.Authorship 155444828039486Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZOncotargetKendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762.Oncotarget2017-01-24T00:00:002017CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming.1Professor3Asst Professor2Assoc Professor4Instructor15173827Pearson CG, Bloom KNature reviews. Molecular cell biologyPearson CG, Bloom K. Dynamic microtubules lead the way for spindle positioning. Nat Rev Mol Cell Biol. 2004 Jun; 5(6):481-92.Nat Rev Mol Cell Biol2004-06-01T00:00:002004Dynamic microtubules lead the way for spindle positioning.15668173Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey MCurrent biology : CBJones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr Biol. 2005 Jan 26; 15(2):160-5.Curr Biol2005-01-26T00:00:002005Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.2021-07-31NIHPEARSON, CHAD G2012-09-24Mechanisms of basal body assembly, stability and positioningR01GM099820Principal Investigator16807354Pearson CG, Gardner MK, Paliulis LV, Salmon ED, Odde DJ, Bloom KMolecular biology of the cellPearson CG, Gardner MK, Paliulis LV, Salmon ED, Odde DJ, Bloom K. Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy. Mol Biol Cell. 2006 Sep; 17(9):4069-79.Mol Biol Cell2006-06-28T00:00:002006Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy.17468754Beales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, Rix S, Pearson CG, Kai M, Hartley J, Johnson C, Irving M, Elcioglu N, Winey M, Tada M, Scambler PJNature geneticsBeales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, Rix S, Pearson CG, Kai M, Hartley J, Johnson C, Irving M, Elcioglu N, Winey M, Tada M, Scambler PJ. IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet. 2007 Jun; 39(6):727-9.Nat Genet2007-04-29T00:00:002007IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy.17765674Pearson CG, Culver BP, Winey MDevelopmental cellPearson CG, Culver BP, Winey M. Centrioles want to move out and make cilia. Dev Cell. 2007 Sep; 13(3):319-21.Dev Cell2007-09-01T00:00:002007Centrioles want to move out and make cilia.13001 East 17th Place2SOMSchool of Medicine13001 East 17th PlaceAurora80045-2570CO21663786Pearson CGCellPearson CG. A kinesin in command of primary ciliogenesis. Cell. 2011 Jun 10; 145(6):817-9.Cell2011-06-10T00:00:002011A kinesin in command of primary ciliogenesis.11257125Pearson CG, Maddox PS, Salmon ED, Bloom KThe Journal of cell biologyPearson CG, Maddox PS, Salmon ED, Bloom K. Budding yeast chromosome structure and dynamics during mitosis. J Cell Biol. 2001 Mar 19; 152(6):1255-66.J Cell Biol2001-03-19T00:00:002001Budding yeast chromosome structure and dynamics during mitosis.22444152Winey M, Stemm-Wolf AJ, Giddings TH, Pearson CGMethods in cell biologyWiney M, Stemm-Wolf AJ, Giddings TH, Pearson CG. Cytological analysis of Tetrahymena thermophila. Methods Cell Biol. 2012; 109:357-78.Methods Cell Biol2012-01-01T00:00:002012Cytological analysis of Tetrahymena thermophila.22493317Backer CB, Gutzman JH, Pearson CG, Cheeseman IMMolecular biology of the cellBacker CB, Gutzman JH, Pearson CG, Cheeseman IM. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. Mol Biol Cell. 2012 Jun; 23(11):2122-30.Mol Biol Cell2012-04-04T00:00:002012CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development.14517328Pearson CG, Maddox PS, Zarzar TR, Salmon ED, Bloom KMolecular biology of the cellPearson CG, Maddox PS, Zarzar TR, Salmon ED, Bloom K. Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Mol Biol Cell. 2003 Oct; 14(10):4181-95.Mol Biol Cell2003-07-25T00:00:002003Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics.15530400Pearson CG, Yeh E, Gardner M, Odde D, Salmon ED, Bloom KCurrent biology : CBPearson CG, Yeh E, Gardner M, Odde D, Salmon ED, Bloom K. Stable kinetochore-microtubule attachment constrains centromere positioning in metaphase. Curr Biol. 2004 Nov 09; 14(21):1962-7.Curr Biol2004-11-09T00:00:002004Stable kinetochore-microtubule attachment constrains centromere positioning in metaphase.15694304De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio ACurrent biology : CBDe Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio A. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol. 2005 Feb 08; 15(3):214-25.Curr Biol2005-02-08T00:00:002005The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.11451998Hoffman DB, Pearson CG, Yen TJ, Howell BJ, Salmon EDMolecular biology of the cellHoffman DB, Pearson CG, Yen TJ, Howell BJ, Salmon ED. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell. 2001 Jul; 12(7):1995-2009.Mol Biol Cell2001-07-01T00:00:002001Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores.12770865Sprague BL, Pearson CG, Maddox PS, Bloom KS, Salmon ED, Odde DJBiophysical journalSprague BL, Pearson CG, Maddox PS, Bloom KS, Salmon ED, Odde DJ. Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophys J. 2003 Jun; 84(6):3529-46.Biophys J2003-06-01T00:00:002003Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle.15930123Gardner MK, Pearson CG, Sprague BL, Zarzar TR, Bloom K, Salmon ED, Odde DJMolecular biology of the cellGardner MK, Pearson CG, Sprague BL, Zarzar TR, Bloom K, Salmon ED, Odde DJ. Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast. Mol Biol Cell. 2005 Aug; 16(8):3764-75.Mol Biol Cell2005-06-01T00:00:002005Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast.19056680Pearson CG, Giddings TH, Winey MMolecular biology of the cellPearson CG, Giddings TH, Winey M. Basal body components exhibit differential protein dynamics during nascent basal body assembly. Mol Biol Cell. 2009 Feb; 20(3):904-14.Mol Biol Cell2008-12-03T00:00:002008Basal body components exhibit differential protein dynamics during nascent basal body assembly.17785518Kilburn CL, Pearson CG, Romijn EP, Meehl JB, Giddings TH, Culver BP, Yates JR, Winey MThe Journal of cell biologyKilburn CL, Pearson CG, Romijn EP, Meehl JB, Giddings TH, Culver BP, Yates JR, Winey M. New Tetrahymena basal body protein components identify basal body domain structure. J Cell Biol. 2007 Sep 10; 178(6):905-12.J Cell Biol2007-09-04T00:00:002007New Tetrahymena basal body protein components identify basal body domain structure.20869521Giddings TH, Meehl JB, Pearson CG, Winey MMethods in cell biologyGiddings TH, Meehl JB, Pearson CG, Winey M. Electron tomography and immuno-labeling of Tetrahymena thermophila basal bodies. Methods Cell Biol. 2010; 96:117-41.Methods Cell Biol2010-01-01T00:00:002010Electron tomography and immuno-labeling of Tetrahymena thermophila basal bodies.19192246Pearson CG, Winey MTraffic (Copenhagen, Denmark)Pearson CG, Winey M. Basal body assembly in ciliates: the power of numbers. Traffic. 2009 May; 10(5):461-71.Traffic2009-01-24T00:00:002009Basal body assembly in ciliates: the power of numbers.20008567Pearson CG, Osborn DP, Giddings TH, Beales PL, Winey MThe Journal of cell biologyPearson CG, Osborn DP, Giddings TH, Beales PL, Winey M. Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol. 2009 Dec 14; 187(6):905-20.J Cell Biol2009-12-14T00:00:002009Basal body stability and ciliogenesis requires the conserved component Poc1.21173875Pearson CG, Winey MF1000 biology reportsPearson CG, Winey M. Plk4/SAK/ZYG-1 in the regulation of centriole duplication. F1000 Biol Rep. 2010 Aug 09; 2:58.F1000 Biol Rep2010-08-09T00:00:002010Plk4/SAK/ZYG-1 in the regulation of centriole duplication.22004680Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TGGenome biologyCoyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100.Genome Biol2011-10-17T00:00:002011Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.23115304Bayless BA, Giddings TH, Winey M, Pearson CGMolecular biology of the cellBayless BA, Giddings TH, Winey M, Pearson CG. Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces. Mol Biol Cell. 2012 Dec; 23(24):4820-32.Mol Biol Cell2012-10-31T00:00:002012Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces.Authorship 1828381129930198Baschal EE, Terhune EA, Wethey CI, Baschal RM, Robinson KD, Cuevas MT, Pradhan S, Sutphin BS, Taylor MRG, Gowan K, Pearson CG, Niswander LA, Jones KL, Miller NHG3 (Bethesda, Md.)Baschal EE, Terhune EA, Wethey CI, Baschal RM, Robinson KD, Cuevas MT, Pradhan S, Sutphin BS, Taylor MRG, Gowan K, Pearson CG, Niswander LA, Jones KL, Miller NH. Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology. G3 (Bethesda). 2018 07 31; 8(8):2663-2672.G3 (Bethesda)2018-07-31T00:00:002018Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology.D002923Anatomy601640.880901CiliaD016808Living Beings12600.943881Tetrahymena thermophilaAuthorship 186146530100262Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CGDevelopmental cellGalati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. Trisomy 21 Represses Cilia Formation and Function. Dev Cell. 2018 09 10; 46(5):641-650.e6.Dev Cell2018-08-09T00:00:002018Trisomy 21 Represses Cilia Formation and Function.Authorship 1880831030217954Louka P, Vasudevan KK, Guha M, Joachimiak E, Wloga D, Tomasi RF, Baroud CN, Dupuis-Williams P, Galati DF, Pearson CG, Rice LM, Moresco JJ, Yates JR, Jiang YY, Lechtreck K, Dentler W, Gaertig JThe Journal of cell biologyLouka P, Vasudevan KK, Guha M, Joachimiak E, Wloga D, Tomasi RF, Baroud CN, Dupuis-Williams P, Galati DF, Pearson CG, Rice LM, Moresco JJ, Yates JR, Jiang YY, Lechtreck K, Dentler W, Gaertig J. Proteins that control the geometry of microtubules at the ends of cilia. J Cell Biol. 2018 12 03; 217(12):4298-4313.J Cell Biol2018-09-14T00:00:002018Proteins that control the geometry of microtubules at the ends of cilia.Authorship 192772330584065Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CWJournal of cell scienceHan KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW. Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein. J Cell Sci. 2019 01 22; 132(2).J Cell Sci2019-01-22T00:00:002019Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.D002502Anatomy14370.955047CentriolesAuthorship 196744330811267Ganapathi Sankaran D, Stemm-Wolf AJ, Pearson CGMolecular biology of the cellGanapathi Sankaran D, Stemm-Wolf AJ, Pearson CG. CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells. Mol Biol Cell. 2019 05 01; 30(10):1230-1244.Mol Biol Cell2019-02-27T00:00:002019CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells.D064652Anatomy5140.967689Basal BodiesAuthorship 100851D008870Anatomy822470.819875MicrotubulesAuthorship 203216931243050Junker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CGJournal of cell scienceJunker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CG. Microtubule glycylation promotes attachment of basal bodies to the cell cortex. J Cell Sci. 2019 08 07; 132(15).J Cell Sci2019-08-07T00:00:002019Microtubule glycylation promotes attachment of basal bodies to the cell cortex.SOM-PHARM General OperationsBiology-MCD InstructionBiochemistrySOM-BioChem&Molecular GeneticsSOM-Cell and Devopmental BioSOM-PEDSDevl BiologyUniversity of Colorado BoulderUniversity of Colorado Denver - Anschutz Medical CampusVictorSpitzerVictor M Spitzer39.74528180000000-104.837572700000001142Spitzer, VictorProfessorRytisPrekerisRytis Prekeris39.74389450000000-104.839435200000001613Prekeris, RytisProfessorNormaWagonerNorma Elizabeth Wagoner39.74528180000000-104.837572700000001853Wagoner, NormaSenior Clinical Instructor7.417890.00811334257research areas2.335270.029861524coauthor of61.28655.8766160similar to1162selected publicationsJoaquinEspinosaJoaquin Maximiliano Espinosa39.74545800000000-104.839369100000002157Espinosa, JoaquinProfessorAndreasHoengerAndreas Hoenger40.00825400000000-105.268079500000002412Hoenger, AndreasProfessorElanEisenmesserElan Zohar Eisenmesser39.74389450000000-104.839435200000002563Eisenmesser, ElanAssociate ProfessorKellySullivanKelly D Sullivan39.74528180000000-104.837572700000003379Sullivan, KellyAsst ProfessorMichaelMcMurrayMichael Andres McMurray39.74528180000000-104.837572700000004185McMurray, MichaelAssociate ProfessorThomasCechThomas R Cech40.00830860000000-105.24906720000000807Cech, ThomasDistinguished ProfessorJeffreyMooreJeffrey Kyle Moore39.74528180000000-104.837572700000005428Moore, JeffreyAssociate ProfessorMi-JungLeeMi-Jung Lisa Lee39.74528180000000-104.837572700000006083Lee, Mi-JungAssociate ProfessorAuthorship 99219523936495Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZPloS oneRedzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ. Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-?1 and EMMPRIN. PLoS One. 2013; 8(8):e71225.PLoS One2013-08-01T00:00:002013Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-?1 and EMMPRIN.Authorship 140574Authorship 212034731740506Soh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CGThe Journal of cell biologySoh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CG. Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. J Cell Biol. 2020 01 06; 219(1).J Cell Biol2020-01-06T00:00:002020Ciliary force-responsive striated fibers promote basal body connections and cortical interactions.Authorship 220573332435796Ruehle MD, Stemm-Wolf AJ, Pearson CGThe Journal of cell biologyRuehle MD, Stemm-Wolf AJ, Pearson CG. Sas4 links basal bodies to cell division via Hippo signaling. J Cell Biol. 2020 08 03; 219(8).J Cell Biol2020-08-03T00:00:002020Sas4 links basal bodies to cell division via Hippo signaling.Authorship 222225532591487Sankaran DG, Stemm-Wolf AJ, McCurdy BL, Hariharan B, Pearson CGJournal of cell scienceSankaran DG, Stemm-Wolf AJ, McCurdy BL, Hariharan B, Pearson CG. A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization. J Cell Sci. 2020 07 30; 133(14).J Cell Sci2020-07-30T00:00:002020A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization.2024-07-31NIHPEARSON, CHAD G2020-08-14Centrosome regulation of trafficking, ciliogenesis and cilia-dependent signalingR01GM138415Principal InvestigatorAuthorship 235650733561422Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris RDevelopmental cellJewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021 02 08; 56(3):325-340.e8.Dev Cell2021-02-08T00:00:002021RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.Authorship 238834233848487Jewett CE, Pearson CGCurrent biology : CBJewett CE, Pearson CG. Cancer biology: Messages in extracellular vesicles depend on centrosome number. Curr Biol. 2021 04 12; 31(7):R337-R340.Curr Biol2021-04-12T00:00:002021Cancer biology: Messages in extracellular vesicles depend on centrosome number.2026-03-31NIHPEARSON, CHAD G2021-06-01Centriole assembly and function for centrosome and cilia biologyR35GM140813Principal InvestigatorAuthorship 2456045Authorship 246121534406792Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CGMolecular biology of the cellStemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG. The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis. Mol Biol Cell. 2021 10 01; 32(20):ar4.Mol Biol Cell2021-08-18T00:00:002021The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis.34430806Junker AD, Jacob S, Philippe H, Legrand D, Pearson CGiScienceJunker AD, Jacob S, Philippe H, Legrand D, Pearson CG. Plastic cell morphology changes during dispersal. iScience. 2021 Aug 20; 24(8):102915.iScience2021-07-27T00:00:002021Plastic cell morphology changes during dispersal.Authorship 254120234897878Soh AWJ, Pearson CGThe Journal of eukaryotic microbiologySoh AWJ, Pearson CG. Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates. J Eukaryot Microbiol. 2022 09; 69(5):e12880.J Eukaryot Microbiol2022-01-12T00:00:002022Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates.Authorship 259986835476505McCurdy BL, Jewett CE, Stemm-Wolf AJ, Duc HN, Joshi M, Espinosa JM, Prekeris R, Pearson CGMolecular biology of the cellMcCurdy BL, Jewett CE, Stemm-Wolf AJ, Duc HN, Joshi M, Espinosa JM, Prekeris R, Pearson CG. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Mol Biol Cell. 2022 07 01; 33(8).Mol Biol Cell2022-04-27T00:00:002022Trisomy 21 increases microtubules and disrupts centriolar satellite localization.Authorship 2640451135767367Soh AWJ, Woodhams LG, Junker AD, Enloe CM, Noren BE, Harned A, Westlake CJ, Narayan K, Oakey JS, Bayly PV, Pearson CGMolecular biology of the cellSoh AWJ, Woodhams LG, Junker AD, Enloe CM, Noren BE, Harned A, Westlake CJ, Narayan K, Oakey JS, Bayly PV, Pearson CG. Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. Mol Biol Cell. 2022 09 15; 33(11):br18.Mol Biol Cell2022-06-29T00:00:002022Intracellular connections between basal bodies promote the coordinated behavior of motile cilia.Authorship 246821Authorship 27543114Authorship 2740366Authorship 270873436656118Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CGeLifeJewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 01 19; 12.Elife2023-01-19T00:00:002023Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development.36630324Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RFMolecular biology of the cellSun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023 05 15; 34(6):ar53.Mol Biol Cell2023-01-11T00:00:002023Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila.36287828Junker AD, Woodhams LG, Soh AWJ, O'Toole ET, Bayly PV, Pearson CGMolecular biology of the cellJunker AD, Woodhams LG, Soh AWJ, O'Toole ET, Bayly PV, Pearson CG. Basal bodies bend in response to ciliary forces. Mol Biol Cell. 2022 12 01; 33(14):ar146.Mol Biol Cell2022-10-26T00:00:002022Basal bodies bend in response to ciliary forces.Authorship 280282536945534Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JBbioRxiv : the preprint server for biologyLeggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants. bioRxiv. 2023 Mar 09.bioRxiv2023-03-09T00:00:002023Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants.true1Asst ProfessorAsst ProfessorAuthorship 282781Authorship 285182Authorship 295281438014135Ruehle MD, Li S, Agard DA, Pearson CGbioRxiv : the preprint server for biologyRuehle MD, Li S, Agard DA, Pearson CG. Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections. bioRxiv. 2023 Nov 28.bioRxiv2023-11-28T00:00:002023Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections.Authorship 297896538170584Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JBMolecular biology of the cellLeggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants. Mol Biol Cell. 2024 Mar 01; 35(3):ar39.Mol Biol Cell2024-01-03T00:00:002024Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants.Authorship 315583true1ProfessorProfessortrue1Senior Clinical InstructorSenior Clinical Instructortrue1ProfessorProfessortrue1InstructorInstructortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Distinguished ProfessorDistinguished Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 337491Authorship 359862Authorship 361881Authorship 389111Authorship 423312Authorship 426071Authorship 4387121Authorship 494782Authorship 50783Authorship 509398Authorship 518311Authorship 554784Authorship 112370124895399Pearson CGJournal of cell sciencePearson CG. Choosing sides--asymmetric centriole and basal body assembly. J Cell Sci. 2014 Jul 01; 127(Pt 13):2803-10.J Cell Sci2014-06-03T00:00:002014Choosing sides--asymmetric centriole and basal body assembly.Authorship 591072Authorship 647642Authorship 677853MaureenStabioMaureen E Stabio39.74528180000000-104.837572700000009294Stabio, MaureenAssociate ProfessorAuthorship 701411Authorship 708551Authorship 709612