RobertKuchtaRobert Kuchta40.00830860000000-105.24906720000000205Kuchta, Robert303/492-7027Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 8085Authorship 809432CarlosCatalanoCarlos E Catalano39.74688660000000-104.838256700000009520Catalano, CarlosProfessorAuthorship 850128Authorship 851025Authorship 853212Authorship 8676Authorship 877854Authorship 88132Authorship 888758Authorship 894843Authorship 121463225517265Vashishtha AK, Kuchta RDBiochemistryVashishtha AK, Kuchta RD. Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated. Biochemistry. 2015 Jan 20; 54(2):240-9.Biochemistry2015-01-06T00:00:002015Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated.Authorship 940551Authorship 947004Authorship 951991Authorship 953722Authorship 963182Authorship 969243Authorship 97043Authorship 9712947575571Catalano CE, Kuchta RDBiochemical and biophysical research communicationsCatalano CE, Kuchta RD. Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate. Biochem Biophys Res Commun. 1995 Sep 25; 214(3):971-7.Biochem Biophys Res Commun1995-09-25T00:00:001995Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate.7681326Sheaff RJ, Kuchta RDBiochemistrySheaff RJ, Kuchta RD. Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination. Biochemistry. 1993 Mar 30; 32(12):3027-37.Biochemistry1993-03-30T00:00:001993Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination.7873530Ilsley DD, Lee SH, Miller WH, Kuchta RDBiochemistryIlsley DD, Lee SH, Miller WH, Kuchta RD. Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action. Biochemistry. 1995 Feb 28; 34(8):2504-10.Biochemistry1995-02-28T00:00:001995Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action.8117681Sheaff RJ, Kuchta RD, Ilsley DBiochemistrySheaff RJ, Kuchta RD, Ilsley D. Calf thymus DNA polymerase alpha-primase: "communication" and primer-template movement between the two active sites. Biochemistry. 1994 Mar 01; 33(8):2247-54.Biochemistry1994-03-01T00:00:001994Calf thymus DNA polymerase alpha-primase: "communication" and primer-template movement between the two active sites.QuanbinXuQuanbin Xu40.00830860000000-105.2490672000000011203Xu, QuanbinResearch AssociateAuthorship 138765226836009Vashishtha AK, Kuchta RDBiochemistryVashishtha AK, Kuchta RD. Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA. Biochemistry. 2016 Feb 23; 55(7):1168-77.Biochemistry2016-02-11T00:00:002016Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.9026642Kuchta RDMethods in enzymologyKuchta RD. Isotopic assays of viral polymerases and related proteins. Methods Enzymol. 1996; 275:241-57.Methods Enzymol1996-01-01T00:00:001996Isotopic assays of viral polymerases and related proteins.7479073Thompson HC, Sheaff RJ, Kuchta RDNucleic acids researchThompson HC, Sheaff RJ, Kuchta RD. Interactions of calf thymus DNA polymerase alpha with primer/templates. Nucleic Acids Res. 1995 Oct 25; 23(20):4109-15.Nucleic Acids Res1995-10-25T00:00:001995Interactions of calf thymus DNA polymerase alpha with primer/templates.7545435Thompson HC, Kuchta RDBiochemistryThompson HC, Kuchta RD. Arabinofuranosyl nucleotides are not chain-terminators during initiation of new strands of DNA by DNA polymerase alpha-primase. Biochemistry. 1995 Sep 05; 34(35):11198-203.Biochemistry1995-09-05T00:00:001995Arabinofuranosyl nucleotides are not chain-terminators during initiation of new strands of DNA by DNA polymerase alpha-primase.7559416Yan JP, Ilsley DD, Frohlick C, Steet R, Hall ET, Kuchta RD, Melan?on PThe Journal of biological chemistryYan JP, Ilsley DD, Frohlick C, Steet R, Hall ET, Kuchta RD, Melan?on P. 3'-Azidothymidine (zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations. J Biol Chem. 1995 Sep 29; 270(39):22836-41.J Biol Chem1995-09-29T00:00:0019953'-Azidothymidine (zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations.10433721Kirk BW, Kuchta RDBiochemistryKirk BW, Kuchta RD. Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection. Biochemistry. 1999 Aug 03; 38(31):10126-34.Biochemistry1999-08-03T00:00:001999Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection.10504261Arezi B, Kirk BW, Copeland WC, Kuchta RDBiochemistryArezi B, Kirk BW, Copeland WC, Kuchta RD. Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit. Biochemistry. 1999 Sep 28; 38(39):12899-907.Biochemistry1999-09-28T00:00:001999Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit.10504262Zerbe LK, Goodman MF, Efrati E, Kuchta RDBiochemistryZerbe LK, Goodman MF, Efrati E, Kuchta RD. Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase alpha during the synthesis of new DNA strands. Biochemistry. 1999 Sep 28; 38(39):12908-14.Biochemistry1999-09-28T00:00:001999Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase alpha during the synthesis of new DNA strands.10704933Richardson FC, Kuchta RD, Mazurkiewicz A, Richardson KABiochemical pharmacologyRichardson FC, Kuchta RD, Mazurkiewicz A, Richardson KA. Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase. Biochem Pharmacol. 2000 May 01; 59(9):1045-52.Biochem Pharmacol2000-05-01T00:00:002000Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase.Authorship 149239427598582Opalach C, Romaszko J, Jaracz M, Kuchta R, Borkowska A, Bucinski APloS oneOpalach C, Romaszko J, Jaracz M, Kuchta R, Borkowska A, Bucinski A. Coping Styles and Alcohol Dependence among Homeless People. PLoS One. 2016; 11(9):e0162381.PLoS One2016-09-06T00:00:002016Coping Styles and Alcohol Dependence among Homeless People.8709123Traynor AJ, Hall ET, Walker G, Miller WH, Melan?on P, Kuchta RDJournal of medicinal chemistryTraynor AJ, Hall ET, Walker G, Miller WH, Melan?on P, Kuchta RD. Inhibition of UDP-N-acetylglucosamine import into Golgi membranes by nucleoside monophosphates. J Med Chem. 1996 Jul 19; 39(15):2894-9.J Med Chem1996-07-19T00:00:001996Inhibition of UDP-N-acetylglucosamine import into Golgi membranes by nucleoside monophosphates.Authorship 150982121822500Kuchta RDCurrent protocols in chemical biologyKuchta RD. Nucleotide Analogues as Probes for DNA and RNA Polymerases. Curr Protoc Chem Biol. 2010; 2(2):111-124.Curr Protoc Chem Biol2010-01-01T00:00:002010Nucleotide Analogues as Probes for DNA and RNA Polymerases.9184153Kirk BW, Harrington C, Perrino FW, Kuchta RDBiochemistryKirk BW, Harrington C, Perrino FW, Kuchta RD. Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells. Biochemistry. 1997 Jun 03; 36(22):6725-31.Biochemistry1997-06-03T00:00:001997Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells.12950174Chiaramonte M, Moore CL, Kincaid K, Kuchta RDBiochemistryChiaramonte M, Moore CL, Kincaid K, Kuchta RD. Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I). Biochemistry. 2003 Sep 09; 42(35):10472-81.Biochemistry2003-09-09T00:00:002003Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I).5Other Faculty1ProfessorAuthorship 158223311749228Michl J, Gladysz JA, Kuchta RDChemical reviewsMichl J, Gladysz JA, Kuchta RD. Over four hundred million characters served: 99 volumes, 2567 articles, 85623 pages, and more than 85 million words. Chem Rev. 2000 Jan 12; 100(1):1-6.Chem Rev2000-01-12T00:00:002000Over four hundred million characters served: 99 volumes, 2567 articles, 85623 pages, and more than 85 million words.15548380Richardson KA, Vega TP, Richardson FC, Moore CL, Rohloff JC, Tomkinson B, Bendele RA, Kuchta RDBiochemical pharmacologyRichardson KA, Vega TP, Richardson FC, Moore CL, Rohloff JC, Tomkinson B, Bendele RA, Kuchta RD. Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase. Biochem Pharmacol. 2004 Dec 15; 68(12):2337-46.Biochem Pharmacol2004-12-15T00:00:002004Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase.Authorship 1597451028282138Okochi KD, Monfregola L, Dickerson SM, McCaffrey R, Domaille DW, Yu C, Hafenstine GR, Jin Y, Cha JN, Kuchta RD, Caruthers M, Zhang WThe Journal of organic chemistryOkochi KD, Monfregola L, Dickerson SM, McCaffrey R, Domaille DW, Yu C, Hafenstine GR, Jin Y, Cha JN, Kuchta RD, Caruthers M, Zhang W. Synthesis of Small-Molecule/DNA Hybrids through On-Bead Amide-Coupling Approach. J Org Chem. 2017 10 20; 82(20):10803-10811.J Org Chem2017-03-20T00:00:002017Synthesis of Small-Molecule/DNA Hybrids through On-Bead Amide-Coupling Approach.1909569Sheaff R, Ilsley D, Kuchta RBiochemistrySheaff R, Ilsley D, Kuchta R. Mechanism of DNA polymerase alpha inhibition by aphidicolin. Biochemistry. 1991 Sep 03; 30(35):8590-7.Biochemistry1991-09-03T00:00:001991Mechanism of DNA polymerase alpha inhibition by aphidicolin.1991125Eger BT, Kuchta RD, Carroll SS, Benkovic PA, Dahlberg ME, Joyce CM, Benkovic SJBiochemistryEger BT, Kuchta RD, Carroll SS, Benkovic PA, Dahlberg ME, Joyce CM, Benkovic SJ. Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-). Biochemistry. 1991 Feb 05; 30(5):1441-8.Biochemistry1991-02-05T00:00:001991Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-).Authorship 161981228399352Romaszko J, Kuchta R, Opalach C, Bertrand-Bucinska A, Romaszko AM, Giergielewicz-Januszko B, Bucinski ACentral European journal of public healthRomaszko J, Kuchta R, Opalach C, Bertrand-Bucinska A, Romaszko AM, Giergielewicz-Januszko B, Bucinski A. Socioeconomic Characteristics, Health Risk Factors and Alcohol Consumption among the Homeless in North-Eastern Part of Poland. Cent Eur J Public Health. 2017 Mar; 25(1):29-34.Cent Eur J Public Health2017-03-01T00:00:002017Socioeconomic Characteristics, Health Risk Factors and Alcohol Consumption among the Homeless in North-Eastern Part of Poland.2016-06-30NIHKUCHTA, ROBERT D2004-12-01Mechanism of Herpes DNA ReplicationR01AI0597642008-07-31NIHKUCHTA, ROBERT D2006-02-01A High-Throughput Assay for Influenza Replicase/RNA Polymerase InhibitorsR01AI0713382014-08-31NIHKUCHTA, ROBERT D2011-09-21Development of Novel Nucleoside Triphosphate ProdrugsR21AI0925402004-08-31NIHKUCHTA, ROBERT D2002-09-15Mechanism and Inhibition of Herpes ReplicationR21AI0522772002-05-31NIHKUCHTA, ROBERT D1997-06-01DEVELOPMENT OF NOVEL GLYCOSYLATION INHIBITORSR01GM0557092008-07-31NIHKUCHTA, ROBERT D2005-08-01Interaction of DNA Polymerase alpha with Novel Base-PairsR03TW0073722010-11-30NIHKUCHTA, ROBERT D1996-05-01Mechanism of DNA Polymerase Alpha-PrimaseR01GM0541941900-01-01NIHKUCHTA, ROBERT D1987-12-10MECHANISM OF TYROSINE HYDROXULASEF32GM011309Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator16266686Mehlmann M, Townsend MB, Stears RL, Kuchta RD, Rowlen KLAnalytical biochemistryMehlmann M, Townsend MB, Stears RL, Kuchta RD, Rowlen KL. Optimization of fragmentation conditions for microarray analysis of viral RNA. Anal Biochem. 2005 Dec 15; 347(2):316-23.Anal Biochem2005-10-17T00:00:002005Optimization of fragmentation conditions for microarray analysis of viral RNA.16300408Ramirez-Aguilar KA, Moore CL, Kuchta RDBiochemistryRamirez-Aguilar KA, Moore CL, Kuchta RD. Herpes simplex virus 1 primase employs watson-crick hydrogen bonding to identify cognate nucleoside triphosphates. Biochemistry. 2005 Nov 29; 44(47):15585-93.Biochemistry2005-11-29T00:00:002005Herpes simplex virus 1 primase employs watson-crick hydrogen bonding to identify cognate nucleoside triphosphates.17209555Beckman J, Kincaid K, Hocek M, Spratt T, Engels J, Cosstick R, Kuchta RDBiochemistryBeckman J, Kincaid K, Hocek M, Spratt T, Engels J, Cosstick R, Kuchta RD. Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Biochemistry. 2007 Jan 16; 46(2):448-60.Biochemistry2007-01-16T00:00:002007Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.17301287Mehlmann M, Bonner AB, Williams JV, Dankbar DM, Moore CL, Kuchta RD, Podsiad AB, Tamerius JD, Dawson ED, Rowlen KLJournal of clinical microbiologyMehlmann M, Bonner AB, Williams JV, Dankbar DM, Moore CL, Kuchta RD, Podsiad AB, Tamerius JD, Dawson ED, Rowlen KL. Comparison of the MChip to viral culture, reverse transcription-PCR, and the QuickVue influenza A+B test for rapid diagnosis of influenza. J Clin Microbiol. 2007 Apr; 45(4):1234-7.J Clin Microbiol2007-02-14T00:00:002007Comparison of the MChip to viral culture, reverse transcription-PCR, and the QuickVue influenza A+B test for rapid diagnosis of influenza.17855577Moore CL, Smagala JA, Smith CB, Dawson ED, Cox NJ, Kuchta RD, Rowlen KLJournal of clinical microbiologyMoore CL, Smagala JA, Smith CB, Dawson ED, Cox NJ, Kuchta RD, Rowlen KL. Evaluation of MChip with historic subtype H1N1 influenza A viruses, including the 1918 "Spanish Flu" strain. J Clin Microbiol. 2007 Nov; 45(11):3807-10.J Clin Microbiol2007-09-12T00:00:002007Evaluation of MChip with historic subtype H1N1 influenza A viruses, including the 1918 "Spanish Flu" strain.18299250Townsend MB, Smagala JA, Dawson ED, Deyde V, Gubareva L, Klimov AI, Kuchta RD, Rowlen KLJournal of clinical virology : the official publication of the Pan American Society for Clinical VirologyTownsend MB, Smagala JA, Dawson ED, Deyde V, Gubareva L, Klimov AI, Kuchta RD, Rowlen KL. Detection of adamantane-resistant influenza on a microarray. J Clin Virol. 2008 Jun; 42(2):117-23.J Clin Virol2008-03-04T00:00:002008Detection of adamantane-resistant influenza on a microarray.Authorship 162935228505413Dickerson SM, Kuchta RDBiochemistryDickerson SM, Kuchta RD. Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry. 2017 05 30; 56(21):2651-2662.Biochemistry2017-05-19T00:00:002017Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase.18672908Keller KE, Cavanaugh N, Kuchta RDBiochemistryKeller KE, Cavanaugh N, Kuchta RD. Interaction of herpes primase with the sugar of a NTP. Biochemistry. 2008 Aug 26; 47(34):8977-84.Biochemistry2008-08-02T00:00:002008Interaction of herpes primase with the sugar of a NTP.19028696Cavanaugh NA, Kuchta RDThe Journal of biological chemistryCavanaugh NA, Kuchta RD. Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. J Biol Chem. 2009 Jan 16; 284(3):1523-32.J Biol Chem2008-11-20T00:00:002008Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha.19072331Patro JN, Urban M, Kuchta RDBiochemistryPatro JN, Urban M, Kuchta RD. Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha. Biochemistry. 2009 Jan 13; 48(1):180-9.Biochemistry2009-01-13T00:00:002009Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha.19348507Trostler M, Delier A, Beckman J, Urban M, Patro JN, Spratt TE, Beese LS, Kuchta RDBiochemistryTrostler M, Delier A, Beckman J, Urban M, Patro JN, Spratt TE, Beese LS, Kuchta RD. Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. Biochemistry. 2009 Jun 02; 48(21):4633-41.Biochemistry2009-06-02T00:00:002009Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.2398049Kuchta RD, Reid B, Chang LMThe Journal of biological chemistryKuchta RD, Reid B, Chang LM. DNA primase. Processivity and the primase to polymerase alpha activity switch. J Biol Chem. 1990 Sep 25; 265(27):16158-65.J Biol Chem1990-09-25T00:00:001990DNA primase. Processivity and the primase to polymerase alpha activity switch.19540940Kuchta RD, Stengel GBiochimica et biophysica actaKuchta RD, Stengel G. Mechanism and evolution of DNA primases. Biochim Biophys Acta. 2010 May; 1804(5):1180-9.Biochim Biophys Acta2009-06-21T00:00:002009Mechanism and evolution of DNA primases.19580325Stengel G, Purse BW, Wilhelmsson LM, Urban M, Kuchta RDBiochemistryStengel G, Purse BW, Wilhelmsson LM, Urban M, Kuchta RD. Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment. Biochemistry. 2009 Aug 11; 48(31):7547-55.Biochemistry2009-08-11T00:00:002009Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment.19642651Patro JN, Urban M, Kuchta RDBiochemistryPatro JN, Urban M, Kuchta RD. Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides. Biochemistry. 2009 Sep 01; 48(34):8271-8.Biochemistry2009-09-01T00:00:002009Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides.19583428Shewach DS, Kuchta RDChemical reviewsShewach DS, Kuchta RD. Introduction to cancer chemotherapeutics. Chem Rev. 2009 Jul; 109(7):2859-61.Chem Rev2009-07-01T00:00:002009Introduction to cancer chemotherapeutics.19788334Cavanaugh NA, Ramirez-Aguilar KA, Urban M, Kuchta RDBiochemistryCavanaugh NA, Ramirez-Aguilar KA, Urban M, Kuchta RD. Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Biochemistry. 2009 Nov 03; 48(43):10199-207.Biochemistry2009-11-03T00:00:002009Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation.19810708Stengel G, Urban M, Purse BW, Kuchta RDAnalytical chemistryStengel G, Urban M, Purse BW, Kuchta RD. High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo. Anal Chem. 2009 Nov 01; 81(21):9079-85.Anal Chem2009-11-01T00:00:002009High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo.19835416Urban M, Joubert N, Hocek M, Alexander RE, Kuchta RDBiochemistryUrban M, Joubert N, Hocek M, Alexander RE, Kuchta RD. Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase. Biochemistry. 2009 Nov 24; 48(46):10866-81.Biochemistry2009-11-24T00:00:002009Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase.3415 Colorado Avenue1JSCBJennie Caruthers Biotech Bldg3415 Colorado AvenueBoulder80303-1904CO20337438Johnson LM, Hansen RR, Urban M, Kuchta RD, Bowman CNBiomacromoleculesJohnson LM, Hansen RR, Urban M, Kuchta RD, Bowman CN. Photoinitiator nucleotide for quantifying nucleic Acid hybridization. Biomacromolecules. 2010 Apr 12; 11(4):1133-8.Biomacromolecules2010-04-12T00:00:002010Photoinitiator nucleotide for quantifying nucleic Acid hybridization.10387012Kirk BW, Kuchta RDBiochemistryKirk BW, Kuchta RD. Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology. Biochemistry. 1999 Jun 15; 38(24):7727-36.Biochemistry1999-06-15T00:00:001999Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology.10842182Steet RA, Melancon P, Kuchta RDThe Journal of biological chemistrySteet RA, Melancon P, Kuchta RD. 3'-Azidothymidine potently inhibits the biosynthesis of highly branched N-linked oligosaccharides and poly-N-acetyllactosamine chains in cells. J Biol Chem. 2000 Sep 01; 275(35):26812-20.J Biol Chem2000-09-01T00:00:0020003'-Azidothymidine potently inhibits the biosynthesis of highly branched N-linked oligosaccharides and poly-N-acetyllactosamine chains in cells.11084371Arezi B, Kuchta RDTrends in biochemical sciencesArezi B, Kuchta RD. Eukaryotic DNA primase. Trends Biochem Sci. 2000 Nov; 25(11):572-6.Trends Biochem Sci2000-11-01T00:00:002000Eukaryotic DNA primase.21600183Stengel G, Purse BW, Kuchta RDAnalytical biochemistryStengel G, Purse BW, Kuchta RD. Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine analogs. Anal Biochem. 2011 Sep 01; 416(1):53-60.Anal Biochem2011-04-27T00:00:002011Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine analogs.11714280Chiaramonte M, Koviach JL, Moore C, Iyer VV, Wagner CR, Halcomb RL, Miller W, Melan?on P, Kuchta RDBiochemistryChiaramonte M, Koviach JL, Moore C, Iyer VV, Wagner CR, Halcomb RL, Miller W, Melan?on P, Kuchta RD. Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates. Biochemistry. 2001 Nov 27; 40(47):14260-7.Biochemistry2001-11-27T00:00:002001Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates.22274912Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu XJournal of biomolecular screeningUngermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen. 2012 Apr; 17(4):421-34.J Biomol Screen2012-01-24T00:00:002012Identification and mechanistic studies of a novel ubiquitin E1 inhibitor.11939784Zerbe LK, Kuchta RDBiochemistryZerbe LK, Kuchta RD. The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting. Biochemistry. 2002 Apr 16; 41(15):4891-900.Biochemistry2002-04-16T00:00:002002The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.23316816Olson AC, Patro JN, Urban M, Kuchta RDJournal of the American Chemical SocietyOlson AC, Patro JN, Urban M, Kuchta RD. The energetic difference between synthesis of correct and incorrect base pairs accounts for highly accurate DNA replication. J Am Chem Soc. 2013 Jan 30; 135(4):1205-8.J Am Chem Soc2013-01-17T00:00:002013The energetic difference between synthesis of correct and incorrect base pairs accounts for highly accurate DNA replication.14769053Ramirez-Aguilar KA, Kuchta RDBiochemistryRamirez-Aguilar KA, Kuchta RD. Mechanism of primer synthesis by the herpes simplex virus 1 helicase-primase. Biochemistry. 2004 Feb 17; 43(6):1754-62.Biochemistry2004-02-17T00:00:002004Mechanism of primer synthesis by the herpes simplex virus 1 helicase-primase.15248765Ramirez-Aguilar KA, Kuchta RDBiochemistryRamirez-Aguilar KA, Kuchta RD. Herpes simplex virus-1 primase: a polymerase with extraordinarily low fidelity. Biochemistry. 2004 Jul 20; 43(28):9084-91.Biochemistry2004-07-20T00:00:002004Herpes simplex virus-1 primase: a polymerase with extraordinarily low fidelity.8034683Sheaff RJ, Kuchta RDThe Journal of biological chemistrySheaff RJ, Kuchta RD. Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase alpha. J Biol Chem. 1994 Jul 29; 269(30):19225-31.J Biol Chem1994-07-29T00:00:001994Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase alpha.8182037Hall ET, Yan JP, Melan?on P, Kuchta RDThe Journal of biological chemistryHall ET, Yan JP, Melan?on P, Kuchta RD. 3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity. J Biol Chem. 1994 May 20; 269(20):14355-8.J Biol Chem1994-05-20T00:00:0019943'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity.8395209Cheng CH, Kuchta RDBiochemistryCheng CH, Kuchta RD. DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Biochemistry. 1993 Aug 24; 32(33):8568-74.Biochemistry1993-08-24T00:00:001993DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity.10596899Steet R, Alizadeh M, Melan?on P, Kuchta RDGlycoconjugate journalSteet R, Alizadeh M, Melan?on P, Kuchta RD. 3'-Azidothymidine significantly alters glycosphingolipid synthesis in melanoma cells and decreases the shedding of gangliosides. Glycoconj J. 1999 Mar; 16(3):237-45.Glycoconj J1999-03-01T00:00:0019993'-Azidothymidine significantly alters glycosphingolipid synthesis in melanoma cells and decreases the shedding of gangliosides.1581321Kuchta RD, Ilsley D, Kravig KD, Schubert S, Harris BBiochemistryKuchta RD, Ilsley D, Kravig KD, Schubert S, Harris B. Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds. Biochemistry. 1992 May 19; 31(19):4720-8.Biochemistry1992-05-19T00:00:001992Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds.16840321Richards OC, Spagnolo JF, Lyle JM, Vleck SE, Kuchta RD, Kirkegaard KJournal of virologyRichards OC, Spagnolo JF, Lyle JM, Vleck SE, Kuchta RD, Kirkegaard K. Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase. J Virol. 2006 Aug; 80(15):7405-15.J Virol2006-08-01T00:00:002006Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase.16891503Mehlmann M, Dawson ED, Townsend MB, Smagala JA, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KLJournal of clinical microbiologyMehlmann M, Dawson ED, Townsend MB, Smagala JA, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Robust sequence selection method used to develop the FluChip diagnostic microarray for influenza virus. J Clin Microbiol. 2006 Aug; 44(8):2857-62.J Clin Microbiol2006-08-01T00:00:002006Robust sequence selection method used to develop the FluChip diagnostic microarray for influenza virus.16891504Townsend MB, Dawson ED, Mehlmann M, Smagala JA, Dankbar DM, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KLJournal of clinical microbiologyTownsend MB, Dawson ED, Mehlmann M, Smagala JA, Dankbar DM, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Experimental evaluation of the FluChip diagnostic microarray for influenza virus surveillance. J Clin Microbiol. 2006 Aug; 44(8):2863-71.J Clin Microbiol2006-08-01T00:00:002006Experimental evaluation of the FluChip diagnostic microarray for influenza virus surveillance.16945949Kincaid K, Kuchta RDNucleic acids researchKincaid K, Kuchta RD. A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues. Nucleic Acids Res. 2006; 34(16):e109.Nucleic Acids Res2006-08-31T00:00:002006A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues.17105150Dawson ED, Moore CL, Smagala JA, Dankbar DM, Mehlmann M, Townsend MB, Smith CB, Cox NJ, Kuchta RD, Rowlen KLAnalytical chemistryDawson ED, Moore CL, Smagala JA, Dankbar DM, Mehlmann M, Townsend MB, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. MChip: a tool for influenza surveillance. Anal Chem. 2006 Nov 15; 78(22):7610-5.Anal Chem2006-11-15T00:00:002006MChip: a tool for influenza surveillance.17194164Dawson ED, Moore CL, Dankbar DM, Mehlmann M, Townsend MB, Smagala JA, Smith CB, Cox NJ, Kuchta RD, Rowlen KLAnalytical chemistryDawson ED, Moore CL, Dankbar DM, Mehlmann M, Townsend MB, Smagala JA, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray. Anal Chem. 2007 Jan 01; 79(1):378-84.Anal Chem2007-01-01T00:00:002007Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray.1703021Kuchta RD, Willhelm LBiochemistryKuchta RD, Willhelm L. Inhibition of DNA primase by 9-beta-D-arabinofuranosyladenosine triphosphate. Biochemistry. 1991 Jan 22; 30(3):797-803.Biochemistry1991-01-22T00:00:001991Inhibition of DNA primase by 9-beta-D-arabinofuranosyladenosine triphosphate.15379576Moore CL, Zivkovic A, Engels JW, Kuchta RDBiochemistryMoore CL, Zivkovic A, Engels JW, Kuchta RD. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004 Sep 28; 43(38):12367-74.Biochemistry2004-09-28T00:00:002004Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates.15879351Kincaid K, Beckman J, Zivkovic A, Halcomb RL, Engels JW, Kuchta RDNucleic acids researchKincaid K, Beckman J, Zivkovic A, Halcomb RL, Engels JW, Kuchta RD. Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha. Nucleic Acids Res. 2005; 33(8):2620-8.Nucleic Acids Res2005-05-06T00:00:002005Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha.16239306Smagala JA, Dawson ED, Mehlmann M, Townsend MB, Kuchta RD, Rowlen KLBioinformatics (Oxford, England)Smagala JA, Dawson ED, Mehlmann M, Townsend MB, Kuchta RD, Rowlen KL. ConFind: a robust tool for conserved sequence identification. Bioinformatics. 2005 Dec 15; 21(24):4420-2.Bioinformatics2005-10-20T00:00:002005ConFind: a robust tool for conserved sequence identification.19166354Cavanaugh NA, Urban M, Beckman J, Spratt TE, Kuchta RDBiochemistryCavanaugh NA, Urban M, Beckman J, Spratt TE, Kuchta RD. Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. Biochemistry. 2009 Apr 21; 48(15):3554-64.Biochemistry2009-04-21T00:00:002009Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase.17222795Blair RH, Rosenblum ES, Dawson ED, Kuchta RD, Kuck LR, Rowlen KLAnalytical biochemistryBlair RH, Rosenblum ES, Dawson ED, Kuchta RD, Kuck LR, Rowlen KL. Real-time quantification of RNA polymerase activity using a "broken beacon". Anal Biochem. 2007 Mar 15; 362(2):213-20.Anal Biochem2006-12-29T00:00:002006Real-time quantification of RNA polymerase activity using a "broken beacon".17326602Dankbar DM, Dawson ED, Mehlmann M, Moore CL, Smagala JA, Shaw MW, Cox NJ, Kuchta RD, Rowlen KLAnalytical chemistryDankbar DM, Dawson ED, Mehlmann M, Moore CL, Smagala JA, Shaw MW, Cox NJ, Kuchta RD, Rowlen KL. Diagnostic microarray for influenza B viruses. Anal Chem. 2007 Mar 01; 79(5):2084-90.Anal Chem2007-03-01T00:00:002007Diagnostic microarray for influenza B viruses.20030400Urban M, Joubert N, Purse BW, Hocek M, Kuchta RDBiochemistryUrban M, Joubert N, Purse BW, Hocek M, Kuchta RD. Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. Biochemistry. 2010 Feb 02; 49(4):727-35.Biochemistry2010-02-02T00:00:002010Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.20884615Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu XThe Journal of biological chemistrySun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu X. Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment. J Biol Chem. 2010 Dec 03; 285(49):38730-9.J Biol Chem2010-09-30T00:00:002010Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.21033726Olson AC, Rosenblum E, Kuchta RDBiochemistryOlson AC, Rosenblum E, Kuchta RD. Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase. Biochemistry. 2010 Nov 30; 49(47):10208-15.Biochemistry2010-11-08T00:00:002010Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase.20067253Stengel G, Urban M, Purse BW, Kuchta RDAnalytical chemistryStengel G, Urban M, Purse BW, Kuchta RD. Incorporation of the fluorescent ribonucleotide analogue tCTP by T7 RNA polymerase. Anal Chem. 2010 Feb 01; 82(3):1082-9.Anal Chem2010-02-01T00:00:002010Incorporation of the fluorescent ribonucleotide analogue tCTP by T7 RNA polymerase.21068232Stengel G, Kuchta RDJournal of virologyStengel G, Kuchta RD. Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates. J Virol. 2011 Jan; 85(2):957-67.J Virol2010-11-10T00:00:002010Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates.21068246Chen Y, Bai P, Mackay S, Korza G, Carson JH, Kuchta RD, Weller SKJournal of virologyChen Y, Bai P, Mackay S, Korza G, Carson JH, Kuchta RD, Weller SK. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. J Virol. 2011 Jan; 85(2):968-78.J Virol2010-11-10T00:00:002010Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation.21771534Houck JA, Hojgaard A, Piesman J, Kuchta RDTicks and tick-borne diseasesHouck JA, Hojgaard A, Piesman J, Kuchta RD. Low-density microarrays for the detection of Borrelia burgdorferi s.s. (the Lyme disease spirochete) in nymphal Ixodes scapularis. Ticks Tick Borne Dis. 2011 Mar; 2(1):27-36.Ticks Tick Borne Dis2010-11-27T00:00:002010Low-density microarrays for the detection of Borrelia burgdorferi s.s. (the Lyme disease spirochete) in nymphal Ixodes scapularis.22279528Ungermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu XPloS oneUngermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu X. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). PLoS One. 2012; 7(1):e29208.PLoS One2012-01-18T00:00:002012Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1).3224760Kuchta RD, Cowart M, Allen D, Benkovic SJBiochemical Society transactionsKuchta RD, Cowart M, Allen D, Benkovic SJ. Kinetic and structural investigations of the replicative fidelity of the Klenow fragment. Biochem Soc Trans. 1988 Dec; 16(6):947-9.Biochem Soc Trans1988-12-01T00:00:001988Kinetic and structural investigations of the replicative fidelity of the Klenow fragment.21761848Lund TJ, Cavanaugh NA, Joubert N, Urban M, Patro JN, Hocek M, Kuchta RDBiochemistryLund TJ, Cavanaugh NA, Joubert N, Urban M, Patro JN, Hocek M, Kuchta RD. B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry. 2011 Aug 23; 50(33):7243-50.Biochemistry2011-07-26T00:00:002011B family DNA polymerases asymmetrically recognize pyrimidines and purines.3026450Kuchta RD, Hanson GR, Holmquist B, Abeles RHBiochemistryKuchta RD, Hanson GR, Holmquist B, Abeles RH. Fe-S centers in lactyl-CoA dehydratase. Biochemistry. 1986 Nov 18; 25(23):7301-7.Biochemistry1986-11-18T00:00:001986Fe-S centers in lactyl-CoA dehydratase.3058205Kuchta RD, Benkovic P, Benkovic SJBiochemistryKuchta RD, Benkovic P, Benkovic SJ. Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity. Biochemistry. 1988 Sep 06; 27(18):6716-25.Biochemistry1988-09-06T00:00:001988Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity.Authorship 173630429267330Romaszko J, Cymes I, Draganska E, Kuchta R, Glinska-Lewczuk KPloS oneRomaszko J, Cymes I, Draganska E, Kuchta R, Glinska-Lewczuk K. Mortality among the homeless: Causes and meteorological relationships. PLoS One. 2017; 12(12):e0189938.PLoS One2017-12-21T00:00:002017Mortality among the homeless: Causes and meteorological relationships.3327522Kuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic SJBiochemistryKuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic SJ. Kinetic mechanism of DNA polymerase I (Klenow). Biochemistry. 1987 Dec 15; 26(25):8410-7.Biochemistry1987-12-15T00:00:001987Kinetic mechanism of DNA polymerase I (Klenow).D004259Chemicals & Drugs21450.96586DNA-Directed DNA PolymeraseD018259Living Beings40820.911161Herpesvirus 1, HumanSOM-IMM MICRO GENERAL OPERD004256Chemicals & Drugs9260.977548DNA Polymerase ID014764Chemicals & Drugs1263000.826491Viral ProteinsD019915Chemicals & Drugs8430.966167DNA PrimaseSOM-PHARM General OperationsBiochemistryChemical & Biological EnginSOM-BioChem&Molecular GeneticsSOP-AdministrationChemistryUniversity of Colorado BoulderUniversity of Colorado Denver - Anschutz Medical CampusTatianaKutateladzeTatiana Grigori Kutateladze39.74545800000000-104.839369100000001029Kutateladze, TatianaProfessorXuedongLiuXuedong Liu40.00830860000000-105.249067200000001467Liu, XuedongProfessorNatalieAhnNatalie Ahn40.00830860000000-105.249067200000001376Ahn, NatalieDistinguished ProfessorRobertBateyRobert T. Batey40.00830860000000-105.249067200000001604Batey, RobertProfessorJeffreyKieftJeffrey Scott Kieft39.74389450000000-104.839435200000001812Kieft, JeffreyProfessor Adjoint5.785440.00580914345research areas0.3130150.02453167coauthor of39.49596.4232860similar to1192selected publicationsAuthorship 111724DavidBartonDavid J Barton39.74545800000000-104.83936910000000457Barton, DavidProfessorChristopherBowmanChristopher Bowman40.00679120000000-105.26281830000000495Bowman, ChristopherDistinguished ProfessorJosefMichlJosef Michl40.00788870000000-105.27048580000000730Michl, JosefProfessorMarvinCaruthersMarvin H Caruthers40.00830860000000-105.24906720000000824Caruthers, MarvinDistinguished ProfessorThomasCechThomas R Cech40.00830860000000-105.24906720000000807Cech, ThomasDistinguished ProfessorJosephFalkeJoseph Falke40.00830860000000-105.24906720000000476Falke, JosephProfessorAuthorship 14792Authorship 161255Authorship 164884Authorship 101178223930666Weller SK, Kuchta RDExpert opinion on therapeutic targetsWeller SK, Kuchta RD. The DNA helicase-primase complex as a target for herpes viral infection. Expert Opin Ther Targets. 2013 Oct; 17(10):1119-32.Expert Opin Ther Targets2013-08-12T00:00:002013The DNA helicase-primase complex as a target for herpes viral infection.Authorship 244803334291038Bricelj A, Steinebach C, Kuchta R, G?tschow M, Sosic IFrontiers in chemistryBricelj A, Steinebach C, Kuchta R, G?tschow M, Sosic I. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points. Front Chem. 2021; 9:707317.Front Chem2021-07-05T00:00:002021E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points.Authorship 251775434795861Bricelj A, Dora Ng YL, Ferber D, Kuchta R, M?ller S, Monschke M, Wagner KG, Kr?nke J, Sosic I, G?tschow M, Steinebach CACS medicinal chemistry lettersBricelj A, Dora Ng YL, Ferber D, Kuchta R, M?ller S, Monschke M, Wagner KG, Kr?nke J, Sosic I, G?tschow M, Steinebach C. Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands. ACS Med Chem Lett. 2021 Nov 11; 12(11):1733-1738.ACS Med Chem Lett2021-10-18T00:00:002021Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands.Authorship 196087Authorship 206352Authorship 216384Authorship 246703Authorship 251852Authorship 278300136908700Kuchta R, Heim C, Herrmann A, Maiwald S, Ng YLD, Sosic I, Keuler T, Kr?nke J, G?tschow M, Hartmann MD, Steinebach CRSC chemical biologyKuchta R, Heim C, Herrmann A, Maiwald S, Ng YLD, Sosic I, Keuler T, Kr?nke J, G?tschow M, Hartmann MD, Steinebach C. Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC Chem Biol. 2023 Mar 08; 4(3):229-234.RSC Chem Biol2023-01-03T00:00:002023Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design.Authorship 275102Authorship 279293Authorship 28706Authorship 287684Authorship 294852Authorship 316246Authorship 316596Authorship 323595true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Distinguished ProfessorDistinguished Professortrue1Research AssociateResearch Associatetrue1Distinguished ProfessorDistinguished Professortrue1Professor AdjointProfessor Adjointtrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Distinguished ProfessorDistinguished Professortrue1Distinguished ProfessorDistinguished ProfessorAuthorship 347427Authorship 348847Authorship 351698Authorship 364009Authorship 365572Authorship 379272Authorship 379887Authorship 379895Authorship 388666Authorship 425471Authorship 434862Authorship 439954Authorship 442234Authorship 109025724311229Rodgers BJ, Elsharif NA, Vashisht N, Mingus MM, Mulvahill MA, Stengel G, Kuchta RD, Purse BWChemistry (Weinheim an der Bergstrasse, Germany)Rodgers BJ, Elsharif NA, Vashisht N, Mingus MM, Mulvahill MA, Stengel G, Kuchta RD, Purse BW. Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities. Chemistry. 2014 Feb 10; 20(7):2010-5.Chemistry2013-12-05T00:00:002013Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities.Authorship 454994Authorship 459539Authorship 461051Authorship 465631Authorship 475129Authorship 506214Authorship 526032Authorship 537806Authorship 538531Authorship 540926Authorship 542721Authorship 562673Authorship 568045Authorship 574838Authorship 586554Authorship 609734Authorship 630213Authorship 632562Authorship 665549Authorship 683673Authorship 715532Authorship 71862Authorship 73394Authorship 737983Authorship 743754Authorship 746394Authorship 759687Authorship 779281Authorship 782202Authorship 793921