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Jonathan David Port

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-5438

    Collapse Research 
    Collapse research activities and funding
    P20HL101435     (BUTTRICK, PETER)Apr 1, 2010 - Mar 31, 2013
    NIH
    Using Molecular Pathology to Predict Response in Heart Failure
    Role: Co-Principal Investigator
    R01HL051239     (PORT, JONATHAN DAVID)Jan 1, 1994 - Jun 30, 2010
    NIH
    Regulation of beta-adrenergic receptor mRNA stability
    Role: Principal Investigator
    R29HL051239     (PORT, JONATHAN DAVID)Jan 1, 1994 - Sep 29, 1999
    NIH
    REGULATION OF BETA-ADRENERGIC RECEPTOR MRNA STABILITY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Port JD. Dissecting Beta-Adrenergic Receptors: The Sum of Many Parts. JACC Basic Transl Sci. 2023 Aug; 8(8):989-991. PMID: 37719428.
      View in: PubMed
    2. Port JD. Potential of AT1-R-Biased Agonists in Pediatric Heart?Failure. JACC Basic Transl Sci. 2020 Nov; 5(11):1070-1072. PMID: 33296444.
      View in: PubMed
    3. Port JD, Bristow MR. Fine Tuning Adenylyl Cyclase as a (Gene)?Therapy for Heart Failure. JACC Basic Transl Sci. 2016 Dec; 1(7):630-632. PMID: 30167546.
      View in: PubMed
    4. Lindenfeld J, Cleveland JC, Kao DP, White M, Wichman S, Bristow JC, Peterson V, Rodegheri-Brito J, Korst A, Blain-Nelson P, Sederberg J, Hunt SA, Gilbert EM, Ambardekar AV, Minobe W, Port JD, Bristow MR. Sex-related differences in age-associated downregulation of human ventricular myocardial ?1-adrenergic receptors. J Heart Lung Transplant. 2016 Mar; 35(3):352-361. PMID: 26970472.
      View in: PubMed
    5. Hinterberg MA, Kao DP, Bristow MR, Hunter LE, Port JD, G?rg C. Peax: interactive visual analysis and exploration of complex clinical phenotype and gene expression association. Pac Symp Biocomput. 2015; 419-30. PMID: 25592601.
      View in: PubMed
    6. Aleong RG, Sauer WH, Davis G, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of atrial fibrillation by bucindolol is dependent on the beta1389 Arg/Gly adrenergic receptor polymorphism. JACC Heart Fail. 2013 Aug; 1(4):338-344. PMID: 24159564.
      View in: PubMed
    7. Dockstader K, Nunley K, Karimpour-Fard A, Medway A, Nelson P, Port JD, Liggett SB, Bristow MR, Sucharov CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the ?1-adrenergic receptor. Physiol Genomics. 2011 Dec 05; 43(23):1294-306. PMID: 21954455.
      View in: PubMed
    8. Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 06; 43(19):1087-95. PMID: 21771878.
      View in: PubMed
    9. Port JD, Sucharov C. Role of microRNAs in cardiovascular disease: therapeutic challenges and potentials. J Cardiovasc Pharmacol. 2010 Nov; 56(5):444-53. PMID: 20729754.
      View in: PubMed
    10. David Gerecht PS, Taylor MA, Port JD. Intracellular localization and interaction of mRNA binding proteins as detected by FRET. BMC Cell Biol. 2010 Sep 15; 11:69. PMID: 20843363.
      View in: PubMed
    11. Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circ Heart Fail. 2010 Jan; 3(1):21-8. PMID: 19880803.
      View in: PubMed
    12. Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol. 2008 Aug; 45(2):185-92. PMID: 18582896.
      View in: PubMed
    13. Vest RS, Davies KD, O'Leary H, Port JD, Bayer KU. Dual mechanism of a natural CaMKII inhibitor. Mol Biol Cell. 2007 Dec; 18(12):5024-33. PMID: 17942605.
      View in: PubMed
    14. David PS, Tanveer R, Port JD. FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1. RNA. 2007 Sep; 13(9):1453-68. PMID: 17626845.
      View in: PubMed
    15. Zerbe LK, Pino I, Pio R, Cosper PF, Dwyer-Nield LD, Meyer AM, Port JD, Montuenga LM, Malkinson AM. Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. Mol Carcinog. 2004 Dec; 41(4):187-96. PMID: 15390079.
      View in: PubMed
    16. Headley VV, Tanveer R, Greene SM, Zweifach A, Port JD. Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition. Mol Cell Biochem. 2004 Mar; 258(1-2):109-19. PMID: 15030175.
      View in: PubMed
    17. Blaxall BC, Pende A, Wu SC, Port JD. Correlation between intrinsic mRNA stability and the affinity of AUF1 (hnRNP D) and HuR for A+U-rich mRNAs. Mol Cell Biochem. 2002 Mar; 232(1-2):1-11. PMID: 12030365.
      View in: PubMed
    18. Port JD, Bristow MR. beta-Adrenergic receptors, transgenic mice, and pharmacological model systems. Mol Pharmacol. 2001 Oct; 60(4):629-31. PMID: 11562422.
      View in: PubMed
    19. Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol. 2001 May; 33(5):887-905. PMID: 11343413.
      View in: PubMed
    20. Blaxall BC, Dwyer-Nield LD, Bauer AK, Bohlmeyer TJ, Malkinson AM, Port JD. Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue. Mol Carcinog. 2000 Jun; 28(2):76-83. PMID: 10900464.
      View in: PubMed
    21. Blaxall BC, Pellett AC, Wu SC, Pende A, Port JD. Purification and characterization of beta-adrenergic receptor mRNA-binding proteins. J Biol Chem. 2000 Feb 11; 275(6):4290-7. PMID: 10660597.
      View in: PubMed
    22. Blaxall BC, Port JD. Determination of mRNA stability and characterization of proteins interacting with adrenergic receptor mRNAs. Methods Mol Biol. 2000; 126:453-65. PMID: 10685429.
      View in: PubMed
    23. Mitchusson KD, Blaxall BC, Pende A, Port JD. Agonist-mediated destabilization of human beta1-adrenergic receptor mRNA: role of the 3' untranslated translated region. Biochem Biophys Res Commun. 1998 Nov 18; 252(2):357-62. PMID: 9826534.
      View in: PubMed
    24. Bristow M, Port JD. Beta-adrenergic blockade in chronic heart failure. Scand Cardiovasc J Suppl. 1998; 47:45-55. PMID: 9540133.
      View in: PubMed
    25. Asano K, Dutcher DL, Port JD, Minobe WA, Tremmel KD, Roden RL, Bohlmeyer TJ, Bush EW, Jenkin MJ, Abraham WT, Raynolds MV, Zisman LS, Perryman MB, Bristow MR. Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium. Circulation. 1997 Mar 04; 95(5):1193-200. PMID: 9054849.
      View in: PubMed
    26. Pende A, Tremmel KD, DeMaria CT, Blaxall BC, Minobe WA, Sherman JA, Bisognano JD, Bristow MR, Brewer G, Port J. Regulation of the mRNA-binding protein AUF1 by activation of the beta-adrenergic receptor signal transduction pathway. J Biol Chem. 1996 Apr 05; 271(14):8493-501. PMID: 8626551.
      View in: PubMed
    27. White M, Wiechmann RJ, Roden RL, Hagan MB, Wollmering MM, Port JD, Hammond E, Abraham WT, Wolfel EE, Lindenfeld J, et al. Cardiac beta-adrenergic neuroeffector systems in acute myocardial dysfunction related to brain injury. Evidence for catecholamine-mediated myocardial damage. Circulation. 1995 Oct 15; 92(8):2183-9. PMID: 7554200.
      View in: PubMed
    28. Farrukh HM, White M, Port JD, Handwerger D, Larrabee P, Klein J, Roden RA, Skerl L, Renlund DG, Feldman AM, et al. Up-regulation of beta 2-adrenergic receptors in previously transplanted, denervated nonfailing human hearts. J Am Coll Cardiol. 1993 Dec; 22(7):1902-8. PMID: 8245347.
      View in: PubMed
    29. Bristow MR, Minobe WA, Raynolds MV, Port JD, Rasmussen R, Ray PE, Feldman AM. Reduced beta 1 receptor messenger RNA abundance in the failing human heart. J Clin Invest. 1993 Dec; 92(6):2737-45. PMID: 8254027.
      View in: PubMed
    30. Port JD, Malbon CC. Integration of transmembrane signaling Cross-talk among G-protein-linked receptors and other signal transduction pathways. Trends Cardiovasc Med. 1993 May-Jun; 3(3):85-92. PMID: 21244945.
      View in: PubMed
    31. Bristow MR, Larrabee P, M?ller-Beckmann B, Minobe W, Roden R, Skerl L, Klein J, Handwerger D, Port JD. Effects of carvedilol on adrenergic receptor pharmacology in human ventricular myocardium and lymphocytes. Clin Investig. 1992; 70 Suppl 1:S105-13. PMID: 1350478.
      View in: PubMed
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