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Subbiah Pugazhenthi

TitleProfessor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/399-8020

    Collapse Research 
    Collapse research activities and funding
    I01BX004480     (PUGAZHENTHI, SUBBIAH)Jul 1, 2019 - Jun 30, 2024
    NIH
    SIRT3 Deficiency-mediated Metabolic Dysregulation in Comorbid Alzheimer's Disease
    Role: Principal Investigator
    I01BX001837     (PUGAZHENTHI, SUBBIAH)Apr 1, 2013 - Mar 31, 2017
    NIH
    Mechanism of CREB dysregulation in Alzheimer brain
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Raju RP, Cai L, Tyagi A, Pugazhenthi S. Interactions of Cellular Energetic Gene Clusters in the Alzheimer's Mouse Brain. Mol Neurobiol. 2024 Jan; 61(1):476-486. PMID: 37632678.
      View in: PubMed
    2. Tyagi A, Pugazhenthi S. A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation. Int J Mol Sci. 2023 Jan 13; 24(2). PMID: 36675125.
      View in: PubMed
    3. Tyagi A, Musa M, Labeikovsky W, Pugazhenthi S. Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome. Sci Rep. 2022 11 17; 12(1):19808. PMID: 36396721.
      View in: PubMed
    4. Tyagi A, Mirita C, Shah I, Reddy PH, Pugazhenthi S. Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease. Front Aging Neurosci. 2021; 13:716616. PMID: 34393764.
      View in: PubMed
    5. Tyagi A, Pugazhenthi S. Targeting Insulin Resistance to Treat Cognitive Dysfunction. Mol Neurobiol. 2021 Jun; 58(6):2672-2691. PMID: 33483903.
      View in: PubMed
    6. Tyagi A, Mirita C, Taher N, Shah I, Moeller E, Tyagi A, Chong T, Pugazhenthi S. Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model. Biochim Biophys Acta Mol Basis Dis. 2020 10 01; 1866(10):165849. PMID: 32485218.
      View in: PubMed
    7. Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S. SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep. 2018 12 03; 8(1):17547. PMID: 30510203.
      View in: PubMed
    8. Pugazhenthi S. Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease. Prog Mol Biol Transl Sci. 2017; 146:243-258. PMID: 28253987.
      View in: PubMed
    9. Goalstone ML, Pugazhenthi S. Editorial: Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain. Front Endocrinol (Lausanne). 2016; 7:45. PMID: 27242668.
      View in: PubMed
    10. Pugazhenthi S, Qin L, Reddy PH. Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2017 May; 1863(5):1037-1045. PMID: 27156888.
      View in: PubMed
    11. Qin L, Bouchard R, Pugazhenthi S. Regulation of cyclic AMP response element-binding protein during neuroglial interactions. J Neurochem. 2016 Mar; 136(5):918-30. PMID: 26677139.
      View in: PubMed
    12. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Alg?l H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, B?nhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolom? A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, B?dard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, B?nard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, B?ckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouch? M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, B?tikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ce?a V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
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    13. Qin L, Chong T, Rodriguez R, Pugazhenthi S. Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease. Curr Alzheimer Res. 2016; 13(12):1346-1355. PMID: 27033055.
      View in: PubMed
    14. Pugazhenthi S, Qin L, Bouchard R. Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in ?-cells. Eur J Pharmacol. 2015 May 15; 755:42-9. PMID: 25720341.
      View in: PubMed
    15. Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr; 42(2):231-8. PMID: 24646223.
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    16. Bouchard R, Chong T, Pugazhenthi S. Laser capture microdissection of neurons from differentiated human neuroprogenitor cells in culture. J Vis Exp. 2013 Sep 16; (79):e50487. PMID: 24084642.
      View in: PubMed
    17. Pugazhenthi S, Zhang Y, Bouchard R, Mahaffey G. Induction of an inflammatory loop by interleukin-1? and tumor necrosis factor-a involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells. PLoS One. 2013; 8(7):e69585. PMID: 23922745.
      View in: PubMed
    18. Balamurugan AN, Kumaravel V, Pugazhenthi S, Naziruddin B. Islet cell biology, regeneration, and transplantation. Int J Endocrinol. 2012; 2012:139787. PMID: 23326263.
      View in: PubMed
    19. Velmurugan K, Bouchard R, Mahaffey G, Pugazhenthi S. Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells. J Neurochem. 2012 Dec; 123(6):919-31. PMID: 23020846.
      View in: PubMed
    20. Wang M, Crager M, Pugazhenthi S. Modulation of apoptosis pathways by oxidative stress and autophagy in ? cells. Exp Diabetes Res. 2012; 2012:647914. PMID: 22474427.
      View in: PubMed
    21. Velmurugan K, Balamurugan AN, Loganathan G, Ahmad A, Hering BJ, Pugazhenthi S. Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB. Endocrinology. 2012 Mar; 153(3):1116-28. PMID: 22253425.
      View in: PubMed
    22. Loganathan G, Dawra RK, Pugazhenthi S, Guo Z, Soltani SM, Wiseman A, Sanders MA, Papas KK, Velayutham K, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN. Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of a-1 antitrypsin treatment. Transplantation. 2011 Dec 15; 92(11):1222-30. PMID: 22089666.
      View in: PubMed
    23. Pugazhenthi S, Wang M, Pham S, Sze CI, Eckman CB. Downregulation of CREB expression in Alzheimer's brain and in A?-treated rat hippocampal neurons. Mol Neurodegener. 2011 Aug 19; 6:60. PMID: 21854604.
      View in: PubMed
    24. Gilden D, Mahalingam R, Nagel MA, Pugazhenthi S, Cohrs RJ. Review: The neurobiology of varicella zoster virus infection. Neuropathol Appl Neurobiol. 2011 Aug; 37(5):441-63. PMID: 21342215.
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    25. Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BJ. 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways. Free Radic Biol Med. 2011 Sep 15; 51(6):1146-54. PMID: 21712085.
      View in: PubMed
    26. Pugazhenthi S, Nair S, Velmurugan K, Liang Q, Mahalingam R, Cohrs RJ, Nagel MA, Gilden D. Varicella-zoster virus infection of differentiated human neural stem cells. J Virol. 2011 Jul; 85(13):6678-86. PMID: 21525352.
      View in: PubMed
    27. Brazeau E, Wellish M, Kaufer BB, Tischer BK, Gray W, Zhou F, Osterrieder N, Hanlon T, Golive A, Hall T, Nair S, Owens GP, Mueller NH, Cohrs RJ, Pugazhenthi S, Gilden D, Mahalingam R. Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture. J Neurovirol. 2011 Jun; 17(3):274-80. PMID: 21479719.
      View in: PubMed
    28. Pugazhenthi U, Velmurugan K, Tran A, Mahaffey G, Pugazhenthi S. Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients. Diabetologia. 2010 Nov; 53(11):2357-68. PMID: 20635178.
      View in: PubMed
    29. Loganathan G, Dawra RK, Pugazhenthi S, Wiseman AC, Sanders MA, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN. Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery. Transplant Proc. 2010 Jul-Aug; 42(6):2055-7. PMID: 20692406.
      View in: PubMed
    30. Brazeau E, Mahalingam R, Gilden D, Wellish M, Kaufer BB, Osterrieder N, Pugazhenthi S. Varicella-zoster virus-induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression. J Neurovirol. 2010 Mar; 16(2):133-40. PMID: 20345323.
      View in: PubMed
    31. Li MY, Lai FJ, Hsu LJ, Lo CP, Cheng CL, Lin SR, Lee MH, Chang JY, Subhan D, Tsai MS, Sze CI, Pugazhenthi S, Chang NS, Chen ST. Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS One. 2009 Nov 12; 4(11):e7820. PMID: 19918364.
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    32. Son KN, Pugazhenthi S, Lipton HL. Activation of tumor suppressor protein p53 is required for Theiler's murine encephalomyelitis virus-induced apoptosis in M1-D macrophages. J Virol. 2009 Oct; 83(20):10770-7. PMID: 19656889.
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    33. Pugazhenthi S, Gilden DH, Nair S, McAdoo A, Wellish M, Brazeau E, Mahalingam R. Simian varicella virus induces apoptosis in monkey kidney cells by the intrinsic pathway and involves downregulation of bcl-2 expression. J Virol. 2009 Sep; 83(18):9273-82. PMID: 19605493.
      View in: PubMed
    34. Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S. Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. Pancreas. 2009 May; 38(4):454-60. PMID: 19188863.
      View in: PubMed
    35. Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia. 2009 Jun; 52(6):1092-101. PMID: 19343319.
      View in: PubMed
    36. Gilden D, Nagel MA, Mahalingam R, Mueller NH, Brazeau EA, Pugazhenthi S, Cohrs RJ. Clinical and molecular aspects of varicella zoster virus infection. Future Neurol. 2009 Jan 01; 4(1):103-117. PMID: 19946620.
      View in: PubMed
    37. Velmurugan K, Alam J, McCord JM, Pugazhenthi S. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic Biol Med. 2009 Feb 01; 46(3):430-40. PMID: 19056485.
      View in: PubMed
    38. Sivam SP, Pugazhenthi S, Pugazhenthi V, Brown H. L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: relevance to self-injurious behavior. J Neurosci Res. 2008 Feb 01; 86(2):339-49. PMID: 17893915.
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    39. Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia. 2007 Aug; 50(8):1649-59. PMID: 17593347.
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    40. Pugazhenthi S, Akhov L, Selvaraj G, Wang M, Alam J. Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E645-55. PMID: 17535857.
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    41. Mahalingam R, Gilden DH, Wellish M, Pugazhenthi S. Transactivation of the simian varicella virus (SVV) open reading frame (ORF) 21 promoter by SVV ORF 62 is upregulated in neuronal cells but downregulated in non-neuronal cells by SVV ORF 63 protein. Virology. 2006 Feb 05; 345(1):244-50. PMID: 16242745.
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    42. Pugazhenthi S, Phansalkar K, Audesirk G, West A, Cabell L. Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. Free Radic Biol Med. 2006 Jan 01; 40(1):21-34. PMID: 16337876.
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    43. Sze CI, Su M, Pugazhenthi S, Jambal P, Hsu LJ, Heath J, Schultz L, Chang NS. Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem. 2004 Jul 16; 279(29):30498-506. PMID: 15126504.
      View in: PubMed
    44. Haskins K, Kench J, Powers K, Bradley B, Pugazhenthi S, Reusch J, McDuffie M. Role for oxidative stress in the regeneration of islet beta cells? J Investig Med. 2004 Jan; 52(1):45-9. PMID: 14989369.
      View in: PubMed
    45. Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:43-54. PMID: 14679039.
      View in: PubMed
    46. Vaishnav D, Jambal P, Reusch JE, Pugazhenthi S. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun. 2003 Aug 08; 307(4):855-60. PMID: 12878189.
      View in: PubMed
    47. Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S. Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells. J Biol Chem. 2003 Jun 20; 278(25):23055-65. PMID: 12679364.
      View in: PubMed
    48. Pugazhenthi S, Nesterova A, Jambal P, Audesirk G, Kern M, Cabell L, Eves E, Rosner MR, Boxer LM, Reusch JE. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem. 2003 Mar; 84(5):982-96. PMID: 12603823.
      View in: PubMed
    49. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 2000 Apr 14; 275(15):10761-6. PMID: 10753867.
      View in: PubMed
    50. Pugazhenthi S, Miller E, Sable C, Young P, Heidenreich KA, Boxer LM, Reusch JE. Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J Biol Chem. 1999 Sep 24; 274(39):27529-35. PMID: 10488088.
      View in: PubMed
    51. Pugazhenthi S, Boras T, O'Connor D, Meintzer MK, Heidenreich KA, Reusch JE. Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway. J Biol Chem. 1999 Jan 29; 274(5):2829-37. PMID: 9915817.
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    52. Pugazhenthi S, Khandelwal RL. Insulin action on protein phosphatase-1 activation is enhanced by the antidiabetic agent pioglitazone in cultured diabetic hepatocytes. Mol Cell Biochem. 1998 May; 182(1-2):185-91. PMID: 9609128.
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    53. Pugazhenthi S, Tanha F, Dahl B, Khandelwal RL. Inhibition of a Src homology 2 domain containing protein tyrosine phosphatase by vanadate in the primary culture of hepatocytes. Arch Biochem Biophys. 1996 Nov 15; 335(2):273-82. PMID: 8914924.
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    54. Rao PV, Pugazhenthi S, Khandelwal RL. Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver. Biochem Biophys Res Commun. 1995 Dec 05; 217(1):250-6. PMID: 8526919.
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    55. King MJ, Pugazhenthi S, Khandelwal RL, Sharma RK. In vivo modulation of N-myristoyltransferase activity by orthovanadate. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):151-5. PMID: 8927031.
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    56. Pugazhenthi S, Tanha F, Dahl B, Khandelwal RL. Decrease in protein tyrosine phosphatase activities in vanadate-treated obese Zucker (fa/fa) rat liver. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):125-9. PMID: 8927027.
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    57. Khandelwal RL, Pugazhenthi S. In vivo effects of vanadate on hepatic glycogen metabolizing and lipogenic enzymes in insulin-dependent and insulin-resistant diabetic animals. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):87-94. PMID: 8927052.
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    58. Pugazhenthi S, Hussain A, Yu B, Brownsey RW, Angel JF, Khandelwal RL. Vanadate induces normolipidemia and a reduction in the levels of hepatic lipogenic enzymes in obese Zucker rat. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):211-5. PMID: 8927041.
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    59. Rao PV, Pugazhenthi S, Khandelwal RL. The effects of streptozotocin-induced diabetes and insulin supplementation on expression of the glycogen phosphorylase gene in rat liver. J Biol Chem. 1995 Oct 20; 270(42):24955-60. PMID: 7559622.
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    60. Pugazhenthi S, Khandelwal RL. Regulation of glycogen synthase activation in isolated hepatocytes. Mol Cell Biochem. 1995 Aug-Sep; 149-150:95-101. PMID: 8569754.
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    61. Yu B, Pugazhenthi S, Khandelwal RL. Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes. Biochem Pharmacol. 1994 Aug 30; 48(5):949-54. PMID: 8093107.
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    62. Pugazhenthi S, Yu B, Gali RR, Khandelwal RL. Differential effects of calyculin A and okadaic acid on the glucose-induced regulation of glycogen synthase and phosphorylase activities in cultured hepatocytes. Biochim Biophys Acta. 1993 Nov 24; 1179(3):271-6. PMID: 8218371.
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    63. Pugazhenthi S, Khandelwal RL. Does the insulin-mimetic action of vanadate involve insulin receptor kinase? Mol Cell Biochem. 1993 Nov; 127-128:211-8. PMID: 7523848.
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    64. Gali RR, Pugazhenthi S, Khandelwal RL. Reciprocal effects of the protein kinase C inhibitors staurosporine and H-7 on the regulation of glycogen synthase and phosphorylase in the primary culture of hepatocytes. Metabolism. 1993 Nov; 42(11):1475-80. PMID: 8231844.
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    65. King MJ, Pugazhenthi S, Khandelwal RL, Sharma RK. Membrane-associated N-myristoyltransferase activity is reduced in obese (fa/fa) Zucker rat liver. Biochem Biophys Res Commun. 1993 Oct 29; 196(2):665-70. PMID: 8240341.
      View in: PubMed
    66. Pugazhenthi S, Angel JF, Khandelwal RL. Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats. Mol Cell Biochem. 1993 May 12; 122(1):77-84. PMID: 8350867.
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    67. Pugazhenthi S, Angel JF, Khandelwal RL. Effects of vanadate administration on the high sucrose diet-induced aberrations in normal rats. Mol Cell Biochem. 1993 May 12; 122(1):69-75. PMID: 8350866.
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    68. King MJ, Pugazhenthi S, Khandelwal RL, Sharma RK. Elevated N-myristoyl transferase activity is reversed by sodium orthovanadate in streptozotocin-induced diabetic rat. Biochim Biophys Acta. 1993 Jan 10; 1165(3):259-62. PMID: 8418883.
      View in: PubMed
    69. Pugazhenthi S, Khandelwal RL. Vanadate increases protein kinase C-induced phosphorylation of endogenous proteins of liver in vitro. Biochem Int. 1992 Feb; 26(2):241-7. PMID: 1558536.
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    70. Pugazhenthi S, Angel JF, Khandelwal RL. Long-term effects of vanadate treatment on glycogen metabolizing and lipogenic enzymes of liver in genetically diabetic (db/db) mice. Metabolism. 1991 Sep; 40(9):941-6. PMID: 1910143.
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    71. Pugazhenthi S, Khandelwal RL, Angel JF. Insulin-like effect of vanadate on malic enzyme and glucose-6-phosphate dehydrogenase activities in streptozotocin-induced diabetic rat liver. Biochim Biophys Acta. 1991 Jun 03; 1083(3):310-2. PMID: 2049397.
      View in: PubMed
    72. Pugazhenthi S, Khandelwal RL. Kinases and phosphatases of hepatic glycogen metabolism during fasted to refed transition in normal and streptozotocin-induced diabetic rats. Biochem Int. 1991 Feb; 23(3):515-24. PMID: 1652246.
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    73. Pugazhenthi S, Khandelwal RL. Insulinlike effects of vanadate on hepatic glycogen metabolism in nondiabetic and streptozocin-induced diabetic rats. Diabetes. 1990 Jul; 39(7):821-7. PMID: 2113014.
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    74. Roesler WJ, Pugazhenthi S, Khandelwal RL. Hepatic glycogen metabolism in the db/db mouse. Mol Cell Biochem. 1990 Feb 09; 92(2):99-106. PMID: 2407941.
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    75. Pugazhenthi S, Mantha SV, Khandelwal RL. Inhibitory effect of H-7, H-8 and polymyxin B on liver protein kinase C-induced phosphorylation of endogenous substrates. Biochem Int. 1990; 20(5):941-8. PMID: 2161662.
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    76. Pugazhenthi S, Mantha SV, Khandelwal RL. Decrease of liver protein kinase C in streptozotocin-induced diabetic rats and restoration by vanadate treatment. Biochem Int. 1990; 21(4):651-7. PMID: 2241991.
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    77. Babu BV, Moorti R, Pugazhenthi S, Prabhu KM, Murthy PS. Alloxan recovered rabbits as animal model for screening for hypoglycaemic activity of compounds. Indian J Biochem Biophys. 1988 Dec; 25(6):714-8. PMID: 3255686.
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