 Connection
Natalie Ahn to Enzyme Activation
This is a "connection" page, showing publications Natalie Ahn has written about Enzyme Activation.
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Connection Strength |
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1.875 |
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Xiao Y, Lee T, Latham MP, Warner LR, Tanimoto A, Pardi A, Ahn NG. Phosphorylation releases constraints to domain motion in ERK2. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2506-11.
Score: 0.384
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Pegram L, Riccardi D, Ahn N. Activation Loop Plasticity and Active Site Coupling in the MAP Kinase, ERK2. J Mol Biol. 2023 12 01; 435(23):168309.
Score: 0.187
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Iverson DB, Xiao Y, Jones DN, Eisenmesser EZ, Ahn NG. Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2. Biochemistry. 2020 07 28; 59(29):2698-2706.
Score: 0.150
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Sours KM, Ahn NG. Analysis of MAP kinases by hydrogen exchange mass spectrometry. Methods Mol Biol. 2010; 661:239-55.
Score: 0.072
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Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct; 8(10):2308-20.
Score: 0.070
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Sours KM, Kwok SC, Rachidi T, Lee T, Ring A, Hoofnagle AN, Resing KA, Ahn NG. Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinase. J Mol Biol. 2008 Jun 20; 379(5):1075-93.
Score: 0.064
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Emrick MA, Lee T, Starkey PJ, Mumby MC, Resing KA, Ahn NG. The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18101-6.
Score: 0.058
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Roberts EC, Hammond K, Traish AM, Resing KA, Ahn NG. Identification of G2/M targets for the MAP kinase pathway by functional proteomics. Proteomics. 2006 Aug; 6(16):4541-53.
Score: 0.057
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Lee T, Hoofnagle AN, Resing KA, Ahn NG. Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation. J Mol Biol. 2005 Oct 28; 353(3):600-12.
Score: 0.053
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Lee T, Hoofnagle AN, Kabuyama Y, Stroud J, Min X, Goldsmith EJ, Chen L, Resing KA, Ahn NG. Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry. Mol Cell. 2004 Apr 09; 14(1):43-55.
Score: 0.049
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Hoofnagle AN, Stoner JW, Lee T, Eaton SS, Ahn NG. Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by SDSL and EPR. Biophys J. 2004 Jan; 86(1 Pt 1):395-403.
Score: 0.048
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Roberts EC, Shapiro PS, Nahreini TS, Pages G, Pouyssegur J, Ahn NG. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol Cell Biol. 2002 Oct; 22(20):7226-41.
Score: 0.044
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Emrick MA, Hoofnagle AN, Miller AS, Ten Eyck LF, Ahn NG. Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations. J Biol Chem. 2001 Dec 07; 276(49):46469-79.
Score: 0.041
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Ahn NG, Nahreini TS, Tolwinski NS, Resing KA. Pharmacologic inhibitors of MKK1 and MKK2. Methods Enzymol. 2001; 332:417-31.
Score: 0.039
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Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol Cell. 2000 Dec; 6(6):1343-54.
Score: 0.038
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Lopez ED, Burastero O, Arcon JP, Defelipe LA, Ahn NG, Marti MA, Turjanski AG. Kinase Activation by Small Conformational Changes. J Chem Inf Model. 2020 02 24; 60(2):821-832.
Score: 0.036
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Shapiro PS, Whalen AM, Tolwinski NS, Wilsbacher J, Froelich-Ammon SJ, Garcia M, Osheroff N, Ahn NG. Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. Mol Cell Biol. 1999 May; 19(5):3551-60.
Score: 0.034
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Shapiro PS, Vaisberg E, Hunt AJ, Tolwinski NS, Whalen AM, McIntosh JR, Ahn NG. Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J Cell Biol. 1998 Sep 21; 142(6):1533-45.
Score: 0.033
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Shapiro PS, Ahn NG. Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). J Biol Chem. 1998 Jan 16; 273(3):1788-93.
Score: 0.032
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Resing KA, Ahn NG. Deuterium exchange mass spectrometry as a probe of protein kinase activation. Analysis of wild-type and constitutively active mutants of MAP kinase kinase-1. Biochemistry. 1998 Jan 13; 37(2):463-75.
Score: 0.032
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Whalen AM, Galasinski SC, Shapiro PS, Nahreini TS, Ahn NG. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol Cell Biol. 1997 Apr; 17(4):1947-58.
Score: 0.030
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Mansour SJ, Candia JM, Matsuura JE, Manning MC, Ahn NG. Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1. Biochemistry. 1996 Dec 03; 35(48):15529-36.
Score: 0.029
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Resing KA, Mansour SJ, Hermann AS, Johnson RS, Candia JM, Fukasawa K, Vande Woude GF, Ahn NG. Determination of v-Mos-catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS. Biochemistry. 1995 Feb 28; 34(8):2610-20.
Score: 0.026
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Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science. 1994 Aug 12; 265(5174):966-70.
Score: 0.025
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Mansour SJ, Resing KA, Candi JM, Hermann AS, Gloor JW, Herskind KR, Wartmann M, Davis RJ, Ahn NG. Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. J Biochem. 1994 Aug; 116(2):304-14.
Score: 0.025
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Ahn NG, Seger R, Bratlien RL, Krebs EG. Growth factor-stimulated phosphorylation cascades: activation of growth factor-stimulated MAP kinase. Ciba Found Symp. 1992; 164:113-26; discussion 126-31.
Score: 0.021
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Ahn NG, Seger R, Bratlien RL, Diltz CD, Tonks NK, Krebs EG. Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem. 1991 Mar 05; 266(7):4220-7.
Score: 0.020
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Ahn NG, Krebs EG. Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. J Biol Chem. 1990 Jul 15; 265(20):11495-501.
Score: 0.019
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Wang W, Yang Y, Gao Y, Xu Q, Wang F, Zhu S, Old W, Resing K, Ahn N, Lei M, Liu X. Structural and mechanistic insights into Mps1 kinase activation. J Cell Mol Med. 2009 Aug; 13(8B):1679-1694.
Score: 0.018
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Mattison CP, Old WM, Steiner E, Huneycutt BJ, Resing KA, Ahn NG, Winey M. Mps1 activation loop autophosphorylation enhances kinase activity. J Biol Chem. 2007 Oct 19; 282(42):30553-61.
Score: 0.015
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Ahn NG, Klinman JP. Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts. J Biol Chem. 1987 Feb 05; 262(4):1485-92.
Score: 0.015
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Downer J, Sevinsky JR, Ahn NG, Resing KA, Betterton MD. Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase. J Theor Biol. 2006 Jun 07; 240(3):464-74.
Score: 0.014
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Vaish NK, Dong F, Andrews L, Schweppe RE, Ahn NG, Blatt L, Seiwert SD. Monitoring post-translational modification of proteins with allosteric ribozymes. Nat Biotechnol. 2002 Aug; 20(8):810-5.
Score: 0.011
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Holmstr?m TH, Tran SE, Johnson VL, Ahn NG, Chow SC, Eriksson JE. Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis. Mol Cell Biol. 1999 Sep; 19(9):5991-6002.
Score: 0.009
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Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD, Vande Woude GF. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science. 1998 May 01; 280(5364):734-7.
Score: 0.008
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Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 1997 Nov 03; 16(21):6426-38.
Score: 0.008
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Font de Mora J, Porras A, Ahn N, Santos E. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol Cell Biol. 1997 Oct; 17(10):6068-75.
Score: 0.008
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Robinson MJ, Cheng M, Khokhlatchev A, Ebert D, Ahn N, Guan KL, Stein B, Goldsmith E, Cobb MH. Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity. J Biol Chem. 1996 Nov 22; 271(47):29734-9.
Score: 0.007
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Voyno-Yasenetskaya TA, Faure MP, Ahn NG, Bourne HR. Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J Biol Chem. 1996 Aug 30; 271(35):21081-7.
Score: 0.007
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Bokemeyer D, Sorokin A, Yan M, Ahn NG, Templeton DJ, Dunn MJ. Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts. J Biol Chem. 1996 Jan 12; 271(2):639-42.
Score: 0.007
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Thorburn J, Carlson M, Mansour SJ, Chien KR, Ahn NG, Thorburn A. Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Mol Biol Cell. 1995 Nov; 6(11):1479-90.
Score: 0.007
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al-Alawi N, Rose DW, Buckmaster C, Ahn N, Rapp U, Meinkoth J, Feramisco JR. Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade. Mol Cell Biol. 1995 Mar; 15(3):1162-8.
Score: 0.006
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Gause KC, Homma MK, Licciardi KA, Seger R, Ahn NG, Peterson MJ, Krebs EG, Meier KE. Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. J Biol Chem. 1993 Aug 05; 268(22):16124-9.
Score: 0.006
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Posada J, Yew N, Ahn NG, Vande Woude GF, Cooper JA. Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. Mol Cell Biol. 1993 Apr; 13(4):2546-53.
Score: 0.006
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Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG. Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J Biol Chem. 1992 Jul 15; 267(20):14373-81.
Score: 0.005
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Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6142-6.
Score: 0.005
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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