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Connection

Uwe Christians to Rats

This is a "connection" page, showing publications Uwe Christians has written about Rats.

 
Connection Strength
  
 
 
1.057
  
  1. Heischmann S, Dzieciatkowska M, Hansen K, Leibfritz D, Christians U. The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model. Sci Rep. 2017 03 22; 7:45088.
    View in: PubMed
    Score: 0.074
  2. Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res. 2012 Nov 02; 11(11):5135-44.
    View in: PubMed
    Score: 0.054
  3. Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L, Tran ZV, Leibfritz D, Christians U. Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron Exp Nephrol. 2009; 111(4):e80-91.
    View in: PubMed
    Score: 0.042
  4. Kupfer R, Swanson L, Chow S, Staub RE, Zhang YL, Cohen I, Christians U. Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101. Drug Metab Dispos. 2008 Nov; 36(11):2261-9.
    View in: PubMed
    Score: 0.041
  5. Christians U, Schmitz V, Sch?ning W, Bendrick-Peart J, Klawitter J, Haschke M, Klawitter J. Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges. Ther Drug Monit. 2008 Apr; 30(2):151-8.
    View in: PubMed
    Score: 0.040
  6. Klawitter J, Schmitz V, Klawitter J, Leibfritz D, Christians U. Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS. Anal Biochem. 2007 Jun 15; 365(2):230-9.
    View in: PubMed
    Score: 0.037
  7. Ng KY, Zhou H, Zhang YL, Hybertson B, Randolph T, Christians U. Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 01; 847(2):188-98.
    View in: PubMed
    Score: 0.036
  8. Serkova NJ, Christians U. Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Ther Drug Monit. 2005 Dec; 27(6):733-7.
    View in: PubMed
    Score: 0.034
  9. Jakobs M, Trautmann L, Hadamitzky M, Bihorac J, Jacquet L, Christians U, Schniedewind B, L?ckemann L, Schedlowski M. Behavioral Analyses in Dark Agouti Rats Following Repeated Systemic Treatment With Fingolimod (FTY720). Brain Behav. 2024 Nov; 14(11):e70146.
    View in: PubMed
    Score: 0.031
  10. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96.
    View in: PubMed
    Score: 0.031
  11. Jakobs M, H?rbelt-Gr?nheidt T, Hadamitzky M, Bihorac J, Salem Y, Leisengang S, Christians U, Schniedewind B, Schedlowski M, L?ckemann L. The Effects of Fingolimod (FTY720) on Leukocyte Subset Circulation cannot be Behaviourally Conditioned in Rats. J Neuroimmune Pharmacol. 2024 May 11; 19(1):18.
    View in: PubMed
    Score: 0.030
  12. Klawitter J, Weissenborn W, Gvon I, Walz M, Klawitter J, Jackson M, Sempio C, Joksimovic SL, Shokati T, Just I, Christians U, Todorovic SM. ?-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia? Mol Pharmacol. 2024 Jan 10; 105(2):75-83.
    View in: PubMed
    Score: 0.030
  13. Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. Effects of oral ?9-tetrahydrocannabinol and cannabidiol combinations on a sustained attention task in rats. Exp Clin Psychopharmacol. 2023 Oct; 31(5):881-887.
    View in: PubMed
    Score: 0.028
  14. Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. ?9-Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats. Cannabis Cannabinoid Res. 2024 02; 9(1):111-120.
    View in: PubMed
    Score: 0.027
  15. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52.
    View in: PubMed
    Score: 0.026
  16. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol. 2001 Jul; 133(6):875-85.
    View in: PubMed
    Score: 0.025
  17. Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol. 2000 Feb; 129(3):485-92.
    View in: PubMed
    Score: 0.023
  18. Serkova N, Litt L, James TL, Sad?e W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther. 1999 May; 289(2):800-6.
    View in: PubMed
    Score: 0.021
  19. Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB. A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction. Eur J Nutr. 2019 Dec; 58(8):3059-3068.
    View in: PubMed
    Score: 0.021
  20. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther. 1998 Jun; 285(3):1104-12.
    View in: PubMed
    Score: 0.020
  21. Heischmann S, Gano LB, Quinn K, Liang LP, Klepacki J, Christians U, Reisdorph N, Patel M. Regulation of kynurenine metabolism by a ketogenic diet. J Lipid Res. 2018 06; 59(6):958-966.
    View in: PubMed
    Score: 0.020
  22. Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 Sep; 95(9):1009-1018.
    View in: PubMed
    Score: 0.019
  23. Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB. Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data. J Proteome Res. 2017 04 07; 16(4):1515-1525.
    View in: PubMed
    Score: 0.019
  24. Hadamitzky M, B?sche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, L?ckemann L, G?nt?rk?n O, Engler H, Schedlowski M. Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun. 2016 Feb; 52:40-48.
    View in: PubMed
    Score: 0.017
  25. Fernandez-Bustamante A, Klawitter J, Wilson P, Elkins ND, Agazio A, Shibata T, Uchida K, Christians U, Repine JE. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation. 2013 Oct; 36(5):1030-40.
    View in: PubMed
    Score: 0.015
  26. Klawitter J, Zafar I, Klawitter J, Pennington AT, Klepacki J, Gitomer BY, Schrier RW, Christians U, Edelstein CL. Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease. BMC Nephrol. 2013 Jul 31; 14:165.
    View in: PubMed
    Score: 0.014
  27. Niederlechner S, Klawitter J, Baird C, Kallweit AR, Christians U, Wischmeyer PE. Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. PLoS One. 2012; 7(11):e50185.
    View in: PubMed
    Score: 0.014
  28. Bohra R, Sch?ning W, Klawitter J, Brunner N, Schmitz V, Shokati T, Lawrence R, Arbelaez MF, Schniedewind B, Christians U, Klawitter J. Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PLoS One. 2012; 7(10):e48063.
    View in: PubMed
    Score: 0.014
  29. Christians U, Sattler M, Schiebel HM, Kruse C, Radeke HH, Linck A, Sewing KF. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metab Dispos. 1992 Mar-Apr; 20(2):186-91.
    View in: PubMed
    Score: 0.013
  30. Pacheco-L?pez G, Doenlen R, Kr?gel U, Arnold M, Wirth T, Riether C, Engler A, Niemi MB, Christians U, Engler H, Schedlowski M. Neurobehavioural activation during peripheral immunosuppression. Int J Neuropsychopharmacol. 2013 Feb; 16(1):137-49.
    View in: PubMed
    Score: 0.013
  31. Christians U, Braun F, Sattler M, Almeidal VM, Linck A, Sewing KF. Interactions of FK 506 and cyclosporine metabolism. Transplant Proc. 1991 Dec; 23(6):2794-6.
    View in: PubMed
    Score: 0.013
  32. Christians U, Radeke HH, Kownatzki R, Schiebel HM, Schottmann R, Sewing KF. Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations. Clin Biochem. 1991 Jun; 24(3):271-5.
    View in: PubMed
    Score: 0.012
  33. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7.
    View in: PubMed
    Score: 0.012
  34. Klawitter J, Gottschalk S, Hainz C, Leibfritz D, Christians U, Serkova NJ. Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism. Chem Res Toxicol. 2010 Mar 15; 23(3):608-19.
    View in: PubMed
    Score: 0.011
  35. Klawitter J, Klawitter J, Kushner E, Jonscher K, Bendrick-Peart J, Leibfritz D, Christians U, Schmitz V. Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study. J Proteome Res. 2010 Feb 05; 9(2):865-75.
    View in: PubMed
    Score: 0.011
  36. Elkiweri IA, Zhang YL, Christians U, Ng KY, Tissot van Patot MC, Henthorn TK. Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesth Analg. 2009 Jan; 108(1):149-59.
    View in: PubMed
    Score: 0.010
  37. Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V. Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chem Res Toxicol. 2009 Jan; 22(1):118-28.
    View in: PubMed
    Score: 0.010
  38. Laudi S, Steudel W, Jonscher K, Sch?ning W, Schniedewind B, Kaisers U, Christians U, Trump S. Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension. Proteomics. 2007 Jul; 7(14):2469-78.
    View in: PubMed
    Score: 0.009
  39. Laudi S, Trump S, Schmitz V, West J, McMurtry IF, Mutlak H, Christians U, Weimann J, Kaisers U, Steudel W. Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L630-8.
    View in: PubMed
    Score: 0.009
  40. Laudi S, Weimann J, Haschke M, Trump S, Schmitz V, Christians U, Kaisers U, Steudel W. Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine. J Physiol Pharmacol. 2007 Mar; 58(1):19-32.
    View in: PubMed
    Score: 0.009
  41. Schmelzer E, Acikgoez A, Fr?hauf NR, Crome O, Klempnauer J, Christians U, Bader A. Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures. Xenobiotica. 2006 Aug; 36(8):693-708.
    View in: PubMed
    Score: 0.009
  42. Schmitz V, Klawitter J, Bendrick-Peart J, Haschke M, Beckey VE, Laudi S, Neumann U, Schoening W, Neuhaus P, Christians U, Puhl G. Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation. Eur Surg Res. 2006; 38(4):388-98.
    View in: PubMed
    Score: 0.009
  43. Zhou H, Zhang Y, Biggs DL, Manning MC, Randolph TW, Christians U, Hybertson BM, Ng KY. Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. J Control Release. 2005 Oct 03; 107(2):288-99.
    View in: PubMed
    Score: 0.008
  44. Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova N. Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec; 27(6):396-403.
    View in: PubMed
    Score: 0.007
  45. Niemann CU, Stabernack C, Serkova N, Jacobsen W, Christians U, Eger EI. Cyclosporine can increase isoflurane MAC. Anesth Analg. 2002 Oct; 95(4):930-4, table of contents.
    View in: PubMed
    Score: 0.007
  46. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J Pharmacol Exp Ther. 2002 Sep; 302(3):1123-8.
    View in: PubMed
    Score: 0.007
  47. Cho CW, Liu Y, Cobb WN, Henthorn TK, Lillehei K, Christians U, Ng KY. Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells. Pharm Res. 2002 Aug; 19(8):1123-9.
    View in: PubMed
    Score: 0.007
  48. van Gelder T, Klupp J, Barten MJ, Christians U, Morris RE. Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid. Ther Drug Monit. 2001 Apr; 23(2):119-28.
    View in: PubMed
    Score: 0.006
  49. Hausen B, Boeke K, Berry GJ, Christians U, Sch?ler W, Morris RE. Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD. Ann Thorac Surg. 2000 Mar; 69(3):904-9.
    View in: PubMed
    Score: 0.006
  50. Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment. Transplantation. 1999 Apr 15; 67(7):956-62.
    View in: PubMed
    Score: 0.005
  51. Hausen B, Boeke K, Berry GJ, Gummert JF, Christians U, Morris RE. Potentiation of immunosuppressive efficacy by combining the novel leflunomide analog, HMR 279, with microemulsion cyclosporine in a rat lung transplant model. Transplantation. 1999 Feb 15; 67(3):354-9.
    View in: PubMed
    Score: 0.005
  52. Hausen B, Boeke K, Berry GJ, Segarra IT, Christians U, Morris RE. Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cyclosporine. J Heart Lung Transplant. 1999 Feb; 18(2):150-9.
    View in: PubMed
    Score: 0.005
  53. Gummert JF, Christians U, Barten M, Silva H, Morris RE. High-performance liquid chromatographic assay with a simple extraction procedure for sensitive quantification of mycophenolic acid in rat and human plasma. J Chromatogr B Biomed Sci Appl. 1999 Jan 22; 721(2):321-6.
    View in: PubMed
    Score: 0.005
  54. Serkova N, Christians U, Fl?gel U, Pfeuffer J, Leibfritz D. Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy. Chem Res Toxicol. 1997 Dec; 10(12):1359-63.
    View in: PubMed
    Score: 0.005
  55. Serkova N, Brand A, Christians U, Leibfritz D. Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy. Biochim Biophys Acta. 1996 Nov 08; 1314(1-2):93-104.
    View in: PubMed
    Score: 0.005
  56. Bader A, Knop E, B?ker KH, Crome O, Fr?hauf N, Gonschior AK, Christians U, Esselmann H, Pichlmayr R, Sewing KF. Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. Naunyn Schmiedebergs Arch Pharmacol. 1996 Mar; 353(4):461-73.
    View in: PubMed
    Score: 0.004
  57. Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF. Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos. 1995 Dec; 23(12):1315-24.
    View in: PubMed
    Score: 0.004
  58. Bader A, Knop E, Fr?hauf N, Crome O, B?ker K, Christians U, Oldhafer K, Ringe B, Pichlmayr R, Sewing KF. Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver. Artif Organs. 1995 Sep; 19(9):941-50.
    View in: PubMed
    Score: 0.004
  59. Bader A, Reimer P, Knop E, B?ker K, Christians U, Weissleder R, Sewing KF. An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magn Reson Imaging. 1995; 13(7):991-1002.
    View in: PubMed
    Score: 0.004
  60. Bader A, Zech K, Crome O, Christians U, Ringe B, Pichlmayr R, Sewing KF. Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica. 1994 Jul; 24(7):623-33.
    View in: PubMed
    Score: 0.004
  61. Sattler M, Guengerich FP, Yun CH, Christians U, Sewing KF. Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos. 1992 Sep-Oct; 20(5):753-61.
    View in: PubMed
    Score: 0.003
  62. Sewing KF, Christians U, Kohlhaw K, Radeke H, Strohmeyer S, Kownatzki R, Budniak J, Schottmann R, Bleck JS, Almeida VM, et al. Biologic activity of cyclosporine metabolites. Transplant Proc. 1990 Jun; 22(3):1129-34.
    View in: PubMed
    Score: 0.003
Connection Strength

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