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Connection

Uwe Christians to Humans

This is a "connection" page, showing publications Uwe Christians has written about Humans.

 
Connection Strength
  
 
 
1.025
  
  1. Mayne G, De Bloois E, Dabelea D, Christians U. Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy. Anal Bioanal Chem. 2021 Sep; 413(21):5427-5438.
    View in: PubMed
    Score: 0.019
  2. Jelliffe R, Christians U. The New Direct-Acting Oral Anticoagulants Need to be Monitored! Ther Drug Monit. 2020 06; 42(3):357-359.
    View in: PubMed
    Score: 0.018
  3. Schniedewind B, Meyer EJ, Christians U. Long-Term Performance of Laboratory-Developed Liquid Chromatography-Tandem Mass Spectrometry Tests and a Food and Drug Administration-Approved Immunoassay for the Therapeutic Drug Monitoring of Everolimus. Ther Drug Monit. 2020 06; 42(3):421-426.
    View in: PubMed
    Score: 0.018
  4. Shokati T, Hartmann M, Davari B, Klawitter J, Klawitter J, Christians U. Temsirolimus metabolic pathways revisited. Xenobiotica. 2020 Jun; 50(6):640-653.
    View in: PubMed
    Score: 0.017
  5. Shipkova M, Christians U. Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring. Ther Drug Monit. 2019 04; 41(2):111-114.
    View in: PubMed
    Score: 0.016
  6. Alloway RR, Vinks AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J, Klawitter J, Christians U. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS Med. 2017 Nov; 14(11):e1002428.
    View in: PubMed
    Score: 0.015
  7. Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U. A High-throughput HPLC-MS/MS Assay for the Detection, Quantification and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine. Ther Drug Monit. 2017 10; 39(5):565-574.
    View in: PubMed
    Score: 0.015
  8. Heischmann S, Christians U. Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid. Xenobiotica. 2018 May; 48(5):433-441.
    View in: PubMed
    Score: 0.014
  9. Heischmann S, Dzieciatkowska M, Hansen K, Leibfritz D, Christians U. The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model. Sci Rep. 2017 03 22; 7:45088.
    View in: PubMed
    Score: 0.014
  10. Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U. Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent? Clin Biochem. 2016 Sep; 49(13-14):955-61.
    View in: PubMed
    Score: 0.013
  11. Christians U, Klawitter J, Klawitter J. Biomarkers in Transplantation--Proteomics and Metabolomics. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S70-4.
    View in: PubMed
    Score: 0.013
  12. Christians U, Vinks AA, Langman LJ, Clarke W, Wallemacq P, van Gelder T, Renjen V, Marquet P, Meyer EJ. Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs. Ther Drug Monit. 2015 Dec; 37(6):718-24.
    View in: PubMed
    Score: 0.013
  13. Shokati T, Bodenberger N, Gadpaille H, Schniedewind B, Vinks AA, Jiang W, Alloway RR, Christians U. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. J Vis Exp. 2015 Nov 08; (105):e52424.
    View in: PubMed
    Score: 0.013
  14. Klawitter J, Nashan B, Christians U. Everolimus and sirolimus in transplantation-related but different. Expert Opin Drug Saf. 2015 Jul; 14(7):1055-70.
    View in: PubMed
    Score: 0.012
  15. Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15; 446:43-53.
    View in: PubMed
    Score: 0.012
  16. Pian P, Labovitz E, Hoffman K, Clavijo CF, Rzasa Lynn R, Galinkin JL, Vinks AA, Malik P, Christians U. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 15; 937:79-83.
    View in: PubMed
    Score: 0.011
  17. Taylor RR, Hoffman KL, Schniedewind B, Clavijo C, Galinkin JL, Christians U. Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2013 Sep; 83:1-9.
    View in: PubMed
    Score: 0.011
  18. Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis? Transpl Int. 2013 Mar; 26(3):225-41.
    View in: PubMed
    Score: 0.010
  19. Leitman DC, Christians U. MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms. Expert Opin Investig Drugs. 2012 Jul; 21(7):1031-42.
    View in: PubMed
    Score: 0.010
  20. Christians U, Klawitter J, Hornberger A, Klawitter J. How unbiased is non-targeted metabolomics and is targeted pathway screening the solution? Curr Pharm Biotechnol. 2011 Jul; 12(7):1053-66.
    View in: PubMed
    Score: 0.010
  21. Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel HM, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom. 2011 Jul; 46(7):615-24.
    View in: PubMed
    Score: 0.010
  22. Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U. Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer. 2011 Dec 15; 129(12):2945-57.
    View in: PubMed
    Score: 0.009
  23. Klawitter J, Haschke M, Shokati T, Klawitter J, Christians U. Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared. Rapid Commun Mass Spectrom. 2011 Feb 28; 25(4):463-8.
    View in: PubMed
    Score: 0.009
  24. Christians U, Klawitter J, Klawitter J, Brunner N, Schmitz V. Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions. Expert Opin Drug Metab Toxicol. 2011 Feb; 7(2):175-200.
    View in: PubMed
    Score: 0.009
  25. Klawitter J, Haschke M, Kahle C, Dingmann C, Klawitter J, Leibfritz D, Christians U. Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. Br J Clin Pharmacol. 2010 Aug; 70(2):241-51.
    View in: PubMed
    Score: 0.009
  26. Steudel W, Dingmann C, Zhang YL, Bendrick-Peart J, Clavijo C, Shulze J, Betts R, Christians U. Randomized, double-blind, placebo-controlled, single intravenous dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of the novel coronary smooth muscle cell proliferation inhibitor Biolimus A9 in healthy individuals. J Clin Pharmacol. 2011 Jan; 51(1):29-39.
    View in: PubMed
    Score: 0.009
  27. Christians U, Klawitter J, Clavijo CF. Bioequivalence testing of immunosuppressants: concepts and misconceptions. Kidney Int Suppl. 2010 Mar; (115):S1-7.
    View in: PubMed
    Score: 0.009
  28. Klawitter J, Zhang YL, Klawitter J, Anderson N, Serkova NJ, Christians U. Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture. Biomed Chromatogr. 2009 Dec; 23(12):1251-8.
    View in: PubMed
    Score: 0.009
  29. Clavijo C, Bendrick-Peart J, Zhang YL, Johnson G, Gasparic A, Christians U. An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 15; 874(1-2):33-41.
    View in: PubMed
    Score: 0.008
  30. Kupfer R, Swanson L, Chow S, Staub RE, Zhang YL, Cohen I, Christians U. Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101. Drug Metab Dispos. 2008 Nov; 36(11):2261-9.
    View in: PubMed
    Score: 0.008
  31. Filler G, Bendrick-Peart J, Strom T, Zhang YL, Johnson G, Christians U. Characterization of sirolimus metabolites in pediatric solid organ transplant recipients. Pediatr Transplant. 2009 Feb; 13(1):44-53.
    View in: PubMed
    Score: 0.008
  32. Filler G, Bendrick-Peart J, Christians U. Pharmacokinetics of mycophenolate mofetil and sirolimus in children. Ther Drug Monit. 2008 Apr; 30(2):138-42.
    View in: PubMed
    Score: 0.008
  33. Christians U, Schmitz V, Sch?ning W, Bendrick-Peart J, Klawitter J, Haschke M, Klawitter J. Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges. Ther Drug Monit. 2008 Apr; 30(2):151-8.
    View in: PubMed
    Score: 0.008
  34. Strom T, Haschke M, Boyd J, Roberts M, Arabshahi L, Marbach P, Christians U. Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus. Ther Drug Monit. 2007 Dec; 29(6):743-9.
    View in: PubMed
    Score: 0.007
  35. Strom T, Haschke M, Zhang YL, Bendrick-Peart J, Boyd J, Roberts M, Arabshahi L, Marbach P, Christians U. Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients. Ther Drug Monit. 2007 Oct; 29(5):592-9.
    View in: PubMed
    Score: 0.007
  36. Haschke M, Zhang YL, Kahle C, Klawitter J, Korecka M, Shaw LM, Christians U. HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma. Clin Chem. 2007 Mar; 53(3):489-97.
    View in: PubMed
    Score: 0.007
  37. Filler G, de Barros VR, Jagger JE, Christians U. Cyclosporin twice or three times daily dosing in pediatric transplant patients - it is not the same! Pediatr Transplant. 2006 Dec; 10(8):953-6.
    View in: PubMed
    Score: 0.007
  38. Filler G, Gow RM, Nadarajah R, Jacob P, Johnson G, Zhang YL, Christians U. Pharmacokinetics of pyridostigmine in a child with postural tachycardia syndrome. Pediatrics. 2006 Nov; 118(5):e1563-8.
    View in: PubMed
    Score: 0.007
  39. Filler G, Lathia A, LeBlanc C, Christians U. Unexpectedly high exposure to enteric-coated mycophenolate sodium upon once-daily dosing. Pediatr Nephrol. 2006 Aug; 21(8):1206-8.
    View in: PubMed
    Score: 0.007
  40. Christians U, Strom T, Zhang YL, Steudel W, Schmitz V, Trump S, Haschke M. Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics. Ther Drug Monit. 2006 Feb; 28(1):39-44.
    View in: PubMed
    Score: 0.007
  41. Zhang YL, Bendrick-Peart J, Strom T, Haschke M, Christians U. Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples. Ther Drug Monit. 2005 Dec; 27(6):770-8.
    View in: PubMed
    Score: 0.006
  42. Christians U, Schmitz V, Haschke M. Functional interactions between P-glycoprotein and CYP3A in drug metabolism. Expert Opin Drug Metab Toxicol. 2005 Dec; 1(4):641-54.
    View in: PubMed
    Score: 0.006
  43. Filler G, Womiloju T, Feber J, Lepage N, Christians U. Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure. Am J Transplant. 2005 Aug; 5(8):2005-10.
    View in: PubMed
    Score: 0.006
  44. Trotter JF, Osborne JC, Heller M, Christians U. Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients. Aliment Pharmacol Ther. 2005 Jul 01; 22(1):37-44.
    View in: PubMed
    Score: 0.006
  45. McRae MP, Shokati T, Christians U, Helmke SM, Everson GT. Assessment of the performance of a dual-sample oral cholate challenge test: The HepQuant DuO test. Clin Chim Acta. 2025 Jun 15; 574:120325.
    View in: PubMed
    Score: 0.006
  46. Mayne G, DeWitt PE, Wen J, Schniedewind B, Dabelea D, Christians U, Hurt KJ. Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study. J Clin Endocrinol Metab. 2025 Jan 21; 110(2):523-533.
    View in: PubMed
    Score: 0.006
  47. Moore BF, Mueller NT, Perng W, Sauder KA, H?bert ET, Hoyt AT, Wymore EM, Boyle KE, Su EJ, Shapiro ALB, Kinney G, Sempio C, Klawitter J, Christians U, Dabelea D. Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories. Pediatr Obes. 2025 Jan; 20(1):e13187.
    View in: PubMed
    Score: 0.006
  48. Sempio C, Campos-Palomino J, Klawitter J, Zhao W, Huestis MA, Christians U, Klawitter J. Quantification of 11 kratom alkaloids including mitragynine and its main metabolites in human plasma using LC-MS/MS. Anal Bioanal Chem. 2025 Feb; 417(4):761-769.
    View in: PubMed
    Score: 0.006
  49. Helmke SM, McRae MP, Christians U, Shokati T, Everson GT. A Validated LC-MS/MS Assay for the Quantification of Cholate Isotopes in Human Serum. J Appl Lab Med. 2024 Nov 04; 9(6):1028-1039.
    View in: PubMed
    Score: 0.006
  50. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit. 2004 Oct; 26(5):546-62.
    View in: PubMed
    Score: 0.006
  51. Sempio C, Campos-Palomino J, Klawitter J, Harrison A, Peters EN, MacNair L, Haghdoost M, Bonn-Miller M, Babalonis S, Huestis MA, Christians U, Klawitter J. LC-MS-MS quantification of ?8-THC, ?9-THC, THCV isomers and their main metabolites in human plasma. J Anal Toxicol. 2024 Aug 21; 48(7):499-506.
    View in: PubMed
    Score: 0.006
  52. Odell EP, Jabassini N, Schniedewind B, Pease-Raissi SE, Frymoyer A, Christians U, Green AJ, Chan JR, Ostrem BEL. Minimum effective dose of clemastine in a mouse model of preterm white matter injury. Pediatr Res. 2024 Sep; 96(4):933-941.
    View in: PubMed
    Score: 0.006
  53. Van Hove JLK, Friederich MW, Hock DH, Stroud DA, Caruana NJ, Christians U, Schniedewind B, Michel CR, Reisdorph R, Lopez Gonzalez EDJ, Brenner C, Donovan TE, Lee JC, Chatfield KC, Larson AA, Baker PR, McCandless SE, Moore Burk MF. ACAD9 treatment with bezafibrate and nicotinamide riboside temporarily stabilizes cardiomyopathy and lactic acidosis. Mitochondrion. 2024 Sep; 78:101905.
    View in: PubMed
    Score: 0.006
  54. Spindle TR, Zamarripa CA, Russo E, Pollak L, Bigelow G, Ward AM, Tompson B, Sempio C, Shokati T, Klawitter J, Christians U, Vandrey R. Vaporized D-limonene selectively mitigates the acute anxiogenic effects of ?9-tetrahydrocannabinol in healthy adults who intermittently use cannabis. Drug Alcohol Depend. 2024 Apr 01; 257:111267.
    View in: PubMed
    Score: 0.006
  55. Serkova N, Christians U. Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides. Curr Opin Investig Drugs. 2003 Nov; 4(11):1287-96.
    View in: PubMed
    Score: 0.006
  56. Martin EL, Baker NL, Sempio C, Christians U, Klawitter J, McRae-Clark AL. Sex differences in endocannabinoid tone in a pilot study of cannabis use disorder and acute cannabis abstinence. Addict Biol. 2023 10; 28(10):e13337.
    View in: PubMed
    Score: 0.006
  57. Moore BF, Salmons KA, Hoyt AT, Swenson KS, Bates EA, Sauder KA, Shapiro ALB, Wilkening G, Kinney GL, Neophytou AM, Sempio C, Klawitter J, Christians U, Dabelea D. Associations between Prenatal and Postnatal Exposure to Cannabis with Cognition and Behavior at Age 5 Years: The Healthy Start Study. Int J Environ Res Public Health. 2023 03 10; 20(6).
    View in: PubMed
    Score: 0.005
  58. Crouch CE, Wilkey BJ, Hendrickse A, Kaizer AM, Schniedewind B, Christians U, Henthorn TK, Fernandez-Bustamante A. Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology. 2023 01 01; 138(1):71-81.
    View in: PubMed
    Score: 0.005
  59. Hoffman MC, Hunter SJ, D'Alessandro A, Christians U, Law AJ, Freedman R. Maternal Plasma Choline during Gestation and Small for Gestational Age Infants. Am J Perinatol. 2024 05; 41(S 01):e939-e948.
    View in: PubMed
    Score: 0.005
  60. Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol. 2023 01; 36(1):83-91.
    View in: PubMed
    Score: 0.005
  61. Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids by LC-MS-MS in Human Plasma. J Anal Toxicol. 2022 Apr 21; 46(4):383-392.
    View in: PubMed
    Score: 0.005
  62. Sempio C, Huestis MA, Kaplan B, Klawitter J, Christians U, Henthorn TK. Urinary clearance of 11-nor-9-carboxy-?9 -tetrahydrocannabinol: A detailed pharmacokinetic analysis. Drug Test Anal. 2022 Aug; 14(8):1368-1376.
    View in: PubMed
    Score: 0.005
  63. Klawitter J, Sempio C, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Christians U, Klawitter J. Endocannabinoid System in Polycystic Kidney Disease. Am J Nephrol. 2022; 53(4):264-272.
    View in: PubMed
    Score: 0.005
  64. Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet. 2002; 41(11):813-51.
    View in: PubMed
    Score: 0.005
  65. van Hoogdalem MW, Johnson TN, McPhail BT, Kamatkar S, Wexelblatt SL, Ward LP, Christians U, Akinbi HT, Vinks AA, Mizuno T. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clin Pharmacol Ther. 2022 02; 111(2):496-508.
    View in: PubMed
    Score: 0.005
  66. Peters EN, MacNair L, Mosesova I, Christians U, Sempio C, Klawitter J, Land MH, Ware MA, Turcotte C, Bonn-Miller MO. Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and ?9-tetrahydrocannabinol: a pilot study. Eur J Clin Pharmacol. 2022 Feb; 78(2):259-265.
    View in: PubMed
    Score: 0.005
  67. Hunter SK, Freedman R, Law AJ, Christians U, Holzman JBW, Johnson Z, Hoffman MC. Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability. Neuroreport. 2021 10 06; 32(14):1170-1174.
    View in: PubMed
    Score: 0.005
  68. Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2021 Aug 14; 45(7):686-692.
    View in: PubMed
    Score: 0.005
  69. Sempio C, Bidwell LC, Hutchison K, Huestis MA, Klawitter J, Christians U, Henthorn TK. Using Population Pharmacokinetic Modeling to Estimate Exposure to ?9-Tetrahydrocannabinol in an Observational Study of Cannabis Smokers in Colorado. Ther Drug Monit. 2021 08 01; 43(4):536-545.
    View in: PubMed
    Score: 0.005
  70. Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2021 07 08; 47(4):896-905.
    View in: PubMed
    Score: 0.005
  71. Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Targeting Treatments to Health Disparities. Schizophr Bull. 2021 07 08; 47(4):886-887.
    View in: PubMed
    Score: 0.005
  72. Sempio C, Klawitter J, Jackson M, Freni F, Shillingburg R, Hutchison K, Bidwell LC, Christians U, Klawitter J. Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. Anal Bioanal Chem. 2021 May; 413(12):3381-3392.
    View in: PubMed
    Score: 0.005
  73. Baliga MM, Klawitter J, Christians U, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Klawitter J. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease. Sci Rep. 2021 03 23; 11(1):6629.
    View in: PubMed
    Score: 0.005
  74. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc. 2001 Feb-Mar; 33(1-2):514-5.
    View in: PubMed
    Score: 0.005
  75. Mizuno T, McPhail BT, Kamatkar S, Wexelblatt S, Ward L, Christians U, Akinbi HT, Vinks AA. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clin Pharmacokinet. 2021 02; 60(2):249-259.
    View in: PubMed
    Score: 0.005
  76. Clavijo CF, Oliva AM, Dingmann C, Kaizer A, Christians U, Burger E, Patel V, Kleck CJ, Vogel SA, Scott BK, Janik DJ, Jameson LC, Ginde AA. Toxicology Screening Testing in Patients Undergoing Spine Surgery: A Prospective Observational Pilot Study. Ther Drug Monit. 2021 02 01; 43(1):136-138.
    View in: PubMed
    Score: 0.005
  77. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clin Pharmacol Ther. 2001 Jan; 69(1):24-31.
    View in: PubMed
    Score: 0.005
  78. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos. 2000 Nov; 28(11):1369-78.
    View in: PubMed
    Score: 0.005
  79. Ye H, Minhajuddin M, Krug A, Pei S, Chou CH, Culp-Hill R, Ponder J, De Bloois E, Schniedewind B, Amaya ML, Inguva A, Stevens BM, Pollyea DA, Christians U, Grimes HL, D'Alessandro A, Jordan CT. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discov. 2021 02; 11(2):500-519.
    View in: PubMed
    Score: 0.005
  80. Frymoyer A, Van Meurs KP, Drover DR, Klawitter J, Christians U, Chock VY. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2020 12; 88(6):871-877.
    View in: PubMed
    Score: 0.004
  81. Freedman R, Hunter SK, Noonan K, Wyrwa A, Christians U, Law AJ, Hoffman MC. Maternal Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With C-reactive Protein and Cortisol. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 03; 6(3):310-320.
    View in: PubMed
    Score: 0.004
  82. Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 08; 59(8):1005-1012.
    View in: PubMed
    Score: 0.004
  83. Hinckley JD, Saba L, Raymond K, Bartels K, Klawitter J, Christians U, Hopfer C. An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses. Cannabis Cannabinoid Res. 2022 02; 7(1):65-77.
    View in: PubMed
    Score: 0.004
  84. Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited. Ther Drug Monit. 2000 Jun; 22(3):330-45.
    View in: PubMed
    Score: 0.004
  85. Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar; 129(6):1235-43.
    View in: PubMed
    Score: 0.004
  86. Davari B, Kotecha N, Clavijo CF, Thomas JJ, Rzasa-Lynn R, Galinkin JL, Christians U, Sempio C. A Sensitive LC-MS/MS Assay for the Quantification of Methadone and its Metabolites in Dried Blood Spots: Comparison With Plasma. Ther Drug Monit. 2020 02; 42(1):118-128.
    View in: PubMed
    Score: 0.004
  87. Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 03; 86(3):611-619.
    View in: PubMed
    Score: 0.004
  88. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. J Pharmacol Exp Ther. 1999 Oct; 291(1):131-9.
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    Score: 0.004
  89. Weinberg A, Huo Y, Kacanek D, Patel K, Watts DH, Wara D, Hoffman RM, Klawitter J, Christians U. Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D. J Acquir Immune Defic Syndr. 2019 10 01; 82(2):181-187.
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    Score: 0.004
  90. Canafax DM, Irish WD, Moran HB, Squiers E, Levy R, Pouletty P, First MR, Christians U. An individual bioequivalence approach to compare the intrasubject variability of two ciclosporin formulations, SangCya and Neoral. Pharmacology. 1999 Aug; 59(2):78-88.
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    Score: 0.004
  91. Brunet M, van Gelder T, ?sberg A, Haufroid V, Hesselink DA, Langman L, Lemaitre F, Marquet P, Seger C, Shipkova M, Vinks A, Wallemacq P, Wieland E, Woillard JB, Barten MJ, Budde K, Colom H, Dieterlen MT, Elens L, Johnson-Davis KL, Kunicki PK, MacPhee I, Masuda S, Mathew BS, Mill?n O, Mizuno T, Moes DAR, Monchaud C, Noceti O, Pawinski T, Picard N, van Schaik R, Sommerer C, Vethe NT, de Winter B, Christians U, Bergan S. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Ther Drug Monit. 2019 06; 41(3):261-307.
    View in: PubMed
    Score: 0.004
  92. Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 02; 58(2):124-128.
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    Score: 0.004
  93. Serkova N, Litt L, James TL, Sad?e W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther. 1999 May; 289(2):800-6.
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    Score: 0.004
  94. Christians U. Generic immunosuppressants: the European perspective. Transplant Proc. 1999 May; 31(3A Suppl):19S-22S.
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    Score: 0.004
  95. Golomb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawitter J, Klawitter J, Smith D, Repine JE. Depressed prostaglandins and leukotrienes in veterans with Gulf War illness. J Environ Sci Health B. 2019; 54(8):623-639.
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    Score: 0.004
  96. Lichvar A, Tremblay S, Naik D, Lipscomb J, King E, Vinks AA, Christians U, Alloway RR. Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients. Pharmacotherapy. 2019 05; 39(5):564-575.
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    Score: 0.004
  97. Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ?-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 05; 42(3):424-437.
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    Score: 0.004
  98. Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 06 01; 126(6):1533-1540.
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    Score: 0.004
  99. Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019 05; 208:198-206.e2.
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    Score: 0.004
  100. Emoto C, Johnson TN, Hahn D, Christians U, Alloway RR, Vinks AA, Fukuda T. A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition. CPT Pharmacometrics Syst Pharmacol. 2019 05; 8(5):273-284.
    View in: PubMed
    Score: 0.004
  101. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb; 27(2):173-9.
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    Score: 0.004
  102. Leino AD, King EC, Jiang W, Vinks AA, Klawitter J, Christians U, Woodle ES, Alloway RR, Rohan JM. Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. Am J Transplant. 2019 05; 19(5):1410-1420.
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    Score: 0.004
  103. Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J Am Heart Assoc. 2018 12 18; 7(24):e010711.
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    Score: 0.004
  104. Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. J Chromatogr B Biomed Sci Appl. 1998 Dec 11; 720(1-2):179-87.
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    Score: 0.004
  105. Christians U, Jacobsen W, Floren LC. Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar? Pharmacol Ther. 1998 Oct; 80(1):1-34.
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    Score: 0.004
  106. Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 07 13; 7(14).
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    Score: 0.004
  107. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther. 1998 Jun; 285(3):1104-12.
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    Score: 0.004
  108. Goot BH, Kaufman J, Pan Z, Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, Zuk J, da Cruz EM. Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery. Pediatr Crit Care Med. 2018 05; 19(5):459-467.
    View in: PubMed
    Score: 0.004
  109. Bittersohl H, Schniedewind B, Christians U, Luppa PB. A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples. J Chromatogr A. 2018 Apr 27; 1547:45-52.
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    Score: 0.004
  110. McLay JS, Engelhardt T, Mohammed BS, Cameron G, Cohen MN, Galinkin JL, Christians U, Avram MJ, Henthorn TK, Dsida RM, Hawwa AF, Anderson BJ. The pharmacokinetics of intravenous ketorolac in children aged 2?months to 16?years: A population analysis. Paediatr Anaesth. 2018 02; 28(2):80-86.
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    Score: 0.004
  111. Lesche D, Sigurdardottir V, Leichtle AB, Nakas CT, Christians U, Englberger L, Fiedler M, Largiad?r CR, Mohacsi P, Sistonen J. Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement. Metabolomics. 2017 11 25; 14(1):3.
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    Score: 0.004
  112. Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2018 05; 103(5):888-898.
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    Score: 0.004
  113. Sperschneider H, Wagner C, Korn A, Christians U. [Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients]. Med Klin (Munich). 1997 Oct 15; 92(10):589-96.
    View in: PubMed
    Score: 0.004
  114. Klawitter J, Sempio C, M?rlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 10; 39(5):556-564.
    View in: PubMed
    Score: 0.004
  115. Olbricht C, Wanner C, Eisenhauer T, Kliem V, Doll R, Boddaert M, O'Grady P, Krekler M, Mangold B, Christians U. Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses. Clin Pharmacol Ther. 1997 Sep; 62(3):311-21.
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    Score: 0.004
  116. Klawitter J, Hildreth KL, Christians U, Kohrt WM, Moreau KL. A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition. Physiol Rep. 2017 Sep; 5(17).
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    Score: 0.004
  117. Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R. Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation. Neuropsychopharmacology. 2018 02; 43(3):583-589.
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    Score: 0.004
  118. Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 Sep; 95(9):1009-1018.
    View in: PubMed
    Score: 0.004
  119. Diwan TS, Lichvar AB, Leino AD, Vinks AA, Christians U, Shields AR, Cardi MA, Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR. Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy. Clin Transplant. 2017 06; 31(6).
    View in: PubMed
    Score: 0.004
  120. Christians U. Combination of pravastatin and cyclosporin in transplant patients. Clin Pharmacokinet. 1997 Feb; 32(2):173-4.
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    Score: 0.004
  121. Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M, Vinks AA. Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. Br J Clin Pharmacol. 2017 05; 83(5):1097-1107.
    View in: PubMed
    Score: 0.003
  122. Kliem V, Wanner C, Eisenhauer T, Olbricht CJ, Doll R, Boddaert M, O'Grady P, Krekler M, Mangold B, Christians U. Comparison of pravastatin and lovastatin in renal transplant patients receiving cyclosporine. Transplant Proc. 1996 Dec; 28(6):3126-8.
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    Score: 0.003
  123. Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN. Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med. 2016 12; 121:59-66.
    View in: PubMed
    Score: 0.003
  124. Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians U, Adams DM, Vinks AA. Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. CPT Pharmacometrics Syst Pharmacol. 2016 08; 5(8):411-7.
    View in: PubMed
    Score: 0.003
  125. Christians U, Bleck JS, Lampen A, Bader A, Thiesemann C, Kliem V, Repp H, Westhoff-Bleck M, Manns M, Sewing KF. Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem? Transplant Proc. 1996 Aug; 28(4):2159-61.
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    Score: 0.003
  126. O'Connor S, Zhang YL, Christians U, Morrison JE, Friesen RH. Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia. Paediatr Anaesth. 2016 Jul; 26(7):703-9.
    View in: PubMed
    Score: 0.003
  127. Shipkova M, L?pez OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E. Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S80-92.
    View in: PubMed
    Score: 0.003
  128. Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, L?pez-Hoyos M, Barten MJ, Bergan S, Picard N, Mill?n L?pez O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M. Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S1-20.
    View in: PubMed
    Score: 0.003
  129. Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki PK, Pawinski T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P. Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee. Ther Drug Monit. 2016 Apr; 38(2):170-89.
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    Score: 0.003
  130. Christians U, Schmidt G, Bader A, Lampen A, Schottmann R, Linck A, Sewing KF. Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar; 41(3):187-90.
    View in: PubMed
    Score: 0.003
  131. Christians U, Sewing KF. Alternative cyclosporine metabolic pathways and toxicity. Clin Biochem. 1995 Dec; 28(6):547-59.
    View in: PubMed
    Score: 0.003
  132. Christians U, Kohlhaw K, S?rig T, Bader A, Schottmann R, Linck A, Ringe B, Sewing KF. Parallel blood concentrations of second-generation cyclosporine metabolites and bilirubin in liver graft recipients. Ther Drug Monit. 1995 Oct; 17(5):487-98.
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    Score: 0.003
  133. Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 04; 10(9):1534-41.
    View in: PubMed
    Score: 0.003
  134. Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Ther Drug Monit. 2015 Jun; 37(3):395-9.
    View in: PubMed
    Score: 0.003
  135. Schniedewind B, Niederlechner S, Galinkin JL, Johnson-Davis KL, Christians U, Meyer EJ. Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study. Ther Drug Monit. 2015 Jun; 37(3):296-303.
    View in: PubMed
    Score: 0.003
  136. Winkler M, Christians U. A risk-benefit assessment of tacrolimus in transplantation. Drug Saf. 1995 May; 12(5):348-57.
    View in: PubMed
    Score: 0.003
  137. B?sche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology. 2015 Sep; 96(Pt A):83-93.
    View in: PubMed
    Score: 0.003
  138. Christians U, Kohlhaw K, Esselmann H, S?rig T, Luy M, Kaltefleiter M, Beyrau R, Linck A, Ringe B, Oellerich M, et al. The yin and yang of lidocaine and cyclosporine metabolism in liver graft recipients. Transplant Proc. 1994 Oct; 26(5):2827-8.
    View in: PubMed
    Score: 0.003
  139. Klawitter J, Reed-Gitomer BY, McFann K, Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M, Christians U, Schrier RW. Endothelial dysfunction and oxidative stress in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1198-206.
    View in: PubMed
    Score: 0.003
  140. Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep; 121(3):469-81.
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    Score: 0.003
  141. Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boernsen KO. Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct; 406(25):6399-408.
    View in: PubMed
    Score: 0.003
  142. Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC. Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia. Am J Hematol. 2014 Sep; 89(9):896-903.
    View in: PubMed
    Score: 0.003
  143. Shihab F, Christians U, Smith L, Wellen JR, Kaplan B. Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. Transpl Immunol. 2014 Jun; 31(1):22-32.
    View in: PubMed
    Score: 0.003
  144. Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2014 06; 55(6):1139-49.
    View in: PubMed
    Score: 0.003
  145. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51.
    View in: PubMed
    Score: 0.003
  146. Ogasawara K, Chitnis SD, Gohh RY, Christians U, Akhlaghi F. Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients. Clin Pharmacokinet. 2013 Sep; 52(9):751-62.
    View in: PubMed
    Score: 0.003
  147. Christians U, Spiekermann K, Bader A, Schottmann R, Linck A, Wonigeit K, Sewing KF, Link H. Cyclosporine metabolite pattern in blood from patients with acute GVHD after BMT. Bone Marrow Transplant. 1993 Jul; 12(1):27-33.
    View in: PubMed
    Score: 0.003
  148. Klepacki J, Brunner N, Schmitz V, Klawitter J, Christians U, Klawitter J. Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma. Clin Chim Acta. 2013 Jun 05; 421:91-7.
    View in: PubMed
    Score: 0.003
  149. Christians U, Sewing KF. Cyclosporin metabolism in transplant patients. Pharmacol Ther. 1993 Feb-Mar; 57(2-3):291-345.
    View in: PubMed
    Score: 0.003
  150. Chitnis SD, Ogasawara K, Schniedewind B, Gohh RY, Christians U, Akhlaghi F. Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. Xenobiotica. 2013 Jul; 43(7):641-9.
    View in: PubMed
    Score: 0.003
  151. Christians U, Braun F, Schmidt M, Kosian N, Schiebel HM, Ernst L, Winkler M, Kruse C, Linck A, Sewing KF. Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. Clin Chem. 1992 Oct; 38(10):2025-32.
    View in: PubMed
    Score: 0.003
  152. Macy ME, Duncan T, Whitlock J, Hunger SP, Boklan J, Narendren A, Herzog C, Arceci RJ, Bagatell R, Trippett T, Christians U, Rolla K, Ivy SP, Gore L. A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors. Pediatr Blood Cancer. 2013 Feb; 60(2):230-6.
    View in: PubMed
    Score: 0.003
  153. Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc Res. 2013 Jan 01; 97(1):66-76.
    View in: PubMed
    Score: 0.003
  154. Christians U, Sattler M, Schiebel HM, Kruse C, Radeke HH, Linck A, Sewing KF. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metab Dispos. 1992 Mar-Apr; 20(2):186-91.
    View in: PubMed
    Score: 0.002
  155. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, N?rnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2012 02; 122(2):693-710.
    View in: PubMed
    Score: 0.002
  156. Aquilante CL, Kiser JJ, Anderson PL, Christians U, Kosmiski LA, Daily EB, Hoffman KL, Hopley CW, Predhomme JA, Schniedewind B, Sidhom MS. Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin. J Clin Pharmacol. 2012 Nov; 52(11):1725-38.
    View in: PubMed
    Score: 0.002
  157. Christians U, Braun F, Kosian N, Schmidt M, Schiebel HM, Ernst L, Kruse C, Winkler M, Holze I, Linck A, et al. High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients. Transplant Proc. 1991 Dec; 23(6):2741-4.
    View in: PubMed
    Score: 0.002
  158. Christians U, Braun F, Sattler M, Almeidal VM, Linck A, Sewing KF. Interactions of FK 506 and cyclosporine metabolism. Transplant Proc. 1991 Dec; 23(6):2794-6.
    View in: PubMed
    Score: 0.002
  159. Clavijo CF, Thomas JJ, Cromie M, Schniedewind B, Hoffman KL, Christians U, Galinkin JL. A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children. J Sep Sci. 2011 Dec; 34(24):3568-77.
    View in: PubMed
    Score: 0.002
  160. Christians U, Strohmeyer S, Kownatzki R, Schiebel HM, Bleck J, Greipel J, Kohlhaw K, Schottmann R, Sewing KF. Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile--isolation of 12 new cyclosporine metabolites. Xenobiotica. 1991 Sep; 21(9):1185-98.
    View in: PubMed
    Score: 0.002
  161. Christians U, Strohmeyer S, Kownatzki R, Schiebel HM, Bleck J, Kohlhaw K, Schottmann R, Sewing KF. Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes. Xenobiotica. 1991 Sep; 21(9):1199-210.
    View in: PubMed
    Score: 0.002
  162. Klepacki J, Klawitter J, Bendrick-Peart J, Schniedewind B, Heischmann S, Shokati T, Christians U, Klawitter J. A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 01; 883-884:113-9.
    View in: PubMed
    Score: 0.002
  163. Christians U, Radeke HH, Kownatzki R, Schiebel HM, Schottmann R, Sewing KF. Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations. Clin Biochem. 1991 Jun; 24(3):271-5.
    View in: PubMed
    Score: 0.002
  164. Clavijo CF, Hoffman KL, Thomas JJ, Carvalho B, Chu LF, Drover DR, Hammer GB, Christians U, Galinkin JL. A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011 May; 400(3):715-28.
    View in: PubMed
    Score: 0.002
  165. Sewing KF, Christians U. FK 506. Lancet. 1991 Feb 23; 337(8739):499.
    View in: PubMed
    Score: 0.002
  166. F?ste CK, R?nning HT, Christians U, Granum PE. Liquid chromatography and mass spectrometry in food allergen detection. J Food Prot. 2011 Feb; 74(2):316-45.
    View in: PubMed
    Score: 0.002
  167. Christians U, Kruse C, Kownatzki R, Schiebel HM, Schwinzer R, Sattler M, Schottmann R, Linck A, Almeida VM, Braun F, et al. Measurement of FK 506 by HPLC and isolation and characterization of its metabolites. Transplant Proc. 1991 Feb; 23(1 Pt 2):940-1.
    View in: PubMed
    Score: 0.002
  168. Cohen MN, Christians U, Henthorn T, Vu Tran Z, Moll V, Zuk J, Galinkin J. Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesth Analg. 2011 Mar; 112(3):655-60.
    View in: PubMed
    Score: 0.002
  169. Christians U, Kohlhaw K, Budniak J, Bleck JS, Schottmann R, Schlitt HJ, Almeida VM, Deters M, Wonigeit K, Pichlmayr R, et al. Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I. Association of ciclosporin metabolites with nephrotoxicity. Eur J Clin Pharmacol. 1991; 41(4):285-90.
    View in: PubMed
    Score: 0.002
  170. Christians U, Kohlhaw K, Budniak J, Bleck JS, Schottmann R, Schlitt HJ, Almeida VM, Deters M, Wonigeit K, Pichlmayr R, et al. Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection. Eur J Clin Pharmacol. 1991; 41(4):291-6.
    View in: PubMed
    Score: 0.002
  171. Thethi T, Rajapurkar M, Walker P, McDuffie R, Goff DC, Probstfield J, Yau CL, Shah S, Christians U, Buse J, Fonseca V. Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria--a substudy of the ACCORD Trial. Clin Chem. 2011 Feb; 57(2):341-4.
    View in: PubMed
    Score: 0.002
  172. Ostojic MC, Perisic Z, Sagic D, Jung R, Zhang YL, Bendrick-Peart J, Betts R, Christians U. The pharmacokinetics of Biolimus A9 after elution from the BioMatrix II stent in patients with coronary artery disease: the Stealth PK Study. Eur J Clin Pharmacol. 2011 Apr; 67(4):389-398.
    View in: PubMed
    Score: 0.002
  173. Angst MS, Phillips NG, Drover DR, Tingle M, Galinkin JL, Christians U, Swan GE, Lazzeroni LC, Clark JD. Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability. Twin Res Hum Genet. 2010 Oct; 13(5):412-25.
    View in: PubMed
    Score: 0.002
  174. Klawitter J, Shokati T, Moll V, Christians U, Klawitter J. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. Breast Cancer Res. 2010; 12(2):R16.
    View in: PubMed
    Score: 0.002
  175. Faeste CK, Christians U, Egaas E, Jonscher KR. Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis. J Proteomics. 2010 May 07; 73(7):1321-33.
    View in: PubMed
    Score: 0.002
  176. Clavijo C, Strom T, Moll V, Betts R, Zhang YL, Christians U, Bendrick-Peart J. Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 01; 877(29):3506-14.
    View in: PubMed
    Score: 0.002
  177. Klawitter J, Kominsky DJ, Brown JL, Klawitter J, Christians U, Leibfritz D, Melo JV, Eckhardt SG, Serkova NJ. Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells. Br J Pharmacol. 2009 Sep; 158(2):588-600.
    View in: PubMed
    Score: 0.002
  178. Prior JE, Shokati T, Christians U, Gill RT. Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac. Appl Microbiol Biotechnol. 2010 Jan; 85(3):625-33.
    View in: PubMed
    Score: 0.002
  179. Thethi TK, Rao A, Kawji H, Mallik T, Yau CL, Christians U, Fonseca V. Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion. J Diabetes Complications. 2010 Mar-Apr; 24(2):73-8.
    View in: PubMed
    Score: 0.002
  180. Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Christians U, Henthorn TK, Honigman B. Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m. Free Radic Biol Med. 2009 Jun 01; 46(11):1551-7.
    View in: PubMed
    Score: 0.002
  181. Klawitter J, Anderson N, Klawitter J, Christians U, Leibfritz D, Eckhardt SG, Serkova NJ. Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study. Br J Cancer. 2009 Mar 24; 100(6):923-31.
    View in: PubMed
    Score: 0.002
  182. Ostojic M, Sagic D, Jung R, Zhang YL, Nedeljkovic M, Mangovski L, Stojkovic S, Debeljacki D, Colic M, Beleslin B, Milosavljevic B, Orlic D, Topic D, Karanovic N, Paunovic D, Christians U. The pharmacokinetics of Biolimus A9 after elution from the Nobori stent in patients with coronary artery disease: the NOBORI PK study. Catheter Cardiovasc Interv. 2008 Dec 01; 72(7):901-8.
    View in: PubMed
    Score: 0.002
  183. Christians U, Schlitt HJ, Bleck JS, Schiebel HM, Kownatzki R, Maurer G, Strohmeyer SS, Schottmann R, Wonigeit K, Pichlmayr R, et al. Measurement of cyclosporine and 18 metabolites in blood, bile, and urine by high-performance liquid chromatography. Transplant Proc. 1988 Apr; 20(2 Suppl 2):609-13.
    View in: PubMed
    Score: 0.002
  184. Christians U, Zimmer KO, Wonigeit K, Maurer G, Sewing KF. Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile, and urine. Clin Chem. 1988 Jan; 34(1):34-9.
    View in: PubMed
    Score: 0.002
  185. Perry TW, Christians U, Trotter JF, Bendrick-Peart J. Pharmacokinetics of enteric-coated mycophenolate sodium in stable liver transplant recipients. Clin Transplant. 2007 May-Jun; 21(3):413-6.
    View in: PubMed
    Score: 0.002
  186. Christians U, Zimmer KO, Wonigeit K, Sewing KF. Measurement of cyclosporin A and of four metabolites in whole blood by high-performance liquid chromatography. J Chromatogr. 1987 Jan 23; 413:121-9.
    View in: PubMed
    Score: 0.002
  187. Schmelzer E, Acikgoez A, Fr?hauf NR, Crome O, Klempnauer J, Christians U, Bader A. Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures. Xenobiotica. 2006 Aug; 36(8):693-708.
    View in: PubMed
    Score: 0.002
  188. Van Patot MC, Hill AE, Dingmann C, Gaul L, Fralick K, Christians U, Honigman B, Salman MD. Risk of impaired coagulation in warfarin patients ascending to altitude (>2400 m). High Alt Med Biol. 2006; 7(1):39-46.
    View in: PubMed
    Score: 0.002
  189. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7.
    View in: PubMed
    Score: 0.002
  190. Christians U. [A paraplegic skipper of his own sailing yacht]. Rehabilitation (Stuttg). 1985 May; 24(2):96-9.
    View in: PubMed
    Score: 0.002
  191. Tissot van Patot MC, Leadbetter G, Keyes LE, Bendrick-Peart J, Beckey VE, Christians U, Hackett P. Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness. J Appl Physiol (1985). 2005 May; 98(5):1626-9.
    View in: PubMed
    Score: 0.002
  192. Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107.
    View in: PubMed
    Score: 0.001
  193. Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan; 308(1):143-55.
    View in: PubMed
    Score: 0.001
  194. Wiseman AC, Kam I, Christians U, Jani A, Bak T, Wachs M, Chan L. Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience. Transplant Proc. 2003 May; 35(3 Suppl):122S-124S.
    View in: PubMed
    Score: 0.001
  195. Kirchner G, Mueller L, Winkler M, Loss M, Roechte F, Deters M, Christians U, Kaever V, Klempnauer J, Sewing K, Manns M. Long-term pharmacokinetics of the metabolites of everolimus and cyclosporine in renal transplant recipients. Transplant Proc. 2002 Sep; 34(6):2233-4.
    View in: PubMed
    Score: 0.001
  196. Liu Y, Lillehei K, Cobb WN, Christians U, Ng KY. Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation. Biochem Biophys Res Commun. 2001 Nov 23; 289(1):62-8.
    View in: PubMed
    Score: 0.001
  197. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clin Pharmacol Ther. 2001 Nov; 70(5):462-7.
    View in: PubMed
    Score: 0.001
  198. Hausen B, Klupp J, Christians U, Higgins JP, Baumgartner RE, Hook LE, Friedrich S, Celnicker A, Morris RE. Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys. Transplantation. 2001 Sep 27; 72(6):1128-37.
    View in: PubMed
    Score: 0.001
  199. van Gelder T, Klupp J, Sawamoto T, Christians U, Morris RE. ATP-binding cassette transporters and calcineurin inhibitors: potential clinical implications. Transplant Proc. 2001 May; 33(3):2420-1.
    View in: PubMed
    Score: 0.001
  200. Kirchner GI, Jacobsen W, Deters M, Christians U, Nashan B, Winkler M, Vidal C, Kaever V, Sewing K, Manns MP. Fast quantification method for sirolimus and its major metabolites. Transplant Proc. 2001 Feb-Mar; 33(1-2):1091-2.
    View in: PubMed
    Score: 0.001
  201. Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov; 28(11):1343-51.
    View in: PubMed
    Score: 0.001
  202. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr; 16(4):478-85.
    View in: PubMed
    Score: 0.001
  203. Kirchner GI, Vidal C, Jacobsen W, Franzke A, Hallensleben K, Christians U, Sewing KF. Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl. 1999 Jan 22; 721(2):285-94.
    View in: PubMed
    Score: 0.001
  204. Gummert JF, Christians U, Barten M, Silva H, Morris RE. High-performance liquid chromatographic assay with a simple extraction procedure for sensitive quantification of mycophenolic acid in rat and human plasma. J Chromatogr B Biomed Sci Appl. 1999 Jan 22; 721(2):321-6.
    View in: PubMed
    Score: 0.001
  205. Braun F, Sch?tz E, Christians U, Lorf T, Schiffmann JH, Armstrong VW, Schr?ter W, Sewing KF, Oellerich M, Ringe B. Pitfalls in monitoring tacrolimus (FK 506). Ther Drug Monit. 1997 Dec; 19(6):628-31.
    View in: PubMed
    Score: 0.001
  206. Winkler M, Christians U, Baumann J, Gonschior AK, Wonigeit K, Pichlmayr R. Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. Ther Drug Monit. 1996 Dec; 18(6):640-6.
    View in: PubMed
    Score: 0.001
  207. Braun F, Lorf T, Sch?tz E, Christians U, Grupp C, Sattler B, Canelo R, Sewing KF, Armstrong VW, Oellerich M, Ringe B. Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. Transplant Proc. 1996 Dec; 28(6):3175-6.
    View in: PubMed
    Score: 0.001
  208. Streit F, Christians U, Schiebel HM, Meyer A, Sewing KF. Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes. Drug Metab Dispos. 1996 Nov; 24(11):1272-8.
    View in: PubMed
    Score: 0.001
  209. Winkler M, Haller G, Oldhafer K, Bechstein WO, Kattner A, Maib?cher A, F?rber L, Ringe B, Christians U, Neuhaus P, Pichlmayr R. A new oral formulation of cyclosporine for early oral immunosuppressive therapy in liver transplant recipients. Transplantation. 1996 Oct 27; 62(8):1063-8.
    View in: PubMed
    Score: 0.001
  210. Streit F, Christians U, Schiebel HM, Napoli KL, Ernst L, Linck A, Kahan BD, Sewing KF. Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry. Clin Chem. 1996 Sep; 42(9):1417-25.
    View in: PubMed
    Score: 0.001
  211. Gonschior AK, Christians U, Winkler M, Linck A, Baumann J, Sewing KF. Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. Clin Chem. 1996 Sep; 42(9):1426-32.
    View in: PubMed
    Score: 0.001
  212. Pethig K, Geiger M, Korn A, Grote M, Christians U, Wahlers T. Follow-up after conversion to Neoral in stable heart transplant recipients. Transplant Proc. 1996 Aug; 28(4):2282-4.
    View in: PubMed
    Score: 0.001
  213. Pethig K, Ruhparwar A, Korn A, Christians U, Wahlers T. Conversion from Sandimmune to Neoral in stable heart transplant recipients. Transplant Proc. 1996 Aug; 28(4):2287-9.
    View in: PubMed
    Score: 0.001
  214. Althaus C, Dagres E, Reinhard T, Christians U, Sundmacher R. Cyclosporin-A and its metabolites in the anterior chamber after topical and systemic application as determined with high-performance liquid chromatography-electrospray mass spectrometry. Ger J Ophthalmol. 1996 Jul; 5(4):189-94.
    View in: PubMed
    Score: 0.001
  215. Bleck JS, Thiesemann C, Kliem V, Christians U, Hecker H, Repp H, Frei U, Westhoff-Bleck M, Manns M, Sewing KF. Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients. Br J Clin Pharmacol. 1996 Jun; 41(6):551-6.
    View in: PubMed
    Score: 0.001
  216. Lampen A, Christians U, Bader A, Hackbarth I, Sewing KF. Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine. Pharmacology. 1996 Mar; 52(3):159-68.
    View in: PubMed
    Score: 0.001
  217. Jusko WJ, Thomson AW, Fung J, McMaster P, Wong SH, Zylber-Katz E, Christians U, Winkler M, Fitzsimmons WE, Lieberman R, et al. Consensus document: therapeutic monitoring of tacrolimus (FK-506). Ther Drug Monit. 1995 Dec; 17(6):606-14.
    View in: PubMed
    Score: 0.001
  218. Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF. Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos. 1995 Dec; 23(12):1315-24.
    View in: PubMed
    Score: 0.001
  219. Gonschior AK, Christians U, Winkler M, Schiebel HM, Linck A, Sewing KF. Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay. Ther Drug Monit. 1995 Oct; 17(5):504-10.
    View in: PubMed
    Score: 0.001
  220. Winkler M, Wonigeit K, Undre N, Ringe B, Oldhafer K, Christians U, Pichlmayr R. Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. Transplant Proc. 1995 Feb; 27(1):822-5.
    View in: PubMed
    Score: 0.001
  221. Gonschior AK, Christians U, Braun F, Winkler M, Linck A, Baumann J, Sewing KF. Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). Br J Clin Pharmacol. 1994 Dec; 38(6):567-71.
    View in: PubMed
    Score: 0.001
  222. Kohlhaw K, Christians U, S?rig T, Lamesch P, Hauss J, Sewing KF, Pichlmayr R. Cyclosporine and bilirubin metabolites compete for the hepatic excretory system. Transplant Proc. 1994 Oct; 26(5):2798-9.
    View in: PubMed
    Score: 0.001
  223. Bader A, Zech K, Crome O, Christians U, Ringe B, Pichlmayr R, Sewing KF. Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica. 1994 Jul; 24(7):623-33.
    View in: PubMed
    Score: 0.001
  224. Winkler M, Christians U, Stoll K, Baumann J, Pichlmayr R. Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. Ther Drug Monit. 1994 Jun; 16(3):281-6.
    View in: PubMed
    Score: 0.001
  225. Sattler M, Guengerich FP, Yun CH, Christians U, Sewing KF. Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos. 1992 Sep-Oct; 20(5):753-61.
    View in: PubMed
    Score: 0.001
  226. Radeke HH, Christians U, Sewing KF, Resch K. The synergistic immunosuppressive potential of cyclosporin metabolite combinations. Int J Immunopharmacol. 1992 May; 14(4):595-604.
    View in: PubMed
    Score: 0.001
  227. Schlitt HJ, Christians U, Bleck J, Kohlhaw K, Ringe B, Bunzendahl H, Sewing KF, Wonigeit K, Pichlmayr R. Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction. Transpl Int. 1991 Apr; 4(1):38-44.
    View in: PubMed
    Score: 0.001
  228. Bleck JS, Schlitt HJ, Christians U, Schottmann R, Thiesemann C, Strohmeyer S, Kohlhaw K, Wonigeit K, Pichlmayr R, Sewing KF. Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function. Eur J Clin Pharmacol. 1991; 40(6):565-9.
    View in: PubMed
    Score: 0.001
  229. Sewing KF, Christians U, Kohlhaw K, Radeke H, Strohmeyer S, Kownatzki R, Budniak J, Schottmann R, Bleck JS, Almeida VM, et al. Biologic activity of cyclosporine metabolites. Transplant Proc. 1990 Jun; 22(3):1129-34.
    View in: PubMed
    Score: 0.001
  230. Bleck JS, Nashan B, Christians U, Schottmann R, Wonigeit K, Sewing KF. Single dose pharmacokinetics of ciclosporin and its main metabolites after oral ciclosporin as oily solution or capsule. Arzneimittelforschung. 1990 Jan; 40(1):62-4.
    View in: PubMed
    Score: 0.001
  231. Bleck JS, Schlitt HJ, Christians U, Thiesemann C, Strohmeyer S, Schottmann R, Kohlhaw K, Wonigeit K, Sewing KF. Urinary excretion of ciclosporin and 17 of its metabolites in renal allograft recipients. Pharmacology. 1989; 39(3):160-4.
    View in: PubMed
    Score: 0.001
  232. Nashan B, Bleck J, Wonigeit K, Vogt P, Christians U, Sewing KF, Beveridge T, Pichlmayr R. Effect of the application form of cyclosporine on blood levels: comparison of oral solution and capsules. Transplant Proc. 1988 Apr; 20(2 Suppl 2):637-9.
    View in: PubMed
    Score: 0.000
  233. Sewing KF, Christians U, Bleck JS, Strohmeyer S, Beil W, Kohlhaw K, Wonigeit K. [Drug monitoring of cyclosporin by using high-performance liquid chromatography]. Dtsch Med Wochenschr. 1988 Feb 26; 113(8):311-4.
    View in: PubMed
    Score: 0.000
  234. Sewing KF, Christians U, Bleck JS, Schottmann R, Strohmeyer SS. Measurement and disposition of ciclosporin and its metabolites. Bibl Cardiol. 1988; (43):63-72.
    View in: PubMed
    Score: 0.000
  235. Schlitt HJ, Christians U, Wonigeit K, Sewing KF, Pichlmayr R. Immunosuppressive activity of cyclosporine metabolites in vitro. Transplant Proc. 1987 Oct; 19(5):4248-51.
    View in: PubMed
    Score: 0.000
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