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Connection

Kathryn Horwitz to Breast Neoplasms

This is a "connection" page, showing publications Kathryn Horwitz has written about Breast Neoplasms.

 
Connection Strength
  
 
 
6.982
  
  1. Horwitz KB, Sartorius CA. Response to: Progesterone and breast cancer pathogenesis. J Mol Endocrinol. 2021 01; 66(1):L1-L2.
    View in: PubMed
    Score: 0.336
  2. Horwitz KB, Sartorius CA. 90 YEARS OF PROGESTERONE: Progesterone and progesterone receptors in breast cancer: past, present, future. J Mol Endocrinol. 2020 07; 65(1):T49-T63.
    View in: PubMed
    Score: 0.325
  3. Abdel-Hafiz HA, Horwitz KB. Role of epigenetic modifications in luminal breast cancer. Epigenomics. 2015 Aug; 7(5):847-62.
    View in: PubMed
    Score: 0.224
  4. Ogba N, Manning NG, Bliesner BS, Ambler SK, Haughian JM, Pinto MP, Jedlicka P, Joensuu K, Heikkil? P, Horwitz KB. Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells. Breast Cancer Res. 2014 Dec 05; 16(6):489.
    View in: PubMed
    Score: 0.221
  5. Pinto MP, Dye WW, Jacobsen BM, Horwitz KB. Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling. BMC Cancer. 2014 Oct 01; 14:735.
    View in: PubMed
    Score: 0.218
  6. Knox AJ, Scaling AL, Pinto MP, Bliesner BS, Haughian JM, Abdel-Hafiz HA, Horwitz KB. Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease. Breast Cancer Res. 2014 Aug 13; 16(4):418.
    View in: PubMed
    Score: 0.216
  7. Harvell DM, Kim J, O'Brien J, Tan AC, Borges VF, Schedin P, Jacobsen BM, Horwitz KB. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Cancer. 2013 Jun; 4(3):140-53.
    View in: PubMed
    Score: 0.196
  8. Haughian JM, Pinto MP, Harrell JC, Bliesner BS, Joensuu KM, Dye WW, Sartorius CA, Tan AC, Heikkil? P, Perou CM, Horwitz KB. Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2742-7.
    View in: PubMed
    Score: 0.177
  9. Spillman MA, Manning NG, Dye WW, Sartorius CA, Post MD, Harrell JC, Jacobsen BM, Horwitz KB. Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis. Cancer Res. 2010 Nov 01; 70(21):8927-36.
    View in: PubMed
    Score: 0.166
  10. Pinto MP, Badtke MM, Dudevoir ML, Harrell JC, Jacobsen BM, Horwitz KB. Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancer. Cancer Res. 2010 Apr 01; 70(7):2655-64.
    View in: PubMed
    Score: 0.159
  11. Horwitz KB. The Year in Basic Science: update of estrogen plus progestin therapy for menopausal hormone replacement implicating stem cells in the increased breast cancer risk. Mol Endocrinol. 2008 Dec; 22(12):2743-50.
    View in: PubMed
    Score: 0.144
  12. Horwitz KB, Sartorius CA. Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis. J Clin Endocrinol Metab. 2008 Sep; 93(9):3295-8.
    View in: PubMed
    Score: 0.142
  13. Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5774-9.
    View in: PubMed
    Score: 0.139
  14. Harvell DM, Richer JK, Singh M, Spoelstra N, Finlayson C, Borges VF, Elias AD, Horwitz KB. Estrogen regulated gene expression in response to neoadjuvant endocrine therapy of breast cancers: tamoxifen agonist effects dominate in the presence of an aromatase inhibitor. Breast Cancer Res Treat. 2008 Dec; 112(3):489-501.
    View in: PubMed
    Score: 0.138
  15. Harrell JC, Dye WW, Harvell DM, Pinto M, Jedlicka P, Sartorius CA, Horwitz KB. Estrogen insensitivity in a model of estrogen receptor positive breast cancer lymph node metastasis. Cancer Res. 2007 Nov 01; 67(21):10582-91.
    View in: PubMed
    Score: 0.135
  16. Harrell JC, Dye WW, Harvell DM, Sartorius CA, Horwitz KB. Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: a comparison of experimental breast cancers and their lymph node metastases. Clin Exp Metastasis. 2008; 25(1):81-8.
    View in: PubMed
    Score: 0.135
  17. Harrell JC, Dye WW, Allred DC, Jedlicka P, Spoelstra NS, Sartorius CA, Horwitz KB. Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. Cancer Res. 2006 Sep 15; 66(18):9308-15.
    View in: PubMed
    Score: 0.125
  18. Jacobsen BM, Harrell JC, Jedlicka P, Borges VF, Varella-Garcia M, Horwitz KB. Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Res. 2006 Aug 15; 66(16):8274-9.
    View in: PubMed
    Score: 0.124
  19. Ghatge RP, Jacobsen BM, Schittone SA, Horwitz KB. The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells. Breast Cancer Res. 2005; 7(6):R1036-50.
    View in: PubMed
    Score: 0.118
  20. Sartorius CA, Harvell DM, Shen T, Horwitz KB. Progestins initiate a luminal to myoepithelial switch in estrogen-dependent human breast tumors without altering growth. Cancer Res. 2005 Nov 01; 65(21):9779-88.
    View in: PubMed
    Score: 0.118
  21. Harvell DM, Richer JK, Allred DC, Sartorius CA, Horwitz KB. Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture. Endocrinology. 2006 Feb; 147(2):700-13.
    View in: PubMed
    Score: 0.117
  22. Fuqua SA, Cui Y, Lee AV, Osborne CK, Horwitz KB. Insights into the role of progesterone receptors in breast cancer. J Clin Oncol. 2005 Feb 01; 23(4):931-2; author reply 932-3.
    View in: PubMed
    Score: 0.112
  23. Jacobsen BM, Richer JK, Sartorius CA, Horwitz KB. Expression profiling of human breast cancers and gene regulation by progesterone receptors. J Mammary Gland Biol Neoplasia. 2003 Jul; 8(3):257-68.
    View in: PubMed
    Score: 0.100
  24. Sartorius CA, Shen T, Horwitz KB. Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenografts. Breast Cancer Res Treat. 2003 Jun; 79(3):287-99.
    View in: PubMed
    Score: 0.099
  25. Jacobsen BM, Richer JK, Schittone SA, Horwitz KB. New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation. J Biol Chem. 2002 Aug 02; 277(31):27793-800.
    View in: PubMed
    Score: 0.093
  26. Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem. 2002 Feb 15; 277(7):5209-18.
    View in: PubMed
    Score: 0.089
  27. Graham JD, Bain DL, Richer JK, Jackson TA, Tung L, Horwitz KB. Thoughts on tamoxifen resistant breast cancer. Are coregulators the answer or just a red herring? J Steroid Biochem Mol Biol. 2000 Nov 30; 74(5):255-9.
    View in: PubMed
    Score: 0.084
  28. Graham JD, Bain DL, Richer JK, Jackson TA, Tung L, Horwitz KB. Nuclear receptor conformation, coregulators, and tamoxifen-resistant breast cancer. Steroids. 2000 Oct-Nov; 65(10-11):579-84.
    View in: PubMed
    Score: 0.083
  29. Brechbuhl HM, Barrett AS, Kopin E, Hagen JC, Han AL, Gillen AE, Finlay-Schultz J, Cittelly DM, Owens P, Horwitz KB, Sartorius CA, Hansen K, Kabos P. Fibroblast subtypes define a metastatic matrisome in breast cancer. JCI Insight. 2020 02 27; 5(4).
    View in: PubMed
    Score: 0.079
  30. Lange CA, Richer JK, Horwitz KB. Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol Endocrinol. 1999 Jun; 13(6):829-36.
    View in: PubMed
    Score: 0.075
  31. Takimoto GS, Graham JD, Jackson TA, Tung L, Powell RL, Horwitz LD, Horwitz KB. Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors. J Steroid Biochem Mol Biol. 1999 Apr-Jun; 69(1-6):45-50.
    View in: PubMed
    Score: 0.074
  32. Lange CA, Richer JK, Shen T, Horwitz KB. Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways. J Biol Chem. 1998 Nov 20; 273(47):31308-16.
    View in: PubMed
    Score: 0.073
  33. Richer JK, Lange CA, Manning NG, Owen G, Powell R, Horwitz KB. Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity. J Biol Chem. 1998 Nov 20; 273(47):31317-26.
    View in: PubMed
    Score: 0.073
  34. Richer JK, Lange CA, Wierman AM, Brooks KM, Tung L, Takimoto GS, Horwitz KB. Progesterone receptor variants found in breast cells repress transcription by wild-type receptors. Breast Cancer Res Treat. 1998 Apr; 48(3):231-41.
    View in: PubMed
    Score: 0.069
  35. Horwitz K, Clarke C. Estrogens and progestins in mammary development and neoplasia. Introduction. J Mammary Gland Biol Neoplasia. 1998 Jan; 3(1):1-2.
    View in: PubMed
    Score: 0.068
  36. Groshong SD, Owen GI, Grimison B, Schauer IE, Todd MC, Langan TA, Sclafani RA, Lange CA, Horwitz KB. Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1). Mol Endocrinol. 1997 Oct; 11(11):1593-607.
    View in: PubMed
    Score: 0.067
  37. Horwitz KB, Tung L, Takimoto GS. Novel mechanisms of antiprogestin action. Acta Oncol. 1996; 35(2):129-40.
    View in: PubMed
    Score: 0.059
  38. Horwitz KB. When tamoxifen turns bad. Endocrinology. 1995 Mar; 136(3):821-3.
    View in: PubMed
    Score: 0.056
  39. Sartorius CA, Groshong SD, Miller LA, Powell RL, Tung L, Takimoto GS, Horwitz KB. New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Res. 1994 Jul 15; 54(14):3868-77.
    View in: PubMed
    Score: 0.054
  40. Horwitz KB. How do breast cancers become hormone resistant? J Steroid Biochem Mol Biol. 1994 Jun; 49(4-6):295-302.
    View in: PubMed
    Score: 0.053
  41. Horwitz KB. Hormone 'resistance' in breast cancer: the role of normal and mutant steroid receptors. Cancer Treat Res. 1994; 71:111-27.
    View in: PubMed
    Score: 0.052
  42. Horwitz KB. Hormone-resistant breast cancer or "feeding the hand that bites you". Prog Clin Biol Res. 1994; 387:29-45.
    View in: PubMed
    Score: 0.052
  43. Abdel-Hafiz HA, Horwitz KB. Post-translational modifications of the progesterone receptors. J Steroid Biochem Mol Biol. 2014 Mar; 140:80-9.
    View in: PubMed
    Score: 0.052
  44. Horwitz KB. Can hormone "resistant" breast cancer cells be inappropriately stimulated by tamoxifen? Ann N Y Acad Sci. 1993 Jun 11; 684:63-74.
    View in: PubMed
    Score: 0.050
  45. Horwitz KB. Mechanisms of hormone resistance in breast cancer. Breast Cancer Res Treat. 1993; 26(2):119-30.
    View in: PubMed
    Score: 0.048
  46. Jambal P, Badtke MM, Harrell JC, Borges VF, Post MD, Sollender GE, Spillman MA, Horwitz KB, Jacobsen BM. Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Breast Cancer Res Treat. 2013 Jan; 137(2):431-48.
    View in: PubMed
    Score: 0.048
  47. Horwitz KB. The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev. 1992 May; 13(2):146-63.
    View in: PubMed
    Score: 0.046
  48. Leslie KK, Tasset DM, Horwitz KB. Functional analysis of a mutant estrogen receptor isolated from T47Dco breast cancer cells. Am J Obstet Gynecol. 1992 Apr; 166(4):1053-61.
    View in: PubMed
    Score: 0.046
  49. Abdel-Hafiz HA, Horwitz KB. Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation. BMC Mol Biol. 2012 Mar 22; 13:10.
    View in: PubMed
    Score: 0.046
  50. Horwitz KB. Cellular heterogeneity and mutant oestrogen receptors in hormone resistant breast cancer. Cancer Surv. 1992; 14:41-54.
    View in: PubMed
    Score: 0.045
  51. Badtke MM, Jambal P, Dye WW, Spillman MA, Post MD, Horwitz KB, Jacobsen BM. Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint. Breast Cancer Res Treat. 2012 Jan; 131(1):75-87.
    View in: PubMed
    Score: 0.042
  52. Graham ML, Krett NL, Miller LA, Leslie KK, Gordon DF, Wood WM, Wei LL, Horwitz KB. T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance. Cancer Res. 1990 Oct 01; 50(19):6208-17.
    View in: PubMed
    Score: 0.041
  53. Kabos P, Haughian JM, Wang X, Dye WW, Finlayson C, Elias A, Horwitz KB, Sartorius CA. Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers. Breast Cancer Res Treat. 2011 Jul; 128(1):45-55.
    View in: PubMed
    Score: 0.041
  54. Cappelletti V, Patriarca C, Granata G, Cattoretti G, Coradini D, Di Fronzo G, Horwitz K. Progesterone receptor determination in human breast tumors by immunocytochemical and biochemical techniques. Breast Cancer Res Treat. 1989 Nov; 14(2):217-25.
    View in: PubMed
    Score: 0.039
  55. Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Bar?n AE, Harrell JC, Horwitz KB, Billheimer D, Heichman KA, Welm AL, Schiemann WP, Ford HL. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest. 2009 Sep; 119(9):2678-90.
    View in: PubMed
    Score: 0.038
  56. Graham ML, Dalquist KE, Horwitz KB. Simultaneous measurement of progesterone receptors and DNA indices by flow cytometry: analysis of breast cancer cell mixtures and genetic instability of the T47D line. Cancer Res. 1989 Jul 15; 49(14):3943-9.
    View in: PubMed
    Score: 0.038
  57. Graham ML, Bunn PA, Jewett PB, Gonzalez-Aller C, Horwitz KB. Simultaneous measurement of progesterone receptors and DNA indices by flow cytometry: characterization of an assay in breast cancer cell lines. Cancer Res. 1989 Jul 15; 49(14):3934-42.
    View in: PubMed
    Score: 0.038
  58. Horwitz KB. The central role of progesterone receptors and progestational agents in the management and treatment of breast cancer. Semin Oncol. 1988 Apr; 15(2 Suppl 1):14-9.
    View in: PubMed
    Score: 0.035
  59. Harvell DM, Spoelstra NS, Singh M, McManaman JL, Finlayson C, Phang T, Trapp S, Hunter L, Dye WW, Borges VF, Elias A, Horwitz KB, Richer JK. Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance. Breast Cancer Res Treat. 2008 Dec; 112(3):475-88.
    View in: PubMed
    Score: 0.035
  60. Lange CA, Sartorius CA, Abdel-Hafiz H, Spillman MA, Horwitz KB, Jacobsen BM. Progesterone receptor action: translating studies in breast cancer models to clinical insights. Adv Exp Med Biol. 2008; 630:94-111.
    View in: PubMed
    Score: 0.034
  61. Wei LL, Krett NL, Francis MD, Gordon DF, Wood WM, O'Malley BW, Horwitz KB. Multiple human progesterone receptor messenger ribonucleic acids and their autoregulation by progestin agonists and antagonists in breast cancer cells. Mol Endocrinol. 1988 Jan; 2(1):62-72.
    View in: PubMed
    Score: 0.034
  62. Wei LL, Sheridan PL, Krett NL, Francis MD, Toft DO, Edwards DP, Horwitz KB. Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosphorylation, and processing. Biochemistry. 1987 Sep 22; 26(19):6262-72.
    View in: PubMed
    Score: 0.034
  63. Horwitz KB. The structure and function of progesterone receptors in breast cancer. J Steroid Biochem. 1987; 27(1-3):447-57.
    View in: PubMed
    Score: 0.032
  64. Horwitz KB, Pike AW, Gonzalez-Aller C, Fennessey PV. Progesterone metabolism in T47Dco human breast cancer cells--II. Intracellular metabolic path of progesterone and synthetic progestins. J Steroid Biochem. 1986 Dec; 25(6):911-6.
    View in: PubMed
    Score: 0.032
  65. Fennessey PV, Pike AW, Gonzalez-Aller C, Horwitz KB. Progesterone metabolism in T47Dco human breast cancer cells--I. 5 alpha-pregnan-3 beta,6 alpha-diol-20-one is the secreted product. J Steroid Biochem. 1986 Nov; 25(5A):641-8.
    View in: PubMed
    Score: 0.032
  66. Carvajal A, Espinoza N, Kato S, Pinto M, Sadarangani A, Monso C, Aranda E, Villalon M, Richer JK, Horwitz KB, Brosens JJ, Owen GI. Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75. Breast Cancer Res Treat. 2005 Nov; 94(2):171-83.
    View in: PubMed
    Score: 0.029
  67. Bray JD, Jelinsky S, Ghatge R, Bray JA, Tunkey C, Saraf K, Jacobsen BM, Richer JK, Brown EL, Winneker RC, Horwitz KB, Lyttle CR. Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells. J Steroid Biochem Mol Biol. 2005 Dec; 97(4):328-41.
    View in: PubMed
    Score: 0.029
  68. Horwitz KB. The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells. Endocrinology. 1985 Jun; 116(6):2236-45.
    View in: PubMed
    Score: 0.029
  69. Horwitz KB, Freidenberg GR. Growth inhibition and increase of insulin receptors in antiestrogen-resistant T47DCO human breast cancer cells by progestins: implications for endocrine therapies. Cancer Res. 1985 Jan; 45(1):167-73.
    View in: PubMed
    Score: 0.028
  70. Horwitz KB, Wei LL, Sedlacek SM, d'Arville CN. Progestin action and progesterone receptor structure in human breast cancer: a review. Recent Prog Horm Res. 1985; 41:249-316.
    View in: PubMed
    Score: 0.028
  71. Sedlacek SM, Horwitz KB. The role of progestins and progesterone receptors in the treatment of breast cancer. Steroids. 1984 Dec; 44(6):467-84.
    View in: PubMed
    Score: 0.028
  72. Jacobsen BM, Schittone SA, Richer JK, Horwitz KB. Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology. Mol Endocrinol. 2005 Mar; 19(3):574-87.
    View in: PubMed
    Score: 0.028
  73. Kato S, Pinto M, Carvajal A, Espinoza N, Monso C, Sadarangani A, Villalon M, Brosens JJ, White JO, Richer JK, Horwitz KB, Owen GI. Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1. J Clin Endocrinol Metab. 2005 Feb; 90(2):1181-8.
    View in: PubMed
    Score: 0.028
  74. Hopp TA, Weiss HL, Hilsenbeck SG, Cui Y, Allred DC, Horwitz KB, Fuqua SA. Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival rates. Clin Cancer Res. 2004 Apr 15; 10(8):2751-60.
    View in: PubMed
    Score: 0.026
  75. Wu J, Richer J, Horwitz KB, Hyder SM. Progestin-dependent induction of vascular endothelial growth factor in human breast cancer cells: preferential regulation by progesterone receptor B. Cancer Res. 2004 Mar 15; 64(6):2238-44.
    View in: PubMed
    Score: 0.026
  76. Horwitz KB, Alexander PS. In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation. Endocrinology. 1983 Dec; 113(6):2195-201.
    View in: PubMed
    Score: 0.026
  77. Horwitz KB, Mockus MB, Pike AW, Fennessey PV, Sheridan RL. Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism. J Biol Chem. 1983 Jun 25; 258(12):7603-10.
    View in: PubMed
    Score: 0.025
  78. Mockus MB, Horwitz KB. Progesterone receptors in human breast cancer. Stoichiometric translocation and nuclear receptor processing. J Biol Chem. 1983 Apr 25; 258(8):4778-83.
    View in: PubMed
    Score: 0.025
  79. Lessey BA, Alexander PS, Horwitz KB. The subunit structure of human breast cancer progesterone receptors: characterization by chromatography and photoaffinity labeling. Endocrinology. 1983 Apr; 112(4):1267-74.
    View in: PubMed
    Score: 0.025
  80. Mockus MB, Lessey BA, Bower MA, Horwitz KB. Estrogen-insensitive progesterone receptors in a human breast cancer cell line: characterization of receptors and of a ligand exchange assay. Endocrinology. 1982 May; 110(5):1564-71.
    View in: PubMed
    Score: 0.023
  81. Horwitz KB, Mockus MB, Lessey BA. Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance. Cell. 1982 Mar; 28(3):633-42.
    View in: PubMed
    Score: 0.023
  82. Horwitz KB. Is a functional estrogen receptor always required for progesterone receptor induction in breast cancer? J Steroid Biochem. 1981 Dec; 15:209-17.
    View in: PubMed
    Score: 0.022
  83. Pahl PM, Horwitz MA, Horwitz KB, Horwitz LD. Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res Treat. 2001 Sep; 69(1):69-79.
    View in: PubMed
    Score: 0.022
  84. Horwitz KB, Aiginger P, Kuttenn F, McGuire WL. Nuclear estrogen receptor release from antiestrogen suppression: amplified induction of progesterone receptor in MCF-7 human breast cancer cells. Endocrinology. 1981 May; 108(5):1703-9.
    View in: PubMed
    Score: 0.022
  85. Kinyamu HK, Fryer CJ, Horwitz KB, Archer TK. The mouse mammary tumor virus promoter adopts distinct chromatin structures in human breast cancer cells with and without glucocorticoid receptor. J Biol Chem. 2000 Jun 30; 275(26):20061-8.
    View in: PubMed
    Score: 0.020
  86. Lange CA, Shen T, Horwitz KB. Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1032-7.
    View in: PubMed
    Score: 0.020
  87. Horwitz KB, McGuire WL. Studies on mechanisms of estrogen and antiestrogen action in human breast cancer. Recent Results Cancer Res. 1980; 71:45-58.
    View in: PubMed
    Score: 0.020
  88. Horwitz KB, McGuire WL. Estrogen control of progesterone receptor induction in human breast cancer: role of nuclear estrogen receptor. Adv Exp Med Biol. 1979; 117:95-110.
    View in: PubMed
    Score: 0.018
  89. Horwitz KB, Koseki Y, McGuire WL. Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology. 1978 Nov; 103(5):1742-51.
    View in: PubMed
    Score: 0.018
  90. Horwitz KB, Zava DT, Thilagar AK, Jensen EM, McGuire WL. Steroid receptor analyses of nine human breast cancer cell lines. Cancer Res. 1978 Aug; 38(8):2434-7.
    View in: PubMed
    Score: 0.018
  91. Horwitz KB, McGuire WL. Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor. J Biol Chem. 1978 Apr 10; 253(7):2223-8.
    View in: PubMed
    Score: 0.017
  92. Miller MM, James RA, Richer JK, Gordon DF, Wood WM, Horwitz KB. Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: implications for tamoxifen carcinogenicity. J Clin Endocrinol Metab. 1997 Sep; 82(9):2956-61.
    View in: PubMed
    Score: 0.017
  93. Horwitz KB, Costlow ME, McGuire WL. MCF-7; a human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors. Steroids. 1975 Dec; 26(6):785-95.
    View in: PubMed
    Score: 0.015
  94. Horwitz KB, McGuire WL. Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science. 1975 Aug 29; 189(4204):726-7.
    View in: PubMed
    Score: 0.015
  95. Horwitz KB, McGuire WL. Specific progesterone receptors in human breast cancer. Steroids. 1975 Apr; 25(4):497-505.
    View in: PubMed
    Score: 0.014
  96. Horwitz KB, Sartorius CA, Hovland AR, Jackson TA, Groshong SD, Tung L, Takimoto GS. Surprises with antiprogestins: novel mechanisms of progesterone receptor action. Ciba Found Symp. 1995; 191:235-49; discussion 250-3.
    View in: PubMed
    Score: 0.014
  97. Sartorius CA, Tung L, Takimoto GS, Horwitz KB. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 05; 268(13):9262-6.
    View in: PubMed
    Score: 0.012
  98. Graham ML, Smith JA, Jewett PB, Horwitz KB. Heterogeneity of progesterone receptor content and remodeling by tamoxifen characterize subpopulations of cultured human breast cancer cells: analysis by quantitative dual parameter flow cytometry. Cancer Res. 1992 Feb 01; 52(3):593-602.
    View in: PubMed
    Score: 0.011
  99. Wei LL, Gonzalez-Aller C, Wood WM, Miller LA, Horwitz KB. 5'-Heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated "C"-receptor and unique A-receptor messages. Mol Endocrinol. 1990 Dec; 4(12):1833-40.
    View in: PubMed
    Score: 0.010
  100. Sheridan PL, Krett NL, Gordon JA, Horwitz KB. Human progesterone receptor transformation and nuclear down-regulation are independent of phosphorylation. Mol Endocrinol. 1988 Dec; 2(12):1329-42.
    View in: PubMed
    Score: 0.009
  101. Estes PA, Suba EJ, Lawler-Heavner J, Elashry-Stowers D, Wei LL, Toft DO, Sullivan WP, Horwitz KB, Edwards DP. Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies. Biochemistry. 1987 Sep 22; 26(19):6250-62.
    View in: PubMed
    Score: 0.008
  102. Byron SA, Horwitz KB, Richer JK, Lange CA, Zhang X, Yee D. Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br J Cancer. 2006 Nov 06; 95(9):1220-8.
    View in: PubMed
    Score: 0.008
  103. Horwitz KB, Francis MD, Wei LL. Hormone-dependent covalent modification and processing of human progesterone receptors in the nucleus. DNA. 1985 Dec; 4(6):451-60.
    View in: PubMed
    Score: 0.007
  104. Wei LL, Horwitz KB. The structure of progesterone receptors. Steroids. 1985 Aug-Sep; 46(2-3):677-95.
    View in: PubMed
    Score: 0.007
  105. Qiu M, Olsen A, Faivre E, Horwitz KB, Lange CA. Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol. 2003 Apr; 17(4):628-42.
    View in: PubMed
    Score: 0.006
  106. Horwitz KB, McGuire WL. Nuclear estrogen receptors. Effect of inhibitors on processing and steady state levels. J Biol Chem. 1980 Oct 25; 255(20):9699-705.
    View in: PubMed
    Score: 0.005
  107. Edwards DP, Martin PM, Horwitz KB, Chamness GC, McGuire WL. Subcellular compartmentalization of estrogen receptors in human breast cancer cells. Exp Cell Res. 1980 May; 127(1):197-213.
    View in: PubMed
    Score: 0.005
  108. Martin PM, Horwitz KB, Ryan DS, McGuire WL. Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology. 1978 Nov; 103(5):1860-7.
    View in: PubMed
    Score: 0.005
  109. Horwitz KB, McGuire WL. Actinomycin D prevents nuclear processing of estrogen receptor. J Biol Chem. 1978 Sep 25; 253(18):6319-22.
    View in: PubMed
    Score: 0.004
  110. McGuire WL, Zava DT, Horwitz KB, Garola RE, Chamness GC. Receptors and breast cancer: do we know it all? J Steroid Biochem. 1978 May; 9(5):461-6.
    View in: PubMed
    Score: 0.004
  111. McGuire WL, Horwitz KB, Pearson OH, Segaloff A. Current status of estrogen and progesterone receptors in breast cancer. Cancer. 1977 Jun; 39(6 Suppl):2934-47.
    View in: PubMed
    Score: 0.004
  112. Zava DT, Chamness GC, Horwitz KB, McGuire WL. Human breast cancer: biologically active estrogen receptor in the absence of estrogen? Science. 1977 May 06; 196(4290):663-4.
    View in: PubMed
    Score: 0.004
  113. McGuire WL, Chamness GC, Horwitz KB, Zava DT. Prolactin and estrogen receptors in breast cancer. Pathobiol Annu. 1977; 7:191-211.
    View in: PubMed
    Score: 0.004
  114. McGuire WL, Horwitz KB, Chamness GC, Zava DT. A physiological role for estrogen and progesterone in breast cancer. J Steroid Biochem. 1976 Nov-Dec; 7(11-12):875-82.
    View in: PubMed
    Score: 0.004
  115. McGuire WL, Horwitz KB, De La Garza M. Selecting endocrine therapy in breast cancer. Curr Top Mol Endocrinol. 1976; 4:28-35.
    View in: PubMed
    Score: 0.004
  116. Zava DT, Landrum B, Horwitz KB, McGuire WL. Androgen receptor assay with [3H]methyltrienolone (R1881) in the presence of progesterone receptors. Endocrinology. 1979 Apr; 104(4):1007-12.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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