 Connection
Kathryn Horwitz to Progesterone
This is a "connection" page, showing publications Kathryn Horwitz has written about Progesterone.
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Connection Strength |
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5.205 |
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Horwitz KB, Sartorius CA. Response to: Progesterone and breast cancer pathogenesis. J Mol Endocrinol. 2021 01; 66(1):L1-L2.
Score: 0.636
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Horwitz KB, Sartorius CA. 90 YEARS OF PROGESTERONE: Progesterone and progesterone receptors in breast cancer: past, present, future. J Mol Endocrinol. 2020 07; 65(1):T49-T63.
Score: 0.614
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Ogba N, Manning NG, Bliesner BS, Ambler SK, Haughian JM, Pinto MP, Jedlicka P, Joensuu K, Heikkil? P, Horwitz KB. Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells. Breast Cancer Res. 2014 Dec 05; 16(6):489.
Score: 0.417
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Harvell DM, Kim J, O'Brien J, Tan AC, Borges VF, Schedin P, Jacobsen BM, Horwitz KB. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Cancer. 2013 Jun; 4(3):140-53.
Score: 0.370
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Jacobsen BM, Horwitz KB. Progesterone receptors, their isoforms and progesterone regulated transcription. Mol Cell Endocrinol. 2012 Jun 24; 357(1-2):18-29.
Score: 0.334
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Sartorius CA, Harvell DM, Shen T, Horwitz KB. Progestins initiate a luminal to myoepithelial switch in estrogen-dependent human breast tumors without altering growth. Cancer Res. 2005 Nov 01; 65(21):9779-88.
Score: 0.222
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Jacobsen BM, Schittone SA, Richer JK, Horwitz KB. Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology. Mol Endocrinol. 2005 Mar; 19(3):574-87.
Score: 0.208
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Jacobsen BM, Richer JK, Sartorius CA, Horwitz KB. Expression profiling of human breast cancers and gene regulation by progesterone receptors. J Mammary Gland Biol Neoplasia. 2003 Jul; 8(3):257-68.
Score: 0.189
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Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem. 2002 Feb 15; 277(7):5209-18.
Score: 0.169
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Lange CA, Richer JK, Horwitz KB. Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol Endocrinol. 1999 Jun; 13(6):829-36.
Score: 0.142
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Lange CA, Richer JK, Shen T, Horwitz KB. Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways. J Biol Chem. 1998 Nov 20; 273(47):31308-16.
Score: 0.137
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Richer JK, Lange CA, Manning NG, Owen G, Powell R, Horwitz KB. Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity. J Biol Chem. 1998 Nov 20; 273(47):31317-26.
Score: 0.137
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Owen GI, Richer JK, Tung L, Takimoto G, Horwitz KB. Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem. 1998 Apr 24; 273(17):10696-701.
Score: 0.132
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Groshong SD, Owen GI, Grimison B, Schauer IE, Todd MC, Langan TA, Sclafani RA, Lange CA, Horwitz KB. Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1). Mol Endocrinol. 1997 Oct; 11(11):1593-607.
Score: 0.127
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Miller MM, James RA, Richer JK, Gordon DF, Wood WM, Horwitz KB. Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: implications for tamoxifen carcinogenicity. J Clin Endocrinol Metab. 1997 Sep; 82(9):2956-61.
Score: 0.126
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Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB. Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol. 1993 Oct; 7(10):1256-65.
Score: 0.096
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Sartorius CA, Tung L, Takimoto GS, Horwitz KB. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 05; 268(13):9262-6.
Score: 0.094
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Horwitz KB. The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev. 1992 May; 13(2):146-63.
Score: 0.087
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Takimoto GS, Tasset DM, Eppert AC, Horwitz KB. Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):3050-4.
Score: 0.087
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Wei LL, Krett NL, Francis MD, Gordon DF, Wood WM, O'Malley BW, Horwitz KB. Multiple human progesterone receptor messenger ribonucleic acids and their autoregulation by progestin agonists and antagonists in breast cancer cells. Mol Endocrinol. 1988 Jan; 2(1):62-72.
Score: 0.065
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Horwitz KB. The structure and function of progesterone receptors in breast cancer. J Steroid Biochem. 1987; 27(1-3):447-57.
Score: 0.060
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Horwitz KB, Pike AW, Gonzalez-Aller C, Fennessey PV. Progesterone metabolism in T47Dco human breast cancer cells--II. Intracellular metabolic path of progesterone and synthetic progestins. J Steroid Biochem. 1986 Dec; 25(6):911-6.
Score: 0.060
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Fennessey PV, Pike AW, Gonzalez-Aller C, Horwitz KB. Progesterone metabolism in T47Dco human breast cancer cells--I. 5 alpha-pregnan-3 beta,6 alpha-diol-20-one is the secreted product. J Steroid Biochem. 1986 Nov; 25(5A):641-8.
Score: 0.060
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Jones MC, Fusi L, Higham JH, Abdel-Hafiz H, Horwitz KB, Lam EW, Brosens JJ. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16272-7.
Score: 0.059
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Ghatge RP, Jacobsen BM, Schittone SA, Horwitz KB. The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells. Breast Cancer Res. 2005; 7(6):R1036-50.
Score: 0.056
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Carvajal A, Espinoza N, Kato S, Pinto M, Sadarangani A, Monso C, Aranda E, Villalon M, Richer JK, Horwitz KB, Brosens JJ, Owen GI. Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75. Breast Cancer Res Treat. 2005 Nov; 94(2):171-83.
Score: 0.056
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Bray JD, Jelinsky S, Ghatge R, Bray JA, Tunkey C, Saraf K, Jacobsen BM, Richer JK, Brown EL, Winneker RC, Horwitz KB, Lyttle CR. Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells. J Steroid Biochem Mol Biol. 2005 Dec; 97(4):328-41.
Score: 0.055
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Kato S, Pinto M, Carvajal A, Espinoza N, Monso C, Sadarangani A, Villalon M, Brosens JJ, White JO, Richer JK, Horwitz KB, Owen GI. Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1. J Clin Endocrinol Metab. 2005 Feb; 90(2):1181-8.
Score: 0.052
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Horwitz KB, Mockus MB, Pike AW, Fennessey PV, Sheridan RL. Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism. J Biol Chem. 1983 Jun 25; 258(12):7603-10.
Score: 0.047
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Leslie KK, Kumar NS, Richer J, Owen G, Takimoto G, Horwitz KB, Lange C. Differential expression of the A and B isoforms of progesterone receptor in human endometrial cancer cells. Only progesterone receptor B is induced by estrogen and associated with strong transcriptional activation. Ann N Y Acad Sci. 1997 Sep 26; 828:17-26.
Score: 0.032
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Horwitz KB, McGuire WL. Progesterone and progesterone receptors in experimental breast cancer. Cancer Res. 1977 Jun; 37(6):1733-8.
Score: 0.031
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McGuire WL, Horwitz KB. A role for progesterone in breast cancer. Ann N Y Acad Sci. 1977 Mar 11; 286:90-100.
Score: 0.031
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Horwitz KB, Tung L, Takimoto GS. Novel mechanisms of antiprogestin action. Acta Oncol. 1996; 35(2):129-40.
Score: 0.028
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Horwitz KB, Costlow ME, McGuire WL. MCF-7; a human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors. Steroids. 1975 Dec; 26(6):785-95.
Score: 0.028
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Horwitz KB, McGuire WL. Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science. 1975 Aug 29; 189(4204):726-7.
Score: 0.027
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Horwitz KB, McGuire WL. Specific progesterone receptors in human breast cancer. Steroids. 1975 Apr; 25(4):497-505.
Score: 0.027
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Sheridan PL, Krett NL, Gordon JA, Horwitz KB. Human progesterone receptor transformation and nuclear down-regulation are independent of phosphorylation. Mol Endocrinol. 1988 Dec; 2(12):1329-42.
Score: 0.017
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Lange CA, Sartorius CA, Abdel-Hafiz H, Spillman MA, Horwitz KB, Jacobsen BM. Progesterone receptor action: translating studies in breast cancer models to clinical insights. Adv Exp Med Biol. 2008; 630:94-111.
Score: 0.016
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Hopp TA, Weiss HL, Hilsenbeck SG, Cui Y, Allred DC, Horwitz KB, Fuqua SA. Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival rates. Clin Cancer Res. 2004 Apr 15; 10(8):2751-60.
Score: 0.012
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Wu J, Richer J, Horwitz KB, Hyder SM. Progestin-dependent induction of vascular endothelial growth factor in human breast cancer cells: preferential regulation by progesterone receptor B. Cancer Res. 2004 Mar 15; 64(6):2238-44.
Score: 0.012
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Mockus MB, Horwitz KB. Progesterone receptors in human breast cancer. Stoichiometric translocation and nuclear receptor processing. J Biol Chem. 1983 Apr 25; 258(8):4778-83.
Score: 0.012
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Mockus MB, Lessey BA, Bower MA, Horwitz KB. Estrogen-insensitive progesterone receptors in a human breast cancer cell line: characterization of receptors and of a ligand exchange assay. Endocrinology. 1982 May; 110(5):1564-71.
Score: 0.011
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Horwitz KB, Horwitz LD. Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids. J Clin Invest. 1982 Apr; 69(4):750-8.
Score: 0.011
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McGuire WL, Horwitz KB, Chamness GC, Zava DT. A physiological role for estrogen and progesterone in breast cancer. J Steroid Biochem. 1976 Nov-Dec; 7(11-12):875-82.
Score: 0.007
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Zava DT, Landrum B, Horwitz KB, McGuire WL. Androgen receptor assay with [3H]methyltrienolone (R1881) in the presence of progesterone receptors. Endocrinology. 1979 Apr; 104(4):1007-12.
Score: 0.002
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McGuire WL, Zava DT, Horwitz KB, Garola RE, Chamness GC. Receptors and breast cancer: do we know it all? J Steroid Biochem. 1978 May; 9(5):461-6.
Score: 0.002
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McGuire WL, Horwitz KB, Pearson OH, Segaloff A. Current status of estrogen and progesterone receptors in breast cancer. Cancer. 1977 Jun; 39(6 Suppl):2934-47.
Score: 0.002
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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