Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.
Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. Mol Cancer Ther. 2015 Aug; 14(8):1777-93.
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Animals
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Antineoplastic Agents
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Apoptosis
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Cell Line, Tumor
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Cluster Analysis
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Databases, Factual
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Disease Models, Animal
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Gene Expression
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Gene Expression Profiling
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Genes, Reporter
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Male
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Mice
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Models, Molecular
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Molecular Conformation
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Phosphorylation
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Prostatic Neoplasms
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Protein Multimerization
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Quantitative Structure-Activity Relationship
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Signal Transduction
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Small Molecule Libraries
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STAT5 Transcription Factor
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Tissue Culture Techniques
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Tumor Suppressor Proteins
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Xenograft Model Antitumor Assays