SujathaJagannathanSujatha Jagannathan39.74528180000000-104.8375727000000013682Jagannathan, SujathaRNA quality controlRNA decayNonsense-mediated RNA decayMuscular dystrophyFacioscapulohumeral Muscular DystrophyFSHDnonsense mutationsOur lab studies how cells detect and degrade aberrant RNAs, and how dysregulation of this surveillance process contributes to human muscle development and disease.
More information about our work can be found on our lab website: www.jagannathan-lab.orgAsst Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonJulieHainesJulie Reisz Haines39.74528180000000-104.8375727000000010137Haines, JulieAsst Professor-ResearchLoriSusselLori Gail Sussel39.74404140000000-104.8383945000000011200Sussel, LoriProfessorJohnHardinJohn Wesley Hardin39.74528180000000-104.8375727000000011768Hardin, JohnResearch AssociateAllisonSwainAllison Marly Porman Swain39.74528180000000-104.8375727000000012483Swain, AllisonResearch Instructor5Other Faculty1Professor3Asst Professor2Assoc Professor4Instructor7Fellow or Post DocNeelanjanMukherjeeNeelanjan Mukherjee39.74528180000000-104.8375727000000013119Mukherjee, NeelanjanAsst ProfessorJohnRinnJohn Rinn40.00830860000000-105.2490672000000013280Rinn, JohnProfessorOliviaRisslandOlivia S Rissland39.74528180000000-104.8375727000000013304Rissland, OliviaAssociate Professor13001 East 17th Place2SOMSchool of Medicine13001 East 17th PlaceAurora80045-2570CO5.387770.00614741151research areas0.7250780.1812699coauthor of25.46344.7103660similar to1125selected publicationsD018398Chemicals & Drugs1904840.743739Homeodomain ProteinsD020391Disorders7160.966999Muscular Dystrophy, FacioscapulohumeralD059365Physiology690.982635Nonsense Mediated mRNA DecaySOM-BDC Basic ResearchD018389Chemicals & DrugsPhysiology31380.970081Codon, NonsenseD012270Anatomy541420.906715RibosomesBiology-MCD InstructionBiochemistrySOM-BioChem&Molecular GeneticsUniversity of Colorado BoulderUniversity of Colorado Denver - Anschutz Medical CampusJeffreyKieftJeffrey Scott Kieft39.74389450000000-104.839435200000001812Kieft, JeffreyProfessor AdjointJayHesselberthJay R. Hesselberth39.74389450000000-104.839435200000003529Hesselberth, JayProfessorMarvinCaruthersMarvin H Caruthers40.00830860000000-105.24906720000000824Caruthers, MarvinDistinguished ProfessorThomasCechThomas R Cech40.00830860000000-105.24906720000000807Cech, ThomasDistinguished ProfessorGiaVoeltzGia Kaarina Voeltz40.00825400000000-105.268079500000002557Voeltz, GiaProfessorAuthorship 2051871Authorship 205351431359616Dyle MC, Kolakada D, Cortazar MA, Jagannathan SWiley interdisciplinary reviews. RNADyle MC, Kolakada D, Cortazar MA, Jagannathan S. How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay. Wiley Interdiscip Rev RNA. 2020 01; 11(1):e1560.Wiley Interdiscip Rev RNA2019-07-29T00:00:002019How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay.31398334Jagannathan S, Ramachandran S, Rissland OSCellJagannathan S, Ramachandran S, Rissland OS. Slow Down to Catch Up. Cell. 2019 08 08; 178(4):774-776.Cell2019-08-08T00:00:002019Slow Down to Catch Up.Principal InvestigatorAuthorship 2149891Authorship 2149903Authorship 2149911Authorship 2149922Authorship 2149935Authorship 2149941Authorship 2149951Authorship 2149963Authorship 2149971Authorship 2149981Authorship 2149995Authorship 2150002Authorship 21500112024-07-31NIHJAGANNATHAN, SUJATHA2019-08-01Understanding the variability in nonsense-mediated RNA decayR35GM13343328273136Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJPLoS geneticsShadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017 03; 13(3):e1006658.PLoS Genet2017-03-08T00:00:002017DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.25063809Jagannathan S, Hsu JC, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CVThe Journal of biological chemistryJagannathan S, Hsu JC, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CV. Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. J Biol Chem. 2014 Sep 12; 289(37):25907-24.J Biol Chem2014-07-25T00:00:002014Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum.23251665Lacsina JR, Marks OA, Liu X, Reid DW, Jagannathan S, Nicchitta CVPloS oneLacsina JR, Marks OA, Liu X, Reid DW, Jagannathan S, Nicchitta CV. Premature translational termination products are rapidly degraded substrates for MHC class I presentation. PLoS One. 2012; 7(12):e51968.PLoS One2012-12-14T00:00:002012Premature translational termination products are rapidly degraded substrates for MHC class I presentation.21431749Jagannathan S, Nwosu C, Nicchitta CVMethods in molecular biology (Clifton, N.J.)Jagannathan S, Nwosu C, Nicchitta CV. Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. Methods Mol Biol. 2011; 714:301-21.Methods Mol Biol2011-01-01T00:00:002011Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation.30644821Jagannathan S, Ogata Y, Gafken PR, Tapscott SJ, Bradley RKeLifeJagannathan S, Ogata Y, Gafken PR, Tapscott SJ, Bradley RK. Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy. Elife. 2019 01 15; 8.Elife2019-01-15T00:00:002019Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy.27646533Jagannathan S, Bradley RKGenome researchJagannathan S, Bradley RK. Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population. Genome Res. 2016 12; 26(12):1639-1650.Genome Res2016-09-19T00:00:002016Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population.25564732Feng Q, Snider L, Jagannathan S, Tawil R, van der Maarel SM, Tapscott SJ, Bradley RKeLifeFeng Q, Snider L, Jagannathan S, Tawil R, van der Maarel SM, Tapscott SJ, Bradley RK. A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy. Elife. 2015 Jan 07; 4.Elife2015-01-07T00:00:002015A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy.21613539Chen Q, Jagannathan S, Reid DW, Zheng T, Nicchitta CVMolecular biology of the cellChen Q, Jagannathan S, Reid DW, Zheng T, Nicchitta CV. Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Mol Biol Cell. 2011 Jul 15; 22(14):2646-58.Mol Biol Cell2011-05-25T00:00:002011Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells.29533181Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJeLifeCampbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Elife. 2018 03 13; 7.Elife2018-03-13T00:00:002018NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.28717044Jagannathan S, Bradley RKGenes & developmentJagannathan S, Bradley RK. Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum. Genes Dev. 2017 06 01; 31(11):1067-1068.Genes Dev2017-06-01T00:00:002017Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum.28669802Feng Q, Jagannathan S, Bradley RKMolecular cellFeng Q, Jagannathan S, Bradley RK. The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3?Ubiquitin Ligase Activity. Mol Cell. 2017 Jul 20; 67(2):239-251.e6.Mol Cell2017-06-29T00:00:002017The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3?Ubiquitin Ligase Activity.28171552Jagannathan S, Shadle SC, Resnick R, Snider L, Tawil RN, van der Maarel SM, Bradley RK, Tapscott SJHuman molecular geneticsJagannathan S, Shadle SC, Resnick R, Snider L, Tawil RN, van der Maarel SM, Bradley RK, Tapscott SJ. Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells. Hum Mol Genet. 2016 10 15; 25(20):4419-4431.Hum Mol Genet2016-10-15T00:00:002016Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.25142066Jagannathan S, Reid DW, Cox AH, Nicchitta CVRNA (New York, N.Y.)Jagannathan S, Reid DW, Cox AH, Nicchitta CV. De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. RNA. 2014 Oct; 20(10):1489-98.RNA2014-08-20T00:00:002014De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum.05/2013Duke UniversityDurham, NC, USADuke University, Cell BiologyPh. D. Cell Biology12/2017Fred Hutchinson Cancer Research CenterSeattle, WA, USAFred Hutchinson Cancer Research Center, mRNA surveillancePostdoctoral fellowshipmRNA surveillance05/2006Center for Biotechnology, Anna UniversityChennai, IndiaCenter for Biotechnology, Anna University, Industrial BiotechnologyB. TechIndustrial BiotechnologyAuthorship 243836434244458Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CVRNA (New York, N.Y.)Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CV. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021 10; 27(10):1241-1256.RNA2021-07-08T00:00:002021Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules.MarcinSajekMarcin P Sajek19700Sajek, MarcinPost-Doctoral FellowAuthorship 256032135039091Jagannathan S, de Greef JC, Hayward LJ, Yokomori K, Gabellini D, Mul K, Sacconi S, Arjomand J, Kinoshita J, Harper SQSkeletal muscleJagannathan S, de Greef JC, Hayward LJ, Yokomori K, Gabellini D, Mul K, Sacconi S, Arjomand J, Kinoshita J, Harper SQ. Meeting report: the 2021 FSHD International Research Congress. Skelet Muscle. 2022 01 17; 12(1):1.Skelet Muscle2022-01-17T00:00:002022Meeting report: the 2021 FSHD International Research Congress.Authorship 257132135158020Jagannathan SBiochimica et biophysica acta. Molecular basis of diseaseJagannathan S. The evolution of DUX4 gene regulation and its implication for facioscapulohumeral muscular dystrophy. Biochim Biophys Acta Mol Basis Dis. 2022 05 01; 1868(5):166367.Biochim Biophys Acta Mol Basis Dis2022-02-11T00:00:002022The evolution of DUX4 gene regulation and its implication for facioscapulohumeral muscular dystrophy.Authorship 281569537024263Sherlock ME, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan SRNA (New York, N.Y.)Sherlock ME, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan S. Principles, mechanisms, and biological implications of translation termination-reinitiation. RNA. 2023 07; 29(7):865-884.RNA2023-04-06T00:00:002023Principles, mechanisms, and biological implications of translation termination-reinitiation.Authorship 282886337145092Mu?oz O, Lore M, Jagannathan SBiochemical Society transactionsMu?oz O, Lore M, Jagannathan S. The long and short of EJC-independent nonsense-mediated RNA decay. Biochem Soc Trans. 2023 06 28; 51(3):1121-1129.Biochem Soc Trans2023-06-28T00:00:002023The long and short of EJC-independent nonsense-mediated RNA decay.Authorship 2833851337314931Campbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cort?zar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, Jagannathan SCell reportsCampbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cort?zar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, Jagannathan S. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Rep. 2023 06 27; 42(6):112642.Cell Rep2023-06-13T00:00:002023Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression.Authorship 291567837747887Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJPLoS biologyHamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJ. The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs. PLoS Biol. 2023 09; 21(9):e3002317.PLoS Biol2023-09-25T00:00:002023The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs.Authorship 294440537899061Campbell AE, Arjomand J, King OD, Tawil R, Jagannathan SJournal of neuromuscular diseasesCampbell AE, Arjomand J, King OD, Tawil R, Jagannathan S. A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. J Neuromuscul Dis. 2023; 10(6):1031-1040.J Neuromuscul Dis2023-01-01T00:00:002023A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics.Authorship 295456638014198Kolakada D, Campbell AE, Baquero Galvis L, Li Z, Lore M, Jagannathan SbioRxiv : the preprint server for biologyKolakada D, Campbell AE, Baquero Galvis L, Li Z, Lore M, Jagannathan S. A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay. bioRxiv. 2023 Nov 15.bioRxiv2023-11-15T00:00:002023A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay.Authorship 2991191238260612Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cort?zar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Jagannathan SbioRxiv : the preprint server for biologyKolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cort?zar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Jagannathan S. Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay. bioRxiv. 2024 Jan 11.bioRxiv2024-01-11T00:00:002024Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay.true1Research InstructorResearch Instructortrue1Post-Doctoral FellowPost-Doctoral Fellowtrue1ProfessorProfessortrue1ProfessorProfessortrue1Asst ProfessorAsst Professortrue1Associate ProfessorAssociate Professortrue1Professor AdjointProfessor Adjointtrue1Asst Professor-ResearchAsst Professor-Researchtrue1ProfessorProfessor2Assoc ChairAssoc Chairtrue1ProfessorProfessortrue1ProfessorProfessortrue1Asst ProfessorAsst Professortrue1Distinguished ProfessorDistinguished Professortrue1Distinguished ProfessorDistinguished Professortrue1Research AssociateResearch AssociateAngeloD'AlessandroAngelo D'Alessandro39.74528180000000-104.837572700000008543D'Alessandro, AngeloProfessor