Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise.
Van Guilder GP, Westby CM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension. 2007 Aug; 50(2):403-9.