Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 ?C: identification of a single active site region with enhanced flexibility in the mesophilic protein.
Oyeyemi OA, Sours KM, Lee T, Kohen A, Resing KA, Ahn NG, Klinman JP. Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 ?C: identification of a single active site region with enhanced flexibility in the mesophilic protein. Biochemistry. 2011 Sep 27; 50(38):8251-60.