KaraMouldKara Mould39.74515960000000-104.8406280000000012992Mould, KaraAffiliate - NJHprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonElizabethKovacsElizabeth J Kovacs39.74403280000000-104.8408104000000011212Kovacs, Elizabeth0000-0002-9459=9928ProfessorAlexandraMccubbreyAlexandra Leigh Mccubbrey39.74528180000000-104.8375727000000011566Mccubbrey, AlexandraAffiliate - NJH27190063McCubbrey AL, Barthel L, Mould KJ, Mohning MP, Redente EF, Janssen WJAmerican journal of physiology. Lung cellular and molecular physiologyMcCubbrey AL, Barthel L, Mould KJ, Mohning MP, Redente EF, Janssen WJ. Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems. Am J Physiol Lung Cell Mol Physiol. 2016 07 01; 311(1):L87-L100.Am J Physiol Lung Cell Mol Physiol2016-05-17T00:00:002016Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems.5Other Faculty1Professor4Instructor28421818Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJAmerican journal of respiratory cell and molecular biologyMould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ. Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 09; 57(3):294-306.Am J Respir Cell Mol Biol2017-09-01T00:00:002017Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.12700 East 19th Avenue12700 East 19th AvenueAurora80045-2560CO1.572760.0133118131research areas4.863520.041734529coauthor of28.72274.071160similar to1121selected publicationsAuthorship 1658073Authorship 166270423748533Fan X, Staitieh BS, Jensen JS, Mould KJ, Greenberg JA, Joshi PC, Koval M, Guidot DMAmerican journal of physiology. Lung cellular and molecular physiologyFan X, Staitieh BS, Jensen JS, Mould KJ, Greenberg JA, Joshi PC, Koval M, Guidot DM. Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 01; 305(3):L267-77.Am J Physiol Lung Cell Mol Physiol2013-06-07T00:00:002013Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.Authorship 1684861Authorship 169961428935638Mohning MP, Thomas SM, Barthel L, Mould KJ, McCubbrey AL, Frasch SC, Bratton DL, Henson PM, Janssen WJAmerican journal of physiology. Lung cellular and molecular physiologyMohning MP, Thomas SM, Barthel L, Mould KJ, McCubbrey AL, Frasch SC, Bratton DL, Henson PM, Janssen WJ. Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK. Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L69-L82.Am J Physiol Lung Cell Mol Physiol2017-09-21T00:00:002017Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK.Authorship 174312528850249McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJAmerican journal of respiratory cell and molecular biologyMcCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ. Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis. Am J Respir Cell Mol Biol. 2018 01; 58(1):66-78.Am J Respir Cell Mol Biol2018-01-01T00:00:002018Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.Authorship 1814611029855321Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache IRespiratory researchNi K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I. Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res. 2018 05 31; 19(1):107.Respir Res2018-05-31T00:00:002018Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.D017423Procedures2514200.810233Sequence Analysis, RNAAuthorship 183569129957050Mould KJ, Janssen WJAmerican journal of respiratory cell and molecular biologyMould KJ, Janssen WJ. Recombinant IFN-? for Postseptic Acute Lung Injury-What's the Mechanism? Am J Respir Cell Mol Biol. 2018 07; 59(1):1-2.Am J Respir Cell Mol Biol2018-07-01T00:00:002018Recombinant IFN-? for Postseptic Acute Lung Injury-What's the Mechanism?D011014Disorders2646050.650761PneumoniaD016676Anatomy1283640.77365Macrophages, AlveolarD008264Anatomy41913340.588931MacrophagesAuthorship 189565730296525Madenspacher JH, Stapleton RD, Suratt BT, Dixon AE, Lih FB, Lowe JM, Mould KJ, Janssen WJ, Morrell ED, Wurfel MM, Garantziotis S, Tomer KB, Fessler MBThe Journal of allergy and clinical immunologyMadenspacher JH, Stapleton RD, Suratt BT, Dixon AE, Lih FB, Lowe JM, Mould KJ, Janssen WJ, Morrell ED, Wurfel MM, Garantziotis S, Tomer KB, Fessler MB. Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome. J Allergy Clin Immunol. 2019 01; 143(1):440-442.e8.J Allergy Clin Immunol2018-10-05T00:00:002018Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.2024-03-31NIHMOULD, KARA J2018-04-09Metabolic Reprogramming of Recruited Alveolar Macrophages by Arginine In Acute Lung InjuryK08HL1416482017-06-30NIHMOULD, KARA J2016-07-01Metabolic Programming of Alveolar Macrophages During Lung RepairF32HL131397Principal InvestigatorPrincipal InvestigatorAuthorship 195544130721157Mould KJ, Jackson ND, Henson PM, Seibold M, Janssen WJJCI insightMould KJ, Jackson ND, Henson PM, Seibold M, Janssen WJ. Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets. JCI Insight. 2019 03 07; 4(5).JCI Insight2019-03-07T00:00:002019Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets.D055371Disorders1203130.752005Acute Lung InjurySOM-IMM MICRO GENERAL OPERPUL GENERAL OPERATIONSSOM-MEDSOM-PEDSSOM-SRGGeneral OperationsGI ClinicalInfectious DiseaseUniversity of Colorado Denver - Anschutz Medical CampusRubinTuderRubin M Tuder39.74515960000000-104.840628000000001369Tuder, RubinProfessorRaulTorresRaul Martin Torres39.74545800000000-104.839369100000001539Torres, RaulProfessorCharlesDinarelloCharles A Dinarello39.74528180000000-104.8375727000000023Dinarello, CharlesDistinguished ProfessorPeterHensonPeter M. Henson39.74545800000000-104.839369100000002612Henson, PeterDistinguished ProfessorDavidSchwartzDavid A Schwartz39.74528180000000-104.837572700000003457Schwartz, DavidDistinguished ProfessorDonnaBrattonDonna L Bratton39.74403510000000-104.836059400000004874Bratton, DonnaAffiliate - NJHAliMusaniAli Musani39.74515960000000-104.840628000000004984Musani, AliProfessorKennethMalcolmKenneth Malcolm39.74515960000000-104.840628000000005046Malcolm, KennethAffiliate - NJHWilliamJanssenWilliam J Janssen39.74528180000000-104.837572700000004503Janssen, WilliamProfessorKennethLyn-KewKenneth E. Lyn-Kew39.74515960000000-104.840628000000005001Lyn-Kew, KennethAffiliate - NJHAuthorship 212548431810980Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FF, Hedin BR, D'Alessandro A, Leach SM, Alper SG3 (Bethesda, Md.)Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FF, Hedin BR, D'Alessandro A, Leach SM, Alper S. Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages. G3 (Bethesda). 2020 02 06; 10(2):555-567.G3 (Bethesda)2020-02-06T00:00:002020Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages.Authorship 229139133079572Mould KJ, Moore CM, McManus SA, McCubbrey AL, McClendon JD, Griesmer CL, Henson PM, Janssen WJAmerican journal of respiratory and critical care medicineMould KJ, Moore CM, McManus SA, McCubbrey AL, McClendon JD, Griesmer CL, Henson PM, Janssen WJ. Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults. Am J Respir Crit Care Med. 2021 04 15; 203(8):946-956.Am J Respir Crit Care Med2021-04-15T00:00:002021Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults.Authorship 23392312Authorship 2356171Authorship 235888333405409Douglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier ACritical care medicineDouglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier A. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med. 2021 03 01; 49(3):490-502.Crit Care Med2021-03-01T00:00:002021Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure.33602861Liao SY, Atif SM, Mould K, Konigsberg IR, Fu R, Davidson E, Li L, Fontenot AP, Maier LA, Yang IVThe European respiratory journalLiao SY, Atif SM, Mould K, Konigsberg IR, Fu R, Davidson E, Li L, Fontenot AP, Maier LA, Yang IV. Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases. Eur Respir J. 2021 06; 57(6).Eur Respir J2021-06-17T00:00:002021Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases.33558748Mould KJ, Janssen WJNatureMould KJ, Janssen WJ. Signs of self-sustained inflammatory circuits in severe COVID pneumonia. Nature. 2021 02; 590(7847):553-554.Nature2021-02-01T00:00:002021Signs of self-sustained inflammatory circuits in severe COVID pneumonia.Authorship 251303834699591Gibbings SL, Haist KC, Nick H, Frasch SC, Glass TH, Vestal B, Danhorn T, Mould KJ, Henson PM, Bratton DLBloodGibbings SL, Haist KC, Nick H, Frasch SC, Glass TH, Vestal B, Danhorn T, Mould KJ, Henson PM, Bratton DL. Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease. Blood. 2022 03 17; 139(11):1707-1721.Blood2022-03-17T00:00:002022Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease.Authorship 253626634871770Bouchard BA, Colovos C, Lawson MA, Osborn ZT, Sackheim AM, Mould KJ, Janssen WJ, Cohen MJ, Majumdar D, Freeman KVascular pharmacologyBouchard BA, Colovos C, Lawson MA, Osborn ZT, Sackheim AM, Mould KJ, Janssen WJ, Cohen MJ, Majumdar D, Freeman K. Increased histone-DNA complexes and endothelial-dependent thrombin generation in severe COVID-19. Vascul Pharmacol. 2022 02; 142:106950.Vascul Pharmacol2021-12-03T00:00:002021Increased histone-DNA complexes and endothelial-dependent thrombin generation in severe COVID-19.Authorship 255693835021097McCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJCell reportsMcCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJ. Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells. Cell Rep. 2022 01 11; 38(2):110222.Cell Rep2022-01-11T00:00:002022Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells.Authorship 259172935420627Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RMThe Journal of experimental medicineCastleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 06 06; 219(6).J Exp Med2022-04-14T00:00:002022SARS-CoV-2 infection relaxes peripheral B cell tolerance.36131937Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RMFrontiers in immunologyCastleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022; 13:988125.Front Immunol2022-09-05T00:00:002022Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells.Authorship 2711959Authorship 277739636852927Moore PK, Anderson KC, McManus SA, Tu TH, King EM, Mould KJ, Redente EF, Henson PM, Janssen WJ, McCubbrey ALAmerican journal of physiology. Lung cellular and molecular physiologyMoore PK, Anderson KC, McManus SA, Tu TH, King EM, Mould KJ, Redente EF, Henson PM, Janssen WJ, McCubbrey AL. Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2023 04 01; 324(4):L536-L549.Am J Physiol Lung Cell Mol Physiol2023-02-28T00:00:002023Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation.true1Distinguished ProfessorDistinguished Professortrue1Affiliate - NJHAffiliate - NJHtrue1ProfessorProfessorAuthorship 288480637638016Castleman MJ, Santos AL, Lesteberg KE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RMFrontiers in immunologyCastleman MJ, Santos AL, Lesteberg KE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection. Front Immunol. 2023; 14:1213344.Front Immunol2023-08-10T00:00:002023Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection.true1ProfessorProfessortrue1Affiliate - NJHAffiliate - NJHtrue1ProfessorProfessortrue1InstructorInstructortrue1Affiliate - NJHAffiliate - NJHtrue1Affiliate - NJHAffiliate - NJHtrue1Affiliate - NJHAffiliate - NJHtrue1Distinguished ProfessorDistinguished Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Distinguished ProfessorDistinguished ProfessorNicholasVuongNicholas Huu Vuong39.74515960000000-104.840628000000009432Vuong, NicholasInstructor