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Kambez Benam

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Overview 
    Collapse overview
    Our lab applies a multidisciplinary approach to design and develop bio-inspired technologies that enable us to elucidate cellular and molecular mechanisms that govern tissue pathology or offer protection during lung injury. Our research lies at the intersection of respiratory medicine, immuno-microbiology, tissue engineering, and systems and synthetic biology. Ultimately, our goal is to discover novel druggable targets and personalized diagnostics using microengineered systems that recreate complex human organ pathophysiology in vitro.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vo Q, Benam KH. Advancements in preclinical human-relevant modeling of pulmonary vasculature on-chip. Eur J Pharm Sci. 2024 Apr 01; 195:106709. PMID: 38246431.
      View in: PubMed
    2. Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L. Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Ann Am Thorac Soc. 2024 Jan; 21(1):1-11. PMID: 37903340.
      View in: PubMed
    3. Thomas SN, Niemeyer BF, Jimenez-Valdes RJ, Kaiser AJ, Espinosa JM, Sullivan KD, Goodspeed A, Costello JC, Alder JK, Ca?as-Arranz R, Garc?a-Sastre A, Benam KH. Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection. iScience. 2023 Aug 18; 26(8):107361. PMID: 37554445.
      View in: PubMed
    4. Chandra D, Bogdanoff RF, Bowler RP, Benam KH. Electronic cigarette menthol flavoring is associated with increased inhaled micro and sub-micron particles and worse lung function in combustion cigarette smokers. Respir Res. 2023 Apr 11; 24(1):108. PMID: 37038183.
      View in: PubMed
    5. Bogdanoff RF, Kaiser AJ, Benam KH. Protocol for the operation of a breathing and vaping biomimetic robot to delineate real-time inhaled particle profile of electronic cigarettes. STAR Protoc. 2022 12 16; 3(4):101885. PMID: 36595946.
      View in: PubMed
    6. Clifton C, Niemeyer BF, Novak R, Can UI, Hainline K, Benam KH. BPIFA1 is a secreted biomarker of differentiating human airway epithelium. Front Cell Infect Microbiol. 2022; 12:1035566. PMID: 36519134.
      View in: PubMed
    7. Benam KH, Burgess JK, Stewart AG. Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models. Front Pharmacol. 2021; 12:827172. PMID: 35046832.
      View in: PubMed
    8. Niemeyer BF, Benam KH. Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2. Pharmacol Ther. 2022 05; 233:108027. PMID: 34718070.
      View in: PubMed
    9. Kaiser AJ, Salem C, Alvarenga BJ, Pagliaro A, Smith KP, Valerio LG, Benam KH. A robotic system for real-time analysis of inhaled submicron and microparticles. iScience. 2021 Oct 22; 24(10):103091. PMID: 34755082.
      View in: PubMed
    10. Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia. Nano Sel. 2022 Feb; 3(2):437-449. PMID: 34541574.
      View in: PubMed
    11. Si L, Bai H, Rodas M, Cao W, Oh CY, Jiang A, Moller R, Hoagland D, Oishi K, Horiuchi S, Uhl S, Blanco-Melo D, Albrecht RA, Liu WC, Jordan T, Nilsson-Payant BE, Golynker I, Frere J, Logue J, Haupt R, McGrath M, Weston S, Zhang T, Plebani R, Soong M, Nurani A, Kim SM, Zhu DY, Benam KH, Goyal G, Gilpin SE, Prantil-Baun R, Gygi SP, Powers RK, Carlson KE, Frieman M, tenOever BR, Ingber DE. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nat Biomed Eng. 2021 08; 5(8):815-829. PMID: 33941899.
      View in: PubMed
    12. Jimenez-Valdes RJ, Can UI, Niemeyer BF, Benam KH. Where We Stand: Lung Organotypic Living Systems That Emulate Human-Relevant Host-Environment/Pathogen Interactions. Front Bioeng Biotechnol. 2020; 8:989. PMID: 32903497.
      View in: PubMed
    13. Benam KH, Novak R, Ferrante TC, Choe Y, Ingber DE. Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips. Nat Protoc. 2020 02; 15(2):183-206. PMID: 31925401.
      View in: PubMed
    14. Benam KH, Gilchrist S, Kleensang A, Satz AB, Willett C, Zhang Q. Exploring new technologies in biomedical research. Drug Discov Today. 2019 06; 24(6):1242-1247. PMID: 30953865.
      View in: PubMed
    15. Benam KH, Denney L, Ho LP. How the Respiratory Epithelium Senses and Reacts to Influenza Virus. Am J Respir Cell Mol Biol. 2019 03; 60(3):259-268. PMID: 30372120.
      View in: PubMed
    16. Benam KH, Vladar EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. Ann Am Thorac Soc. 2018 11; 15(Suppl 3):S210-S215. PMID: 30431350.
      View in: PubMed
    17. Kambez H. Benam. Disrupting Experimental Strategies for Inhalation Toxicology: The Emergence of Microengineered Breathing-Smoking Human Lung-on-a-Chip. 2018; 4(2).
      View Publication
    18. Benam KH, K?nigshoff M, Eickelberg O. Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond. Am J Respir Crit Care Med. 2018 04 01; 197(7):869-875. PMID: 29262260.
      View in: PubMed
    19. Niemeyer BF, Zhao P, Tuder RM, Benam KH. Advanced Microengineered Lung Models for Translational Drug Discovery. SLAS Discov. 2018 09; 23(8):777-789. PMID: 29447055.
      View in: PubMed
    20. Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP. M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI Insight. 2017 Apr 06; 2(7). PMID: 28406797.
      View in: PubMed
    21. Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP. M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI Insight. 2017 04 06; 2(7):e91868. PMID: 28405622.
      View in: PubMed
    22. Benam KH, Mazur M, Choe Y, Ferrante TC, Novak R, Ingber DE. Human Lung Small Airway-on-a-Chip Protocol. Methods Mol Biol. 2017; 1612:345-365. PMID: 28634955.
      View in: PubMed
    23. Benam KH, Ingber DE. Commendation for Exposing Key Advantage of Organ Chip Approach. Cell Syst. 2016 11 23; 3(5):411. PMID: 27883885.
      View in: PubMed
    24. Benam KH, Novak R, Nawroth J, Hirano-Kobayashi M, Ferrante TC, Choe Y, Prantil-Baun R, Weaver JC, Bahinski A, Parker KK, Ingber DE. Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Syst. 2016 11 23; 3(5):456-466.e4. PMID: 27894999.
      View in: PubMed
    25. Benam KH, Villenave R, Lucchesi C, Varone A, Hubeau C, Lee HH, Alves SE, Salmon M, Ferrante TC, Weaver JC, Bahinski A, Hamilton GA, Ingber DE. Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nat Methods. 2016 Feb; 13(2):151-7. PMID: 26689262.
      View in: PubMed
    26. Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, Musah S, Torisawa YS, van der Meer AD, Villenave R, Yadid M, Parker KK, Ingber DE. Engineered in vitro disease models. Annu Rev Pathol. 2015; 10:195-262. PMID: 25621660.
      View in: PubMed
    27. Cole SL, Benam KH, McMichael AJ, Ho LP. Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells. J Immunol. 2014 Apr 15; 192(8):3898-907. PMID: 24639347.
      View in: PubMed
    28. Kok WL, Denney L, Benam K, Cole S, Clelland C, McMichael AJ, Ho LP. Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. J Leukoc Biol. 2012 Mar; 91(3):357-68. PMID: 22003207.
      View in: PubMed
    29. Benam KH, Kok WL, McMichael AJ, Ho LP. Alternative spliced CD1d transcripts in human bronchial epithelial cells. PLoS One. 2011; 6(8):e22726. PMID: 21853044.
      View in: PubMed
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