Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Control of Chemokine Production by Memory T Cells


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Collapse Overview 
Collapse abstract
Memory T cells contain large amounts of mRNA for certain chemokines, including RANTES, MIP-1alpha and MIP-1beta. This mRNA is not translated, however, unless the cells are stimulated via their T cell receptors. Experiments will be performed to find out what portion of the chemokine mRNAs is involved in the silencing and which signaling pathways induced by T cell receptor engagement release the mRNAs from translational inhibition.

Memory T cells may use these stores of preformed chemokine mRNA for very rapid responses to antigen. A protocol will be established to find out whether this is so, in animals.
Collapse sponsor award id
R01AI052225

Collapse Time 
Collapse start date
2002-08-01
Collapse end date
2008-07-31

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