 Connection
Derek Bolhuis to Humans
This is a "connection" page, showing publications Derek Bolhuis has written about Humans.
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Connection Strength |
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0.101 |
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Bolhuis DL, Fleifel D, Bonacci T, Wang X, Mouery BL, Cook JG, Brown NG, Emanuele MJ. USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination. Nat Commun. 2025 May 16; 16(1):4575.
Score: 0.022
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Bolhuis DL, Emanuele MJ, Brown NG. Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. Biochem Soc Trans. 2024 02 28; 52(1):241-267.
Score: 0.020
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Yang D, Wang X, Liu J, Gong Y, Nair P, Sun J, Qian X, Cui J, Zeng H, Dong A, Harding RJ, Burgess-Brown N, Beyett TS, Song D, Krause HM, Diamond ML, Bolhuis DL, Brown NG, Arrowsmith CH, Edwards AM, Halabelian L, Peng H. High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds. Proc Natl Acad Sci U S A. 2026 Jun 23; 123(25):e2515940123.
Score: 0.006
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Bukhari Z, Gu L, Nederstigt AE, Cope LJ, Bolhuis DL, Harvey K, Allen T, Hill S, Yang Y, Lawson G, Lu C, Tran T, Pineda L, Low L, Chiang A, Song J, Fong MV, Rangel VM, Chan WK, Kleiger G, Goldfarb D, Vierra CA, Brown NG, Harrison JS. Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response. Cell Chem Biol. 2025 Dec 18; 32(12):1532-1544.e7.
Score: 0.006
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Paul D, Bolhuis DL, Yan H, Das S, Xu X, Abbate CC, Jenkins LMM, Emanuele MJ, Andresson T, Huang J, Albeck JG, Brown NG, Cappell SD. Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry. Nature. 2025 10; 646(8083):198-207.
Score: 0.006
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Bonacci T, Bolhuis DL, Brown NG, Emanuele MJ. Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison. J Biol Chem. 2025 07; 301(7):110288.
Score: 0.006
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Mouery RD, Lukasik K, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Gupton SL, Emanuele MJ. Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton. Cell Rep. 2024 08 27; 43(8):114510.
Score: 0.005
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Ledvin L, Gassaway BM, Tawil J, Urso O, Pizzo D, Welsh KA, Bolhuis DL, Fisher D, Bonni A, Gygi SP, Brown NG, Ferguson CJ. The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment. Dev Cell. 2023 12 04; 58(23):2666-2683.e9.
Score: 0.005
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Bodrug T, Welsh KA, Bolhuis DL, Paul?konis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat Struct Mol Biol. 2023 11; 30(11):1663-1674.
Score: 0.005
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Hodáková Z, Grishkovskaya I, Brunner HL, Bolhuis DL, Belacic K, Schleiffer A, Kotisch H, Brown NG, Haselbach D. Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5. EMBO J. 2023 08 15; 42(16):e113348.
Score: 0.005
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Welsh KA, Bolhuis DL, Nederstigt AE, Boyer J, Temple BRS, Bonacci T, Gu L, Ordureau A, Harper JW, Steimel JP, Zhang Q, Emanuele MJ, Harrison JS, Brown NG. Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes. EMBO J. 2022 02 01; 41(3):e108823.
Score: 0.004
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Franks JL, Martinez-Chacin RC, Wang X, Tiedemann RL, Bonacci T, Choudhury R, Bolhuis DL, Enrico TP, Mouery RD, Damrauer JS, Yan F, Harrison JS, Major MB, Hoadley KA, Suzuki A, Rothbart SB, Brown NG, Emanuele MJ. In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. PLoS Biol. 2020 12; 18(12):e3000975.
Score: 0.004
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Martinez-Chacin RC, Bodrug T, Bolhuis DL, Kedziora KM, Bonacci T, Ordureau A, Gibbs ME, Weissmann F, Qiao R, Grant GD, Cook JG, Peters JM, Wade Harper J, Emanuele MJ, Brown NG. Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nat Struct Mol Biol. 2020 06; 27(6):550-560.
Score: 0.004
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Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17280-17289.
Score: 0.004
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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