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Connection

Slobodan Todorovic to Calcium Channels, T-Type

This is a "connection" page, showing publications Slobodan Todorovic has written about Calcium Channels, T-Type.

 
Connection Strength
  
 
 
20.180
  
  1. Timic Stamenic T, Feseha S, Fine-Raquet B, Tadic VP, Todorovic SM. In vivo silencing of the thalamic CaV3.1 voltage-gated calcium channels demonstrates their region-specific role in anesthetic mediated hypnosis. Exp Biol Med (Maywood). 2025; 250:10553.
    View in: PubMed
    Score: 0.788
  2. Timic Stamenic T, Joksimovic SM, Fine-Raquet B, Tadic VP, Tesic V, Jevtovic-Todorovic V, Todorovic SM. Role of Thalamic CaV3.1 T-Channels in Fear Conditioning. Int J Mol Sci. 2025 Apr 09; 26(8).
    View in: PubMed
    Score: 0.782
  3. Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM. CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. 2023 03 15; 226:109400.
    View in: PubMed
    Score: 0.668
  4. Todorovic SM. Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets? J Clin Invest. 2022 12 15; 132(24).
    View in: PubMed
    Score: 0.666
  5. Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 02; 130(2):154-164.
    View in: PubMed
    Score: 0.663
  6. Timic Stamenic T, Todorovic SM. Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics. Int J Mol Sci. 2022 Feb 21; 23(4).
    View in: PubMed
    Score: 0.630
  7. Coulter I, Timic Stamenic T, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM. Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. Neuropharmacology. 2021 10 01; 197:108739.
    View in: PubMed
    Score: 0.606
  8. Feseha S, Timic Stamenic T, Wallace D, Tamag C, Yang L, Pan JQ, Todorovic SM. Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers. Sci Rep. 2020 12 09; 10(1):21510.
    View in: PubMed
    Score: 0.579
  9. Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2021 01; 126(1):245-255.
    View in: PubMed
    Score: 0.568
  10. Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2020 04; 177(8):1735-1753.
    View in: PubMed
    Score: 0.545
  11. Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM. Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. Cereb Cortex. 2019 12 17; 29(11):4679-4696.
    View in: PubMed
    Score: 0.541
  12. Joksimovic SL, Donald RR, Park JY, Todorovic SM. Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision. Channels (Austin). 2019 12; 13(1):48-61.
    View in: PubMed
    Score: 0.540
  13. Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth. 2019 May; 122(5):643-651.
    View in: PubMed
    Score: 0.512
  14. Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 08 28; 11(545).
    View in: PubMed
    Score: 0.495
  15. Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 06; 135:343-354.
    View in: PubMed
    Score: 0.480
  16. Stamenic TT, Todorovic SM. Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus. eNeuro. 2018 Jan-Feb; 5(1).
    View in: PubMed
    Score: 0.477
  17. Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol. 2017 10 01; 595(19):6327-6348.
    View in: PubMed
    Score: 0.461
  18. Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014 Sep; 231(17):3503-3515.
    View in: PubMed
    Score: 0.367
  19. Todorovic SM, Jevtovic-Todorovic V. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch. 2014 Apr; 466(4):701-6.
    View in: PubMed
    Score: 0.360
  20. Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM. Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience. 2013 Oct 10; 250:263-74.
    View in: PubMed
    Score: 0.347
  21. Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 2013 Nov; 62(11):3828-38.
    View in: PubMed
    Score: 0.346
  22. Lee J, Nelson MT, Rose KE, Todorovic SM. Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels. Mol Neurobiol. 2013 Oct; 48(2):274-80.
    View in: PubMed
    Score: 0.346
  23. Todorovic SM, Jevtovic-Todorovic V. Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. Pflugers Arch. 2013 Jul; 465(7):921-7.
    View in: PubMed
    Score: 0.335
  24. Jacus MO, Uebele VN, Renger JJ, Todorovic SM. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci. 2012 Jul 04; 32(27):9374-82.
    View in: PubMed
    Score: 0.323
  25. Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug; 63(2):266-73.
    View in: PubMed
    Score: 0.317
  26. Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011 Nov; 80(5):900-10.
    View in: PubMed
    Score: 0.303
  27. Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol. 2011 Jun; 163(3):484-95.
    View in: PubMed
    Score: 0.299
  28. Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio MR, Nelson MT, Todorovic SM. Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol. 2011 Jan 01; 589(Pt 1):135-48.
    View in: PubMed
    Score: 0.288
  29. Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010 Jul-Aug; 59(1-2):58-69.
    View in: PubMed
    Score: 0.276
  30. Joksovic PM, Choe WJ, Nelson MT, Orestes P, Brimelow BC, Todorovic SM. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan; 77(1):87-94.
    View in: PubMed
    Score: 0.268
  31. Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM. Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci. 2009 Jul 29; 29(30):9500-9.
    View in: PubMed
    Score: 0.264
  32. Orestes P, Bojadzic D, Chow RM, Todorovic SM. Mechanisms and functional significance of inhibition of neuronal T-type calcium channels by isoflurane. Mol Pharmacol. 2009 Mar; 75(3):542-54.
    View in: PubMed
    Score: 0.252
  33. Jagodic MM, Pathirathna S, Joksovic PM, Lee W, Nelson MT, Naik AK, Su P, Jevtovic-Todorovic V, Todorovic SM. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol. 2008 Jun; 99(6):3151-6.
    View in: PubMed
    Score: 0.241
  34. Joksovic PM, Covey DF, Todorovic SM. Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Ann N Y Acad Sci. 2007 Dec; 1122:83-94.
    View in: PubMed
    Score: 0.235
  35. Nelson MT, Joksovic PM, Su P, Kang HW, Van Deusen A, Baumgart JP, David LS, Snutch TP, Barrett PQ, Lee JH, Zorumski CF, Perez-Reyes E, Todorovic SM. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14; 27(46):12577-83.
    View in: PubMed
    Score: 0.234
  36. Todorovic SM, Jevtovic-Todorovic V. Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin). 2007 Jul-Aug; 1(4):238-45.
    View in: PubMed
    Score: 0.232
  37. Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci. 2007 Aug 01; 27(31):8250-60.
    View in: PubMed
    Score: 0.230
  38. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci. 2007 Mar 21; 27(12):3305-16.
    View in: PubMed
    Score: 0.224
  39. Joksovic PM, Doctor A, Gaston B, Todorovic SM. Functional regulation of T-type calcium channels by s-nitrosothiols in the rat thalamus. J Neurophysiol. 2007 Apr; 97(4):2712-21.
    View in: PubMed
    Score: 0.222
  40. Todorovic SM, Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol Disord Drug Targets. 2006 Dec; 5(6):639-53.
    View in: PubMed
    Score: 0.219
  41. Nelson MT, Todorovic SM. Is there a role for T-type calcium channels in peripheral and central pain sensitization? Mol Neurobiol. 2006 Dec; 34(3):243-8.
    View in: PubMed
    Score: 0.219
  42. Jevtovic-Todorovic V, Todorovic SM. The role of peripheral T-type calcium channels in pain transmission. Cell Calcium. 2006 Aug; 40(2):197-203.
    View in: PubMed
    Score: 0.212
  43. Joksovic PM, Nelson MT, Jevtovic-Todorovic V, Patel MK, Perez-Reyes E, Campbell KP, Chen CC, Todorovic SM. CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol. 2006 Jul 15; 574(Pt 2):415-30.
    View in: PubMed
    Score: 0.210
  44. Nelson MT, Joksovic PM, Perez-Reyes E, Todorovic SM. The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci. 2005 Sep 21; 25(38):8766-75.
    View in: PubMed
    Score: 0.202
  45. Volvovitz B, Miah R, Park K, Kim JH, Vargas R, Xu Y, Qian M, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Novel Neuroactive Steroid Analogs and Voltage-Dependent Blockers of CaV3.2 Currents, B372 and YX23, Are Effective Anti-Nociceptives with Diminished Sedative Properties in Intact Female Mice. Biomolecules. 2025 08 16; 15(8).
    View in: PubMed
    Score: 0.200
  46. Joksovic PM, Bayliss DA, Todorovic SM. Different kinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane. J Physiol. 2005 Jul 01; 566(Pt 1):125-42.
    View in: PubMed
    Score: 0.196
  47. Joksovic PM, Brimelow BC, Murbartián J, Perez-Reyes E, Todorovic SM. Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol. 2005 Jan; 144(1):59-70.
    View in: PubMed
    Score: 0.192
  48. Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol. 2004 Nov; 66(5):1223-35.
    View in: PubMed
    Score: 0.186
  49. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia. Pain. 2004 Jun; 109(3):328-339.
    View in: PubMed
    Score: 0.184
  50. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 2002 Oct 04; 951(2):336-40.
    View in: PubMed
    Score: 0.164
  51. Joksimovic SL, Lamborn N, Jevtovic-Todorovic V, Todorovic SM. Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats. Channels (Austin). 2021 Dec; 15(1):398-407.
    View in: PubMed
    Score: 0.155
  52. Todorovic SM, Jevtovic-Todorovic V, Mennerick S, Perez-Reyes E, Zorumski CF. Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol. 2001 Sep; 60(3):603-10.
    View in: PubMed
    Score: 0.152
  53. Hoffmann T, Kistner K, Joksimovic SLJ, Todorovic SM, Reeh PW, Sauer SK. Painful diabetic neuropathy leads to functional CaV3.2 expression and spontaneous activity in skin nociceptors of mice. Exp Neurol. 2021 12; 346:113838.
    View in: PubMed
    Score: 0.152
  54. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 2001 Jul 19; 31(1):75-85.
    View in: PubMed
    Score: 0.151
  55. Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 12 12; 9(12).
    View in: PubMed
    Score: 0.145
  56. Todorovic SM, Perez-Reyes E, Lingle CJ. Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Mol Pharmacol. 2000 Jul; 58(1):98-108.
    View in: PubMed
    Score: 0.140
  57. Chemin J, Stamenic TT, Cazade M, Llinares J, Blesneac I, Todorovic SM, Lory P. A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels. Sci Rep. 2019 10 30; 9(1):15642.
    View in: PubMed
    Score: 0.134
  58. Todorovic SM. Painful Diabetic Neuropathy: Prevention or Suppression? Int Rev Neurobiol. 2016; 127:211-25.
    View in: PubMed
    Score: 0.105
  59. Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One. 2014; 9(4):e91467.
    View in: PubMed
    Score: 0.091
  60. Todorovic SM, Jevtovic-Todorovic V. Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal. 2014 Aug 20; 21(6):880-91.
    View in: PubMed
    Score: 0.088
  61. Nelson MT, Milescu LS, Todorovic SM, Scroggs RS. A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors. Biophys J. 2010 Jan 20; 98(2):197-206.
    View in: PubMed
    Score: 0.068
  62. Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S178-85.
    View in: PubMed
    Score: 0.067
  63. Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V. In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Pain. 2009 Sep; 145(1-2):184-95.
    View in: PubMed
    Score: 0.066
  64. Nelson MT, Todorovic SM, Perez-Reyes E. The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des. 2006; 12(18):2189-97.
    View in: PubMed
    Score: 0.051
  65. Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 2005 Apr; 114(3):429-443.
    View in: PubMed
    Score: 0.049
  66. Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 04; 120(4):768-778.
    View in: PubMed
    Score: 0.030
  67. Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ. CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Genes Dev. 2015 Jul 15; 29(14):1535-51.
    View in: PubMed
    Score: 0.025
  68. Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 2009 Nov; 58(11):2656-65.
    View in: PubMed
    Score: 0.016
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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