AnastaciaGarciaAnastacia Marie Garcia39.74403510000000-104.8360594000000010697Garcia, AnastaciaMarie0000-0003-2431-2212The overall focus of my current research program is to better understand the unique adaptations governing pathological cardiac remodeling and the progression to heart failure in pediatric patients with complex congenital heart disease (CHD), including hypoplastic left heart syndrome (HLHS) and other single ventricle defects. The ultimate goal of my research is to develop the critical knowledgebase and infrastructure necessary to identify efficacious therapies for improving outcomes in this vulnerable group.
Through our publications we have demonstrated that the heart of patients with single ventricle defects are typified by unique molecular, genetic, and functional changes when compared to the normal heart. By using human cardiac tissue and blood samples in combination with cell and animal models, we have evaluated both the basic biology of complex CHD and interventions that have the potential to address the decline in myocardial function. Currently, a major focus of the lab is to elucidate the molecular mechanisms involved in the modulation of cardiac energy metabolism in single ventricle heart disease. This work will be important for the identification and development of drug therapies that improve cardiac function and enhance transplant-free survival in this population. Additionally, we are actively investigating the use of peripheral blood mononuclear cells (PBMCs) as noninvasive molecular biomarkers in four distinct but complimentary capacities: 1) as a surrogate of the myocardial metabolic environment and presence of HF, 2) as a readout of inflammatory and immune remodeling, 3) for risk stratification and prediction of clinical outcomes, and 4) as a platform to evaluate therapeutic efficacy of novel drug targets to treat complex CHD pathology.Asst Professorprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:descriptiondescriptionDivisionvivo:educationalTrainingeducation and trainingEducational TrainingGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson13065 East 17th Avenue2TCHChildren's Hospital13065 East 17th AvenueAurora80045-2532CO0.9667440.0143147127research areas2.550910.039974817coauthor of20.29514.3209260similar to1122selected publications24861810Padilla PA, Garcia AM, Ladage ML, Toni LSIntegrative and comparative biologyPadilla PA, Garcia AM, Ladage ML, Toni LS. Caenorhabditis elegans: an old genetic model can learn new epigenetic tricks. Integr Comp Biol. 2014 Jul; 54(1):52-60.Integr Comp Biol2014-05-26T00:00:002014Caenorhabditis elegans: an old genetic model can learn new epigenetic tricks.5Other Faculty1Professor3Asst Professor2Assoc ProfessorRoniJacobsenRoni Marie Jacobsen39.74403510000000-104.8360594000000013354Jacobsen, RoniAssociate ProfessorAuthorship 171254329050751Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SDThe Journal of pediatricsNakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 12; 191:82-90.e2.J Pediatr2017-10-16T00:00:002017Fibrosis-Related Gene Expression in Single Ventricle Heart Disease.D013482Chemicals & Drugs1333450.836601Superoxide Dismutase29984193Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CCMethodsXToni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018; 5:599-608.MethodsX2018-05-30T00:00:002018Optimization of phenol-chloroform RNA extraction.30004839Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck EPhysiological genomicsGarcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 09 01; 50(9):807-816.Physiol Genomics2018-07-13T00:00:002018R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways.D017173Living Beings722890.763671Caenorhabditis elegansAuthorship 190101130354365Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SDCirculation. Heart failureGarcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 09; 11(9):e004571.Circ Heart Fail2018-09-01T00:00:002018Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro.D032383Anatomy1354830.712287Myocytes, CardiacD006352Anatomy2297410.663761Heart VentriclesD020257Physiology922300.836818Ventricular RemodelingBenjaminFrankBenjamin Steven Frank39.74403510000000-104.8360594000000015626Frank, BenjaminAsst ProfessorBiology-MCD InstructionSOM-MEDSOM-PEDSCritical CareCardiologyUniversity of Colorado BoulderUniversity of Colorado Denver - Anschutz Medical CampusKurtStenmarkKurt R Stenmark39.74515960000000-104.840628000000001165Stenmark, KurtProfessorMinHanMin Han40.00825400000000-105.268079500000001263Han, MinDistinguished ProfessorShelleyMiyamotoShelley D Miyamoto39.74403510000000-104.836059400000001777Miyamoto, ShelleyProfessorElizabethYeungElizabeth Yeung39.74403510000000-104.836059400000002128Yeung, ElizabethAssoc Professor Clinical PractBrianStaufferBrian L Stauffer39.74515960000000-104.84062800000000291Stauffer, BrianPrincipal InvestigatorCarmenSucharovCarmen Cristina Sucharov39.74515960000000-104.84062800000000326Sucharov, CarmenProfessorLarryAllenLarry Alexander Allen39.74403280000000-104.840810400000003076Allen, LarryProfessorMichaelBristowMichael Bristow39.74515960000000-104.84062800000000523Bristow, MichaelProfessorKathrynChatfieldKathryn C. Chatfield39.74403510000000-104.836059400000007441Chatfield, KathrynAssociate ProfessorTimothyMcKinseyTimothy A McKinsey39.74403280000000-104.840810400000001839McKinsey, TimothyProfessor31625780Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BLAmerican journal of physiology. Heart and circulatory physiologyNakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1221-H1230.Am J Physiol Heart Circ Physiol2019-10-18T00:00:002019Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy.Authorship 2118648Authorship 215658132056460Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KCAmerican journal of physiology. Heart and circulatory physiologyGarcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease. Am J Physiol Heart Circ Physiol. 2020 04 01; 318(4):H787-H800.Am J Physiol Heart Circ Physiol2020-02-14T00:00:002020Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease.Authorship 216865132108525Garcia AM, Beatty JT, Nakano SJAmerican journal of physiology. Heart and circulatory physiologyGarcia AM, Beatty JT, Nakano SJ. Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations. Am J Physiol Heart Circ Physiol. 2020 04 01; 318(4):H947-H965.Am J Physiol Heart Circ Physiol2020-02-28T00:00:002020Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations.Authorship 220743332421439Ohlstrom D, Hernandez-Lagunas L, Garcia AM, Allawzi A, Karimpour-Fard A, Sucharov CC, Nozik-Grayck EPhysiological genomicsOhlstrom D, Hernandez-Lagunas L, Garcia AM, Allawzi A, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways. Physiol Genomics. 2020 06 01; 52(6):245-254.Physiol Genomics2020-05-18T00:00:002020MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways.32770262Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GRPediatric cardiologyRubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR. Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis. Pediatr Cardiol. 2020 Dec; 41(8):1675-1688.Pediatr Cardiol2020-08-07T00:00:002020Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis.32910348Wall JB, Garcia AM, Jacobsen RM, Miyamoto SDCurrent cardiology reportsWall JB, Garcia AM, Jacobsen RM, Miyamoto SD. Important Considerations in Pediatric Heart Failure. Curr Cardiol Rep. 2020 09 10; 22(11):141.Curr Cardiol Rep2020-09-10T00:00:002020Important Considerations in Pediatric Heart Failure.Authorship 2318732Authorship 2318743Authorship 2318751Authorship 2318762Authorship 2318775Authorship 2318781Authorship 2318792Authorship 2318801Authorship 2318813PIThe purpose of this project is to determine changes in mitochondrial bioenergetics in explanted pediatric heart tissue and assess the impact of PDE5 inhibition in human SV myocardium and in primary cardiomyocytes treated with SV patient serum. The PDE5-mediated metabolic consequences of sphingolipid remodeling in vitro and in vivo will also be assessed.PIThe purpose of this pilot project is to evaluate mitochondrial bioenergetics and reactive oxygen species, and the metabolic signature in circulating PBMCs from pediatric SV patients compared to normal non-failing controls. These data will provide new insights into SV heart failure and has the potential to identify novel biomarkers of disease progression in this population.The purpose of this pilot project is to (1) determine the PDE5-mediated changes in carnitine palmitoyltransferase activity and the metabolic lipid profile in the SV failing heart, and (2) to investigate the PDE5-medated changes in mitochondrial lipid oxidation in the SV failing heart.PIThe purpose of this small research project is to evaluate mRNA and lncRNA expression in human cardiac tissue, and to identify mRNA-lncRNA regulatory networks with potential roles in the progression to heart failure in the pediatric single ventricle congenital heart disease population relative to healthy age-matched non-failing controls.PIThe goal of the award is to evaluate mitochondrial function, transcriptomic, metabolomic, and lipidomic alterations, and reactive oxygen species in circulating peripheral blood mononuclear cells in pediatric single ventricle heart disease patients. Completion of her proposal will provide new insights into metabolic remodeling in the single ventricle population and has the potential to identify a novel non-invasive molecular biomarker of myocardial metabolic function and progression to heart failure in this vulnerable group.2022-07-30NIH/NIDDKAnastacia Garcia2020-08-01Mechanistic Investigations of PDE5-Inhibitor Improved Myocardial Energetics in Congenital Heart Disease25M9264 NORC Pilot2023-12-31Additional Ventures FoundationAnastacia Garcia2021-01-01Peripheral Mononuclear Cells as Biomarkers for Myocardial Mitochondrial Function in Single Ventricle Congenital Heart Disease PatientsSingle Ventricle Research Fund Award2021-12-31NIH/NHLBI PRIDE CVD-CGEAnastacia Garcia2020-11-01Defining the Transcriptional Landscape in the Systemic Right VentricleSRP Award2021-04-30NIH/NCATS Colorado CTSIAnastacia Garcia2020-05-01Peripheral Mononuclear Cells as Biomarkers for Myocardial Mitochondrial Function in Single Ventricle Congenital Heart Disease PatientsUL1TR002535 CMH-Pilot2021-11-30NIH/NCATS Colorado CTSIAnastacia Garcia2019-12-01Metabolic Remodeling in the Failing Pediatric Right VentricleKL2-TR00253427507791Ladage ML, King SD, Burks DJ, Quan DL, Garcia AM, Azad RK, Padilla PAG3 (Bethesda, Md.)Ladage ML, King SD, Burks DJ, Quan DL, Garcia AM, Azad RK, Padilla PA. Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans. G3 (Bethesda). 2016 10 13; 6(10):3149-3160.G3 (Bethesda)2016-10-13T00:00:002016Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans.25762526Garcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PAGeneticsGarcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PA. Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans. Genetics. 2015 May; 200(1):167-84.Genetics2015-03-10T00:00:002015Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans.20529148Shi L, Ermis R, Garcia A, Telgenhoff D, Aust DInternational wound journalShi L, Ermis R, Garcia A, Telgenhoff D, Aust D. Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration. Int Wound J. 2010 Apr; 7(2):87-95.Int Wound J2010-04-01T00:00:002010Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration.23242305Garcia AM, Ladage ML, Padilla PAJournal of visualized experiments : JoVEGarcia AM, Ladage ML, Padilla PA. Use of time lapse microscopy to visualize anoxia-induced suspended animation in C. elegans embryos. J Vis Exp. 2012 Dec 03; (70):e4319.J Vis Exp2012-12-03T00:00:002012Use of time lapse microscopy to visualize anoxia-induced suspended animation in C. elegans embryos.2026-01-31NIHMIYAMOTO, SHELLEY DEANNE ;STAUFFER, BRIAN L;SUCHAROV, CARMEN C2021-03-15Targeting Mitochondria in Single Ventricle Heart DiseaseR01HL15667034383712Jeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Pe?a B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CCJCI insightJeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Pe?a B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021 10 08; 6(19).JCI Insight2021-10-08T00:00:002021Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness.Authorship 257044335621863Baybayon-Grandgeorge AN, Pietra AE, Miyamoto SD, Garcia AMJournal of cardiovascular development and diseaseBaybayon-Grandgeorge AN, Pietra AE, Miyamoto SD, Garcia AM. Medical Therapies for Heart Failure in Hypoplastic Left Heart Syndrome. J Cardiovasc Dev Dis. 2022 May 12; 9(5).J Cardiovasc Dev Dis2022-05-12T00:00:002022Medical Therapies for Heart Failure in Hypoplastic Left Heart Syndrome.Authorship 2697687Authorship 2697694Authorship 26977005/2009University of Texas ArlingtonArlington, TXUniversity of Texas Arlington, MicrobiologyBScMicrobiology08/2015University of North TexasDenton, TXUniversity of North Texas, Molecular Biology/GeneticsPhDMolecular Biology/GeneticsAmerican Heart Association, Young Hearts2022Early Career Investigator Award FinalistNIH/NHLBI20232021Loan Repayment Program Award (second renewal)CU Anschutz2021Outstanding Women in STEM (WiSTEM) Mentorship Award NomineeNIH/NHLBI 20192017Loan Repayment Program AwardNIH/NHLBI20212019Loan Repayment Program Award (renewal)Investigator Research Supplement Recipient36206740Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC, Reisz JA, Proenza C, Chatfield KC, Tsai MFMolecular cellTsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC, Reisz JA, Proenza C, Chatfield KC, Tsai MF. Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. Mol Cell. 2022 10 06; 82(19):3661-3676.e8.Mol Cell2022-10-06T00:00:002022Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.Pires da Silva J, Pietra AE, Baybayon-Grandgeorge AN, and Garcia AMInt. J. Transl. Med.Pires da Silva J, Pietra AE, Baybayon-Grandgeorge AN, and Garcia AM. Serum Metabolic Profiling Identifies Key Differences between Patients with Single-Ventricle Heart Disease and Healthy Controls. Int. J. Transl. Med. 2022; 1(2):78-96.2022-02-23T00:00:002022Serum Metabolic Profiling Identifies Key Differences between Patients with Single-Ventricle Heart Disease and Healthy ControlsAuthorship 270115736671725Sparagna GC, Jonscher RL, Shuff SR, Phillips EK, Wilson CE, Woulfe KC, Garcia AM, Stauffer BL, Chatfield KCBiologySparagna GC, Jonscher RL, Shuff SR, Phillips EK, Wilson CE, Woulfe KC, Garcia AM, Stauffer BL, Chatfield KC. Linoleate-Enrichment of Mitochondrial Cardiolipin Molecular Species Is Developmentally Regulated and a Determinant of Metabolic Phenotype. Biology (Basel). 2022 Dec 24; 12(1).Biology (Basel)2022-12-24T00:00:002022Linoleate-Enrichment of Mitochondrial Cardiolipin Molecular Species Is Developmentally Regulated and a Determinant of Metabolic Phenotype.Authorship 282180137034285Garcia AM, Toni LS, Miyano CA, Sparagna GC, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, Miyamoto SDJACC. Basic to translational scienceGarcia AM, Toni LS, Miyano CA, Sparagna GC, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, Miyamoto SD. Cardiac Transcriptome Remodeling and?Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease. JACC Basic Transl Sci. 2023 Mar; 8(3):258-279.JACC Basic Transl Sci2023-01-11T00:00:002023Cardiac Transcriptome Remodeling and?Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease.true1ProfessorProfessortrue1ProfessorProfessortrue1Principal InvestigatorPrincipal Investigatortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Asst ProfessorAsst Professortrue1Associate ProfessorAssociate Professortrue1Asst ProfessorAsst Professortrue1Assoc Professor Clinical PractAssoc Professor Clinical Practtrue1ProfessorProfessorAuthorship 298952337701624Pires Da Silva J, Padilla PA, Garcia AMFrontiers in geneticsPires Da Silva J, Padilla PA, Garcia AM. Editorial: The intersection of gene regulation and metabolism in cardiovascular disease. Front Genet. 2023; 14:1253690.Front Genet2023-08-28T00:00:002023Editorial: The intersection of gene regulation and metabolism in cardiovascular disease.true1Distinguished ProfessorDistinguished ProfessorDaleBurkettDale A. Burkett39.74403510000000-104.836059400000008772Burkett, DaleAssociate ProfessorStephanieNakanoStephanie J. Nakano39.74403510000000-104.836059400000008786Nakano, StephanieAssociate Professor