Ramirez, Dominique
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research areas: Intrinsically Disordered Proteins
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research areas: Antineoplastic Agents, Alkylating
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Goodrich, Laurie
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Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil protein models.
PubMed Identifier: 41272974
author list: Ramirez DA, Shrimpton A, Shirts MR, Hough LE
published in: Biophysical journal
information resource reference: Ramirez DA, Shrimpton A, Shirts MR, Hough LE. Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil protein models. Biophys J. 2026 Jan 06; 125(1):218-234.
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publication date: 2025-11-20T00:00:00
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Authorship 353286
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linked author: Ramirez, Dominique
linked information resource: Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.

Authorship 353470
type: Authorship
author rank in publication: 4
linked author: Ramirez, Dominique
linked information resource: In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease.

Authorship 353488
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author rank in publication: 1
linked author: Ramirez, Dominique
linked information resource: Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models.

Authorship 353506
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author rank in publication: 3
linked author: Ramirez, Dominique
linked information resource: Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism.

Authorship 353396
type: Authorship
author rank in publication: 2
linked author: Ramirez, Dominique
linked information resource: Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells.

Authorship 353392
type: Authorship
author rank in publication: 9
linked author: Ramirez, Dominique
linked information resource: Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.

Authorship 353459
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author rank in publication: 3
linked author: Ramirez, Dominique
linked information resource: Direct comparison of canine and human immune responses using transcriptomic and functional analyses.

Authorship 353622
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author rank in publication: 2
linked author: Ramirez, Dominique
linked information resource: Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method.

Authorship 353223
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author rank in publication: 1
linked author: Ramirez, Dominique
linked information resource: Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics.

Authorship 353288
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author rank in publication: 8
linked author: Ramirez, Dominique
linked information resource: First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.

Authorship 353445
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author rank in publication: 1
linked author: Ramirez, Dominique
linked information resource: Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models.

Authorship 353308
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author rank in publication: 2
linked author: Ramirez, Dominique
linked information resource: Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation.

Authorship 353365
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linked author: Ramirez, Dominique
linked information resource: Programmable de novo designed coiled coil-mediated phase separation in mammalian cells.

Authorship 353533
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author rank in publication: 1
linked author: Ramirez, Dominique
linked information resource: Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models.

Authorship 353548
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author rank in publication: 1
linked author: Ramirez, Dominique
linked information resource: Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil protein models.

Authorship 353551
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author rank in publication: 3
linked author: Ramirez, Dominique
linked information resource: Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers.

Authorship 353319
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author rank in publication: 5
linked author: Ramirez, Dominique
linked information resource: Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells.

Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method.
PubMed Identifier: 30500618
author list: Wittenburg LA, Ramirez D, Conger H, Gustafson DL
published in: Research in veterinary science
information resource reference: Wittenburg LA, Ramirez D, Conger H, Gustafson DL. Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method. Res Vet Sci. 2019 Feb; 122:93-101.
journal title abbreviation: Res Vet Sci
publication date: 2018-11-12T00:00:00
year: 2018
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Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells.
PubMed Identifier: 34456736
author list: Gross C, Ramirez DA, McGrath S, Gustafson DL
published in: Frontiers in pharmacology
information resource reference: Gross C, Ramirez DA, McGrath S, Gustafson DL. Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells. Front Pharmacol. 2021; 12:725136.
journal title abbreviation: Front Pharmacol
publication date: 2021-08-11T00:00:00
year: 2021
type: Academic Article
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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism.
PubMed Identifier: 36631976
author list: Witta S, Collins KP, Ramirez DA, Mannheimer JD, Wittenburg LA, Gustafson DL
published in: Pharmacology research & perspectives
information resource reference: Witta S, Collins KP, Ramirez DA, Mannheimer JD, Wittenburg LA, Gustafson DL. Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism. Pharmacol Res Perspect. 2023 02; 11(1):e01052.
journal title abbreviation: Pharmacol Res Perspect
publication date: 2023-02-01T00:00:00
year: 2023
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Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers.
PubMed Identifier: 30638304
author list: Wittenburg LA, Weishaar K, Ramirez D, Gustafson DL
published in: Veterinary and comparative oncology
information resource reference: Wittenburg LA, Weishaar K, Ramirez D, Gustafson DL. Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers. Vet Comp Oncol. 2019 Jun; 17(2):147-154.
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Direct comparison of canine and human immune responses using transcriptomic and functional analyses.
PubMed Identifier: 38272935
author list: Chow L, Wheat W, Ramirez D, Impastato R, Dow S
published in: Scientific reports
information resource reference: Chow L, Wheat W, Ramirez D, Impastato R, Dow S. Direct comparison of canine and human immune responses using transcriptomic and functional analyses. Sci Rep. 2024 01 26; 14(1):2207.
journal title abbreviation: Sci Rep
publication date: 2024-01-26T00:00:00
year: 2024
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Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics.
PubMed Identifier: 30567881
author list: Ramirez DA, Collins KP, Aradi AE, Conger KA, Gustafson DL
published in: Drug metabolism and disposition: the biological fate of chemicals
information resource reference: Ramirez DA, Collins KP, Aradi AE, Conger KA, Gustafson DL. Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics. Drug Metab Dispos. 2019 03; 47(3):257-268.
journal title abbreviation: Drug Metab Dispos
publication date: 2018-12-19T00:00:00
year: 2018
type: Academic Article
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In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease.
PubMed Identifier: 30307637
author list: Fitzpatrick RL, Quimby JM, Benson KK, Ramirez D, Sieberg LG, Wittenburg LA, Gustafson DL
published in: Journal of veterinary internal medicine
information resource reference: Fitzpatrick RL, Quimby JM, Benson KK, Ramirez D, Sieberg LG, Wittenburg LA, Gustafson DL. In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. J Vet Intern Med. 2018 Nov; 32(6):1951-1957.
journal title abbreviation: J Vet Intern Med
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Antineoplastic Agents, Alkylating
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Intrinsically Disordered Proteins
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Phase Transition
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Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.
PubMed Identifier: 31675229
author list: Abraham AD, Esquer H, Zhou Q, Tomlinson N, Hamill BD, Abbott JM, Li L, Pike LA, Rinaldetti S, Ramirez DA, Lunghofer PJ, Gomez JD, Schaack J, Nemkov T, D'Alessandro A, Hansen KC, Gustafson DL, Messersmith WA, LaBarbera DV
published in: Journal of medicinal chemistry
information resource reference: Abraham AD, Esquer H, Zhou Q, Tomlinson N, Hamill BD, Abbott JM, Li L, Pike LA, Rinaldetti S, Ramirez DA, Lunghofer PJ, Gomez JD, Schaack J, Nemkov T, D'Alessandro A, Hansen KC, Gustafson DL, Messersmith WA, LaBarbera DV. Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer. J Med Chem. 2019 11 27; 62(22):10182-10203.
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Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.
PubMed Identifier: 32341035
author list: Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL
published in: Cancer research
information resource reference: Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL. Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Res. 2020 06 15; 80(12):2689-2702.
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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.
PubMed Identifier: 32499299
author list: Abbott JM, Zhou Q, Esquer H, Pike L, Broneske TP, Rinaldetti S, Abraham AD, Ramirez DA, Lunghofer PJ, Pitts TM, Regan DP, Tan AC, Gustafson DL, Messersmith WA, LaBarbera DV
published in: Molecular cancer therapeutics
information resource reference: Abbott JM, Zhou Q, Esquer H, Pike L, Broneske TP, Rinaldetti S, Abraham AD, Ramirez DA, Lunghofer PJ, Pitts TM, Regan DP, Tan AC, Gustafson DL, Messersmith WA, LaBarbera DV. First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer. Mol Cancer Ther. 2020 08; 19(8):1598-1612.
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Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation.
PubMed Identifier: 35507105
author list: Hsu WT, Ramirez DA, Sammakia T, Tan Z, Shirts MR
published in: Journal of computer-aided molecular design
information resource reference: Hsu WT, Ramirez DA, Sammakia T, Tan Z, Shirts MR. Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation. J Comput Aided Mol Des. 2022 04; 36(4):313-328.
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Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models.
PubMed Identifier: 37398035
author list: Ramirez DA, Hough LE, Shirts MR
published in: bioRxiv : the preprint server for biology
information resource reference: Ramirez DA, Hough LE, Shirts MR. Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models. bioRxiv. 2023 Jul 24.
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Programmable de novo designed coiled coil-mediated phase separation in mammalian cells.
PubMed Identifier: 38042897
author list: Ram?ak M, Ramirez DA, Hough LE, Shirts MR, Vidmar S, Eler?ic Filipic K, Anderluh G, Jerala R
published in: Nature communications
information resource reference: Ram?ak M, Ramirez DA, Hough LE, Shirts MR, Vidmar S, Eler?ic Filipic K, Anderluh G, Jerala R. Programmable de novo designed coiled coil-mediated phase separation in mammalian cells. Nat Commun. 2023 12 02; 14(1):7973.
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Pezzanite, Lynn
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Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells.
PubMed Identifier: 32544273
author list: Pezzanite L, Chow L, Piquini G, Griffenhagen G, Ramirez D, Dow S, Goodrich L
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information resource reference: Pezzanite L, Chow L, Piquini G, Griffenhagen G, Ramirez D, Dow S, Goodrich L. Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells. Equine Vet J. 2021 May; 53(3):579-589.
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position in organization: University of Colorado Denver - Anschutz Medical Campus

SOP-DOPS General Operations
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type: Organization

Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models.
PubMed Identifier: 38356260
author list: Ramirez DA, Hough LE, Shirts MR
published in: Biophysical journal
information resource reference: Ramirez DA, Hough LE, Shirts MR. Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models. Biophys J. 2024 03 19; 123(6):703-717.
journal title abbreviation: Biophys J
publication date: 2024-02-15T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models.
PubMed Identifier: 40463193
author list: Ramirez DA, Shrimpton A, Shirts MR, Hough LE
published in: bioRxiv : the preprint server for biology
information resource reference: Ramirez DA, Shrimpton A, Shirts MR, Hough LE. Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models. bioRxiv. 2025 May 15.
journal title abbreviation: bioRxiv
publication date: 2025-05-15T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

SOM-AN Res General Operations
type: Department
type: Organization