Ramirez DA, Shrimpton A, Shirts MR, Hough LE
Ramirez DA, Shrimpton A, Shirts MR, Hough LE. Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil protein models. Biophys J. 2026 Jan 06; 125(1):218-234.
Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil protein models.
Wittenburg LA, Ramirez D, Conger H, Gustafson DL
Wittenburg LA, Ramirez D, Conger H, Gustafson DL. Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method. Res Vet Sci. 2019 Feb; 122:93-101.
Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method.
Gross C, Ramirez DA, McGrath S, Gustafson DL
Gross C, Ramirez DA, McGrath S, Gustafson DL. Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells. Front Pharmacol. 2021; 12:725136.
Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells.
Witta S, Collins KP, Ramirez DA, Mannheimer JD, Wittenburg LA, Gustafson DL
Witta S, Collins KP, Ramirez DA, Mannheimer JD, Wittenburg LA, Gustafson DL. Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism. Pharmacol Res Perspect. 2023 02; 11(1):e01052.
Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism.
Wittenburg LA, Weishaar K, Ramirez D, Gustafson DL
Wittenburg LA, Weishaar K, Ramirez D, Gustafson DL. Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers. Vet Comp Oncol. 2019 Jun; 17(2):147-154.
Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers.
Chow L, Wheat W, Ramirez D, Impastato R, Dow S
Chow L, Wheat W, Ramirez D, Impastato R, Dow S. Direct comparison of canine and human immune responses using transcriptomic and functional analyses. Sci Rep. 2024 01 26; 14(1):2207.
Direct comparison of canine and human immune responses using transcriptomic and functional analyses.
Ramirez DA, Collins KP, Aradi AE, Conger KA, Gustafson DL
Drug metabolism and disposition: the biological fate of chemicals
Ramirez DA, Collins KP, Aradi AE, Conger KA, Gustafson DL. Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics. Drug Metab Dispos. 2019 03; 47(3):257-268.
Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics.
Fitzpatrick RL, Quimby JM, Benson KK, Ramirez D, Sieberg LG, Wittenburg LA, Gustafson DL
Fitzpatrick RL, Quimby JM, Benson KK, Ramirez D, Sieberg LG, Wittenburg LA, Gustafson DL. In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. J Vet Intern Med. 2018 Nov; 32(6):1951-1957.
In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease.
University of Colorado Denver - Anschutz Medical Campus
Abraham AD, Esquer H, Zhou Q, Tomlinson N, Hamill BD, Abbott JM, Li L, Pike LA, Rinaldetti S, Ramirez DA, Lunghofer PJ, Gomez JD, Schaack J, Nemkov T, D'Alessandro A, Hansen KC, Gustafson DL, Messersmith WA, LaBarbera DV
Abraham AD, Esquer H, Zhou Q, Tomlinson N, Hamill BD, Abbott JM, Li L, Pike LA, Rinaldetti S, Ramirez DA, Lunghofer PJ, Gomez JD, Schaack J, Nemkov T, D'Alessandro A, Hansen KC, Gustafson DL, Messersmith WA, LaBarbera DV. Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer. J Med Chem. 2019 11 27; 62(22):10182-10203.
Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.
Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL
Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL. Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Res. 2020 06 15; 80(12):2689-2702.
Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.
Abbott JM, Zhou Q, Esquer H, Pike L, Broneske TP, Rinaldetti S, Abraham AD, Ramirez DA, Lunghofer PJ, Pitts TM, Regan DP, Tan AC, Gustafson DL, Messersmith WA, LaBarbera DV
Abbott JM, Zhou Q, Esquer H, Pike L, Broneske TP, Rinaldetti S, Abraham AD, Ramirez DA, Lunghofer PJ, Pitts TM, Regan DP, Tan AC, Gustafson DL, Messersmith WA, LaBarbera DV. First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer. Mol Cancer Ther. 2020 08; 19(8):1598-1612.
First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.
Hsu WT, Ramirez DA, Sammakia T, Tan Z, Shirts MR
Journal of computer-aided molecular design
Hsu WT, Ramirez DA, Sammakia T, Tan Z, Shirts MR. Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation. J Comput Aided Mol Des. 2022 04; 36(4):313-328.
Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation.
bioRxiv : the preprint server for biology
Ramirez DA, Hough LE, Shirts MR. Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models. bioRxiv. 2023 Jul 24.
Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models.
Ram?ak M, Ramirez DA, Hough LE, Shirts MR, Vidmar S, Eler?ic Filipic K, Anderluh G, Jerala R
Ram?ak M, Ramirez DA, Hough LE, Shirts MR, Vidmar S, Eler?ic Filipic K, Anderluh G, Jerala R. Programmable de novo designed coiled coil-mediated phase separation in mammalian cells. Nat Commun. 2023 12 02; 14(1):7973.
Programmable de novo designed coiled coil-mediated phase separation in mammalian cells.
Pezzanite L, Chow L, Piquini G, Griffenhagen G, Ramirez D, Dow S, Goodrich L
Pezzanite L, Chow L, Piquini G, Griffenhagen G, Ramirez D, Dow S, Goodrich L. Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells. Equine Vet J. 2021 May; 53(3):579-589.
Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells.
Ramirez DA, Hough LE, Shirts MR. Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models. Biophys J. 2024 03 19; 123(6):703-717.
Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models.
Ramirez DA, Shrimpton A, Shirts MR, Hough LE. Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models. bioRxiv. 2025 May 15.
Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models.