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Mark A Levine

TitleProfessor Adjoint
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    Z01DK053211     (LEVINE, MARK A)
    NIH
    Vitamin C (ascorbic acid) recommended dietary ingestion
    Role: Principal Investigator
    Z01DK053212     (LEVINE, MARK A)
    NIH
    Ascorbic acid as a pharmacologic agent in disease treatment
    Role: Principal Investigator
    Z01DK053213     (LEVINE, MARK A)
    NIH
    Vitamin E Pharmacokinetics And Biomarkers In Normal And Obese Women
    Role: Principal Investigator
    Z01DK053214     (LEVINE, MARK A)
    NIH
    Novel approaches to obesity: modulation of intestinal glucose absorption
    Role: Principal Investigator
    Z01DK053218     (LEVINE, MARK A)
    NIH
    Vitamin C (ascorbic acid) physiology
    Role: Principal Investigator
    Z01DK054506     (LEVINE, MARK A)
    NIH
    Vitamin C (ascorbic acid) Biochemistry and Molecular Biology
    Role: Principal Investigator
    ZIADK053214     (LEVINE, MARK A)
    NIH
    Novel approaches to obesity: modulation of intestinal glucose absorption in humans
    Role: Principal Investigator
    ZIADK053211     (LEVINE, MARK A)Dec 30, 1899
    NIH
    Vitamin C (ascorbic acid) recommended dietary ingestion
    Role: Principal Investigator
    ZIADK053212     (LEVINE, MARK A)Dec 30, 1899
    NIH
    Ascorbic acid as a pharmacologic agent in disease treatment
    Role: Principal Investigator
    ZIADK053213     (LEVINE, MARK A)Dec 30, 1899
    NIH
    Vitamin E Pharmacokinetics And Biomarkers In Normal And Obese Women
    Role: Principal Investigator
    ZIADK053218     (LEVINE, MARK A)Dec 30, 1899
    NIH
    Vitamin C (ascorbic acid) physiology
    Role: Principal Investigator
    ZIADK054506     (LEVINE, MARK A)Dec 30, 1899
    NIH
    Vitamin C (ascorbic acid) Biochemistry and Molecular Biology
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee B, Chou WW, Chen HY, Mossad D, Hsu M, Bowman B, Patra K, Zhang H, Lay FY, Villamena FA, Xin G, Bruno RS, Levine M, Zhu J, Novais F, Lio CJ. SALSA: a novel flow cytometry assay to detect ascorbate at the single-cell level. Redox Biol. 2025 Oct; 86:103823. PMID: 40854263.
      View in: PubMed
    2. Chakravarty D, Vedula P, Coffin M, Chen L, Sterling S, Peshkova AD, Suzuki A, Zhao L, Patra K, Assenmacher CA, Radaelli E, Levine M, Litvinov RI, Abrams CS, Fowler VM, Kashina A. ß-actin function in platelets and red blood cells can be performed by ?-actin and is therefore independent of actin isoform protein sequence. Mol Biol Cell. 2025 Feb 01; 36(2):ar18. PMID: 39705375.
      View in: PubMed
    3. Ebenuwa I, Violet PC, Tu H, Lee C, Munyan N, Wang Y, Niyyati M, Patra K, Wilkins KJ, Parrow N, Levine M. Altered RBC deformability in diabetes: clinical characteristics and RBC pathophysiology. Cardiovasc Diabetol. 2024 10 18; 23(1):370. PMID: 39425096.
      View in: PubMed
    4. Read JS, Singh D, Luebbers KP, Kelso PT, Callas PW, Leyse JL, Levine MA. Chronic Symptomatology Among Infants, Children, and Adolescents Within 12?Months After SARS-CoV-2 Infection. Glob Pediatr Health. 2024; 11:2333794X241287096. PMID: 39483614.
      View in: PubMed
    5. Paller CJ, Zahurak ML, Mandl A, Metri NA, Lalji A, Heath E, Kelly WK, Hoimes C, Barata P, Taksey J, Garrison DA, Patra K, Milne GL, Anders NM, Nauroth JM, Durham JN, Marshall CH, Markowski MC, Eisenberger MA, Antonarakis ES, Carducci MA, Denmeade SR, Levine M. High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial. Cancer Res Commun. 2024 08 01; 4(8):2174-2182. PMID: 39076107.
      View in: PubMed
    6. Kishimoto S, Crooks DR, Yasunori O, Kota Y, Yamamoto K, Linehan WM, Levine M, Krishna MC, Brender JR. Pharmacologic ascorbate induces transient hypoxia sensitizing pancreatic ductal adenocarcinoma to a hypoxia activated prodrug. Free Radic Biol Med. 2024 Sep; 222:579-587. PMID: 38992394.
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    7. Brière R, Émond M, Benhamed A, Blanchard PG, Drolet S, Habashi R, Golbon B, Shellenberger J, Pasternak J, Merchant S, Shellenberger J, La J, Sawhney M, Brogly S, Cadili L, Horkoff M, Ainslie S, Demetrick J, Chai B, Wiseman K, Hwang H, Alhumoud Z, Salem A, Lau R, Aw K, Nessim C, Gawad N, Alibhai K, Towaij C, Doan D, Raîche I, Valji R, Turner S, Balmes PN, Hwang H, Hameed SM, Tan JGK, Wijesuriya R, Tan JGK, Hew NLC, Wijesuriya R, Lund M, Hawel J, Gregor J, Leslie K, Lenet T, McIsaac D, Hallet J, Jerath A, Lalu M, Nicholls S, Presseau J, Tinmouth A, Verret M, Wherrett C, Fergusson D, Martel G, Sharma S, McKechnie T, Talwar G, Patel J, Heimann L, Doumouras A, Hong D, Eskicioglu C, Wang C, Guo M, Huang L, Sun S, Davis N, Wang J, Skulsky S, Sikora L, Raîche I, Son HJ, Gee D, Gomez D, Jung J, Selvam R, Seguin N, Zhang L, Lacaille-Ranger A, Sikora L, McIsaac D, Moloo H, Follett A, Organ M, Pace D, Balvardi S, Kaneva P, Semsar-Kazerooni K, Mueller C, Vassiliou M, Al Mahroos M, Fiore JF, Schwartzman K, Feldman L, Guo M, Karimuddin A, Liu GP, Crump T, Sutherland J, Hickey K, Bonisteel EM, Umali J, Dogar I, Warden G, Boone D, Mathieson A, Hogan M, Pace D, Seguin N, Moloo H, Li Y, Best G, Leong R, Wiseman S, Alaoui AA, Hajjar R, Wassef E, Metellus DS, Dagbert F, Loungnarath R, Ratelle R, Schwenter F, Debroux É, Wassef R, Gagnon-Konamna M, Pomp A, Richard CS, Sebajang H, Alaoui AA, Hajjar R, Dagbert F, Loungnarath R, Sebajang H, Ratelle R, Schwenter F, Debroux É, Wassef R, Gagnon-Konamna M, Pomp A, Santos MM, Richard CS, Shi G, Leung R, Lim C, Knowles S, Parmar S, Wang C, Debru E, Mohamed F, Anakin M, Lee Y, Samarasinghe Y, Khamar J, Petrisor B, McKechnie T, Eskicioglu C, Yang I, Mughal HN, Bhugio M, Gok MA, Khan UA, Fernandes AR, Spence R, Porter G, Hoogerboord CM, Neumann K, Pillar M, Guo M, Manhas N, Melck A, Kazi T, McKechnie T, Jessani G, Heimann L, Lee Y, Hong D, Eskicioglu C, McKechnie T, Tessier L, Archer V, Park L, Cohen D, Parpia S, Bhandari M, Dionne J, Eskicioglu C, Bolin S, Afford R, Armstrong M, Karimuddin A, Leung R, Shi G, Lim C, Grant A, Van Koughnett JA, Knowles S, Clement E, Lange C, Roshan A, Karimuddin A, Scott T, Nadeau K, Macmillan J, Wilson J, Deschenes M, Nurullah A, Cahill C, Chen VH, Patterson KM, Wiseman SM, Wen B, Bhudial J, Barton A, Lie J, Park CM, Yang L, Gouskova N, Kim DH, Afford R, Bolin S, Morris-Janzen D, McLellan A, Karimuddin A, Archer V, Cloutier Z, Berg A, McKechnie T, Wiercioch W, Eskicioglu C, Labonté J, Bisson P, Bégin A, Cheng-Oviedo SG, Collin Y, Fernandes AR, Hossain I, Ellsmere J, El-Kefraoui C, Do U, Miller A, Kouyoumdjian A, Cui D, Khorasani E, Landry T, Amar-Zifkin A, Lee L, Feldman L, Fiore J, Au TM, Oppenheimer M, Logsetty S, AlShammari R, AlAbri M, Karimuddin A, Brown C, Raval MJ, Phang PT, Bird S, Baig Z, Abu-Omar N, Gill D, Suresh S, Ginther N, Karpinski M, Ghuman A, Malik PRA, Alibhai K, Zabolotniuk T, Raîche I, Gawad N, Mashal S, Boulanger N, Watt L, Razek T, Fata P, Grushka J, Wong EG, Hossain I, Landry M, Mackey S, Fairbridge N, Greene A, Borgoankar M, Kim C, DeCarvalho D, Pace D, Wigen R, Walser E, Davidson J, Dorward M, Muszynski L, Dann C, Seemann N, Lam J, Harding K, Lowik AJ, Guinard C, Wiseman S, Ma O, Mocanu V, Lin A, Karmali S, Bigam D, Harding K, Greaves G, Parker B, Nguyen V, Ahmed A, Yee B, Perren J, Norman M, Grey M, Perini R, Jowhari F, Bak A, Drung J, Allen L, Wiseman D, Moffat B, Lee JKH, McGuire C, Raîche I, Tudorache M, Gawad N, Park LJ, Borges FK, Nenshi R, Jacka M, Heels-Ansdell D, Simunovic M, Bogach J, Serrano PE, Thabane L, Devereaux PJ, Farooq S, Lester E, Kung J, Bradley N, Best G, Ahn S, Zhang L, Prince N, Cheng-Boivin O, Seguin N, Wang H, Quartermain L, Tan S, Shamess J, Simard M, Vigil H, Raîche I, Hanna M, Moloo H, Azam R, Ko G, Zhu M, Raveendran Y, Lam C, Tang J, Bajwa A, Englesakis M, Reel E, Cleland J, Snell L, Lorello G, Cil T, Ahn HS, Dube C, McIsaac D, Smith D, Leclerc A, Shamess J, Rostom A, Calo N, Thavorn K, Moloo H, Laplante S, Liu L, et al. 2023 Canadian Surgery Forum: Sept. 20-23, 2023. Can J Surg. 2023 Nov-Dec; 66(6 Suppl 1):S54-S136. PMID: 38173057.
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    8. Ebenuwa I, Violet PC, Michel K, Padayatty SJ, Wang Y, Tu H, Wilkins KJ, Kassaye S, Levine M. Vitamin C Urinary Loss and Deficiency in Human Immunodeficiency Virus (HIV): Cross-sectional Study of Vitamin C Renal Leak in Women With HIV. Clin Infect Dis. 2023 10 13; 77(8):1157-1165. PMID: 37264998.
      View in: PubMed
    9. Ebenuwa I, Violet PC, Padayatty SJ, Wang Y, Tu H, Wilkins KJ, Moore DF, Eck P, Schiffmann R, Levine M. Vitamin C Urinary Loss in Fabry Disease: Clinical and Genomic Characteristics of Vitamin C Renal Leak. J Nutr. 2023 07; 153(7):1994-2003. PMID: 37229630.
      View in: PubMed
    10. Choi DH, Violet PC, Majumdar S, Levine M. Red Blood Cell Vitamin C Concentration and Its Effect on Deformability in Pediatric Sickle Cell Disease. J Pediatr Hematol Oncol. 2023 10 01; 45(7):e936-e939. PMID: 36897309.
      View in: PubMed
    11. Phadke I, Pouzolles M, Machado A, Moraly J, Gonzalez-Menendez P, Zimmermann VS, Kinet S, Levine M, Violet PC, Taylor N. Vitamin C deficiency reveals developmental differences between neonatal and adult hematopoiesis. Front Immunol. 2022; 13:898827. PMID: 36248829.
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    12. Coppock D, Violet PC, Vasquez G, Belden K, Foster M, Mullin B, Magee D, Mikell I, Shah L, Powers V, Curcio B, Monti D, Levine M. Correction: Coppock et al. Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial. Life 2022, 12, 453. Life (Basel). 2022 Aug 31; 12(9). PMID: 36143494.
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    13. Ebenuwa I, Violet PC, Padayatty S, Wang Y, Wang Y, Sun H, Adhikari P, Smith S, Tu H, Niyyati M, Wilkins K, Levine M. Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak. Am J Clin Nutr. 2022 07 06; 116(1):274-284. PMID: 35537862.
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    14. Chen P, Reed G, Jiang J, Wang Y, Sunega J, Dong R, Ma Y, Esparham A, Ferrell R, Levine M, Drisko J, Chen Q. Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study. Clin Pharmacokinet. 2022 09; 61(9):1237-1249. PMID: 35750958.
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    15. Basseville A, Violet PC, Safari M, Sourbier C, Linehan WM, Robey RW, Levine M, Sackett DL, Bates SE. A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells. Cancers (Basel). 2022 May 26; 14(11). PMID: 35681624.
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    16. Coppock D, Violet PC, Vasquez G, Belden K, Foster M, Mullin B, Magee D, Mikell I, Shah L, Powers V, Curcio B, Daskalakis C, Monti D, Levine M. Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial. Life (Basel). 2022 Mar 19; 12(3). PMID: 35330204.
      View in: PubMed
    17. Choi DH, Basu S, Levine M, Steinhorn D. Plasma Ascorbic Acid Levels in Critically Ill Pediatric Patients. J Pediatr Intensive Care. 2024 Jun; 13(2):119-126. PMID: 38919697.
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    18. Galbraith M, Kelso P, Levine M, Wasserman RC, Sikka J, Read JS. Addressing silent hypoxemia with COVID-19: Implementation of an outpatient pulse oximetry program in Vermont. Public Health Pract (Oxf). 2021 Nov; 2:100186. PMID: 34467257.
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    19. DeCamp M, Levine M. Physician Suicide Prevention and the Ethics and Role of a Healing Community: an American College of Physicians Policy Paper. J Gen Intern Med. 2021 09; 36(9):2829-2835. PMID: 34076842.
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    20. Singh M, Gali B, Levine M, Strohl K, Auckley D. Integrating Sleep Knowledge Into the Anesthesiology Curriculum. Anesth Analg. 2021 05 01; 132(5):1296-1305. PMID: 33857971.
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    21. Parrow NL, Violet PC, George NA, Ali F, Bhanvadia S, Wong R, Tisdale JF, Fitzhugh C, Levine M, Thein SL, Fleming RE. Dietary iron restriction improves markers of disease severity in murine sickle cell anemia. Blood. 2021 03 18; 137(11):1553-1555. PMID: 33512468.
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    22. Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA. 2021 02 23; 325(8):742-750. PMID: 33620405.
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    23. van den Broek-Altenburg EM, Atherly AJ, Diehl SA, Gleason KM, Hart VC, MacLean CD, Barkhuff DA, Levine MA, Carney JK. Jobs, Housing, and Mask Wearing: Cross-Sectional Study of Risk Factors for COVID-19. JMIR Public Health Surveill. 2021 01 11; 7(1):e24320. PMID: 33315576.
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    24. Jones A, Fialkowski V, Prinzing L, Trites J, Kelso P, Levine M. Assessment of Day-7 Postexposure Testing of Asymptomatic Contacts of COVID-19 Patients to Evaluate Early Release from Quarantine - Vermont, May-November 2020. MMWR Morb Mortal Wkly Rep. 2021 Jan 08; 70(1):12-13. PMID: 33411700.
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    25. Traber MG, Leonard SW, Ebenuwa I, Violet PC, Niyyati M, Padayatty S, Smith S, Bobe G, Levine M. Vitamin E catabolism in women, as modulated by food and by fat, studied using 2 deuterium-labeled a-tocopherols in a 3-phase, nonrandomized crossover study. Am J Clin Nutr. 2021 Jan 04; 113(1):92-103. PMID: 33184629.
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    26. Silvers WS, Wynia MK, Levine MA, Himber M. Teaching Health Professions Students About the Holocaust. AMA J Ethics. 2021 01 01; 23(1):E26-30. PMID: 33554844.
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    27. Abraham GM, Obley AJ, Humphrey LL, Qaseem A, Centor RM, Akl E, Forceia MA, Haeme R, Hamilton PG, Hood GA, Jokela JA, Kansagara DL, Levine MA, Mason JR, Marcucci M. World Health Organization Guidelines on Treatment of Hepatitis C Virus Infection: Best Practice Advice From the American College of Physicians. Ann Intern Med. 2021 01; 174(1):98-100. PMID: 33017566.
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    28. Podszun MC, Alawad AS, Lingala S, Morris N, Huang WA, Yang S, Schoenfeld M, Rolt A, Ouwerkerk R, Valdez K, Umarova R, Ma Y, Fatima SZ, Lin DD, Mahajan LS, Samala N, Violet PC, Levine M, Shamburek R, Gharib AM, Kleiner DE, Garraffo HM, Cai H, Walter PJ, Rotman Y. Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis. Redox Biol. 2020 10; 37:101710. PMID: 32920226.
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    29. Williams RK, Levine MA. Vermont's comprehensive public health framework for tobacco control and prevention. Prev Med. 2020 11; 140:106152. PMID: 32473268.
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    30. Lindsell CJ, McGlothlin A, Nwosu S, Rice TW, Hall A, Bernard GR, Busse LW, Ely EW, Fowler AA, Gaieski DF, Hinson JS, Hooper MH, Jackson JC, Kelen GD, Levine M, Martin GS, Rothman RE, Sevransky JE, Viele K, Wright DW, Hager DN. In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol. Trials. 2020 Apr 22; 21(1):351. PMID: 32317004.
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    31. Liu Y, Pang Y, Zhu B, Uher O, Caisova V, Huynh TT, Taieb D, Hadrava Vanova K, Ghayee HK, Neuzil J, Levine M, Yang C, Pacak K. Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid. Clin Cancer Res. 2020 07 15; 26(14):3868-3880. PMID: 32152203.
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    32. Goodwin PJ, Segal RJ, Vallis M, Ligibel JA, Pond GR, Robidoux A, Findlay B, Gralow JR, Mukherjee SD, Levine M, Pritchard KI. The LISA randomized trial of a weight loss intervention in postmenopausal breast cancer. NPJ Breast Cancer. 2020; 6:6. PMID: 32133391.
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    33. Violet PC, Ebenuwa IC, Wang Y, Niyyati M, Padayatty SJ, Head B, Wilkins K, Chung S, Thakur V, Ulatowski L, Atkinson J, Ghelfi M, Smith S, Tu H, Bobe G, Liu CY, Herion DW, Shamburek RD, Manor D, Traber MG, Levine M. Vitamin E sequestration by liver fat in humans. JCI Insight. 2020 01 16; 5(1). PMID: 31821172.
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    34. Luchtel RA, Bhagat T, Pradhan K, Jacobs WR, Levine M, Verma A, Shenoy N. High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model. Proc Natl Acad Sci U S A. 2020 01 21; 117(3):1666-1677. PMID: 31911474.
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    35. Novick LF, Levine MA, Novick CG. The National Epidemic of Gun Violence: The Vermont Department of Health Response. J Public Health Manag Pract. 2020 Jan/Feb; 26(1):32-38. PMID: 31764572.
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    36. Lindsell CJ, McGlothlin A, Nwosu S, Rice TW, Hall A, Bernard GR, Busse LW, Ely EW, Fowler AA, Gaieski DF, Hinson JS, Hooper MH, Jackson JC, Kelen GD, Levine M, Martin GS, Rothman RE, Sevransky JE, Viele K, Wright DW, Hager DN. Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. Trials. 2019 Dec 04; 20(1):670. PMID: 31801567.
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    37. Traber MG, Leonard SW, Ebenuwa I, Violet PC, Wang Y, Niyyati M, Padayatty S, Tu H, Courville A, Bernstein S, Choi J, Shamburek R, Smith S, Head B, Bobe G, Ramakrishnan R, Levine M. Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled a-tocopherols in a 3-phase crossover design. Am J Clin Nutr. 2019 11 01; 110(5):1148-1167. PMID: 31495886.
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    38. Marx GE, Leikauskas J, Lindstrom K, Mann E, Reagan-Steiner S, Matkovic E, Read JS, Kelso P, Kwit NA, Hinckley AF, Levine MA, Brown C. Fatal Lyme Carditis in New England: Two Case Reports. Ann Intern Med. 2020 02 04; 172(3):222-224. PMID: 31634915.
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    39. Hager DN, Hooper MH, Bernard GR, Busse LW, Ely EW, Fowler AA, Gaieski DF, Hall A, Hinson JS, Jackson JC, Kelen GD, Levine M, Lindsell CJ, Malone RE, McGlothlin A, Rothman RE, Viele K, Wright DW, Sevransky JE, Martin GS. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. Trials. 2019 Apr 05; 20(1):197. PMID: 30953543.
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    40. Shenoy N, Creagan E, Witzig T, Levine M. Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly. Cancer Cell. 2018 11 12; 34(5):700-706. PMID: 30174242.
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    41. Nauman G, Gray JC, Parkinson R, Levine M, Paller CJ. Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials. Antioxidants (Basel). 2018 Jul 12; 7(7). PMID: 30002308.
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    42. Drisko JA, Serrano OK, Spruce LR, Chen Q, Levine M. Treatment of pancreatic cancer with intravenous vitamin C: a case report. Anticancer Drugs. 2018 04; 29(4):373-379. PMID: 29438178.
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    43. Parrow NL, Violet PC, Tu H, Nichols J, Pittman CA, Fitzhugh C, Fleming RE, Mohandas N, Tisdale JF, Levine M. Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry. J Vis Exp. 2018 01 12; (131). PMID: 29364234.
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    44. Polireddy K, Dong R, Reed G, Yu J, Chen P, Williamson S, Violet PC, Pessetto Z, Godwin AK, Fan F, Levine M, Drisko JA, Chen Q. High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study. Sci Rep. 2017 12 07; 7(1):17188. PMID: 29215048.
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    45. Xi D, Bao T, Chen Q, Chen S, Cheng YC, Cullen J, Frank DA, Friedberg JW, Kronish I, Lee JE, Levine M, Li P, Li S, Lu W, Mao JJ, O'Keefe S, Rubinstein L, Shah MA, Standish L, Paller CJ, Chu E. State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140484.
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    46. Amir Shaghaghi M, Zhouyao H, Tu H, El-Gabalawy H, Crow GH, Levine M, Bernstein CN, Eck P. The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec; 106(6):1508-1513. PMID: 28971850.
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    47. Tu H, Wang Y, Li H, Brinster LR, Levine M. Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo. EBioMedicine. 2017 Sep; 23:125-135. PMID: 28851583.
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    48. Parrow NL, Tu H, Nichols J, Violet PC, Pittman CA, Fitzhugh C, Fleming RE, Mohandas N, Tisdale JF, Levine M. Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia. Blood Cells Mol Dis. 2017 06; 65:41-50. PMID: 28472705.
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    49. Levine M, Violet PC. Data Triumph at C. Cancer Cell. 2017 04 10; 31(4):467-469. PMID: 28399404.
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    50. Levine M, Violet PC. Breaking down, starting up: can a vitamin C-enriched gelatin supplement before exercise increase collagen synthesis? Am J Clin Nutr. 2017 01; 105(1):5-7. PMID: 28003207.
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    51. Eck PK, Corpe C, Levine MA. Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development. Biochem Cell Biol. 2017 06; 95(3):421-427. PMID: 28177761.
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    52. Pereira AG, Chelminski PR, Chheda SG, Angus SV, Becker J, Chudgar SM, Levine MA, Willet LR, Vu TR. Application Inflation for Internal Medicine Applicants in the Match: Drivers, Consequences, and Potential Solutions. Am J Med. 2016 08; 129(8):885-91. PMID: 27154785.
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    53. Schünemann HJ, Ventresca M, Crowther M, Briel M, Zhou Q, Garcia D, Lyman G, Noble S, Macbeth F, Griffiths G, DiNisio M, Iorio A, Beyene J, Mbuagbaw L, Neumann I, Van Es N, Brouwers M, Brozek J, Guyatt G, Levine M, Moll S, Santesso N, Streiff M, Baldeh T, Florez I, Gurunlu Alma O, Solh Z, Ageno W, Marcucci M, Bozas G, Zulian G, Maraveyas A, Lebeau B, Buller H, Evans J, McBane R, Bleker S, Pelzer U, Akl EA. Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol. BMJ Open. 2016 Apr 29; 6(4):e010569. PMID: 27130164.
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    54. Rouleau L, Antony AN, Bisetto S, Newberg A, Doria C, Levine M, Monti DA, Hoek JB. Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity. Free Radic Biol Med. 2016 06; 95:308-322. PMID: 27036367.
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    55. Tu H, Li H, Wang Y, Niyyati M, Wang Y, Leshin J, Levine M. Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid. EBioMedicine. 2015 Nov; 2(11):1735-50. PMID: 26870799.
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    56. Serrano OK, Parrow NL, Violet PC, Yang J, Zornjak J, Basseville A, Levine M. Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model. Free Radic Biol Med. 2015 Oct; 87:193-203. PMID: 26119785.
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    57. Eck P, Kwon O, Chen S, Mian O, Levine M. The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell. Physiol Rep. 2013 Nov; 1(6):e00136. PMID: 24400138.
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    58. Parrow NL, Leshin JA, Levine M. Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics. Antioxid Redox Signal. 2013 Dec 10; 19(17):2141-56. PMID: 23621620.
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    59. Padayatty SJ, Levine M. Standard-dose vs high-dose multivitamin supplements for HIV. JAMA. 2013 Feb 13; 309(6):545-6. PMID: 23403670.
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    60. Corpe CP, Eck P, Wang J, Al-Hasani H, Levine M. Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. J Biol Chem. 2013 Mar 29; 288(13):9092-101. PMID: 23396969.
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    61. Li H, Tu H, Wang Y, Levine M. Vitamin C in mouse and human red blood cells: an HPLC assay. Anal Biochem. 2012 Jul 15; 426(2):109-17. PMID: 22522059.
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    62. Monti DA, Mitchell E, Bazzan AJ, Littman S, Zabrecky G, Yeo CJ, Pillai MV, Newberg AB, Deshmukh S, Levine M. Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS One. 2012; 7(1):e29794. PMID: 22272248.
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    63. Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, Levine M, Chen Q. Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med. 2011 Jun 01; 50(11):1610-9. PMID: 21402145.
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    64. Levine M, Padayatty SJ, Espey MG. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv Nutr. 2011 Mar; 2(2):78-88. PMID: 22332036.
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    65. Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 07; 5(7):e11414. PMID: 20628650.
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    66. Pollard HB, Levine MA, Eidelman O, Pollard M. Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer. In Vivo. 2010 May-Jun; 24(3):249-55. PMID: 20554995.
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    67. Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest. 2010 Apr; 120(4):1069-83. PMID: 20200446.
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    68. Levine M, Eck P. Vitamin C: working on the x-axis. Am J Clin Nutr. 2009 Nov; 90(5):1121-3. PMID: 19812178.
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    69. Levine M, Espey MG, Chen Q. Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic Biol Med. 2009 Jul 01; 47(1):27-9. PMID: 19361554.
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    70. Padayatty SJ, Levine M. Antioxidant supplements and cardiovascular disease in men. JAMA. 2009 Apr 01; 301(13):1336; author reply 1336-7. PMID: 19336705.
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    71. Golden MR, Hogbe M, Levine MA. Ethics of expedited partner therapy. Virtual Mentor. 2008 Nov 01; 10(11):708-18. PMID: 23211884.
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    72. Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11105-9. PMID: 18678913.
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    73. Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, Hayes RB, Chanock S. Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer. 2008; 60(5):652-9. PMID: 18791929.
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    74. Bostick NA, Levine MA, Sade RM. Ethical obligations of physicians participating in public health quarantine and isolation measures. Public Health Rep. 2008 Jan-Feb; 123(1):3-8. PMID: 18348474.
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    75. Black LJ, Levine MA. Ethical prohibition against physician participation in capital punishment. Mayo Clin Proc. 2008 Jan; 83(1):113-4; author reply 121. PMID: 18174013.
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    76. Bostick NA, Sade R, Levine MA, Stewart DM. Placebo use in clinical practice: report of the American Medical Association Council on Ethical and Judicial Affairs. J Clin Ethics. 2008; 19(1):58-61. PMID: 18552054.
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    77. Eck P, Erichsen HC, Taylor JG, Corpe C, Chanock SJ, Levine M. Genomic and functional analysis of the sodium-dependent vitamin C transporter SLC23A1-SVCT1. Genes Nutr. 2007 Oct; 2(1):143-5. PMID: 18850166.
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    78. Levine MA. Role of physicians in interrogations. Virtual Mentor. 2007 Oct 01; 9(10):709-11. PMID: 23228581.
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    79. Levine MA, Wynia MK, Schyve PM, Teagarden JR, Fleming DA, Donohue SK, Anderson RJ, Sabin J, Emanuel EJ. Improving access to health care: a consensus ethical framework to guide proposals for reform. Hastings Cent Rep. 2007 Sep-Oct; 37(5):14-9. PMID: 17966833.
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    80. Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M. Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone. Am J Clin Nutr. 2007 Jul; 86(1):145-9. PMID: 17616774.
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    81. Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8749-54. PMID: 17502596.
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    82. Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M, Levine M. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J. 2007 Feb; 21(2):366-77. PMID: 17172639.
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    83. Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M. Intravenously administered vitamin C as cancer therapy: three cases. CMAJ. 2006 Mar 28; 174(7):937-42. PMID: 16567755.
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    84. Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. Am J Epidemiol. 2006 Feb 01; 163(3):245-54. PMID: 16357110.
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    85. Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13604-9. PMID: 16157892.
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    86. Chen H, Karne RJ, Hall G, Campia U, Panza JA, Cannon RO, Wang Y, Katz A, Levine M, Quon MJ. High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H137-45. PMID: 16126809.
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    87. Corpe CP, Lee JH, Kwon O, Eck P, Narayanan J, Kirk KL, Levine M. 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways. J Biol Chem. 2005 Feb 18; 280(7):5211-20. PMID: 15590689.
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    88. Eck P, Erichsen HC, Taylor JG, Yeager M, Hughes AL, Levine M, Chanock S. Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2. Hum Genet. 2004 Sep; 115(4):285-94. PMID: 15316768.
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    89. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med. 2004 Apr 06; 140(7):533-7. PMID: 15068981.
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    90. Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb; 22(1):18-35. PMID: 12569111.
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    91. Rogers LQ, Bailey JE, Gutin B, Johnson KC, Levine MA, Milan F, Seelig CB, Sherman SE. Teaching resident physicians to provide exercise counseling: a needs assessment. Acad Med. 2002 Aug; 77(8):841-4. PMID: 12176702.
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    92. Corpe CP, Bovelander FJ, Munoz CM, Hoekstra JH, Simpson IA, Kwon O, Levine M, Burant CF. Cloning and functional characterization of the mouse fructose transporter, GLUT5. Biochim Biophys Acta. 2002 Jun 07; 1576(1-2):191-7. PMID: 12031501.
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    93. Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med. 2002 May; 8(5):514-7. PMID: 11984597.
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    94. Song J, Kwon O, Chen S, Daruwala R, Eck P, Park JB, Levine M. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose. J Biol Chem. 2002 May 03; 277(18):15252-60. PMID: 11834736.
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