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Scott Ian Vrieze

TitleElectronic Research Admin
InstitutionUniversity of Colorado Boulder
DepartmentInstitute for Behav Genetics
Phone303/492-1743

    Collapse Research 
    Collapse research activities and funding
    R01AA023974     (VRIEZE, SCOTT IAN)Sep 25, 2014 - Aug 30, 2017
    NIH/NIAAA
    Social Media, Online Measures, and Substance Use Development in Adolescent Twins
    Role: Principal Investigator

    R01DA037904     (VRIEZE, SCOTT IAN)May 1, 2015 - Apr 30, 2020
    NIH/NIDA
    Genetic Association Meta-Analyses of Smoking and Drinking for the Sequencing Age
    Role: Principal Investigator

    R01DA042755     (HOPFER, CHRISTIAN J)Sep 1, 2017 - May 31, 2022
    NIH/NIDA
    Impact of Marijuana Legalization: Comparison of Two Longitudinal Twin Cohorts
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, Choquet H, Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR, Ling Y, Mägi R, Matoba N, McMahon G, Mulas A, Orrù V, Palviainen T, Pandit A, Reginsson GW, Skogholt AH, Smith JA, Taylor AE, Turman C, Willemsen G, Young H, Young KA, Zajac GJM, Zhao W, Zhou W, Bjornsdottir G, Boardman JD, Boehnke M, Boomsma DI, Chen C, Cucca F, Davies GE, Eaton CB, Ehringer MA, Esko T, Fiorillo E, Gillespie NA, Gudbjartsson DF, Haller T, Harris KM, Heath AC, Hewitt JK, Hickie IB, Hokanson JE, Hopfer CJ, Hunter DJ, Iacono WG, Johnson EO, Kamatani Y, Kardia SLR, Keller MC, Kellis M, Kooperberg C, Kraft P, Krauter KS, Laakso M, Lind PA, Loukola A, Lutz SM, Madden PAF, Martin NG, McGue M, McQueen MB, Medland SE, Metspalu A, Mohlke KL, Nielsen JB, Okada Y, Peters U, Polderman TJC, Posthuma D, Reiner AP, Rice JP, Rimm E, Rose RJ, Runarsdottir V, Stallings MC, Stancáková A, Stefansson H, Thai KK, Tindle HA, Tyrfingsson T, Wall TL, Weir DR, Weisner C, Whitfield JB, Winsvold BS, Yin J, Zuccolo L, Bierut LJ, Hveem K, Lee JJ, Munafò MR, Saccone NL, Willer CJ, Cornelis MC, David SP, Hinds DA, Jorgenson E, Kaprio J, Stitzel JA, Stefansson K, Thorgeirsson TE, Abecasis G, Liu DJ, Vrieze S. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat Genet. 2019 Feb; 51(2):237-244. PMID: 30643251.
      View in: PubMed
    2. Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C, Surendran P, Jiang T, Adnan SD, Afaq S, Agrawal A, Altmaier E, Antoniou AC, Asselbergs FW, Baumbach C, Bierut L, Bertelsen S, Boehnke M, Bots ML, Brazel DM, Chambers JC, Chang-Claude J, Chen C, Corley J, Chou YL, David SP, de Boer RA, de Leeuw CA, Dennis JG, Dominiczak AF, Dunning AM, Easton DF, Eaton C, Elliott P, Evangelou E, Faul JD, Foroud T, Goate A, Gong J, Grabe HJ, Haessler J, Haiman C, Hallmans G, Hammerschlag AR, Harris SE, Hattersley A, Heath A, Hsu C, Iacono WG, Kanoni S, Kapoor M, Kaprio J, Kardia SL, Karpe F, Kontto J, Kooner JS, Kooperberg C, Kuulasmaa K, Laakso M, Lai D, Langenberg C, Le N, Lettre G, Loukola A, Luan J, Madden PAF, Mangino M, Marioni RE, Marouli E, Marten J, Martin NG, McGue M, Michailidou K, Mihailov E, Moayyeri A, Moitry M, Müller-Nurasyid M, Naheed A, Nauck M, Neville MJ, Nielsen SF, North K, Perola M, Pharoah PDP, Pistis G, Polderman TJ, Posthuma D, Poulter N, Qaiser B, Rasheed A, Reiner A, Renström F, Rice J, Rohde R, Rolandsson O, Samani NJ, Samuel M, Schlessinger D, Scholte SH, Scott RA, Sever P, Shao Y, Shrine N, Smith JA, Starr JM, Stirrups K, Stram D, Stringham HM, Tachmazidou I, Tardif JC, Thompson DJ, Tindle HA, Tragante V, Trompet S, Turcot V, Tyrrell J, Vaartjes I, van der Leij AR, van der Meer P, Varga TV, Verweij N, Völzke H, Wareham NJ, Warren HR, Weir DR, Weiss S, Wetherill L, Yaghootkar H, Yavas E, Jiang Y, Chen F, Zhan X, Zhang W, Zhao W, Zhao W, Zhou K, Amouyel P, Blankenberg S, Caulfield MJ, Chowdhury R, Cucca F, Deary IJ, Deloukas P, Di Angelantonio E, Ferrario M, Ferrières J, Franks PW, Frayling TM, Frossard P, Hall IP, Hayward C, Jansson JH, Jukema JW, Kee F, Männistö S, Metspalu A, Munroe PB, Nordestgaard BG, Palmer CNA, Salomaa V, Sattar N, Spector T, Strachan DP, van der Harst P, Zeggini E, Saleheen D, Butterworth AS, Wain LV, Abecasis GR, Danesh J, Tobin MD, Vrieze S, Liu DJ, Howson JMM. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry. 2019 Jan 07. PMID: 30617275.
      View in: PubMed
    3. Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD, Liu M, Barnes DR, Bertelsen S, Chou YL, Erzurumluoglu AM, Faul JD, Haessler J, Hammerschlag AR, Hsu C, Kapoor M, Lai D, Le N, de Leeuw CA, Loukola A, Mangino M, Melbourne CA, Pistis G, Qaiser B, Rohde R, Shao Y, Stringham H, Wetherill L, Zhao W, Agrawal A, Bierut L, Chen C, Eaton CB, Goate A, Haiman C, Heath A, Iacono WG, Martin NG, Polderman TJ, Reiner A, Rice J, Schlessinger D, Scholte HS, Smith JA, Tardif JC, Tindle HA, van der Leij AR, Boehnke M, Chang-Claude J, Cucca F, David SP, Foroud T, Howson JMM, Kardia SLR, Kooperberg C, Laakso M, Lettre G, Madden P, McGue M, North K, Posthuma D, Spector T, Stram D, Tobin MD, Weir DR, Kaprio J, Abecasis GR, Liu DJ, Vrieze S. Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. Biol Psychiatry. 2018 Dec 06. PMID: 30679032.
      View in: PubMed
    4. Frieser MJ, Wilson S, Vrieze S. Behavioral impact of return of genetic test results for complex disease: Systematic review and meta-analysis. Health Psychol. 2018 Dec; 37(12):1134-1144. PMID: 30307272.
      View in: PubMed
    5. Jiang Y, Chen S, McGuire D, Chen F, Liu M, Iacono WG, Hewitt JK, Hokanson JE, Krauter K, Laakso M, Li KW, Lutz SM, McGue M, Pandit A, Zajac GJM, Boehnke M, Abecasis GR, Vrieze SI, Zhan X, Jiang B, Liu DJ. Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes. PLoS Genet. 2018 07; 14(7):e1007452. PMID: 30016313.
      View in: PubMed
    6. Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S, Barr PB, Coleman JRI, Grasby KL, Hammerschlag AR, Kaminski JA, Karlsson R, Krapohl E, Lam M, Nygaard M, Reynolds CA, Trampush JW, Young H, Zabaneh D, Hägg S, Hansell NK, Karlsson IK, Linnarsson S, Montgomery GW, Muñoz-Manchado AB, Quinlan EB, Schumann G, Skene NG, Webb BT, White T, Arking DE, Avramopoulos D, Bilder RM, Bitsios P, Burdick KE, Cannon TD, Chiba-Falek O, Christoforou A, Cirulli ET, Congdon E, Corvin A, Davies G, Deary IJ, DeRosse P, Dickinson D, Djurovic S, Donohoe G, Conley ED, Eriksson JG, Espeseth T, Freimer NA, Giakoumaki S, Giegling I, Gill M, Glahn DC, Hariri AR, Hatzimanolis A, Keller MC, Knowles E, Koltai D, Konte B, Lahti J, Le Hellard S, Lencz T, Liewald DC, London E, Lundervold AJ, Malhotra AK, Melle I, Morris D, Need AC, Ollier W, Palotie A, Payton A, Pendleton N, Poldrack RA, Räikkönen K, Reinvang I, Roussos P, Rujescu D, Sabb FW, Scult MA, Smeland OB, Smyrnis N, Starr JM, Steen VM, Stefanis NC, Straub RE, Sundet K, Tiemeier H, Voineskos AN, Weinberger DR, Widen E, Yu J, Abecasis G, Andreassen OA, Breen G, Christiansen L, Debrabant B, Dick DM, Heinz A, Hjerling-Leffler J, Ikram MA, Kendler KS, Martin NG, Medland SE, Pedersen NL, Plomin R, Polderman TJC, Ripke S, van der Sluis S, Sullivan PF, Vrieze SI, Wright MJ, Posthuma D. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018 Jul; 50(7):912-919. PMID: 29942086.
      View in: PubMed
    7. Evans LM, Tahmasbi R, Vrieze SI, Abecasis GR, Das S, Gazal S, Bjelland DW, de Candia TR, Goddard ME, Neale BM, Yang J, Visscher PM, Keller MC. Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. Nat Genet. 2018 May; 50(5):737-745. PMID: 29700474.
      View in: PubMed
    8. Evans LM, Tahmasbi R, Jones M, Vrieze SI, Abecasis GR, Das S, Bjelland DW, de Candia TR, Yang J, Goddard ME, Visscher PM, Keller MC. Narrow-sense heritability estimation of complex traits using identity-by-descent information. Heredity (Edinb). 2018 Dec; 121(6):616-630. PMID: 29588506.
      View in: PubMed
    9. Liu M, Rea-Sandin G, Foerster J, Fritsche L, Brieger K, Clark C, Li K, Pandit A, Zajac G, Abecasis GR, Vrieze S. Validating Online Measures of Cognitive Ability in Genes for Good, a Genetic Study of Health and Behavior. Assessment. 2017 Nov 01; 1073191117744048. PMID: 29182012.
      View in: PubMed
    10. Clark SL, McClay JL, Adkins DE, Kumar G, Aberg KA, Nerella S, Xie L, Collins AL, Crowley JJ, Quackenbush CR, Hilliard CE, Shabalin AA, Vrieze SI, Peterson RE, Copeland WE, Silberg JL, McGue M, Maes H, Iacono WG, Sullivan PF, Costello EJ, van den Oord EJ. Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence. Alcohol Clin Exp Res. 2017 04; 41(4):711-718. PMID: 28196272.
      View in: PubMed
    11. Liu M, Malone SM, Vaidyanathan U, Keller MC, Abecasis G, McGue M, Iacono WG, Vrieze SI. Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Psychol Med. 2017 Apr; 47(6):1116-1125. PMID: 27995817.
      View in: PubMed
    12. Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C. Next-generation genotype imputation service and methods. Nat Genet. 2016 10; 48(10):1284-1287. PMID: 27571263.
      View in: PubMed
    13. Iacono WG, Malone SM, Vrieze SI. Endophenotype best practices. Int J Psychophysiol. 2017 01; 111:115-144. PMID: 27473600.
      View in: PubMed
    14. Chang LC, Li B, Fang Z, Vrieze S, McGue M, Iacono WG, Tseng GC, Chen W. A computational method for genotype calling in family-based sequencing data. BMC Bioinformatics. 2016 Jan 16; 17:37. PMID: 26772743; PMCID: PMC4715317.
    15. Vaidyanathan U, Vrieze SI, Iacono WG. The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward. Psychol Inq. 2015; 26(3):209-230. PMID: 27030789.
      View in: PubMed
    16. Vaidyanathan U, Vrieze SI, Iacono WG. THE ART OF SMART SCIENCE: WEAVING THEORY AND RISKY STUDY DESIGN INTO PSYCHOPATHOLOGY RESEARCH AND RDOC. Psychol Inq. 2015; 26(3):286-292. PMID: 27019570.
      View in: PubMed
    17. Iacono WG, Malone SM, Vaidyanathan U, Vrieze SI. Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview. Psychophysiology. 2014 Dec; 51(12):1207-24. PMID: 25387703; PMCID: PMC4231489.
    18. Vrieze SI, Malone SM, Vaidyanathan U, Kwong A, Kang HM, Zhan X, Flickinger M, Irons D, Jun G, Locke AE, Pistis G, Porcu E, Levy S, Myers RM, Oetting W, McGue M, Abecasis G, Iacono WG. In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes. Psychophysiology. 2014 Dec; 51(12):1309-20. PMID: 25387710; PMCID: PMC4231480.
    19. Vrieze SI, Malone SM, Pankratz N, Vaidyanathan U, Miller MB, Kang HM, McGue M, Abecasis G, Iacono WG. Genetic associations of nonsynonymous exonic variants with psychophysiological endophenotypes. Psychophysiology. 2014 Dec; 51(12):1300-8. PMID: 25387709; PMCID: PMC4231532.
    20. Iacono WG, Vaidyanathan U, Vrieze SI, Malone SM. Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries. Psychophysiology. 2014 Dec; 51(12):1339-47. PMID: 25387720; PMCID: PMC4231488.
    21. Pistis G, Porcu E, Vrieze SI, Sidore C, Steri M, Danjou F, Busonero F, Mulas A, Zoledziewska M, Maschio A, Brennan C, Lai S, Miller MB, Marcelli M, Urru MF, Pitzalis M, Lyons RH, Kang HM, Jones CM, Angius A, Iacono WG, Schlessinger D, McGue M, Cucca F, Abecasis GR, Sanna S. Rare variant genotype imputation with thousands of study-specific whole-genome sequences: implications for cost-effective study designs. Eur J Hum Genet. 2015 Jul; 23(7):975-83. PMID: 25293720; PMCID: PMC4463504.
    22. Irons DE, Iacono WG, Oetting WS, Kirkpatrick RM, Vrieze SI, Miller MB, McGue M. Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample. Alcohol Clin Exp Res. 2014 Apr; 38(4):938-47. PMID: 24460875; PMCID: PMC3984361.
    23. Vrieze SI, Vaidyanathan U, Hicks BM, Iacono WG, McGue M. The role of constraint in the development of nicotine, marijuana, and alcohol dependence in young adulthood. Behav Genet. 2014 Jan; 44(1):14-24. PMID: 24343204; PMCID: PMC3951055.
    24. Vrieze SI, Feng S, Miller MB, Hicks BM, Pankratz N, Abecasis GR, Iacono WG, McGue M. Rare nonsynonymous exonic variants in addiction and behavioral disinhibition. Biol Psychiatry. 2014 May 15; 75(10):783-9. PMID: 24094508; PMCID: PMC3975816.
    25. Vrieze SI, Docherty A, Thuras P, Arbisi P, Iacono WG, Sponheim S, Erbes CR, Siegel W, Leskela J. Best practices: The electronic medical record is an invaluable clinical tool: let's start using it. Psychiatr Serv. 2013 Oct; 64(10):946-9. PMID: 23946012.
      View in: PubMed
    26. McGue M, Zhang Y, Miller MB, Basu S, Vrieze S, Hicks B, Malone S, Oetting WS, Iacono WG. A genome-wide association study of behavioral disinhibition. Behav Genet. 2013 Sep; 43(5):363-73. PMID: 23942779; PMCID: PMC3886341.
    27. Vrieze SI, McGue M, Miller MB, Hicks BM, Iacono WG. Three mutually informative ways to understand the genetic relationships among behavioral disinhibition, alcohol use, drug use, nicotine use/dependence, and their co-occurrence: twin biometry, GCTA, and genome-wide scoring. Behav Genet. 2013 Mar; 43(2):97-107. PMID: 23362009; PMCID: PMC3579160.
    28. Vrieze SI, Iacono WG, McGue M. Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. Dev Psychopathol. 2012 Nov; 24(4):1195-214. PMID: 23062291; PMCID: PMC3476066.
    29. Vrieze SI, Hicks BM, Iacono WG, McGue M. Decline in genetic influence on the co-occurrence of alcohol, marijuana, and nicotine dependence symptoms from age 14 to 29. Am J Psychiatry. 2012 Oct; 169(10):1073-81. PMID: 22983309; PMCID: PMC3513559.
    30. Vrieze SI, McGue M, Iacono WG. The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. Hum Genet. 2012 Jun; 131(6):791-801. PMID: 22492059; PMCID: PMC3407593.
    31. Vrieze SI, Perlman G, Krueger RF, Iacono WG. Is the continuity of externalizing psychopathology the same in adolescents and middle-aged adults? A test of the externalizing spectrum's developmental coherence. J Abnorm Child Psychol. 2012 Apr; 40(3):459-70. PMID: 21932056; PMCID: PMC3292691.
    32. Vrieze SI. Model selection and psychological theory: a discussion of the differences between the Akaike information criterion (AIC) and the Bayesian information criterion (BIC). Psychol Methods. 2012 Jun; 17(2):228-43. PMID: 22309957.
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    33. Vrieze SI, McGue M, Miller MB, Legrand LN, Schork NJ, Iacono WG. An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design. PLoS Genet. 2011 Dec; 7(12):e1002413. PMID: 22174699.
      View in: PubMed
    34. Vrieze SI, Grove WM. Multidimensional assessment of criminal recidivism: problems, pitfalls, and proposed solutions. Psychol Assess. 2010 Jun; 22(2):382-95. PMID: 20528065; PMCID: PMC2922019.
    35. Grove WM, Vrieze SI. An exploration of the base rate scores of the Millon Clinical Multiaxial Inventory-III. Psychol Assess. 2009 Mar; 21(1):57-67. PMID: 19290766.
      View in: PubMed
    36. Vrieze SI, Grove WM. Predicting sex offender recidivism. I. Correcting for item overselection and accuracy overestimation in scale development. II. Sampling error-induced attenuation of predictive validity over base rate information. Law Hum Behav. 2008 Jun; 32(3):266-78. PMID: 17610052.
      View in: PubMed
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