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Sarah Jean Borengasser

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
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    K01DK109077     (BORENGASSER, SARAH JEAN)Apr 1, 2016 - Mar 31, 2019
    NIH/NIDDK
    Maternal obesity, micronutrient supplementation, and epigenetic programming
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Soderborg TK, Borengasser SJ, Barbour LA, Friedman JE. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia. 2016 May; 59(5):895-906. PMID: 26843076; PMCID: PMC4829383 [Available on 05/01/17].
    2. Shankar K, Kang P, Zhong Y, Borengasser SJ, Wingfield C, Saben J, Gomez-Acevedo H, Thakali KM. Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells. Placenta. 2015 Dec; 36(12):1342-51. PMID: 26515927.
      View in: PubMed
    3. Borengasser SJ, Faske J, Kang P, Blackburn ML, Badger TM, Shankar K. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Physiol Genomics. 2014 Dec 01; 46(23):841-50. PMID: 25336449; PMCID: PMC4254938.
    4. Saben J, Kang P, Zhong Y, Thakali KM, Gomez-Acevedo H, Borengasser SJ, Andres A, Badger TM, Shankar K. RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling. Placenta. 2014 Dec; 35(12):1013-20. PMID: 25449029; PMCID: PMC4270847.
    5. Borengasser SJ, Kang P, Faske J, Gomez-Acevedo H, Blackburn ML, Badger TM, Shankar K. High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One. 2014; 9(1):e84209. PMID: 24416203; PMCID: PMC3886966.
    6. Borengasser SJ, Zhong Y, Kang P, Lindsey F, Ronis MJ, Badger TM, Gomez-Acevedo H, Shankar K. Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in male rat offspring. Endocrinology. 2013 Nov; 154(11):4113-25. PMID: 23959936; PMCID: PMC3800750.
    7. Saben J, Zhong Y, Gomez-Acevedo H, Thakali KM, Borengasser SJ, Andres A, Shankar K. Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity. Am J Physiol Endocrinol Metab. 2013 Jul 01; 305(1):E1-14. PMID: 23632636; PMCID: PMC4116409.
    8. Mikus CR, Boyle LJ, Borengasser SJ, Oberlin DJ, Naples SP, Fletcher J, Meers GM, Ruebel M, Laughlin MH, Dellsperger KC, Fadel PJ, Thyfault JP. Simvastatin impairs exercise training adaptations. J Am Coll Cardiol. 2013 Aug 20; 62(8):709-14. PMID: 23583255; PMCID: PMC3745788.
    9. Ronis MJ, Sharma N, Vantrease J, Borengasser SJ, Ferguson M, Mercer KE, Cleves MA, Gomez-Acevedo H, Badger TM. Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity. Physiol Genomics. 2013 May 01; 45(9):351-66. PMID: 23482812.
      View in: PubMed
    10. Mikus CR, Roseguini BT, Uptergrove GM, Morris EM, Rector RS, Libla JL, Oberlin DJ, Borengasser SJ, Taylor AM, Ibdah JA, Laughlin MH, Thyfault JP. Voluntary wheel running selectively augments insulin-stimulated vasodilation in arterioles from white skeletal muscle of insulin-resistant rats. Microcirculation. 2012 Nov; 19(8):729-38. PMID: 22804760; PMCID: PMC3498513.
    11. Jackson KC, Wohlers LM, Valencia AP, Cilenti M, Borengasser SJ, Thyfault JP, Spangenburg EE. Wheel running prevents the accumulation of monounsaturated fatty acids in the liver of ovariectomized mice by attenuating changes in SCD-1 content. Appl Physiol Nutr Metab. 2011 Dec; 36(6):798-810. PMID: 22026420.
      View in: PubMed
    12. Borengasser SJ, Rector RS, Uptergrove GM, Morris EM, Perfield JW, Booth FW, Fritsche KL, Ibdah JA, Thyfault JP. Exercise and Omega-3 Polyunsaturated Fatty Acid Supplementation for the Treatment of Hepatic Steatosis in Hyperphagic OLETF Rats. J Nutr Metab. 2012; 2012:268680. PMID: 21918718; PMCID: PMC3171760.
    13. Borengasser SJ, Lau F, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. PLoS One. 2011; 6(8):e24068. PMID: 21901160; PMCID: PMC3162035.
    14. Shankar K, Zhong Y, Kang P, Lau F, Blackburn ML, Chen JR, Borengasser SJ, Ronis MJ, Badger TM. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Endocrinology. 2011 Nov; 152(11):4158-70. PMID: 21862610; PMCID: PMC3199010.
    15. Rector RS, Uptergrove GM, Morris EM, Borengasser SJ, Laughlin MH, Booth FW, Thyfault JP, Ibdah JA. Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model. Am J Physiol Gastrointest Liver Physiol. 2011 May; 300(5):G874-83. PMID: 21350190; PMCID: PMC3094141.
    16. Naples SP, Borengasser SJ, Rector RS, Uptergrove GM, Morris EM, Mikus CR, Koch LG, Britton SL, Ibdah JA, Thyfault JP. Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Appl Physiol Nutr Metab. 2010 Apr; 35(2):151-62. PMID: 20383225; PMCID: PMC2894534.
    17. Rector RS, Uptergrove GM, Borengasser SJ, Mikus CR, Morris EM, Naples SP, Laye MJ, Laughlin MH, Booth FW, Ibdah JA, Thyfault JP. Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1179-87. PMID: 20233940; PMCID: PMC2886529.
    18. Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, Mikus CR, Laye MJ, Laughlin MH, Booth FW, Ibdah JA. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010 May; 52(5):727-36. PMID: 20347174; PMCID: PMC3070177.
    19. Thyfault JP, Rector RS, Uptergrove GM, Borengasser SJ, Morris EM, Wei Y, Laye MJ, Burant CF, Qi NR, Ridenhour SE, Koch LG, Britton SL, Ibdah JA. Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. J Physiol. 2009 Apr 15; 587(Pt 8):1805-16. PMID: 19237421; PMCID: PMC2683966.
    20. Laye MJ, Rector RS, Borengasser SJ, Naples SP, Uptergrove GM, Ibdah JA, Booth FW, Thyfault JP. Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue. J Appl Physiol (1985). 2009 Jan; 106(1):161-8. PMID: 18974364; PMCID: PMC2636938.
    21. Rector RS, Thyfault JP, Laye MJ, Morris RT, Borengasser SJ, Uptergrove GM, Chakravarthy MV, Booth FW, Ibdah JA. Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. J Physiol. 2008 Sep 01; 586(17):4241-9. PMID: 18617560; PMCID: PMC2652173.
    22. Rector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW, Ibdah JA. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G619-26. PMID: 18174272.
      View in: PubMed
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