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Carlos Zgheib

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    Dr. Carlos Zgheib is a Postdoctoral Fellow at the Laboratory for Fetal and Regenerative Biology at the Department of Surgery at University of Colorado Denver – Anschutz Medical Campus.

    Currently, Dr. Zgheib is conducting studies to elucidate the contribution of inflammation, oxidative stress, and cardiac progenitor cell recruitment, and the mechanisms that regulate these processes, during regeneration of functional myocardium following in utero myocardial infarction in sheep. The overall goal of the studies is to determine the mechanisms involved in the fetal regenerative response to myocardial injury, in order to develop potential therapeutic targets for modification of the adult response to myocardial infarction to promote cardiac regeneration. Understanding the mechanisms behind the differential response to myocardial infarction between the fetal and adult hearts could be used to identify and target factors that are crucial to promote a regenerative response and may allow the development of potential treatment strategies to promote cardiac regeneration in the adults.

    Dr. Zgheib is also studying the role of specific miRNAs in diabetic wound healing and how can these be targeted therapeutically in the Db/Db C57BKS.Cg-m/Leprdb/J diabetic mouse model of impaired wound healing. Specifically miRNAs directly involved in the regulation of the inflammatory response, oxidative stress, extracellular matrix homeostasis and collagen deposition in impaired diabetic wounds. Dr. Zgheib also investigates the use of Stem Cells, Nanotherapy, Nanofibers, Gene Therapy, and MiRNA Therapy to correct impaired pathophysiologic signaling pathways and improve diabetic wound healing.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zgheib C, Hilton SA, Dewberry LC, Hodges MM, Ghatak S, Xu J, Singh S, Roy S, Sen CK, Seal S, Liechty KW. Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment. J Am Coll Surg. 2019 Jan; 228(1):107-115. PMID: 30359833.
      View in: PubMed
    2. Xu J, Zgheib C, Hodges MM, Caskey RC, Hu J, Liechty KW. Mesenchymal stem cells correct impaired diabetic wound healing by decreasing ECM proteolysis. Physiol Genomics. 2017 Oct 01; 49(10):541-548. PMID: 28842435.
      View in: PubMed
    3. Zgheib C, Hodges MM, Allukian MW, Xu J, Spiller KL, Gorman JH, Gorman RC, Liechty KW. Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis. Ann Thorac Surg. 2017 Dec; 104(6):1968-1975. PMID: 28821329.
      View in: PubMed
    4. Zgheib C, Hodges MM, Hu J, Liechty KW, Xu J. Long non-coding RNA Lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages. PLoS One. 2017; 12(5):e0177453. PMID: 28494015.
      View in: PubMed
    5. Zgheib C, Hodges M, Hu J, Beason DP, Soslowsky LJ, Liechty KW, Xu J. Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a. Wound Repair Regen. 2016 03; 24(2):237-46. PMID: 26808714.
      View in: PubMed
    6. Zgheib C, Liechty KW. Shedding light on miR-26a: Another key regulator of angiogenesis in diabetic wound healing. J Mol Cell Cardiol. 2016 Mar; 92:203-5. PMID: 26906635.
      View in: PubMed
    7. Zgheib C, Xu J, Mallette AC, Caskey RC, Zhang L, Hu J, Liechty KW. SCF increases in utero-labeled stem cells migration and improves wound healing. Wound Repair Regen. 2015 Jul-Aug; 23(4):583-90. PMID: 26032674.
      View in: PubMed
    8. Xu J, Zgheib C, Hu J, Wu W, Zhang L, Liechty KW. The role of microRNA-15b in the impaired angiogenesis in diabetic wounds. Wound Repair Regen. 2014 Sep-Oct; 22(5):671-7. PMID: 25059098.
      View in: PubMed
    9. Caskey RC, Zgheib C, Morris M, Allukian M, Dorsett-Martin W, Xu J, Wu W, Liechty KW. Dysregulation of collagen production in diabetes following recurrent skin injury: contribution to the development of a chronic wound. Wound Repair Regen. 2014 Jul-Aug; 22(4):515-20. PMID: 24898050.
      View in: PubMed
    10. Gergi R, Osta N, Bourbouze G, Zgheib C, Arbab-Chirani R, Naaman A. Effects of three nickel titanium instrument systems on root canal geometry assessed by micro-computed tomography. Int Endod J. 2015 Feb; 48(2):162-70. PMID: 24717063.
      View in: PubMed
    11. Zgheib C, Allukian MW, Xu J, Morris MW, Caskey RC, Herdrich BJ, Hu J, Gorman JH, Gorman RC, Liechty KW. Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult. Ann Thorac Surg. 2014 May; 97(5):1643-50. PMID: 24792251; PMCID: PMC4010943.
    12. Morris MW, Allukian M, Herdrich BJ, Caskey RC, Zgheib C, Xu J, Dorsett-Martin W, Mitchell ME, Liechty KW. Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation. Wound Repair Regen. 2014 May-Jun; 22(3):406-14. PMID: 24844340.
      View in: PubMed
    13. Zgheib C, Xu J, Liechty KW. Targeting Inflammatory Cytokines and Extracellular Matrix Composition to Promote Wound Regeneration. Adv Wound Care (New Rochelle). 2014 Apr 01; 3(4):344-355. PMID: 24757589.
      View in: PubMed
    14. Werner T, Dombrowski SM, Zgheib C, Zouein FA, Keen HL, Kurdi M, Booz GW. Elucidating functional context within microarray data by integrated transcription factor-focused gene-interaction and regulatory network analysis. Eur Cytokine Netw. 2013 Jun; 24(2):75-90. PMID: 23822978; PMCID: PMC3873763.
    15. Zouein FA, Zgheib C, Hamza S, Fuseler JW, Hall JE, Soljancic A, Lopez-Ruiz A, Kurdi M, Booz GW. Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation. Hypertens Res. 2013 Jun; 36(6):496-503. PMID: 23364341; PMCID: PMC3674130.
    16. Zgheib C, Zouein FA, Kurdi M, Booz GW. Chronic treatment of mice with leukemia inhibitory factor does not cause adverse cardiac remodeling but improves heart function. Eur Cytokine Netw. 2012 Oct-Dec; 23(4):191-7. PMID: 23291613; PMCID: PMC3595094.
    17. Zgheib C, Kurdi M, Zouein FA, Gunter BW, Stanley BA, Zgheib J, Romero DG, King SB, Paolocci N, Booz GW. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS One. 2012; 7(8):e43313. PMID: 22905257; PMCID: PMC3419695.
    18. Zouein FA, Zgheib C, Liechty KW, Booz GW. Post-infarct biomaterials, left ventricular remodeling, and heart failure: is good good enough? Congest Heart Fail. 2012 Sep-Oct; 18(5):284-90. PMID: 22612796; PMCID: PMC3427425.
    19. Zgheib C, Zouein FA, Kurdi M, Booz GW. Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress. JAKSTAT. 2012 Apr 01; 1(2):101-10. PMID: 23904970; PMCID: PMC3670289.
    20. Alturkmani HJ, Zgheib C, Zouein FA, Alshaaer NE, Kurdi M, Booz GW. Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability. J Inorg Biochem. 2012 Apr; 109:9-15. PMID: 22366233; PMCID: PMC3322285.
    21. Zgheib C, Zouein FA, Chidiac R, Kurdi M, Booz GW. Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. J Interferon Cytokine Res. 2012 Feb; 32(2):87-94. PMID: 22142222; PMCID: PMC3275095.
    22. Kurdi M, Chidiac R, Hoemann C, Zouein F, Zgheib C, Booz GW. Hydrogels as a platform for stem cell delivery to the heart. Congest Heart Fail. 2010 May-Jun; 16(3):132-5. PMID: 20557335; PMCID: PMC2921949.
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