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Carlos Zgheib

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG

    Collapse Biography 
    Collapse education and training
    University Of Colorado Denver and Children's Hospital Colorado, Aurora, COAssistant Professor of SurgeryRegenerative Medicine/Nanotechnology
    University Of Colorado Denver and Children's Hospital Colorado, Aurora, COInstructor06/2018Regenerative Medicine/Nanotechnology
    Sanford Burnham Prebys Medical Discovery Institute and Nemours Children’s Hospital, Orlando, FLPost-doctoral Fellow07/2014Regenerative Medicine
    University of Mississippi Medical Center, Jackson, MSPhD06/2012Medical Pharmacology and Toxicology
    University of Mississippi Medical Center, Jackson, MSMS06/2010Biomedical Sciences
    Holy Spirit University of Kaslik, Kaslik, LBMS07/2009Pharmacology and Cosmetology
    Holy Spirit University of Kaslik, Kaslik, LBBS06/2007Biochemistry
    Collapse awards and honors
    2018 - 2019Wound Healing Society Shark Tank Finalist (Wound Healing), The Wound Healing Society
    2017 - 2018The Owen H. Wangensteen Excellence in Research Award (Wound Healing), The American College of Surgeons
    2016 - 2017The Wound Healing Society Junior Faculty Travel Award, The Wound Healing Society
    2011 - 2012Academic Excellence and Superior Scholarship, The Honor Society of Phi Kappa Phi Award for Academic Excellence

    Collapse Overview 
    Collapse overview
    Enterprising and innovative expert with diverse scientific background, strong experience in developing and driving strategic partnerships, and elegant managerial skills in both direct and matrix environments.

    THERAPEUTIC AREA / DISEASE STATE EXPERIENCE
    • Pharmacology and Pharmacotherapy
    • Regenerative Medicine
    • Biomaterials and Nanotechnology
    • Inflammation and Inflammatory Diseases
    • Diabetic Foot Ulcers
    • Non-healing Wounds
    • Myocardial Infarction and Heart Failure
    • Acute Respiratory Distress Syndrome and Acute Lung Injury
    • Ulcerative Colitis

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Niemiec SM, Louiselle AE, Liechty KW, Zgheib C. Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment. Int J Mol Sci. 2020 Dec 23; 22(1). PMID: 33374656.
      View in: PubMed
    2. Niemiec SM, Louiselle AE, Hilton SA, Dewberry LC, Zhang L, Azeltine M, Xu J, Singh S, Sakthivel TS, Seal S, Liechty KW, Zgheib C. Nanosilk Increases the Strength of Diabetic Skin and Delivers CNP-miR146a to Improve Wound Healing. Front Immunol. 2020; 11:590285. PMID: 33193424.
      View in: PubMed
    3. Singh S, Cortes G, Kumar U, Sakthivel TS, Niemiec SM, Louiselle AE, Azeltine-Bannerman M, Zgheib C, Liechty KW, Seal S. Silk fibroin nanofibrous mats for visible sensing of oxidative stress in cutaneous wounds. Biomater Sci. 2020 Nov 07; 8(21):5900-5910. PMID: 32975269.
      View in: PubMed
    4. Azeltine MW, Chavez EJ, Nemec KM, Bednarek JM, Asokan R, Balasubramaniyan N, Zgheib C, Mack CL, Roach JP. Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia. J Surg Res. 2020 12; 256:663-672. PMID: 32818799.
      View in: PubMed
    5. Hodges MM, Zgheib C, Liechty KW. A Large Mammalian Model of Myocardial Regeneration After Myocardial Infarction in Fetal Sheep. Adv Wound Care (New Rochelle). 2021 Apr; 10(4):174-190. PMID: 32496979.
      View in: PubMed
    6. Hu J, Zhang L, Liechty C, Zgheib C, Hodges MM, Liechty KW, Xu J. Long Noncoding RNA GAS5 Regulates Macrophage Polarization and Diabetic Wound Healing. J Invest Dermatol. 2020 08; 140(8):1629-1638. PMID: 32004569.
      View in: PubMed
    7. Sener G, Hilton SA, Osmond MJ, Zgheib C, Newsom JP, Dewberry L, Singh S, Sakthivel TS, Seal S, Liechty KW, Krebs MD. Injectable, self-healable zwitterionic cryogels with sustained microRNA - cerium oxide nanoparticle release promote accelerated wound healing. Acta Biomater. 2020 01 01; 101:262-272. PMID: 31726250.
      View in: PubMed
    8. Hilton SA, Dewberry LC, Hodges MM, Hu J, Xu J, Liechty KW, Zgheib C. Mesenchymal stromal cells contract collagen more efficiently than dermal fibroblasts: Implications for cytotherapy. PLoS One. 2019; 14(7):e0218536. PMID: 31306414.
      View in: PubMed
    9. Hodges MM, Zgheib C, Xu J, Hu J, Dewberry LC, Hilton SA, Allukian MW, Gorman JH, Gorman RC, Liechty KW. Differential Expression of Transforming Growth Factor-ß1 Is Associated With Fetal Regeneration After Myocardial Infarction. Ann Thorac Surg. 2019 07; 108(1):59-66. PMID: 30690019.
      View in: PubMed
    10. Kurdi M, Zgheib C, Booz GW. Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease. Front Immunol. 2018; 9:3029. PMID: 30619368.
      View in: PubMed
    11. Zgheib C, Hilton SA, Dewberry LC, Hodges MM, Ghatak S, Xu J, Singh S, Roy S, Sen CK, Seal S, Liechty KW. Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment. J Am Coll Surg. 2019 01; 228(1):107-115. PMID: 30359833.
      View in: PubMed
    12. Xu J, Zgheib C, Hodges MM, Caskey RC, Hu J, Liechty KW. Mesenchymal stem cells correct impaired diabetic wound healing by decreasing ECM proteolysis. Physiol Genomics. 2017 Oct 01; 49(10):541-548. PMID: 28842435.
      View in: PubMed
    13. Zgheib C, Hodges MM, Allukian MW, Xu J, Spiller KL, Gorman JH, Gorman RC, Liechty KW. Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis. Ann Thorac Surg. 2017 Dec; 104(6):1968-1975. PMID: 28821329.
      View in: PubMed
    14. Zgheib C, Hodges MM, Hu J, Liechty KW, Xu J. Long non-coding RNA Lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages. PLoS One. 2017; 12(5):e0177453. PMID: 28494015.
      View in: PubMed
    15. Zgheib C, Hodges M, Hu J, Beason DP, Soslowsky LJ, Liechty KW, Xu J. Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a. Wound Repair Regen. 2016 03; 24(2):237-46. PMID: 26808714.
      View in: PubMed
    16. Zgheib C, Liechty KW. Shedding light on miR-26a: Another key regulator of angiogenesis in diabetic wound healing. J Mol Cell Cardiol. 2016 Mar; 92:203-5. PMID: 26906635.
      View in: PubMed
    17. Zgheib C, Xu J, Mallette AC, Caskey RC, Zhang L, Hu J, Liechty KW. SCF increases in utero-labeled stem cells migration and improves wound healing. Wound Repair Regen. 2015 Jul-Aug; 23(4):583-90. PMID: 26032674.
      View in: PubMed
    18. Xu J, Zgheib C, Hu J, Wu W, Zhang L, Liechty KW. The role of microRNA-15b in the impaired angiogenesis in diabetic wounds. Wound Repair Regen. 2014 Sep-Oct; 22(5):671-7. PMID: 25059098.
      View in: PubMed
    19. Caskey RC, Zgheib C, Morris M, Allukian M, Dorsett-Martin W, Xu J, Wu W, Liechty KW. Dysregulation of collagen production in diabetes following recurrent skin injury: contribution to the development of a chronic wound. Wound Repair Regen. 2014 Jul-Aug; 22(4):515-20. PMID: 24898050.
      View in: PubMed
    20. Gergi R, Osta N, Bourbouze G, Zgheib C, Arbab-Chirani R, Naaman A. Effects of three nickel titanium instrument systems on root canal geometry assessed by micro-computed tomography. Int Endod J. 2015 Feb; 48(2):162-70. PMID: 24717063.
      View in: PubMed
    21. Zgheib C, Allukian MW, Xu J, Morris MW, Caskey RC, Herdrich BJ, Hu J, Gorman JH, Gorman RC, Liechty KW. Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult. Ann Thorac Surg. 2014 May; 97(5):1643-50. PMID: 24792251.
      View in: PubMed
    22. Morris MW, Allukian M, Herdrich BJ, Caskey RC, Zgheib C, Xu J, Dorsett-Martin W, Mitchell ME, Liechty KW. Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation. Wound Repair Regen. 2014 May-Jun; 22(3):406-14. PMID: 24844340.
      View in: PubMed
    23. Zgheib C, Xu J, Liechty KW. Targeting Inflammatory Cytokines and Extracellular Matrix Composition to Promote Wound Regeneration. Adv Wound Care (New Rochelle). 2014 Apr 01; 3(4):344-355. PMID: 24757589.
      View in: PubMed
    24. Werner T, Dombrowski SM, Zgheib C, Zouein FA, Keen HL, Kurdi M, Booz GW. Elucidating functional context within microarray data by integrated transcription factor-focused gene-interaction and regulatory network analysis. Eur Cytokine Netw. 2013 Jun; 24(2):75-90. PMID: 23822978.
      View in: PubMed
    25. Zouein FA, Zgheib C, Hamza S, Fuseler JW, Hall JE, Soljancic A, Lopez-Ruiz A, Kurdi M, Booz GW. Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation. Hypertens Res. 2013 Jun; 36(6):496-503. PMID: 23364341.
      View in: PubMed
    26. Zgheib C, Zouein FA, Kurdi M, Booz GW. Chronic treatment of mice with leukemia inhibitory factor does not cause adverse cardiac remodeling but improves heart function. Eur Cytokine Netw. 2012 Oct-Dec; 23(4):191-7. PMID: 23291613.
      View in: PubMed
    27. Zgheib C, Kurdi M, Zouein FA, Gunter BW, Stanley BA, Zgheib J, Romero DG, King SB, Paolocci N, Booz GW. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS One. 2012; 7(8):e43313. PMID: 22905257.
      View in: PubMed
    28. Zouein FA, Zgheib C, Liechty KW, Booz GW. Post-infarct biomaterials, left ventricular remodeling, and heart failure: is good good enough? Congest Heart Fail. 2012 Sep-Oct; 18(5):284-90. PMID: 22612796.
      View in: PubMed
    29. Zgheib C, Zouein FA, Kurdi M, Booz GW. Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress. JAKSTAT. 2012 Apr 01; 1(2):101-10. PMID: 23904970.
      View in: PubMed
    30. Alturkmani HJ, Zgheib C, Zouein FA, Alshaaer NE, Kurdi M, Booz GW. Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability. J Inorg Biochem. 2012 Apr; 109:9-15. PMID: 22366233.
      View in: PubMed
    31. Zgheib C, Zouein FA, Chidiac R, Kurdi M, Booz GW. Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. J Interferon Cytokine Res. 2012 Feb; 32(2):87-94. PMID: 22142222.
      View in: PubMed
    32. Kurdi M, Chidiac R, Hoemann C, Zouein F, Zgheib C, Booz GW. Hydrogels as a platform for stem cell delivery to the heart. Congest Heart Fail. 2010 May-Jun; 16(3):132-5. PMID: 20557335.
      View in: PubMed
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