Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.
El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15; 193(2):597-609.
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Animals
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Animals, Newborn
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Cattle
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CCAAT-Enhancer-Binding Protein-beta
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Cell Line, Tumor
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Cells, Cultured
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Culture Media, Conditioned
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Fibroblasts
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Fibrosis
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Gene Expression
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Humans
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Hypertension, Pulmonary
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Hypoxia-Inducible Factor 1, alpha Subunit
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Immunoblotting
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Inflammation
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Interleukin-6
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Macrophage Activation
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Macrophages
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Knockout
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Phenotype
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Rats, Inbred WKY
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Reverse Transcriptase Polymerase Chain Reaction
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STAT3 Transcription Factor