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Mario Enrico Canonico

TitleAssistant Research Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rafei AE, Harrington JA, Tavares CAM, Guimar?es PO, Ambrosy AP, Bonaca MP, Sauer AJ, Vardeny O, Canonico ME. Heart failure with preserved ejection fraction therapeutics: in search of the pillars. Heart Fail Rev. 2025 May 22. PMID: 40399553.
      View in: PubMed
    2. Gargiulo G, Cirillo P, Sperandeo L, Castiello DS, Manzi L, Forzano I, Florimonte D, Simonetti F, Canonico ME, Avvedimento M, Paolillo R, Spinelli A, Buongiorno F, Serafino LD, Spaccarotella CAM, Franzone A, Piccolo R, Stabile E, Valgimigli M, Esposito G. Pharmacodynamic effects of cangrelor in patients with acute or chronic coronary syndrome undergoing percutaneous coronary intervention: the POMPEII Registry. EuroIntervention. 2025 May 16; 21(10):560-570. PMID: 40375762.
      View in: PubMed
    3. Biegus J, Ponikowska B, Canonico ME, Damman K, Palazzuoli A, Ambrosy AP. Bumetanide nasal spray: a novel approach to enhancing diuretic response and advancing ambulatory heart failure care? Heart Fail Rev. 2025 May 13. PMID: 40360832.
      View in: PubMed
    4. Hogan SE, Canonico ME, King RW, Low Wang CC, Nehler MR, Parr J, Rogers RK, Lu W, Albanese J, Barnathan ES, Spyropoulos AC, Douketis JD, Bonaca MP, Capell WH. Preserving Trial Endpoint Specificity and Cause of Death Attribution in Cardiovascular Trials: Insights From MARINER. JACC Adv. 2025 May 12; 4(6 Pt 1):101763. PMID: 40359642.
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    5. Canonico ME, Hess CN, Naveh S, Rogers RK, Nehler MR, Hogan SE, Hsia JA, Berkowitz SD, Bonaca MP. Prescription of aspirin plus low-dose rivaroxaban in patients with peripheral artery disease after lower-extremity revascularization. Vasc Med. 2025 Apr 30; 1358863X251331561. PMID: 40305186.
      View in: PubMed
    6. Gupta P, Bast JA, Razavi AC, Canonico ME, Shahzad A, Naeem M, Bonaca MP, Sperling LS, Quintana RA. Hypertension in atherosclerotic cardiovascular disease: insights into epidemiology, management strategies, and outcomes. Curr Opin Cardiol. 2025 Apr 24. PMID: 40305167.
      View in: PubMed
    7. Canonico ME, Avvedimento M, Piccolo R, Hess CN, Bardi L, Ilardi F, Giugliano G, Franzone A, Gargiulo G, Berkowitz SD, Cannon CP, Esposito G, Bonaca MP. Long-term Antithrombotic Therapy in Patients With Chronic Coronary Syndrome: An Updated Review of Current Evidence. Clin Ther. 2025 Apr 13. PMID: 40229176.
      View in: PubMed
    8. Basile C, Rodolico D, Villaschi A, Canonico ME, Fucile I, Giugliano G, Mancusi C, Morisco C, Esposito G. Time-to-first clinical benefit in heart failure with preserved ejection fraction: A reconstructed time-to-event meta-analysis of randomized controlled trials. Eur J Prev Cardiol. 2025 Apr 09. PMID: 40200554.
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    9. Castiello DS, Buongiorno F, Manzi L, Narciso V, Forzano I, Florimonte D, Sperandeo L, Canonico ME, Avvedimento M, Paolillo R, Spinelli A, Cristiano S, Simonetti F, Semplice F, D'Alconzo D, Vallone DM, Giugliano G, Sciahbasi A, Cirillo P, Gragnano F, Calabr? P, Esposito G, Gargiulo G. Procedural and Antithrombotic Therapy Optimization in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Narrative Review. J Cardiovasc Dev Dis. 2025 Apr 08; 12(4). PMID: 40278201.
      View in: PubMed
    10. Manzi L, Buongiorno F, Narciso V, Florimonte D, Forzano I, Castiello DS, Sperandeo L, Paolillo R, Verde N, Spinelli A, Cristiano S, Avvedimento M, Canonico ME, Bardi L, Giugliano G, Gargiulo G. Acute Heart Failure and Non-Ischemic Cardiomyopathies: A Comprehensive Review and Critical Appraisal. Diagnostics (Basel). 2025 Feb 23; 15(5). PMID: 40075788.
      View in: PubMed
    11. Canonico ME, Bauersachs R, Bonaca MP. Reply: Where the Definition of Fragility Came From and Where It Will Go. J Am Coll Cardiol. 2025 Jan 28; 85(3):e45-e46. PMID: 39843038.
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    12. Canonico ME, Ambrosy AP, Samsky MD. Lessons learned and future perspectives from the PRO-HF trial. Heart Fail Rev. 2025 May; 30(3):525-527. PMID: 39794682.
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    13. Gluckman TJ, Chiu ST, Rider D, Tseng PK, Mudd JO, Remick JD, Granowitz C, Carroll A, Sikirica S, Canonico ME, Hsia J, Bonaca MP. Relationship Between Left Ventricular Ejection Fraction and ICD-10 Codes Among Patients Hospitalized With Heart Failure. Clin Cardiol. 2024 12; 47(12):e70055. PMID: 39686565.
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    14. Piccolo R, Simonetti F, Avvedimento M, Cutillo M, Canonico ME, Conti V, Gargiulo G, Paolillo R, Dal Piaz F, Filippelli A, Charlier B, Spinelli A, Cristiano S, Cirillo P, Di Serafino L, Franzone A, Esposito G. Ticagrelor 60 vs. 90 mg in elderly ACS patients undergoing PCI: a randomized, crossover trial. Eur Heart J Cardiovasc Pharmacother. 2024 Nov 06; 10(7):578-587. PMID: 39025785.
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    15. Halaseh R, Sauer AJ, Vardeny O, Canonico ME, Harrington J, Svetlichnaya J, Ambrosy AP. A fine addition: Finerenone in the evolving landscape of heart failure with preserved ejection fraction. Heart Fail Rev. 2025 Mar; 30(2):287-291. PMID: 39476221.
      View in: PubMed
    16. Canonico ME, Low Wang CC, Hsia J, Debus ES, Nehler MR, Patel MR, Anand SS, Ycas J, Capell WH, Muehlhofer E, Haskell LP, Berkowitz SD, Bauersachs R, Bonaca MP. Low-Dose Rivaroxaban Plus Aspirin in?Fragile Patients After Lower Extremity?Revascularization. J Am Coll Cardiol. 2024 Aug 27; 84(9):801-811. PMID: 39168566.
      View in: PubMed
    17. Nardi E, Santoro C, Prastaro M, Canonico ME, Paolillo S, Gargiulo G, Gargiulo P, Parlati ALM, Basile C, Bardi L, Giuliano M, Esposito G. Crosslink between atrial fibrillation and cancer: a therapeutic conundrum. Cardiooncology. 2024 Aug 07; 10(1):48. PMID: 39113118.
      View in: PubMed
    18. Canonico ME, Verde N, Avvedimento M, Leone A, Cutillo M, Simonetti F, Esposito S, Bardi L, Giugliano G, Stabile E, Piccolo R, Esposito G. Safety and Efficacy of Combined Coronary and Peripheral Percutaneous Revascularization: A Proof-of-Concept Study. J Clin Med. 2024 Aug 02; 13(15). PMID: 39124782.
      View in: PubMed
    19. Canonico ME, Hess CN, Secemsky EA, Bonaca MP. Antithrombotic Therapy in Patients Undergoing Peripheral Artery Interventions. Interv Cardiol Clin. 2024 Oct; 13(4):553-559. PMID: 39245554.
      View in: PubMed
    20. Morrison JT, Canonico ME, Anand SS, Patel MR, Debus ES, Nehler MR, Hess CN, Hsia J, Capell WH, Muehlhofer E, Haskell LP, Berkowitz SD, Bauersachs RM, Bonaca MP. Low-Dose Rivaroxaban Plus Aspirin in Patients With Peripheral Artery Disease Undergoing Lower Extremity Revascularization With and Without Concomitant Coronary Artery Disease: Insights From VOYAGER PAD. Circulation. 2024 May 07; 149(19):1536-1539. PMID: 38709838.
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    21. Canonico ME, Hess CN, Rogers RK, Bonaca MP. Medical Therapy for Peripheral Artery Disease. Curr Cardiol Rep. 2024 Jun; 26(6):651-659. PMID: 38696099.
      View in: PubMed
    22. Gupta P, Canonico ME, Faaborg-Andersen C, Prabhu N, Kondapalli L, Quintana RA. Updates in the management of cancer therapy-related hypertension. Curr Opin Cardiol. 2024 Jul 01; 39(4):235-243. PMID: 38391284.
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    23. Parodi G, Dossi F, Raccis M, Talanas G, Mura E, Siciliano R, Guarino S, Marini A, Franca P, Saba PS, Sanna GD, Canonico ME. Platelet inhibition with orodispersible ticagrelor in acute coronary syndromes according to morphine use: the TASTER study final results. Eur Heart J Cardiovasc Pharmacother. 2023 Dec 14; 9(8):692-700. PMID: 37591636.
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    24. Manzo R, Ilardi F, Nappa D, Mariani A, Angellotti D, Immobile Molaro M, Sgherzi G, Castiello DS, Simonetti F, Santoro C, Canonico ME, Avvedimento M, Piccolo R, Franzone A, Esposito G. Echocardiographic Evaluation of Aortic Stenosis: A Comprehensive Review. Diagnostics (Basel). 2023 Jul 29; 13(15). PMID: 37568890.
      View in: PubMed
    25. Canonico ME, Hess CN, Cannon CP. In-Hospital Use of PCSK9 Inhibitors in the Post ACS Patient: What Does the Evidence Show? Curr Atheroscler Rep. 2023 07; 25(7):381-389. PMID: 37223853.
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    26. Angellotti D, Manzo R, Castiello DS, Immobile Molaro M, Mariani A, Iapicca C, Nappa D, Simonetti F, Avvedimento M, Leone A, Canonico ME, Spaccarotella CAM, Franzone A, Ilardi F, Esposito G, Piccolo R. Hemodynamic Performance of Transcatheter Aortic Valves: A Comprehensive Review. Diagnostics (Basel). 2023 May 13; 13(10). PMID: 37238215.
      View in: PubMed
    27. Saba PS, Canonico ME, Gambaro A, Gazale G, Piga S, Santomauro M, Roscio G. Systematic basic and advanced resuscitation training in medical students and fellows: a proposal from the Working Group on Cardiovascular Urgences and Emergencies of the Italian Society of Cardiology. J Cardiovasc Med (Hagerstown). 2023 05 01; 24(Suppl 2):e128-e133. PMID: 37186563.
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    28. Angellotti D, Manzo R, Castiello DS, Immobile Molaro M, Mariani A, Iapicca C, Nappa D, Simonetti F, Avvedimento M, Leone A, Canonico ME, Spaccarotella CAM, Franzone A, Ilardi F, Esposito G, Piccolo R. Echocardiographic Evaluation after Transcatheter Aortic Valve Implantation: A Comprehensive Review. Life (Basel). 2023 Apr 24; 13(5). PMID: 37240724.
      View in: PubMed
    29. Canonico ME, Piccolo R, Avvedimento M, Leone A, Esposito S, Franzone A, Giugliano G, Gargiulo G, Hess CN, Berkowitz SD, Hsia J, Cirillo P, Esposito G, Bonaca MP. Antithrombotic Therapy in Peripheral Artery Disease: Current Evidence and Future Directions. J Cardiovasc Dev Dis. 2023 Apr 10; 10(4). PMID: 37103043.
      View in: PubMed
    30. Gargiulo G, Marenna A, Sperandeo L, Manzi L, Avvedimento M, Simonetti F, Canonico ME, Paolillo R, Spinelli A, Borgia F, Diserafino L, Franzone A, Stabile E, Piccolo R, Cirillo P, Valgimigli M, Esposito G. Pharmacodynamic effects of cangrelor in elective complex PCI: insights from the POMPEII Registry. EuroIntervention. 2023 03 20; 18(15):1266-1268. PMID: 36512429.
      View in: PubMed
    31. Canonico ME, Hsia J, Hess CN, Bonaca MP. Sex differences in guideline-directed medical therapy in 2021-22 among patients with peripheral artery disease. Vasc Med. 2023 06; 28(3):233-235. PMID: 36847166.
      View in: PubMed
    32. Canonico ME, Hsia J, Cannon CP, Bonaca MP. Uptake of Newer Guideline-Directed Therapies in Heart?Failure Patients With Diabetes or Chronic Kidney Disease. JACC Heart Fail. 2022 12; 10(12):989-991. PMID: 36456073.
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    33. King RW, Canonico ME, Bonaca MP, Hess CN. Management of Peripheral Arterial Disease: Lifestyle Modifications and Medical Therapies. J Soc Cardiovasc Angiogr Interv. 2022 Nov-Dec; 1(6):100513. PMID: 39132343.
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    34. Santoro C, Buonauro A, Canora A, Rea G, Canonico ME, Esposito R, Sanduzzi A, Esposito G, Bocchino M. Non-Invasive Assessment of Right Ventricle to Arterial Coupling for Prognosis Stratification of Fibrotic Interstitial Lung Diseases. J Clin Med. 2022 Oct 17; 11(20). PMID: 36294435.
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    35. Canonico ME, Sanna GD, Siciliano R, Scudiero F, Esposito G, Parodi G. Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report. Front Pharmacol. 2022; 13:916361. PMID: 36016569.
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    36. Santoro C, Ilardi F, Esposito R, Mandoli GE, Canonico ME, Buongiorno F, Canciello G, Prastaro M, Losi MA, Esposito G. Impact of Age and Heart Rate on Strain-Derived Myocardial Work in a Population of Healthy Subjects. Diagnostics (Basel). 2022 Jul 12; 12(7). PMID: 35885601.
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    37. Canonico ME, Hsia J, Guthrie NL, Simmons M, Mehta P, Lupinacci P, Edwards K, Mosesso K, Gearhart M, Skuban A, Bonaca MP, Berman MA. Cognitive behavioral therapy delivered via digital mobile application for the treatment of type 2 diabetes: Rationale, design, and baseline characteristics of a randomized, controlled trial. Clin Cardiol. 2022 Aug; 45(8):850-856. PMID: 35778834.
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    38. Sanna GD, Moccia E, Canonico ME, Sanna S, De Toni C, Santoro C, Masia SL, Saderi L, Sotgiu G, Parodi G. Left atrial remodeling in heart failure: the role of sphericity index (the SPHERICAT-HF study). Int J Cardiovasc Imaging. 2022 Aug; 38(8):1723-1732. PMID: 35212852.
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    39. Scudiero F, Canonico ME, Sanna GD, Dossi F, Silverio A, Galasso G, Esposito G, Porto I, Parodi G. Dual Antiplatelet Therapy with 3rd Generation P2Y12 Inhibitors in STEMI Patients: Impact of Body Mass Index on Loading Dose-Response. Cardiovasc Drugs Ther. 2023 08; 37(4):695-703. PMID: 35175499.
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    40. Canonico ME, Santoro C, Avvedimento M, Giugliano G, Mandoli GE, Prastaro M, Franzone A, Piccolo R, Ilardi F, Cameli M, Esposito G. Venous Thromboembolism and Cancer: A Comprehensive Review from Pathophysiology to Novel Treatment. Biomolecules. 2022 02 04; 12(2). PMID: 35204760.
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    41. Scudiero F, Silverio A, Muraca I, Russo V, Di Maio M, Silvestro A, Personeni D, Citro R, Canonico ME, Galasso G, Porto I, Parodi G. Long-Term Prognostic Impact of Right Ventricular Dysfunction in Patients with COVID-19. J Pers Med. 2022 Jan 26; 12(2). PMID: 35207651.
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    42. Piccolo R, Avvedimento M, Canonico ME, Gargiulo P, Paolillo R, Conti V, Dal Piaz F, Filippelli A, Morisco C, Simonetti F, Leone A, Marenna A, Bruzzese D, Gargiulo G, Stabile E, Di Serafino L, Franzone A, Cirillo P, Esposito G. Platelet Inhibition with Ticagrelor 60?mg Versus 90?mg Twice Daily in Elderly Patients with Acute Coronary Syndrome: Rationale and Design of the PLINY THE ELDER Trial. Cardiovasc Drugs Ther. 2023 10; 37(5):1031-1038. PMID: 35048203.
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    43. Sanna GD, Canonico ME, Siciliano R, Guarino S, Montereggi F, Ponti E, Corda G, Talanas G, Parodi G. Impact of glucose-6-phosphate dehydrogenase deficiency on the severity of coronary atherosclerosis in patients with acute coronary syndromes. J Cardiovasc Med (Hagerstown). 2021 Nov 01; 22(11):813-817. PMID: 34261077.
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    44. Sanna GD, De Bellis A, Zecchin M, Beccu E, Carta P, Moccia E, Canonico ME, Parodi G, Sinagra G, Merlo M. Prevalence, clinical and instrumental features of left bundle branch block-induced cardiomyopathy: the CLIMB registry. ESC Heart Fail. 2021 12; 8(6):5589-5593. PMID: 34510787.
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    45. Sanna GD, Canonico ME, Santoro C, Esposito R, Masia SL, Galderisi M, Parodi G, Nihoyannopoulos P. Echocardiographic Longitudinal Strain Analysis in Heart Failure: Real Usefulness for Clinical Management Beyond Diagnostic Value and Prognostic Correlations? A Comprehensive Review. Curr Heart Fail Rep. 2021 10; 18(5):290-303. PMID: 34398411.
      View in: PubMed
    46. Parodi G, Talanas G, Mura E, Canonico ME, Siciliano R, Guarino S, Marini A, Dossi F, Franca P, Raccis M, Saba PS, Sanna GD. Orodispersible Ticagrelor in Acute Coronary Syndromes: The TASTER Study. J Am Coll Cardiol. 2021 07 20; 78(3):292-294. PMID: 34266583.
      View in: PubMed
    47. Santoro C, Capone V, Canonico ME, Gargiulo G, Esposito R, Sanna GD, Parodi G, Esposito G. Single, Dual, and Triple Antithrombotic Therapy in Cancer Patients with Coronary Artery Disease: Searching for Evidence and Personalized Approaches. Semin Thromb Hemost. 2021 Nov; 47(8):950-961. PMID: 34261150.
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    48. Esposito R, Fedele T, Orefice S, Cuomo V, Prastaro M, Canonico ME, Ilardi F, De Stefano F, Fiorillo L, Santoro C, Esposito G. An Emergent Form of Cardiotoxicity: Acute Myocarditis Induced by Immune Checkpoint Inhibitors. Biomolecules. 2021 05 22; 11(6). PMID: 34067474.
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    49. Russo V, Bottino R, D'Andrea A, Silverio A, Di Maio M, Golino P, Nigro G, Valsecchi O, Attena E, Canonico ME, Galasso G, Parodi G, Scudiero F. Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients. Cardiovasc Drugs Ther. 2022 08; 36(4):705-712. PMID: 33988835.
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    50. Canonico ME, Sanna GD, Siciliano R, Guarino S, Bellandi B, Scudiero F, Saba PS, Esposito G, Alexopoulos D, Parodi G. Not-high before-treatment platelet reactivity in patients with STEMI: prevalence, clinical characteristics, response to therapy and outcomes. Platelets. 2022 Apr 03; 33(3):390-397. PMID: 33856272.
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    51. Talanas G, Guarino S, Canonico ME, Parodi G. Balloon Angioplasty of the Radial Artery to Solve a Challenging Radial Sheath Insertion. J Invasive Cardiol. 2021 01; 33(1):E69. PMID: 33385991.
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    52. Fedele T, Orefice S, Fiorillo L, Cuomo V, Capone V, Casciano O, Luciano F, Canonico ME, Santoro C, Esposito R. 77 Routine outpatients visits during SARS-CoV2 global pandemic. Eur Heart J Suppl. 2020 Dec; 22(Suppl N):N135-N137. PMID: 38626258.
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    53. Scudiero F, Silverio A, Di Maio M, Russo V, Citro R, Personeni D, Cafro A, D'Andrea A, Attena E, Pezzullo S, Canonico ME, Galasso G, Pit? A, Parodi G. Pulmonary embolism in COVID-19 patients: prevalence, predictors and clinical outcome. Thromb Res. 2021 02; 198:34-39. PMID: 33271421.
      View in: PubMed
    54. Talanas G, Siciliano R, Canonico ME, Parodi G. [Coronary wire entrapment and unintended extraction of a just deployed stent]. G Ital Cardiol (Rome). 2020 11; 21(11 Suppl 1):58S-59S. PMID: 33295336.
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    55. Scudiero F, Valenti R, Marcucci R, Sanna GD, Gori AM, Migliorini A, Vitale R, Giusti B, De Vito E, Corda G, Paniccia R, Zirolia D, Canonico ME, Parodi G. Platelet Reactivity in Hepatitis C Virus-Infected Patients on Dual Antiplatelet Therapy for Acute Coronary Syndrome. J Am Heart Assoc. 2020 09 15; 9(18):e016441. PMID: 32885738.
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    56. Siciliano R, Canonico ME, Talanas G, Saba PS, Parodi G. Cangrelor-supported primary percutaneous coronary intervention in a patient with cardiogenic shock due to left main acute occlusion. J Cardiovasc Med (Hagerstown). 2020 Aug; 21(8):616-617. PMID: 32520863.
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    57. Capone V, Cuomo V, Esposito R, Canonico ME, Ilardi F, Prastaro M, Esposito G, Santoro C. Epidemiology, prognosis, and clinical manifestation of cardiovascular disease in COVID-19. Expert Rev Cardiovasc Ther. 2020 Aug; 18(8):531-539. PMID: 32672482.
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    58. Canonico ME, Siciliano R, Scudiero F, Sanna GD, Parodi G. The tug-of-war between coagulopathy and anticoagulant agents in patients with COVID-19. Eur Heart J Cardiovasc Pharmacother. 2020 07 01; 6(4):262-264. PMID: 32383737.
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    59. Buonauro A, Santoro C, Galderisi M, Canora A, Sorrentino R, Esposito R, Lembo M, Canonico ME, Ilardi F, Fazio V, Golia B, Sanduzzi A, Bocchino M. Impaired Right and Left Ventricular Longitudinal Function in Patients with Fibrotic Interstitial Lung Diseases. J Clin Med. 2020 Feb 21; 9(2). PMID: 32098133.
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    60. Lembo M, Santoro C, Sorrentino R, Canonico ME, Fazio V, Trimarco B, Tadic M, Galderisi M, Esposito R. Interrelation between midwall mechanics and longitudinal strain in newly diagnosed and never-treated hypertensive patients without clinically defined hypertrophy. J Hypertens. 2020 02; 38(2):295-302. PMID: 31584519.
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    61. Lembo M, Santoro C, Sorrentino R, Fazio V, Canonico ME, Chiariello L, Galderisi M, Esposito R. Prominent basal and middle strain longitudinal involvement in newly-diagnosed and never treated hypertensive patients without clear-cut hypertrophy. Int J Cardiol. 2020 04 01; 304:179-184. PMID: 31982160.
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    62. Bianchi R, D'Acierno L, Crisci M, Tartaglione D, Cappelli Bigazzi M, Canonico M, Albanese M, Gragnano F, Fimiani F, Russo M, Cirillo P, Calabr? P. From Femoral to Radial Approach in Coronary Intervention. Angiology. 2017 Apr; 68(4):281-287. PMID: 27401210.
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