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Heather Tye

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N. BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. Mol Cancer Ther. 2015 Dec; 14(12):2762-72. PMID: 26438154.
      View in: PubMed
    2. Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T. Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem. 2015 Feb 26; 58(4):1669-90. PMID: 25671290.
      View in: PubMed
    3. Lou?rat F, Tye H, Napier S, Garrigou M, Whittaker M, Gros PC. TBAF-catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds. Org Biomol Chem. 2011 Mar 21; 9(6):1768-73. PMID: 21264409.
      View in: PubMed
    4. Tye H, Mueller SG, Prestle J, Scheuerer S, Schindler M, Nosse B, Prevost N, Brown CJ, Heifetz A, Moeller C, Pedret-Dunn A, Whittaker M. Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):34-7. PMID: 21146986.
      View in: PubMed
    5. Moss N, Choi Y, Cogan D, Flegg A, Kahrs A, Loke P, Meyn O, Nagaraja R, Napier S, Parker A, Thomas Peterson J, Ramsden P, Sarko C, Skow D, Tomlinson J, Tye H, Whitaker M. A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2206-10. PMID: 19307114.
      View in: PubMed
    6. East SP, White CB, Barker O, Barker S, Bennett J, Brown D, Boyd EA, Brennan C, Chowdhury C, Collins I, Convers-Reignier E, Dymock BW, Fletcher R, Haydon DJ, Gardiner M, Hatcher S, Ingram P, Lancett P, Mortenson P, Papadopoulos K, Smee C, Thomaides-Brears HB, Tye H, Workman J, Czaplewski LG. DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):894-9. PMID: 19095445.
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    7. Tye H, Whittaker M, Ramdeehul S. Minimisation of palladium content in Suzuki cross-coupling reactions. Comb Chem High Throughput Screen. 2006 Nov; 9(9):703-10. PMID: 17100575.
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    8. Leadbeatera NE, Torenius HM, Tye H. Microwave-promoted organic synthesis using ionic liquids: a mini review. Comb Chem High Throughput Screen. 2004 Aug; 7(5):511-28. PMID: 15320715.
      View in: PubMed
    9. Tye H. Application of statistical 'design of experiments' methods in drug discovery. Drug Discov Today. 2004 Jun 01; 9(11):485-91. PMID: 15149624.
      View in: PubMed
    10. Tye H, Whittaker M. Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction. Org Biomol Chem. 2004 Mar 21; 2(6):813-5. PMID: 15007407.
      View in: PubMed
    11. Arvela RK, Leadbeater NE, Torenius HM, Tye H. Rapid cyanation of aryl iodides in water using microwave promotion. Org Biomol Chem. 2003 Apr 07; 1(7):1119-21. PMID: 12926385.
      View in: PubMed
    12. Leadbeater NE, Torenius HM, Tye H. Microwave-assisted Mannich-type three-component reactions. Mol Divers. 2003; 7(2-4):135-44. PMID: 14870842.
      View in: PubMed
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