Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Colorado PETAL Clinical Center

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cute Respiratory Distress Syndrome (ARDS) is a serious form of acute ling injury that affects nearly 200,000 individuals in the United States each year. Due to advances in mechanical ventilatory and fluid strategies, the outcomes of ARDS patients have improved significantly over the last decade. The goal of this new NHLBI PETAL initiative is to test therapies that will either prevent the development of ARDS in patients at risk for developing the syndrome, or improve outcomes for patients with early ARDS. The University of Colorado Division of Pulmonary and Critical Care and Department of Emergency Medicine have previously collaborated on clinical initiatives including optimizing the transition of care for critically ill patients from the Emergency Department to the Intensive Care Units. In addition, investigators from each group have a long standing history of performing outstanding ARDS and critical care research, and conducting multi-center clinical trials. The overarching aims of the Colorado Clinical Center for the PETAL network will be: 1) To be an effective clinical center that achieves seamless coordination of care between Critical Care and Emergency Medicine and continues to exceed our contractual obligations to enroll patients; 2) To actively participate in the selection of the clinical trials to be performed by the PETAL network and to contribute to the subsequent responsibilities of the steering and other PETAL committees; 3) To improve the conduct of clinical trials by facilitating the Institutional Review Board process; 4) To maintain excellence and disseminate methodology to improve the quality of protocol compliance, data acquisition, and regulatory responsibilities across the PETAL network.
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