Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Thomas R Germe

TitleResearch Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kolaric A, Germe T, Hrast M, Stevenson CEM, Lawson DM, Burton NP, Vörös J, Maxwell A, Minovski N, Anderluh M. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. Nat Commun. 2021 01 08; 12(1):150. PMID: 33420011.
      View in: PubMed
    2. Bax BD, Murshudov G, Maxwell A, Germe T. DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion. J Mol Biol. 2019 08 23; 431(18):3427-3449. PMID: 31301408.
      View in: PubMed
    3. Germe T, Vörös J, Jeannot F, Taillier T, Stavenger RA, Bacqué E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res. 2018 05 04; 46(8):4114-4128. PMID: 29538767.
      View in: PubMed
    4. Germe T, Vörös J, Jeannot F, Taillier T, Stavenger RA, Bacqué E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res. 2018 05 04; 46(8):4325. PMID: 29596599.
      View in: PubMed
    5. Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, Huseby DL, Hughes D, Bacqué E. Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. J Med Chem. 2018 04 26; 61(8):3565-3581. PMID: 29596745.
      View in: PubMed
    6. Chan PF, Germe T, Bax BD, Huang J, Thalji RK, Bacqué E, Checchia A, Chen D, Cui H, Ding X, Ingraham K, McCloskey L, Raha K, Srikannathasan V, Maxwell A, Stavenger RA. Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4492-E4500. PMID: 28507124.
      View in: PubMed
    7. Gaggioli V, Le Viet B, Germe T, Hyrien O. DNA topoisomerase IIa controls replication origin cluster licensing and firing time in Xenopus egg extracts. Nucleic Acids Res. 2013 Aug; 41(15):7313-31. PMID: 23757188.
      View in: PubMed
    8. Germe T, Miller K, Cooper JP. A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres. EMBO J. 2009 Sep 16; 28(18):2803-11. PMID: 19680223.
      View in: PubMed
    9. Labit H, Perewoska I, Germe T, Hyrien O, Marheineke K. DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. Nucleic Acids Res. 2008 Oct; 36(17):5623-34. PMID: 18765475.
      View in: PubMed
    10. Germe T, Hyrien O. Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure. . 2005 Aug; 6(8):729-35. PMID: 16025133.
      View in: PubMed
    11. Lucas I, Germe T, Chevrier-Miller M, Hyrien O. Topoisomerase II can unlink replicating DNA by precatenane removal. EMBO J. 2001 Nov 15; 20(22):6509-19. PMID: 11707421.
      View in: PubMed
    Germe's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description

    Copyright © 2022 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)