 Thomas R Germe
| Title | Research Instructor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-BioChem&Molecular Genetics |
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 Bibliographic
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Kolaric A, Germe T, Hrast M, Stevenson CEM, Lawson DM, Burton NP, Vörös J, Maxwell A, Minovski N, Anderluh M. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. Nat Commun. 2021 01 08; 12(1):150. PMID: 33420011.
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Bax BD, Murshudov G, Maxwell A, Germe T. DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion. J Mol Biol. 2019 08 23; 431(18):3427-3449. PMID: 31301408.
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Germe T, Vörös J, Jeannot F, Taillier T, Stavenger RA, Bacqué E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res. 2018 05 04; 46(8):4114-4128. PMID: 29538767.
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Germe T, Vörös J, Jeannot F, Taillier T, Stavenger RA, Bacqué E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res. 2018 05 04; 46(8):4325. PMID: 29596599.
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Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, Huseby DL, Hughes D, Bacqué E. Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. J Med Chem. 2018 04 26; 61(8):3565-3581. PMID: 29596745.
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Chan PF, Germe T, Bax BD, Huang J, Thalji RK, Bacqué E, Checchia A, Chen D, Cui H, Ding X, Ingraham K, McCloskey L, Raha K, Srikannathasan V, Maxwell A, Stavenger RA. Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4492-E4500. PMID: 28507124.
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Gaggioli V, Le Viet B, Germe T, Hyrien O. DNA topoisomerase IIa controls replication origin cluster licensing and firing time in Xenopus egg extracts. Nucleic Acids Res. 2013 Aug; 41(15):7313-31. PMID: 23757188.
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Germe T, Miller K, Cooper JP. A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres. EMBO J. 2009 Sep 16; 28(18):2803-11. PMID: 19680223.
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Labit H, Perewoska I, Germe T, Hyrien O, Marheineke K. DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. Nucleic Acids Res. 2008 Oct; 36(17):5623-34. PMID: 18765475.
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Germe T, Hyrien O. Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure. EMBO Rep. 2005 Aug; 6(8):729-35. PMID: 16025133.
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Lucas I, Germe T, Chevrier-Miller M, Hyrien O. Topoisomerase II can unlink replicating DNA by precatenane removal. EMBO J. 2001 Nov 15; 20(22):6509-19. PMID: 11707421.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2001 | 1 | | 2005 | 1 | | 2008 | 1 | | 2009 | 1 | | 2013 | 1 | | 2017 | 1 | | 2018 | 3 | | 2019 | 1 | | 2021 | 1 |
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