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Thomas R Germe

TitleResearch Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
ORCID ORCID Icon0000-0002-6885-0971 Additional info

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Orritt KM, Feng L, Newell JF, Sutton JN, Grossman S, Germe T, Abbott LR, Jackson HL, Bury BKL, Maxwell A, McPhillie MJ, Fishwick CWG. De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region. RSC Med Chem. 2022 Jul 20; 13(7):831-839. PMID: 35919336.
      View in: PubMed
    2. Kolaric A, Germe T, Hrast M, Stevenson CEM, Lawson DM, Burton NP, V?r?s J, Maxwell A, Minovski N, Anderluh M. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. Nat Commun. 2021 01 08; 12(1):150. PMID: 33420011.
      View in: PubMed
    3. Bax BD, Murshudov G, Maxwell A, Germe T. DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion. J Mol Biol. 2019 08 23; 431(18):3427-3449. PMID: 31301408.
      View in: PubMed
    4. Germe T, V?r?s J, Jeannot F, Taillier T, Stavenger RA, Bacqu? E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res. 2018 05 04; 46(8):4325. PMID: 29596599.
      View in: PubMed
    5. Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, Huseby DL, Hughes D, Bacqu? E. Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. J Med Chem. 2018 04 26; 61(8):3565-3581. PMID: 29596745.
      View in: PubMed
    6. Gaggioli V, Le Viet B, Germe T, Hyrien O. DNA topoisomerase IIa controls replication origin cluster licensing and firing time in Xenopus egg extracts. Nucleic Acids Res. 2013 Aug; 41(15):7313-31. PMID: 23757188.
      View in: PubMed
    7. Germe T, Miller K, Cooper JP. A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres. EMBO J. 2009 Sep 16; 28(18):2803-11. PMID: 19680223.
      View in: PubMed
    8. Labit H, Perewoska I, Germe T, Hyrien O, Marheineke K. DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. Nucleic Acids Res. 2008 Oct; 36(17):5623-34. PMID: 18765475.
      View in: PubMed
    9. Germe T, Hyrien O. Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure. EMBO Rep. 2005 Aug; 6(8):729-35. PMID: 16025133.
      View in: PubMed
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