Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Contralateral Knee Osteoarthritis after Primary Total Knee Arthroplasty


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Collapse abstract
The purpose is to determine how longstanding, aberrant movement patterns might contribute to early, contralateral knee OA before TKA, and how persistent, aberrant movement patterns after rehabilitation might further contribute to accelerated contralateral knee OA progression after primary TKA.
AIM 1: Determine if greater knee joint loading and less knee joint excursion in the contralateral knee preoperatively are associated with greater baseline contralateral knee OA.
Hypothesis: Greater loading (peak knee adduction moment) and less joint excursion (sagittal knee motion) during walking will be associated with worse baseline (H1a) whole organ MRI score (WORMS) total sum score and (H1b) quantitative MRI values (cartilage thickness, T2, and T1?).
AIM 2: Determine if greater knee joint loading and less knee joint excursion in the contralateral knee immediately after TKA rehabilitation are associated with contralateral knee OA progression from baseline to 2 years after primary TKA.
Hypothesis: Greater knee loading (peak knee adduction moment) and less joint excursion (sagittal knee motion) during walking 10 weeks after primary TKA will be associated with greater OA progression following TKA as measured with baseline to 2-year changes in (H2a) WORMS total sum score and (H2b) quantitative MRI values (cartilage thickness, T2, and T1?).
Collapse sponsor award id
Advanced Geriatrics Fellowship

Collapse Time 
Collapse start date
2019-09-01
Collapse end date
2021-08-31

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