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Kartik Shankar

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Biography 
    Collapse education and training
    University of Mumbai, Mumbai, IndiaBachelor’s degree Pharmacy (B.Pharm)06/1998Pharmaceutical Sciences
    The University of Louisiana at Monroe, Louisiana, USAPh.D.06/2003Toxicology
    University of Arkansas for Medical Sciences, Little Rock, AR USAPost-doctoral fellow06/2005Nutrition and Pregnancy

    Collapse Overview 
    Collapse overview
    Over the course of my career, I have conducted research related to nutrition, pregnancy, obesity and metabolism. My work has focused on understanding developmental programming associated with maternal diet and obesity, especially alterations of metabolism, epigenetics and non-genetic transmissible factors such as the microbiome. The larger vision here is to seamlessly integrate the spectrum from cell to community research by developing and nurturing team-based research.

    Collapse Research 
    Collapse research activities and funding
    R01DK084225     (SHANKAR, KARTIK)Jul 1, 2009 - Jun 30, 2014
    NIH/NIDDK
    Maternal Overweight: Consequences for Insulin Signaling in the Offspring
    Role: Principal Investigator

    R21HD086194     (SHANKAR, KARTIK)Aug 1, 2017 - Jul 31, 2020
    NIH/NICHD
    Epigenetic Mechanisms Underlying Trophoblast Syncytialization
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ronis MJ, Mercer KE, Shankar K, Pulliam C, Pedersen K, Ingelman-Sundberg M, Friso S, Samuelson D, Del Valle L, Taylor C, Welsh DA. Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein. Chem Biol Interact. 2020 May 14; 325:109131. PMID: 32417163.
      View in: PubMed
    2. Williams AE, Watt J, Robertson LW, Gadupudi G, Osborn ML, Soares MJ, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti NA, Suva LJ, Ronis MJJ. Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent. Toxicol Sci. 2020 May 01; 175(1):113-125. PMID: 32119087.
      View in: PubMed
    3. Brink LR, Mercer KE, Piccolo BD, Chintapalli SV, Elolimy A, Bowlin AK, Matazel KS, Pack L, Adams SH, Shankar K, Badger TM, Andres A, Yeruva L. Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula. Am J Clin Nutr. 2020 Apr 24. PMID: 32330237.
      View in: PubMed
    4. Thakali KM, Zhong Y, Cleves M, Andres A, Shankar K. Associations between maternal body mass index and diet composition with placental DNA methylation at term. Placenta. 2020 Apr; 93:74-82. PMID: 32250742.
      View in: PubMed
    5. Heard-Lipsmeyer ME, Diaz EC, Sims CR, Sobik SR, Ruebel ML, Thakali KM, Krukowski RA, Cleves M, Børsheim E, Shankar K, Andres A. Maternal Adiposity is Associated with Fat Mass Accretion in Female but not Male Offspring During the First 2 Years of Life. Obesity (Silver Spring). 2020 Mar; 28(3):624-630. PMID: 32030918.
      View in: PubMed
    6. Chen JR, Zhao H, Lazarenko OP, Blackburn ML, Shankar K. Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring. FASEB J. 2020 Feb; 34(2):2511-2523. PMID: 31908011.
      View in: PubMed
    7. Diaz EC, Cleves MA, DiCarlo M, Sobik SR, Ruebel ML, Thakali KM, Sims CR, Dajani NK, Krukowski RA, Børsheim E, Badger TM, Shankar K, Andres A. Parental adiposity differentially associates with newborn body composition. Pediatr Obes. 2020 Apr; 15(4):e12596. PMID: 31856430.
      View in: PubMed
    8. Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2020 Apr; 158(5):1402-1416.e2. PMID: 31838076.
      View in: PubMed
    9. Brink LR, Matazel K, Piccolo BD, Bowlin AK, Chintapalli SV, Shankar K, Yeruva L. Neonatal Diet Impacts Bioregional Microbiota Composition in Piglets Fed Human Breast Milk or Infant Formula. J Nutr. 2019 Dec 01; 149(12):2236-2246. PMID: 31373372.
      View in: PubMed
    10. Chen JR, Wankhade UD, Alund AW, Blackburn ML, Shankar K, Lazarenko OP. 3-(3-Hydroxyphenyl)-Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice. JBMR Plus. 2019 Sep; 3(9):e10201. PMID: 31667457.
      View in: PubMed
    11. Ronis MJ, Blackburn ML, Shankar K, Ferguson M, Cleves MA, Badger TM. Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice. Exp Biol Med (Maywood). 2019 07; 244(10):834-845. PMID: 31161785.
      View in: PubMed
    12. Morris EM, Meers GME, Ruegsegger GN, Wankhade UD, Robinson T, Koch LG, Britton SL, Rector RS, Shankar K, Thyfault JP. Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance. Endocrinology. 2019 05 01; 160(5):1179-1192. PMID: 31144719.
      View in: PubMed
    13. Diaz EC, Børsheim E, Shankar K, Cleves MA, Andres A. Prepregnancy Fat Free Mass and Associations to Glucose Metabolism Before and During Pregnancy. J Clin Endocrinol Metab. 2019 05 01; 104(5):1394-1403. PMID: 30496579.
      View in: PubMed
    14. McCoin CS, Von Schulze A, Allen J, Fuller KNZ, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn GW, Shankar K, Morris EM, Thyfault JP. Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity. Am J Physiol Endocrinol Metab. 2019 08 01; 317(2):E298-E311. PMID: 31039007.
      View in: PubMed
    15. Pedersen KB, Pulliam CF, Patel A, Del Piero F, Watanabe TTN, Wankhade UD, Shankar K, Hicks C, Ronis MJ. Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus. Carcinogenesis. 2019 04 29; 40(2):349-359. PMID: 30325408.
      View in: PubMed
    16. Wankhade UD, Zhong Y, Lazarenko OP, Chintapalli SV, Piccolo BD, Chen JR, Shankar K. Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice. Nutrients. 2019 Feb 01; 11(2). PMID: 30717265.
      View in: PubMed
    17. Petersen C, Wankhade UD, Bharat D, Wong K, Mueller JE, Chintapalli SV, Piccolo BD, Jalili T, Jia Z, Symons JD, Shankar K, Anandh Babu PV. Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice. J Nutr Biochem. 2019 04; 66:63-69. PMID: 30771735.
      View in: PubMed
    18. Ruebel ML, Piccolo BD, Mercer KE, Pack L, Moutos D, Shankar K, Andres A. Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization. Am J Physiol Endocrinol Metab. 2019 03 01; 316(3):E383-E396. PMID: 30601701.
      View in: PubMed
    19. Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Piccolo BD, Mercer KE, Andres A, Thakali KM, Shankar K. Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice. Sci Rep. 2018 11 07; 8(1):16502. PMID: 30405201.
      View in: PubMed
    20. Miklavcic JJ, Badger TM, Bowlin AK, Matazel KS, Cleves MA, LeRoith T, Saraf MK, Chintapalli SV, Piccolo BD, Shankar K, Yeruva L. Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets. J Nutr. 2018 11 01; 148(11):1860-1870. PMID: 30247686.
      View in: PubMed
    21. Chen JR, Lazarenko OP, Zhao H, Alund AW, Shankar K. Maternal obesity impairs skeletal development in adult offspring J Endocrinol. 2018 10 01; 239(1):33–47. PMID: 30307152.
      View in: PubMed
    22. Chen JR, Lazarenko OP, Zhao H, Alund AW, Shankar K. Maternal obesity impairs skeletal development in adult offspring. J Endocrinol. 2018 Jul 26. PMID: 30049822.
      View in: PubMed
    23. Piccolo BD, Graham JL, Stanhope KL, Nookaew I, Mercer KE, Chintapalli SV, Wankhade UD, Shankar K, Havel PJ, Adams SH. Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E961-E972. PMID: 30016149.
      View in: PubMed
    24. Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR. A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. Am J Obstet Gynecol. 2018 10; 219(4):367.e1-367.e7. PMID: 29959933.
      View in: PubMed
    25. Ronis MJ, Gomez-Acevedo H, Shankar K, Sharma N, Blackburn M, Singhal R, Mercer KE, Badger TM. EB 2017 Article: Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Exp Biol Med (Maywood). 2018 05; 243(8):695-707. PMID: 29763383.
      View in: PubMed
    26. Mercer KE, Bhattacharyya S, Diaz-Rubio ME, Piccolo BD, Pack LM, Sharma N, Chaudhury M, Cleves MA, Chintapalli SV, Shankar K, Ronis MJJ, Yeruva L. Infant Formula Feeding Increases Hepatic Cholesterol 7a Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets. J Nutr. 2018 05 01; 148(5):702-711. PMID: 30053282.
      View in: PubMed
    27. Piccolo BD, Wankhade UD, Chintapalli SV, Bhattacharyya S, Chunqiao L, Shankar K. Dynamic assessment of microbial ecology (DAME): a web app for interactive analysis and visualization of microbial sequencing data. Bioinformatics. 2018 03 15; 34(6):1050-1052. PMID: 29087435.
      View in: PubMed
    28. Panasevich MR, Wankhade UD, Chintapalli SV, Shankar K, Rector RS. Cecal versus fecal microbiota in Ossabaw swine and implications for obesity. Physiol Genomics. 2018 05 01; 50(5):355-368. PMID: 29521600.
      View in: PubMed
    29. Morris JK, Piccolo BD, Shankar K, Thyfault JP, Adams SH. The serum metabolomics signature of type 2 diabetes is obscured in Alzheimer's disease. Am J Physiol Endocrinol Metab. 2018 06 01; 314(6):E584-E596. PMID: 29351484.
      View in: PubMed
    30. Shankar K, Pivik RT, Johnson SL, van Ommen B, Demmer E, Murray R. Environmental Forces that Shape Early Development: What We Know and Still Need to Know. Curr Dev Nutr. 2018 Aug; 2(8):nzx002. PMID: 30167570.
      View in: PubMed
    31. Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS. High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Am J Physiol Endocrinol Metab. 2018 01 01; 314(1):E78-E92. PMID: 28899857.
      View in: PubMed
    32. Saraf MK, Piccolo BD, Bowlin AK, Mercer KE, LeRoith T, Chintapalli SV, Shankar K, Badger TM, Yeruva L. Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon?. Microbiome. 2017 07 14; 5(1):77. PMID: 28705171.
      View in: PubMed
    33. Thakali KM, Faske JB, Ishwar A, Alfaro MP, Cleves MA, Badger TM, Andres A, Shankar K. Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation. Placenta. 2017 Sep; 57:194-203. PMID: 28864012.
      View in: PubMed
    34. Piccolo BD, Mercer KE, Bhattacharyya S, Bowlin AK, Saraf MK, Pack L, Chintapalli SV, Shankar K, Adams SH, Badger TM, Yeruva L. Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs. J Nutr. 2017 08; 147(8):1499-1509. PMID: 28659406.
      View in: PubMed
    35. Ruebel ML, Cotter M, Sims CR, Moutos DM, Badger TM, Cleves MA, Shankar K, Andres A. Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective. J Clin Endocrinol Metab. 2017 06 01; 102(6):2029-2038. PMID: 28323970.
      View in: PubMed
    36. Panasevich MR, Schuster CM, Phillips KE, Meers GM, Chintapalli SV, Wankhade UD, Shankar K, Butteiger DN, Krul ES, Thyfault JP, Rector RS. Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. J Nutr Biochem. 2017 08; 46:125-136. PMID: 28605664.
      View in: PubMed
    37. Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Thakali KM, Shankar K. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 2017; 12(4):e0175675. PMID: 28414763.
      View in: PubMed
    38. Krukowski RA, West D, DiCarlo M, Shankar K, Cleves MA, Tedford E, Andres A. A Behavioral Intervention to Reduce Excessive Gestational Weight Gain. Matern Child Health J. 2017 03; 21(3):485-491. PMID: 27449652.
      View in: PubMed
    39. Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017 Feb 08; 356:j1. PMID: 28179267.
      View in: PubMed
    40. Buckberry S, Bianco-Miotto T, Bent SJ, Clifton V, Shoubridge C, Shankar K, Roberts CT. Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation. BMC Genomics. 2017 01 03; 18(1):10. PMID: 28049421.
      View in: PubMed
    41. Krukowski RA, West DS, DiCarlo M, Shankar K, Cleves MA, Saylors ME, Andres A. Are early first trimester weights valid proxies for preconception weight? BMC Pregnancy Childbirth. 2016 11 21; 16(1):357. PMID: 27871260.
      View in: PubMed
    42. Chen JR, Lazarenko OP, Blackburn ML, Shankar K. Dietary factors during early life program bone formation in female rats. FASEB J. 2017 01; 31(1):376-387. PMID: 27733448.
      View in: PubMed
    43. Li X, Andres A, Shankar K, Pivik RT, Glasier CM, Ramakrishnaiah RH, Zhang Y, Badger TM, Ou X. Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers. Int J Obes (Lond). 2016 12; 40(12):1931-1934. PMID: 27677619.
      View in: PubMed
    44. Chen JR, Lazarenko OP, Blackburn ML, Rose S, Frye RE, Badger TM, Andres A, Shankar K. Maternal Obesity Programs Senescence Signaling and Glucose Metabolism in Osteo-Progenitors From Rat and Human. Endocrinology. 2016 Nov; 157(11):4172-4183. PMID: 27653035.
      View in: PubMed
    45. Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Fu X, Shankar K, Burgess SC, Ibdah JA, Rector RS, Thyfault JP. Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab. 2016 10 01; 311(4):E749-E760. PMID: 27600823.
      View in: PubMed
    46. Wankhade UD, Thakali KM, Shankar K. Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies. Mol Cell Endocrinol. 2016 11 05; 435:7-19. PMID: 27392497.
      View in: PubMed
    47. Panasevich MR, Morris EM, Chintapalli SV, Wankhade UD, Shankar K, Britton SL, Koch LG, Thyfault JP, Rector RS. Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G166-79. PMID: 27288420.
      View in: PubMed
    48. Ruebel M, Shankar K, Gaddy D, Lindsey F, Badger T, Andres A. Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1. Am J Physiol Endocrinol Metab. 2016 07 01; 311(1):E269-77. PMID: 27279249.
      View in: PubMed
    49. Yeruva L, Spencer NE, Saraf MK, Hennings L, Bowlin AK, Cleves MA, Mercer K, Chintapalli SV, Shankar K, Rank RG, Badger TM, Ronis MJ. Erratum to: Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016 May 26; 16(1):55. PMID: 27229864.
      View in: PubMed
    50. Yeruva L, Spencer NE, Saraf MK, Hennings L, Bowlin AK, Cleves MA, Mercer K, Chintapalli SV, Shankar K, Rank RG, Badger TM, Ronis MJ. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016 Mar 22; 16:40. PMID: 27005303.
      View in: PubMed
    51. Shankar K, Kang P, Zhong Y, Borengasser SJ, Wingfield C, Saben J, Gomez-Acevedo H, Thakali KM. Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells. Placenta. 2015 Dec; 36(12):1342-51. PMID: 26515927.
      View in: PubMed
    52. Shankar K. Reversing Fetal Undernutrition by Kick-Starting Early Growth. Endocrinology. 2015 Sep; 156(9):3059-62. PMID: 26295490.
      View in: PubMed
    53. Andres A, Hull HR, Shankar K, Casey PH, Cleves MA, Badger TM. Longitudinal body composition of children born to mothers with normal weight, overweight, and obesity. Obesity (Silver Spring). 2015 Jun; 23(6):1252-8. PMID: 25960251.
      View in: PubMed
    54. Ou X, Thakali KM, Shankar K, Andres A, Badger TM. Maternal adiposity negatively influences infant brain white matter development. Obesity (Silver Spring). 2015 May; 23(5):1047-54. PMID: 25919924.
      View in: PubMed
    55. Hinton PS, Shankar K, Eaton LM, Rector RS. Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running. Metabolism. 2015 Aug; 64(8):905-16. PMID: 25963848.
      View in: PubMed
    56. Borengasser SJ, Faske J, Kang P, Blackburn ML, Badger TM, Shankar K. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Physiol Genomics. 2014 Dec 01; 46(23):841-50. PMID: 25336449.
      View in: PubMed
    57. Saben J, Kang P, Zhong Y, Thakali KM, Gomez-Acevedo H, Borengasser SJ, Andres A, Badger TM, Shankar K. RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling. Placenta. 2014 Dec; 35(12):1013-20. PMID: 25449029.
      View in: PubMed
    58. Saben J, Thakali KM, Lindsey FE, Zhong Y, Badger TM, Andres A, Shankar K. Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions. Exp Biol Med (Maywood). 2014 Oct; 239(10):1340-51. PMID: 24951473.
      View in: PubMed
    59. Thakali KM, Saben J, Faske JB, Lindsey F, Gomez-Acevedo H, Lowery CL, Badger TM, Andres A, Shankar K. Maternal pregravid obesity changes gene expression profiles toward greater inflammation and reduced insulin sensitivity in umbilical cord. Pediatr Res. 2014 Aug; 76(2):202-10. PMID: 24819376.
      View in: PubMed
    60. Saben J, Lindsey F, Zhong Y, Thakali K, Badger TM, Andres A, Gomez-Acevedo H, Shankar K. Maternal obesity is associated with a lipotoxic placental environment. Placenta. 2014 Mar; 35(3):171-7. PMID: 24484739.
      View in: PubMed
    61. Borengasser SJ, Kang P, Faske J, Gomez-Acevedo H, Blackburn ML, Badger TM, Shankar K. High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One. 2014; 9(1):e84209. PMID: 24416203.
      View in: PubMed
    62. Saben J, Zhong Y, McKelvey S, Dajani NK, Andres A, Badger TM, Gomez-Acevedo H, Shankar K. A comprehensive analysis of the human placenta transcriptome. Placenta. 2014 Feb; 35(2):125-31. PMID: 24333048.
      View in: PubMed
    63. Miousse IR, Sharma N, Blackburn M, Vantrease J, Gomez-Acevedo H, Hennings L, Shankar K, Cleves MA, Badger TM, Ronis MJ. Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats. Physiol Genomics. 2013 Nov 15; 45(22):1072-83. PMID: 24046281.
      View in: PubMed
    64. Borengasser SJ, Zhong Y, Kang P, Lindsey F, Ronis MJ, Badger TM, Gomez-Acevedo H, Shankar K. Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in male rat offspring. Endocrinology. 2013 Nov; 154(11):4113-25. PMID: 23959936.
      View in: PubMed
    65. Miousse IR, Gomez-Acevedo H, Sharma N, Vantrease J, Hennings L, Shankar K, Cleves MA, Badger TM, Ronis MJ. Mammary gland morphology and gene expression signature of weanling male and female rats following exposure to exogenous estradiol. Exp Biol Med (Maywood). 2013 Sep; 238(9):1033-46. PMID: 23925648.
      View in: PubMed
    66. Saben J, Zhong Y, Gomez-Acevedo H, Thakali KM, Borengasser SJ, Andres A, Shankar K. Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity. Am J Physiol Endocrinol Metab. 2013 Jul 01; 305(1):E1-14. PMID: 23632636.
      View in: PubMed
    67. Ronis MJ, Shankar K, Gomez-Acevedo H, Hennings L, Singhal R, Blackburn ML, Badger TM. Mammary gland morphology and gene expression differ in female rats treated with 17ß-estradiol or fed soy protein isolate. Endocrinology. 2012 Dec; 153(12):6021-32. PMID: 23027806.
      View in: PubMed
    68. Ronis MJ, Baumgardner JN, Marecki JC, Hennings L, Wu X, Shankar K, Cleves MA, Gomez-Acevedo H, Badger TM. Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition. Physiol Genomics. 2012 Nov 15; 44(22):1073-89. PMID: 22991207.
      View in: PubMed
    69. Andres A, Shankar K, Badger TM. Body fat mass of exclusively breastfed infants born to overweight mothers. J Acad Nutr Diet. 2012 Jul; 112(7):991-5. PMID: 22889630.
      View in: PubMed
    70. Zhang J, Lazarenko OP, Wu X, Tong Y, Blackburn ML, Gomez-Acevedo H, Shankar K, Badger TM, Ronis MJ, Chen JR. Differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat. PLoS One. 2012; 7(4):e35736. PMID: 22536432.
      View in: PubMed
    71. Shankar K, Zhong Y, Kang P, Blackburn ML, Soares MJ, Badger TM, Gomez-Acevedo H. RNA-seq analysis of the functional compartments within the rat placentation site. Endocrinology. 2012 Apr; 153(4):1999-2011. PMID: 22355068.
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    72. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012 Mar; 97(3):E376-92. PMID: 22259059.
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    73. Chen JR, Zhang J, Lazarenko OP, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet. FASEB J. 2012 Mar; 26(3):1131-41. PMID: 22131269.
      View in: PubMed
    74. Ronis MJ, Chen Y, Shankar K, Gomez-Acevedo H, Cleves MA, Badeaux J, Blackburn ML, Badger TM. Formula feeding alters hepatic gene expression signature, iron and cholesterol homeostasis in the neonatal pig. Physiol Genomics. 2011 Dec 05; 43(23):1281-93. PMID: 21954453.
      View in: PubMed
    75. Zhang J, Lazarenko OP, Blackburn ML, Shankar K, Badger TM, Ronis MJ, Chen JR. Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats. PLoS One. 2011; 6(9):e24486. PMID: 21912699.
      View in: PubMed
    76. Borengasser SJ, Lau F, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. PLoS One. 2011; 6(8):e24068. PMID: 21901160.
      View in: PubMed
    77. Shankar K, Zhong Y, Kang P, Lau F, Blackburn ML, Chen JR, Borengasser SJ, Ronis MJ, Badger TM. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Endocrinology. 2011 Nov; 152(11):4158-70. PMID: 21862610.
      View in: PubMed
    78. Su Y, Shankar K, Rahal O, Simmen RC. Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer--preventive actions of dietary factors. J Nutr Biochem. 2011 Jul; 22(7):605-11. PMID: 21292471.
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    79. Marecki JC, Ronis MJ, Shankar K, Badger TM. Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. J Nutr Biochem. 2011 Feb; 22(2):142-52. PMID: 20435456.
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    80. Wu X, Tong Y, Shankar K, Baumgardner JN, Kang J, Badeaux J, Badger TM, Ronis MJ. Lipid fatty acid profile analyses in liver and serum in rats with nonalcoholic steatohepatitis using improved gas chromatography-mass spectrometry methodology. J Agric Food Chem. 2011 Jan 26; 59(2):747-54. PMID: 21162572.
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    81. Chen JR, Lazarenko OP, Shankar K, Blackburn ML, Lumpkin CK, Badger TM, Ronis MJ. Inhibition of NADPH oxidases prevents chronic ethanol-induced bone loss in female rats. J Pharmacol Exp Ther. 2011 Mar; 336(3):734-42. PMID: 21098090.
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    82. Ronis MJ, Chen Y, Liu X, Blackburn ML, Shankar K, Landes RD, Fang N, Badger TM. Enhanced expression and glucocorticoid-inducibility of hepatic cytochrome P450 3A involve recruitment of the pregnane-X-receptor to promoter elements in rats fed soy protein isolate. J Nutr. 2011 Jan; 141(1):10-6. PMID: 21084653.
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    83. Chen JR, Lazarenko OP, Wu X, Kang J, Blackburn ML, Shankar K, Badger TM, Ronis MJ. Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/ß-catenin canonical Wnt signaling. J Bone Miner Res. 2010 Nov; 25(11):2399-411. PMID: 20499363.
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    84. Chen JR, Lazarenko OP, Wu X, Tong Y, Blackburn ML, Shankar K, Badger TM, Ronis MJ. Obesity reduces bone density associated with activation of PPAR? and suppression of Wnt/ß-catenin in rapidly growing male rats. PLoS One. 2010 Oct 28; 5(10):e13704. PMID: 21060836.
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    85. Chen JR, Lazarenko OP, Shankar K, Blackburn ML, Badger TM, Ronis MJ. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res. 2010 May; 25(5):1117-27. PMID: 20200986.
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    86. Shankar K, Kang P, Harrell A, Zhong Y, Marecki JC, Ronis MJ, Badger TM. Maternal overweight programs insulin and adiponectin signaling in the offspring. Endocrinology. 2010 Jun; 151(6):2577-89. PMID: 20371699.
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    87. Shankar K, Harrell A, Kang P, Singhal R, Ronis MJ, Badger TM. Carbohydrate-responsive gene expression in the adipose tissue of rats. Endocrinology. 2010 Jan; 151(1):153-64. PMID: 19880807.
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    88. Singhal R, Shankar K, Badger TM, Ronis MJ. Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17{beta}-estradiol treatment. J Endocrinol. 2009 Jul; 202(1):141-52. PMID: 19372191.
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    89. Badger TM, Gilchrist JM, Pivik RT, Andres A, Shankar K, Chen JR, Ronis MJ. The health implications of soy infant formula. Am J Clin Nutr. 2009 May; 89(5):1668S-1672S. PMID: 19357221.
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    90. Su Y, Shankar K, Simmen RC. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr. 2009 May; 139(5):945-51. PMID: 19321580.
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    91. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J Nutr. 2008 Oct; 138(10):1872-9. PMID: 18806095.
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    92. Badger TM, Ronis MJ, Wolff G, Stanley S, Ferguson M, Shankar K, Simpson P, Jo CH. Soy protein isolate reduces hepatosteatosis in yellow Avy/a mice without altering coat color phenotype. Exp Biol Med (Maywood). 2008 Oct; 233(10):1242-54. PMID: 18791133.
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    93. Ronis MJ, Butura A, Korourian S, Shankar K, Simpson P, Badeaux J, Albano E, Ingelman-Sundberg M, Badger TM. Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition. Exp Biol Med (Maywood). 2008 Mar; 233(3):344-55. PMID: 18296740.
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    94. Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, Perrien DS, Skinner RA, Lumpkin CK, Badger TM, Ronis MJ. Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats. J Bone Miner Res. 2008 Mar; 23(3):338-49. PMID: 17967133.
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    95. Singhal R, Shankar K, Badger TM, Ronis MJ. Estrogenic status modulates aryl hydrocarbon receptor--mediated hepatic gene expression and carcinogenicity. Carcinogenesis. 2008 Feb; 29(2):227-36. PMID: 18174242.
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    96. Shankar K, Liu X, Singhal R, Chen JR, Nagarajan S, Badger TM, Ronis MJ. Chronic ethanol consumption leads to disruption of vitamin D3 homeostasis associated with induction of renal 1,25 dihydroxyvitamin D3-24-hydroxylase (CYP24A1). Endocrinology. 2008 Apr; 149(4):1748-56. PMID: 18162528.
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    97. Shankar K, Harrell A, Liu X, Gilchrist JM, Ronis MJ, Badger TM. Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol. 2008 Feb; 294(2):R528-38. PMID: 18032473.
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    98. Baumgardner JN, Shankar K, Hennings L, Badger TM, Ronis MJ. A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G27-38. PMID: 17947452.
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    99. Chen JR, Shankar K, Nagarajan S, Badger TM, Ronis MJ. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J Pharmacol Exp Ther. 2008 Jan; 324(1):50-9. PMID: 17916759.
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    100. Wang T, Shankar K, Ronis MJ, Mehendale HM. Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes. Crit Rev Toxicol. 2007 Jun; 37(5):413-59. PMID: 17612954.
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    101. Baumgardner JN, Shankar K, Korourian S, Badger TM, Ronis MJ. Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G355-64. PMID: 17510198.
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    102. Shankar K, Ronis MJ, Badger TM. Effects of pregnancy and nutritional status on alcohol metabolism. Alcohol Res Health. 2007; 30(1):55-9. PMID: 17718402.
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    103. Chilakapati J, Korrapati MC, Shankar K, Hill RA, Warbritton A, Latendresse JR, Mehendale HM. Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital. Toxicol Appl Pharmacol. 2007 Feb 15; 219(1):72-84. PMID: 17234228.
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    104. Chen JR, Haley RL, Hidestrand M, Shankar K, Liu X, Lumpkin CK, Simpson PM, Badger TM, Ronis MJ. Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts. J Pharmacol Exp Ther. 2006 Dec; 319(3):1182-90. PMID: 16971503.
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    105. Shankar K, Hidestrand M, Liu X, Xiao R, Skinner CM, Simmen FA, Badger TM, Ronis MJ. Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity. Exp Biol Med (Maywood). 2006 Sep; 231(8):1379-97. PMID: 16946407.
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    106. Shankar K, Hidestrand M, Haley R, Skinner RA, Hogue W, Jo CH, Simpson P, Lumpkin CK, Aronson J, Badger TM, Ronis MJ. Different molecular mechanisms underlie ethanol-induced bone loss in cycling and pregnant rats. Endocrinology. 2006 Jan; 147(1):166-78. PMID: 16239303.
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    107. Chilakapati J, Shankar K, Korrapati MC, Hill RA, Mehendale HM. Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos. 2005 Dec; 33(12):1877-85. PMID: 16183780.
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    108. Badger TM, Hidestrand M, Shankar K, McGuinn WD, Ronis MJ. The effects of pregnancy on ethanol clearance. Life Sci. 2005 Sep 09; 77(17):2111-26. PMID: 15925387.
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    109. Ronis MJ, Butura A, Sampey BP, Shankar K, Prior RL, Korourian S, Albano E, Ingelman-Sundberg M, Petersen DR, Badger TM. Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med. 2005 Sep 01; 39(5):619-30. PMID: 16085180.
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    110. Hidestrand M, Shankar K, Ronis MJ, Badger TM. Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition. Alcohol Clin Exp Res. 2005 May; 29(5):888-95. PMID: 15897735.
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    111. Sawant SP, Dnyanmote AV, Shankar K, Limaye PB, Latendresse JR, Mehendale HM. Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. J Pharmacol Exp Ther. 2004 Feb; 308(2):694-704. PMID: 14610242.
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    112. Vaidya VS, Shankar K, Lock EA, Dixon D, Mehendale HM. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway. Toxicol Pathol. 2003 Nov-Dec; 31(6):604-18. PMID: 14585728.
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    113. Limaye PB, Apte UM, Shankar K, Bucci TJ, Warbritton A, Mehendale HM. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol Appl Pharmacol. 2003 Sep 15; 191(3):211-26. PMID: 13678654.
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    114. Shankar K, Vaidya VS, Corton JC, Bucci TJ, Liu J, Waalkes MP, Mehendale HM. Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. FASEB J. 2003 Sep; 17(12):1748-50. PMID: 12958197.
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    115. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse. Toxicol Sci. 2003 Jul; 74(1):215-27. PMID: 12730612.
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    116. Shankar K, Vaidya VS, Apte UM, Manautou JE, Ronis MJ, Bucci TJ, Mehendale HM. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol Sci. 2003 Jun; 73(2):220-34. PMID: 12700423.
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    117. Shankar K, Vaidya VS, Wang T, Bucci TJ, Mehendale HM. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol Appl Pharmacol. 2003 Apr 15; 188(2):122-34. PMID: 12691730.
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    118. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice. Toxicol Appl Pharmacol. 2003 Apr 15; 188(2):110-21. PMID: 12691729.
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    119. Wang T, Shankar K, Bucci TJ, Warbritton A, Mehendale HM. Diallyl sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality. Toxicol Appl Pharmacol. 2001 May 15; 173(1):27-37. PMID: 11350212.
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    120. Wang T, Shankar K, Ronis MJ, Mehendale HM. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. J Pharmacol Exp Ther. 2000 Aug; 294(2):473-9. PMID: 10900221.
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