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Cheryl Lynne Ackert-Bicknell

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-ORTHO General Operations

    Collapse Research 
    Collapse research activities and funding
    R01AR079839     (ACKERT-BICKNELL, CHERYL LYNNE ;FARBER, CHARLES R)Jul 12, 2021 - Jun 30, 2026
    NIH
    Identification of Novel Genes Impacting Osteoblast Activity
    Role: Principal Investigator
    R01AR073346     (ACKERT-BICKNELL, CHERYL LYNNE ;ADAMS, DOUGLAS J)Sep 1, 2019 - Jul 31, 2024
    NIH
    Identification of Genes Regulating PTH-Mediated Skeletal Strength
    Role: Principal Investigator
    R01AR064790     (FARBER, CHARLES R)Sep 21, 2015 - Jun 30, 2021
    NIH
    Systems Genetics of Osteoblast Activity
    Role: Co-Principal Investigator
    R56AR064790     (FARBER, CHARLES R.)Sep 27, 2013 - Sep 20, 2015
    NIH
    Systems Genetics of Osteoblast Activity
    Role: Co-Principal Investigator
    R01AR063702     (ROWE, DAVID W.)Aug 1, 2013 - May 31, 2019
    NIH
    Skeletal Phenotyping of KOMP Mice
    Role: Co-Principal Investigator
    R21AR060981     (HIBBS, MATTHEW AARON)Mar 15, 2011 - Feb 28, 2014
    NIH
    Genetics of Osteoblast Differentiation
    Role: Co-Principal Investigator
    R01AR060234     (ACKERT-BICKNELL, CHERYL LYNNE)Sep 20, 2010 - May 31, 2016
    NIH
    Co-localizing Quantitative Trait Loci for Bone Mineral Density and HDL in Mice
    Role: Principal Investigator
    F32AG034019     (ACKERT-BICKNELL, CHERYL LYNNE)Mar 9, 2009 - Mar 8, 2011
    NIH
    Examination of Co-inheritance of Bone Mineral Density, IGF-1 and Lifespan
    Role: Principal Investigator
    F31AG030910     (ACKERT-BICKNELL, CHERYL)Jul 7, 2007 - Jan 4, 2008
    NIH
    The effects of allelic variation in Pparg on skeletal metabolism
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ben-Zvi I, Karasik D, Ackert-Bicknell CL. Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies. Curr Osteoporos Rep. 2023 Dec; 21(6):650-659. PMID: 37971665.
      View in: PubMed
    2. Wu EY, Singh NP, Choi K, Zakeri M, Vincent M, Churchill GA, Ackert-Bicknell CL, Patro R, Love MI. SEESAW: detecting isoform-level allelic imbalance accounting for inferential uncertainty. Genome Biol. 2023 07 12; 24(1):165. PMID: 37438847.
      View in: PubMed
    3. Medina-Gomez C, Mullin BH, Chesi A, Prijatelj V, Kemp JP, Shochat-Carvalho C, Trajanoska K, Wang C, Joro R, Evans TE, Schraut KE, Li-Gao R, Ahluwalia TS, Zillikens MC, Zhu K, Mook-Kanamori DO, Evans DS, Nethander M, Knol MJ, Thorleifsson G, Prokic I, Zemel B, Broer L, McGuigan FE, van Schoor NM, Reppe S, Pawlak MA, Ralston SH, van der Velde N, Lorentzon M, Stefansson K, Adams HHH, Wilson SG, Ikram MA, Walsh JP, Lakka TA, Gautvik KM, Wilson JF, Orwoll ES, van Duijn CM, B?nnelykke K, Uitterlinden AG, Styrk?rsd?ttir U, Akesson KE, Spector TD, Tobias JH, Ohlsson C, Felix JF, Bisgaard H, Grant SFA, Richards JB, Evans DM, van der Eerden B, van de Peppel J, Ackert-Bicknell C, Karasik D, Kague E, Rivadeneira F. Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Commun Biol. 2023 07 04; 6(1):691. PMID: 37402774.
      View in: PubMed
    4. Ackert-Bicknell CL. Functional screens refine height GWAS loci. Cell Genom. 2023 May 10; 3(5):100325. PMID: 37228748.
      View in: PubMed
    5. Ackert-Bicknell C, Karasik D. Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop. Curr Osteoporos Rep. 2023 04; 21(2):184-192. PMID: 36869984.
      View in: PubMed
    6. Ou-Yang DC, Kleck CJ, Ackert-Bicknell CL. Genetics of Intervertebral Disc Degeneration. Curr Osteoporos Rep. 2023 02; 21(1):56-64. PMID: 36680730.
      View in: PubMed
    7. Kuhns BD, Reuter JM, Hansen VL, Soles GL, Jonason JH, Ackert-Bicknell CL, Wu CL, Giordano BD. Whole-genome RNA?sequencing identifies distinct transcriptomic profiles in impingement cartilage between patients with femoroacetabular impingement and hip osteoarthritis. J Orthop Res. 2023 07; 41(7):1517-1530. PMID: 36463522.
      View in: PubMed
    8. Al-Barghouthi BM, Rosenow WT, Du KP, Heo J, Maynard R, Mesner L, Calabrese G, Nakasone A, Senwar B, Gerstenfeld L, Larner J, Ferguson V, Ackert-Bicknell C, Morgan E, Brautigan D, Farber CR. Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. Elife. 2022 11 23; 11. PMID: 36416764.
      View in: PubMed
    9. Sabri SA, Chavarria JC, Ackert-Bicknell C, Swanson C, Burger E. Osteoporosis: An Update on Screening, Diagnosis, Evaluation, and Treatment. Orthopedics. 2023 Jan-Feb; 46(1):e20-e26. PMID: 35876780.
      View in: PubMed
    10. Dulmovits BM, Tang Y, Papoin J, He M, Li J, Yang H, Addorisio ME, Kennedy L, Khan M, Brindley E, Ashley RJ, Ackert-Bicknell C, Hale J, Kurita R, Nakamura Y, Diamond B, Barnes BJ, Hermine O, Gallagher PG, Steiner LA, Lipton JM, Taylor N, Mohandas N, Andersson U, Al-Abed Y, Tracey KJ, Blanc L. HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation. Blood. 2022 05 26; 139(21):3181-3193. PMID: 35040907.
      View in: PubMed
    11. Thomas SM, Ackert-Bicknell CL, Zuscik MJ, Payne KA. Understanding the Transcriptomic Landscape to Drive New Innovations in Musculoskeletal Regenerative Medicine. Curr Osteoporos Rep. 2022 04; 20(2):141-152. PMID: 35156183.
      View in: PubMed
    12. Sabik OL, Ackert-Bicknell CL, Farber CR. A computational approach for identification of core modules from a co-expression network and GWAS data. STAR Protoc. 2021 09 17; 2(3):100768. PMID: 34467232.
      View in: PubMed
    13. Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo CL, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, Luan J, Sarnowski C, Lunetta KL, Tanaka T, Wojczynski MK, Cvejkus R, Nethander M, Ghasemi S, Yang J, Zillikens MC, Walter S, Sicinski K, Kague E, Ackert-Bicknell CL, Arking DE, Windham BG, Boerwinkle E, Grove ML, Graff M, Spira D, Demuth I, van der Velde N, de Groot LCPGM, Psaty BM, Odden MC, Fohner AE, Langenberg C, Wareham NJ, Bandinelli S, van Schoor NM, Huisman M, Tan Q, Zmuda J, Mellstr?m D, Karlsson M, Bennett DA, Buchman AS, De Jager PL, Uitterlinden AG, V?lker U, Kocher T, Teumer A, Rodrigu?z-Ma?as L, Garc?a FJ, Carnicero JA, Herd P, Bertram L, Ohlsson C, Murabito JM, Melzer D, Kuchel GA, Ferrucci L, Karasik D, Rivadeneira F, Kiel DP, Pilling LC. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021 01 28; 12(1):654. PMID: 33510174.
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    14. Doolittle ML, Ackert-Bicknell CL, Jonason JH. Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts. Methods Mol Biol. 2021; 2230:425-436. PMID: 33197030.
      View in: PubMed
    15. Sabik OL, Calabrese GM, Taleghani E, Ackert-Bicknell CL, Farber CR. Identification of a Core Module for Bone Mineral Density through the Integration of a Co-expression Network and GWAS Data. Cell Rep. 2020 09 15; 32(11):108145. PMID: 32937138.
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    16. Muthukrishnan G, Soin S, Beck CA, Grier A, Brodell JD, Lee CC, Ackert-Bicknell CL, Lee FE, Schwarz EM, Daiss JL. A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against Staphylococcus aureus to Detect Challenging Musculoskeletal Infections. Immunohorizons. 2020 06 22; 4(6):339-351. PMID: 32571786.
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    17. Doolittle ML, Calabrese GM, Mesner LD, Godfrey DA, Maynard RD, Ackert-Bicknell CL, Farber CR. Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass. PLoS Genet. 2020 06; 16(6):e1008805. PMID: 32497039.
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    18. Lu L, Huang J, Xu F, Xiao Z, Wang J, Zhang B, David NV, Arends D, Gu W, Ackert-Bicknell C, Sabik OL, Farber CR, Quarles LD, Williams RW. Genetic Dissection of Femoral and Tibial Microarchitecture. JBMR Plus. 2019 Dec; 3(12):e10241. PMID: 31844829.
      View in: PubMed
    19. Maynard RD, Ackert-Bicknell CL. Mouse Models and Online Resources for Functional Analysis of Osteoporosis Genome-Wide Association Studies. Front Endocrinol (Lausanne). 2019; 10:277. PMID: 31133984.
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    20. Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB. Author Correction: An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet. 2019 05; 51(5):920. PMID: 30988516.
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    21. Mesner LD, Calabrese GM, Al-Barghouthi B, Gatti DM, Sundberg JP, Churchill GA, Godfrey DA, Ackert-Bicknell CL, Farber CR. Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass. PLoS Genet. 2019 05; 15(5):e1008123. PMID: 31042701.
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    22. Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens MC, Rivadeneira F, Kiel DP, Karasik D. Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone Miner Res. 2019 07; 34(7):1284-1296. PMID: 30888730.
      View in: PubMed
    23. Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB. An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet. 2019 02; 51(2):258-266. PMID: 30598549.
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    24. Maynard RD, Godfrey DA, Medina-Gomez C, Ackert-Bicknell CL. Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1). Gene. 2018 Oct 20; 674:127-133. PMID: 29935354.
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    25. Schott EM, Farnsworth CW, Grier A, Lillis JA, Soniwala S, Dadourian GH, Bell RD, Doolittle ML, Villani DA, Awad H, Ketz JP, Kamal F, Ackert-Bicknell C, Ashton JM, Gill SR, Mooney RA, Zuscik MJ. Targeting the gut microbiome to treat the osteoarthritis of obesity. JCI Insight. 2018 04 19; 3(8). PMID: 29669931.
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    26. Rowe DW, Adams DJ, Hong SH, Zhang C, Shin DG, Renata Rydzik C, Chen L, Wu Z, Garland G, Godfrey DA, Sundberg JP, Ackert-Bicknell C. Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by ?CT and Histomorphometry. Curr Osteoporos Rep. 2018 04; 16(2):77-94. PMID: 29508144.
      View in: PubMed
    27. Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, B?nnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrk?rsd?ttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F. Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet. 2018 01 04; 102(1):88-102. PMID: 29304378.
      View in: PubMed
    28. Kemp JP, Morris JA, Medina-Gomez C, Forgetta V, Warrington NM, Youlten SE, Zheng J, Gregson CL, Grundberg E, Trajanoska K, Logan JG, Pollard AS, Sparkes PC, Ghirardello EJ, Allen R, Leitch VD, Butterfield NC, Komla-Ebri D, Adoum AT, Curry KF, White JK, Kussy F, Greenlaw KM, Xu C, Harvey NC, Cooper C, Adams DJ, Greenwood CMT, Maurano MT, Kaptoge S, Rivadeneira F, Tobias JH, Croucher PI, Ackert-Bicknell CL, Bassett JHD, Williams GR, Richards JB, Evans DM. Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet. 2017 Oct; 49(10):1468-1475. PMID: 28869591.
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    29. Medina-Gomez C, Kemp JP, Dimou NL, Kreiner E, Chesi A, Zemel BS, B?nnelykke K, Boer CG, Ahluwalia TS, Bisgaard H, Evangelou E, Heppe DHM, Bonewald LF, Gorski JP, Ghanbari M, Demissie S, Duque G, Maurano MT, Kiel DP, Hsu YH, C J van der Eerden B, Ackert-Bicknell C, Reppe S, Gautvik KM, Raastad T, Karasik D, van de Peppel J, Jaddoe VWV, Uitterlinden AG, Tobias JH, Grant SFA, Bagos PG, Evans DM, Rivadeneira F. Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus. Nat Commun. 2017 07 25; 8(1):121. PMID: 28743860.
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    30. Charette JR, Earp SE, Bell BA, Ackert-Bicknell CL, Godfrey DA, Rao S, Anand-Apte B, Nishina PM, Peachey NS. A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density. Mol Vis. 2017; 23:140-148. PMID: 28356706.
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    31. Dyment NA, Jiang X, Chen L, Hong SH, Adams DJ, Ackert-Bicknell C, Shin DG, Rowe DW. High-Throughput, Multi-Image Cryohistology of Mineralized Tissues. J Vis Exp. 2016 09 14; (115). PMID: 27684089.
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    32. Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellstr?m D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res. 2016 12; 31(12):2085-2097. PMID: 27476799.
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    33. Parker CC, Gopalakrishnan S, Carbonetto P, Gonzales NM, Leung E, Park YJ, Aryee E, Davis J, Blizard DA, Ackert-Bicknell CL, Lionikas A, Pritchard JK, Palmer AA. Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Nat Genet. 2016 08; 48(8):919-26. PMID: 27376237.
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    34. Adams DJ, Rowe DW, Ackert-Bicknell CL. Genetics of aging bone. Mamm Genome. 2016 08; 27(7-8):367-80. PMID: 27272104.
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    35. Ackert-Bicknell CL, Rosen CJ. Passenger Gene Mutations: Unwanted Guests in Genetically Modified Mice. J Bone Miner Res. 2016 Feb; 31(2):270-3. PMID: 26684928.
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    36. Kates SL, Ackert-Bicknell CL. How do bisphosphonates affect fracture healing? Injury. 2016 Jan; 47 Suppl 1:S65-8. PMID: 26768295.
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    37. Berndt A, Ackert-Bicknell C, Silva KA, Kennedy VE, Sundberg BA, Cates JM, Schofield PN, Sundberg JP. Genetic determinants of fibro-osseous lesions in aged inbred mice. Exp Mol Pathol. 2016 Feb; 100(1):92-100. PMID: 26589134.
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    38. Pallares LF, Carbonetto P, Gopalakrishnan S, Parker CC, Ackert-Bicknell CL, Palmer AA, Tautz D. Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination. PLoS Genet. 2015 Nov; 11(11):e1005607. PMID: 26523602.
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    39. Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J, Danecek P, Wilmot B, Li R, Chou WC, Mokry LE, Moayyeri A, Claussnitzer M, Cheng CH, Cheung W, Medina-G?mez C, Ge B, Chen SH, Choi K, Oei L, Fraser J, Kraaij R, Hibbs MA, Gregson CL, Paquette D, Hofman A, Wibom C, Tranah GJ, Marshall M, Gardiner BB, Cremin K, Auer P, Hsu L, Ring S, Tung JY, Thorleifsson G, Enneman AW, van Schoor NM, de Groot LC, van der Velde N, Melin B, Kemp JP, Christiansen C, Sayers A, Zhou Y, Calderari S, van Rooij J, Carlson C, Peters U, Berlivet S, Dostie J, Uitterlinden AG, Williams SR, Farber C, Grinberg D, LaCroix AZ, Haessler J, Chasman DI, Giulianini F, Rose LM, Ridker PM, Eisman JA, Nguyen TV, Center JR, Nogues X, Garcia-Giralt N, Launer LL, Gudnason V, Mellstr?m D, Vandenput L, Amin N, van Duijn CM, Karlsson MK, Ljunggren ?, Svensson O, Hallmans G, Rousseau F, Giroux S, Bussi?re J, Arp PP, Koromani F, Prince RL, Lewis JR, Langdahl BL, Hermann AP, Jensen JE, Kaptoge S, Khaw KT, Reeve J, Formosa MM, Xuereb-Anastasi A, ?kesson K, McGuigan FE, Garg G, Olmos JM, Zarrabeitia MT, Riancho JA, Ralston SH, Alonso N, Jiang X, Goltzman D, Pastinen T, Grundberg E, Gauguier D, Orwoll ES, Karasik D, Davey-Smith G, Smith AV, Siggeirsdottir K, Harris TB, Zillikens MC, van Meurs JB, Thorsteinsdottir U, Maurano MT, Timpson NJ, Soranzo N, Durbin R, Wilson SG, Ntzani EE, Brown MA, Stefansson K, Hinds DA, Spector T, Cupples LA, Ohlsson C, Greenwood CM, Jackson RD, Rowe DW, Loomis CA, Evans DM, Ackert-Bicknell CL, Joyner AL, Duncan EL, Kiel DP, Rivadeneira F, Richards JB. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature. 2015 Oct 01; 526(7571):112-7. PMID: 26367794.
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    40. Adams DJ, Ackert-Bicknell CL. Genetic regulation of bone strength: a review of animal model studies. Bonekey Rep. 2015; 4:714. PMID: 26157577.
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    41. Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL. Aging Research Using Mouse Models. Curr Protoc Mouse Biol. 2015 Jun 01; 5(2):95-133. PMID: 26069080.
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    42. Hagiwara Y, Dyment NA, Jiang X, Jiang Ping H, Ackert-Bicknell C, Adams DJ, Rowe DW. Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair. J Orthop Res. 2015 Jul; 33(7):948-56. PMID: 25639792.
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    43. Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ. Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span. J Gerontol A Biol Sci Med Sci. 2016 Feb; 71(2):170-7. PMID: 25533306.
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    44. Kemp JP, Medina-Gomez C, Estrada K, St Pourcain B, Heppe DH, Warrington NM, Oei L, Ring SM, Kruithof CJ, Timpson NJ, Wolber LE, Reppe S, Gautvik K, Grundberg E, Ge B, van der Eerden B, van de Peppel J, Hibbs MA, Ackert-Bicknell CL, Choi K, Koller DL, Econs MJ, Williams FM, Foroud T, Zillikens MC, Ohlsson C, Hofman A, Uitterlinden AG, Davey Smith G, Jaddoe VW, Tobias JH, Rivadeneira F, Evans DM. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genet. 2014 Jun; 10(6):e1004423. PMID: 24945404.
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    45. Yu W, Ackert-Bicknell C, Larigakis JD, MacIver B, Steers WD, Churchill GA, Hill WG, Zeidel ML. Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait. Am J Physiol Renal Physiol. 2014 Jun 01; 306(11):F1296-307. PMID: 24717733.
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    46. Ackert-Bicknell CL, Karasik D. Impact of the environment on the skeleton: is it modulated by genetic factors? Curr Osteoporos Rep. 2013 Sep; 11(3):219-28. PMID: 23846556.
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    47. Hochrath K, Ehnert S, Ackert-Bicknell CL, Lau Y, Schmid A, Krawczyk M, Hengstler JG, Dunn J, Hiththetiya K, Rathkolb B, Micklich K, Hans W, Fuchs H, Gailus-Durner V, Wolf E, de Angelis MH, Dooley S, Paigen B, Wildemann B, Lammert F, N?ssler AK. Modeling hepatic osteodystrophy in Abcb4 deficient mice. Bone. 2013 Aug; 55(2):501-11. PMID: 23545228.
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    48. Ackert-Bicknell C, Paigen B, Korstanje R. Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis. J Lipid Res. 2013 Apr; 54(4):984-94. PMID: 23393305.
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    49. Ackert-Bicknell CL, Hibbs MA. The need for mouse models in osteoporosis genetics research. Bonekey Rep. 2012; 1:98. PMID: 23951485.
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    50. Gu T, Buaas FW, Simons AK, Ackert-Bicknell CL, Braun RE, Hibbs MA. Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. PLoS One. 2012; 7(3):e33720. PMID: 22448268.
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    51. Ackert-Bicknell CL. HDL cholesterol and bone mineral density: is there a genetic link? Bone. 2012 Feb; 50(2):525-33. PMID: 21810493.
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    52. Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D. Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density. Bone. 2012 May; 50(5):1188-95. PMID: 22306695.
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    53. Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Shaw GS, Shinpock S, Manly KF, Miller DR, Donohue KD, Culiat CT, Churchill GA, Lariviere WR, Palmer AA, O'Hara BF, Voy BH, Chesler EJ. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug; 21(8):1223-38. PMID: 21734011.
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    54. Beamer WG, Shultz KL, Coombs HF, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR. BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat. J Bone Miner Res. 2011 Jan; 26(1):88-99. PMID: 20687154.
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    55. Guan Y, Ackert-Bicknell CL, Kell B, Troyanskaya OG, Hibbs MA. Functional genomics complements quantitative genetics in identifying disease-gene associations. PLoS Comput Biol. 2010 Nov 11; 6(11):e1000991. PMID: 21085640.
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    56. Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug; 25(8):1808-20. PMID: 20200990.
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    57. Kawai M, Green CB, Lecka-Czernik B, Douris N, Gilbert MR, Kojima S, Ackert-Bicknell C, Garg N, Horowitz MC, Adamo ML, Clemmons DR, Rosen CJ. A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10508-13. PMID: 20498072.
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    58. Kawai M, Green CB, Horowitz M, Ackert-Bicknell C, Lecka-Czernik B, Rosen CJ. Nocturnin: a circadian target of Pparg-induced adipogenesis. Ann N Y Acad Sci. 2010 Mar; 1192:131-8. PMID: 20392228.
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    59. Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW. A new standard genetic map for the laboratory mouse. Genetics. 2009 Aug; 182(4):1335-44. PMID: 19535546.
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    60. Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 2009; 19(2):109-24. PMID: 19392647.
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    61. Ackert-Bicknell CL, Shockley KR, Horton LG, Lecka-Czernik B, Churchill GA, Rosen CJ. Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I. Endocrinology. 2009 Mar; 150(3):1330-40. PMID: 18948404.
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    62. Ackert-Bicknell CL, Demissie S, Mar?n de Evsikova C, Hsu YH, DeMambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ. PPARG by dietary fat interaction influences bone mass in mice and humans. J Bone Miner Res. 2008 Sep; 23(9):1398-408. PMID: 18707223.
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    63. Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Delahunty KM, Coombs HF, Donahue LR, Canalis E, Rosen CJ. Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes. J Bone Miner Res. 2007 Aug; 22(8):1187-96. PMID: 17451375.
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    64. Ackert-Bicknell CL, Salisbury JL, Horowitz M, DeMambro VE, Horton LG, Shultz KL, Lecka-Czernik B, Rosen CJ. A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesis. Ann N Y Acad Sci. 2007 Nov; 1116:291-305. PMID: 17584978.
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    65. Wergedal JE, Ackert-Bicknell CL, Beamer WG, Mohan S, Baylink DJ, Srivastava AK. Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains. J Lipid Res. 2007 Aug; 48(8):1724-34. PMID: 17496333.
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    66. Lecka-Czernik B, Ackert-Bicknell C, Adamo ML, Marmolejos V, Churchill GA, Shockley KR, Reid IR, Grey A, Rosen CJ. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology. 2007 Feb; 148(2):903-11. PMID: 17122083.
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    67. Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ. Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. J Bone Miner Res. 2006 Aug; 21(8):1256-66. PMID: 16869724.
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    68. Delahunty KM, Shultz KL, Gronowicz GA, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo J, Donahue LR, Ackert-Bicknell C, Kream BE, Beamer WG, Rosen CJ. Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology. 2006 Aug; 147(8):3915-23. PMID: 16675518.
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    69. Adamo ML, Ma X, Ackert-Bicknell CL, Donahue LR, Beamer WG, Rosen CJ. Genetic increase in serum insulin-like growth factor-I (IGF-I) in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter. Endocrinology. 2006 Jun; 147(6):2944-55. PMID: 16527837.
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    70. Mikaelian I, Hovick M, Silva KA, Burzenski LM, Shultz LD, Ackert-Bicknell CL, Cox GA, Sundberg JP. Expression of terminal differentiation proteins defines stages of mouse mammary gland development. Vet Pathol. 2006 Jan; 43(1):36-49. PMID: 16407485.
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    71. Ackert-Bicknell C, Rosen C. The Genetics of PPARG and the Skeleton. PPAR Res. 2006; 2006:93258. PMID: 17347532.
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    72. Akeson EC, Donahue LR, Beamer WG, Shultz KL, Ackert-Bicknell C, Rosen CJ, Corrigan J, Davisson MT. Chromosomal inversion discovered in C3H/HeJ mice. Genomics. 2006 Feb; 87(2):311-3. PMID: 16309882.
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    73. Iida K, Rosen CJ, Ackert-Bicknell C, Thorner MO. Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels. J Endocrinol. 2005 Sep; 186(3):481-9. PMID: 16135668.
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    74. Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ. Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density. Bone. 2005 Jan; 36(1):111-22. PMID: 15664009.
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    75. Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC. Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol. 2005 Mar; 20(3):255-60. PMID: 15549416.
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    76. Rosen CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, Horton LG, Delahunty KM, Beamer WG, Sipos J, Clemmons D, Nelson T, Bouxsein ML, Horowitz M. Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone. 2004 Nov; 35(5):1046-58. PMID: 15542029.
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    77. Dorward AM, Shultz KL, Ackert-Bicknell CL, Eicher EM, Beamer WG. High-resolution genetic map of X-linked juvenile-type granulosa cell tumor susceptibility genes in mouse. Cancer Res. 2003 Dec 01; 63(23):8197-202. PMID: 14678975.
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    78. Fan X, Roy E, Zhu L, Murphy TC, Ackert-Bicknell C, Hart CM, Rosen C, Nanes MS, Rubin J. Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology. 2004 Feb; 145(2):751-9. PMID: 14563699.
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    79. Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ. Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains. Bone. 2002 Dec; 31(6):670-4. PMID: 12531560.
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    80. Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest. 2002 Sep; 110(6):771-81. PMID: 12235108.
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    81. Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ. IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo. J Clin Endocrinol Metab. 2002 Sep; 87(9):4273-9. PMID: 12213884.
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