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Mary Elaine Reyland

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology
Phone303/724-4572

    Collapse Research 
    Collapse research activities and funding
    R01HL032868     (MALBON, CRAIG C)Jun 1, 1984 - Jun 30, 2009
    NIH/NHLBI
    Atherosclerosis And Peripheral Apoliprotein E Synthesis
    Role: Co-Principal Investigator

    F32CA007658     (REYLAND, MARY ELAINE)Aug 1, 1985
    NIH/NCI
    ERROR-PRONE BYPASS OF NON-INSTRUCTIVE LESIONS
    Role: Principal Investigator

    R03DE012422     (REYLAND, MARY ELAINE)Jul 15, 1997 - Jul 14, 2000
    NIH/NIDCR
    MOLECULAR BIOLOGY OF SALIVARY ACINAR CELL APOPTOSIS
    Role: Principal Investigator

    R01DK050690     (REYLAND, MARY ELAINE)Sep 26, 1997 - Aug 31, 2002
    NIH/NIDDK
    SUPPRESSION OF STEROIDOGENESIS BY PROTEIN KINASE C
    Role: Principal Investigator

    F33DE014314     (REYLAND, MARY ELAINE)Sep 15, 2001
    NIH/NIDCR
    Phosphorylation of PKC delta and Apoptosis
    Role: Principal Investigator

    R01DE015648     (REYLAND, MARY ELAINE)Dec 1, 2003 - Dec 31, 2019
    NIH/NIDCR
    PKCdelta and Salivary Gland Apoptosis
    Role: Principal Investigator

    R13DE019733     (REYLAND, MARY ELAINE)Jan 1, 2009 - Dec 31, 2009
    NIH/NIDCR
    2009 Salivary Glands and Exocrine Secretion Gordon Research Conference
    Role: Principal Investigator

    R13DE021655     (REYLAND, MARY ELAINE)Jan 7, 2011 - Dec 31, 2011
    NIH/NIDCR
    2011 Salivary Glands and Exocrine Biology Gordon Research Conference
    Role: Principal Investigator

    R21DC011713     (BARLOW, LINDA A)Apr 1, 2011 - Mar 31, 2014
    NIH/NIDCD
    PKC delta and cell renewal in irradiated taste epithelium
    Role: Co-Principal Investigator

    R56DE023245     (REYLAND, MARY ELAINE)Sep 26, 2012 - Aug 31, 2014
    NIH/NIDCR
    Functional characterization of salivary gland cancers and development of patient
    Role: Principal Investigator

    R13CA189353     (REYLAND, MARY ELAINE)Jul 18, 2014 - Jul 17, 2015
    NIH/NCI
    FASEB SRC on Lipids and Lipid Regulated Kinases in Cancer
    Role: Principal Investigator

    R21DE024309     (REYLAND, MARY ELAINE)Aug 1, 2014 - Jul 31, 2016
    NIH/NIDCR
    Radio-protection of the salivary gland
    Role: Principal Investigator

    T32CA190216     (CRAMER, SCOTT D)Jul 7, 2016 - Jun 30, 2021
    NIH/NCI
    Training Program in Cancer Biology
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Moua P, Checketts M, Xu LG, Shu HB, Reyland ME, Cusick JK. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Biochem Biophys Res Commun. 2017 Sep 09; 491(1):25-32. PMID: 28688764.
      View in: PubMed
    2. Wie SM, Wellberg E, Karam SD, Reyland ME. Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-d. Mol Cancer Ther. 2017 Jun 21. PMID: 28637715.
      View in: PubMed
    3. Ohm AM, Tan AC, Heasley LE, Reyland ME. Co-dependency of PKCd and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer. Oncogene. 2017 Jul 27; 36(30):4370-4378. PMID: 28368426.
      View in: PubMed
    4. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16; 6(1):e287. PMID: 28092369.
      View in: PubMed
    5. Reyland ME, Jones DN. Multifunctional roles of PKCd: Opportunities for targeted therapy in human disease. Pharmacol Ther. 2016 Sep; 165:1-13. PMID: 27179744.
      View in: PubMed
    6. Symonds JM, Ohm AM, Tan AC, Reyland ME. PKCd regulates integrin aVß3 expression and transformed growth of K-ras dependent lung cancer cells. Oncotarget. 2016 Apr 05; 7(14):17905-19. PMID: 26918447; PMCID: PMC4951259.
    7. Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME. Inhibiting tyrosine phosphorylation of protein kinase Cd (PKCd) protects the salivary gland from radiation damage. J Biol Chem. 2014 Apr 11; 289(15):10900-8. PMID: 24569990; PMCID: PMC4036201.
    8. Allen-Petersen BL, Carter CJ, Ohm AM, Reyland ME. Protein kinase Cd is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer. Oncogene. 2014 Mar 06; 33(10):1306-15. PMID: 23474764; PMCID: PMC4292929.
    9. Larroque-Cardoso P, Swiader A, Ingueneau C, Nègre-Salvayre A, Elbaz M, Reyland ME, Salvayre R, Vindis C. Role of protein kinase C d in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells. Cell Death Dis. 2013 Feb 28; 4:e520. PMID: 23449456; PMCID: PMC3734829.
    10. Nguyen HM, Reyland ME, Barlow LA. Mechanisms of taste bud cell loss after head and neck irradiation. J Neurosci. 2012 Mar 07; 32(10):3474-84. PMID: 22399770; PMCID: PMC3320161.
    11. Cusick JK, Mustian A, Jacobs AT, Reyland ME. Identification of PLSCR1 as a protein that interacts with RELT family members. Mol Cell Biochem. 2012 Mar; 362(1-2):55-63. PMID: 22052202.
      View in: PubMed
    12. Adwan TS, Ohm AM, Jones DN, Humphries MJ, Reyland ME. Regulated binding of importin-a to protein kinase Cd in response to apoptotic signals facilitates nuclear import. J Biol Chem. 2011 Oct 14; 286(41):35716-24. PMID: 21865164; PMCID: PMC3195609.
    13. Banninger GP, Cha S, Said MS, Pauley KM, Carter CJ, Onate M, Pauley BA, Anderson SM, Reyland ME. Loss of PKCd results in characteristics of Sjögren's syndrome including salivary gland dysfunction. Oral Dis. 2011 Sep; 17(6):601-9. PMID: 21702866; PMCID: PMC3293255.
    14. Reneau J, Reyland ME, Popp RL. Acute ethanol exposure prevents PMA-mediated augmentation of N-methyl-D-aspartate receptor function in primary cultured cerebellar granule cells. Alcohol. 2011 Sep; 45(6):595-605. PMID: 21624785; PMCID: PMC3154614.
    15. Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA, Reyland ME. Protein kinase C d is a downstream effector of oncogenic K-ras in lung tumors. Cancer Res. 2011 Mar 15; 71(6):2087-97. PMID: 21335545; PMCID: PMC3271733.
    16. Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, Elting LS, Langendijk JA, Coppes RP, Reyland ME. Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys. 2010 Nov 15; 78(4):983-91. PMID: 20970030; PMCID: PMC2964345.
    17. Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience. 2010 Nov 10; 170(4):1065-79. PMID: 20691763.
      View in: PubMed
    18. Allen-Petersen BL, Miller MR, Neville MC, Anderson SM, Nakayama KI, Reyland ME. Loss of protein kinase C delta alters mammary gland development and apoptosis. Cell Death Dis. 2010; 1:e17. PMID: 21364618; PMCID: PMC3032509.
    19. Cusick JK, Mustian A, Goldberg K, Reyland ME. RELT induces cellular death in HEK 293 epithelial cells. Cell Immunol. 2010; 261(1):1-8. PMID: 19969290; PMCID: PMC3407663.
    20. Perry C, Baker OJ, Reyland ME, Grichtchenko II. PKC{alpha}{beta}{gamma}- and PKC{delta}-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1409-23. PMID: 19783762; PMCID: PMC2793054.
    21. Reneau JC, Reyland ME, Phillips J, Kindy C, Popp RL. Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha. J Pharmacol Exp Ther. 2009 Aug; 330(2):641-9. PMID: 19429793; PMCID: PMC2713095.
    22. Reyland ME. Protein kinase C isoforms: Multi-functional regulators of cell life and death. Front Biosci (Landmark Ed). 2009 Jan 01; 14:2386-99. PMID: 19273207.
      View in: PubMed
    23. Perry C, Quissell DO, Reyland ME, Grichtchenko II. Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1385-98. PMID: 18815229; PMCID: PMC2584990.
    24. Nakashima H, Frank GD, Shirai H, Hinoki A, Higuchi S, Ohtsu H, Eguchi K, Sanjay A, Reyland ME, Dempsey PJ, Inagami T, Eguchi S. Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II. Hypertension. 2008 Feb; 51(2):232-8. PMID: 18180404; PMCID: PMC2728048.
    25. Humphries MJ, Ohm AM, Schaack J, Adwan TS, Reyland ME. Tyrosine phosphorylation regulates nuclear translocation of PKCdelta. Oncogene. 2008 May 08; 27(21):3045-53. PMID: 18059334; PMCID: PMC3285468.
    26. Reyland ME. Protein kinase Cdelta and apoptosis. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1001-4. PMID: 17956263.
      View in: PubMed
    27. DeVries-Seimon TA, Ohm AM, Humphries MJ, Reyland ME. Induction of apoptosis is driven by nuclear retention of protein kinase C delta. J Biol Chem. 2007 Aug 03; 282(31):22307-14. PMID: 17562707.
      View in: PubMed
    28. Clavijo C, Chen JL, Kim KJ, Reyland ME, Ann DK. Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. Am J Physiol Cell Physiol. 2007 Jun; 292(6):C2150-60. PMID: 17563398.
      View in: PubMed
    29. McManaman JL, Reyland ME, Thrower EC. Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):249-68. PMID: 17136613.
      View in: PubMed
    30. Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME. Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem. 2006 Apr 07; 281(14):9728-37. PMID: 16452485.
      View in: PubMed
    31. Mingo-Sion AM, Ferguson HA, Koller E, Reyland ME, Van Den Berg CL. PKCdelta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells. Breast Cancer Res Treat. 2005 Jun; 91(3):259-69. PMID: 15952059.
      View in: PubMed
    32. Tse SM, Mason D, Botelho RJ, Chiu B, Reyland M, Hanada K, Inman RD, Grinstein S. Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. J Biol Chem. 2005 Jul 01; 280(26):25210-5. PMID: 15863503.
      View in: PubMed
    33. Jackson D, Zheng Y, Lyo D, Shen Y, Nakayama K, Nakayama KI, Humphries MJ, Reyland ME, Foster DA. Suppression of cell migration by protein kinase Cdelta. Oncogene. 2005 Apr 21; 24(18):3067-72. PMID: 15735725.
      View in: PubMed
    34. DeVries TA, Kalkofen RL, Matassa AA, Reyland ME. Protein kinase Cdelta regulates apoptosis via activation of STAT1. J Biol Chem. 2004 Oct 29; 279(44):45603-12. PMID: 15322115.
      View in: PubMed
    35. King SR, Matassa AA, White EK, Walsh LP, Jo Y, Rao RM, Stocco DM, Reyland ME. Oxysterols regulate expression of the steroidogenic acute regulatory protein. J Mol Endocrinol. 2004 Apr; 32(2):507-17. PMID: 15072555.
      View in: PubMed
    36. Matassa AA, Kalkofen RL, Carpenter L, Biden TJ, Reyland ME. Inhibition of PKCalpha induces a PKCdelta-dependent apoptotic program in salivary epithelial cells. Cell Death Differ. 2003 Mar; 10(3):269-77. PMID: 12700627.
      View in: PubMed
    37. Limesand KH, Barzen KA, Sanders LA, Sclafani RA, Raynolds MV, Reyland ME, Anderson SM, Quissell DO. Characterization of rat parotid and submandibular acinar cell apoptosis in primary culture. In Vitro Cell Dev Biol Anim. 2003 Mar-Apr; 39(3-4):170-7. PMID: 14505429; PMCID: PMC2879403.
    38. DeVries TA, Neville MC, Reyland ME. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J. 2002 Nov 15; 21(22):6050-60. PMID: 12426377; PMCID: PMC137198.
    39. Shizukuda Y, Reyland ME, Buttrick PM. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1625-34. PMID: 11959624.
      View in: PubMed
    40. Helt CE, Hoernig GR, Albeck DS, Gerhardt GA, Ickes B, Reyland ME, Quissell DO, Strömberg I, Granholm AC. Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail. Exp Neurol. 2001 Aug; 170(2):258-69. PMID: 11476591.
      View in: PubMed
    41. Matassa AA, Carpenter L, Biden TJ, Humphries MJ, Reyland ME. PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells. J Biol Chem. 2001 Aug 10; 276(32):29719-28. PMID: 11369761.
      View in: PubMed
    42. Smith L, Chen L, Reyland ME, DeVries TA, Talanian RV, Omura S, Smith JB. Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system. J Biol Chem. 2000 Dec 22; 275(51):40620-7. PMID: 11016947.
      View in: PubMed
    43. Reyland ME, Barzen KA, Anderson SM, Quissell DO, Matassa AA. Activation of PKC is sufficient to induce an apoptotic program in salivary gland acinar cells. Cell Death Differ. 2000 Dec; 7(12):1200-9. PMID: 11175257.
      View in: PubMed
    44. Reyland ME, Evans RM, White EK. Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells. J Biol Chem. 2000 Nov 24; 275(47):36637-44. PMID: 10960482.
      View in: PubMed
    45. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol. 2000 Sep; 279(3):L429-38. PMID: 10956616.
      View in: PubMed
    46. Granholm AC, Reyland M, Albeck D, Sanders L, Gerhardt G, Hoernig G, Shen L, Westphal H, Hoffer B. Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. J Neurosci. 2000 May 01; 20(9):3182-90. PMID: 10777782.
      View in: PubMed
    47. Das M, Dempsey EC, Bouchey D, Reyland ME, Stenmark KR. Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):15-25. PMID: 10615061.
      View in: PubMed
    48. Holwell TA, Schweitzer SC, Reyland ME, Evans RM. Vimentin-dependent utilization of LDL-cholesterol in human adrenal tumor cells is not associated with the level of expression of apoE, sterol carrier protein-2, or caveolin. J Lipid Res. 1999 Aug; 40(8):1440-52. PMID: 10428980.
      View in: PubMed
    49. Reyland ME, Anderson SM, Matassa AA, Barzen KA, Quissell DO. Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. J Biol Chem. 1999 Jul 02; 274(27):19115-23. PMID: 10383415.
      View in: PubMed
    50. Anderson SM, Reyland ME, Hunter S, Deisher LM, Barzen KA, Quissell DO. Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug-induced apoptosis in salivary gland acinar cells. Cell Death Differ. 1999 May; 6(5):454-62. PMID: 10381634.
      View in: PubMed
    51. Lee RC, Walters JA, Reyland ME, Anderson SM. Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules. J Biol Chem. 1999 Apr 09; 274(15):10024-34. PMID: 10187780.
      View in: PubMed
    52. Reyland ME, Williams DL, White EK. Inducible expression of protein kinase Calpha suppresses steroidogenesis in Y-1 adrenocortical cells. Am J Physiol. 1998 Sep; 275(3 Pt 1):C780-9. PMID: 9730962.
      View in: PubMed
    53. Swarnakar S, Reyland ME, Deng J, Azhar S, Williams DL. Selective uptake of low density lipoprotein-cholesteryl ester is enhanced by inducible apolipoprotein E expression in cultured mouse adrenocortical cells. J Biol Chem. 1998 May 15; 273(20):12140-7. PMID: 9575160.
      View in: PubMed
    54. Prack MM, Rothblat GH, Erickson SK, Reyland ME, Williams DL. Apolipoprotein E expression in Y1 adrenal cells is associated with increased intracellular cholesterol content and reduced free cholesterol efflux. Biochemistry. 1994 May 03; 33(17):5049-55. PMID: 8172880.
      View in: PubMed
    55. Reyland ME. Protein kinase C is a tonic negative regulator of steroidogenesis and steroid hydroxylase gene expression in Y1 adrenal cells and functions independently of protein kinase A. Mol Endocrinol. 1993 Aug; 7(8):1021-30. PMID: 7694083.
      View in: PubMed
    56. Reyland ME, Prack MM, Williams DL. Elevated levels of protein kinase C in Y1 cells which express apolipoprotein E decrease basal steroidogenesis by inhibiting expression of P450-cholesterol side chain cleavage mRNA. J Biol Chem. 1992 Sep 05; 267(25):17933-8. PMID: 1517229.
      View in: PubMed
    57. Reyland ME, Williams DL. Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E. J Biol Chem. 1991 Nov 05; 266(31):21099-104. PMID: 1657949.
      View in: PubMed
    58. Reyland ME, Gwynne JT, Forgez P, Prack MM, Williams DL. Expression of the human apolipoprotein E gene suppresses steroidogenesis in mouse Y1 adrenal cells. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2375-9. PMID: 1848701; PMCID: PMC51234.
    59. Reyland ME, Lehman IR, Loeb LA. Specificity of proofreading by the 3'----5' exonuclease of the DNA polymerase-primase of Drosophila melanogaster. J Biol Chem. 1988 May 15; 263(14):6518-24. PMID: 3129427.
      View in: PubMed
    60. Reyland ME, Loeb LA. On the fidelity of DNA replication. Isolation of high fidelity DNA polymerase-primase complexes by immunoaffinity chromatography. J Biol Chem. 1987 Aug 05; 262(22):10824-30. PMID: 3038898.
      View in: PubMed
    61. Cotterill SM, Reyland ME, Loeb LA, Lehman IR. A cryptic proofreading 3'----5' exonuclease associated with the polymerase subunit of the DNA polymerase-primase from Drosophila melanogaster. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5635-9. PMID: 3112771; PMCID: PMC298917.
    62. Reyland ME, Scott RB, Keefe WE, Cooper LW. Differentiation-associated changes in in-vitro mRNA translation in the HL60 cell line. Leuk Res. 1986; 10(10):1183-91. PMID: 3464811.
      View in: PubMed
    63. Reyland ME, Scott RB, Keefe WE, Cooper LW, Collins JM. Proliferation-associated changes in in vitro mRNA translation in the HL60 cell line. Exp Cell Res. 1985 Sep; 160(1):63-72. PMID: 4043246.
      View in: PubMed
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