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Thomas J LaRocca

InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
ORCID ORCID Icon0000-0002-2393-7299 Additional info

    Collapse Research 
    Collapse research activities and funding
    F31AG039210     (LAROCCA, THOMAS JOSEPH)Apr 7, 2011 - Apr 6, 2013
    Role of Autophagy in Vascular Endothelial Dysfunction with Aging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Saldi TK, Gonzales PK, LaRocca TJ, Link CD. Neurodegeneration, Heterochromatin, and Double-Stranded RNA. J Exp Neurosci. 2019; 13:1179069519830697. PMID: 30792577.
      View in: PubMed
    2. Rossman MJ, LaRocca TJ, Martens CR, Seals DR. Healthy lifestyle-based approaches for successful vascular aging. J Appl Physiol (1985). 2018 Dec 01; 125(6):1888-1900. PMID: 30212305.
      View in: PubMed
    3. Jarrah AA, Schwarskopf M, Wang ER, LaRocca T, Dhume A, Zhang S, Hadri L, Hajjar RJ, Schecter AD, Tarzami ST. SDF-1 induces TNF-mediated apoptosis in cardiac myocytes. Apoptosis. 2018 Jan; 23(1):79-91. PMID: 29236198.
      View in: PubMed
    4. Pagliassotti MJ, Estrada AL, Hudson WM, Wei Y, Wang D, Seals DR, Zigler ML, LaRocca TJ. Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice. J Nutr Biochem. 2017 07; 45:15-23. PMID: 28431320.
      View in: PubMed
    5. LaRocca TJ, Martens CR, Seals DR. Nutrition and other lifestyle influences on arterial aging. Ageing Res Rev. 2017 Oct; 39:106-119. PMID: 27693830.
      View in: PubMed
    6. Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ. Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell. 2017 Feb; 16(1):17-26. PMID: 27660040.
      View in: PubMed
    7. LaRocca TJ, Justice JN, Seals DR, Martens CR. Adding value to a graduate physiology seminar by focusing on public communication skills. Adv Physiol Educ. 2016 Sep; 40(3):365-9. PMID: 27445287.
      View in: PubMed
    8. Kaplon RE, Hill SD, Bispham NZ, Santos-Parker JR, Nowlan MJ, Snyder LL, Chonchol M, LaRocca TJ, McQueen MB, Seals DR. Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults. Aging (Albany NY). 2016 06; 8(6):1167-83. PMID: 27208415.
      View in: PubMed
    9. Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D'Escamard V, Kovacic JC, Kwak TH, Hajjar RJ, Park WJ. Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis. J Am Coll Cardiol. 2016 04 05; 67(13):1556-1568. PMID: 27150688.
      View in: PubMed
    10. Seals DR, Justice JN, LaRocca TJ. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2016 Apr 15; 594(8):2001-24. PMID: 25639909; PMCID: PMC4933122 [Available on 04/15/17].
    11. Santos-Parker JR, LaRocca TJ, Seals DR. Aerobic exercise and other healthy lifestyle factors that influence vascular aging. Adv Physiol Educ. 2014 Dec; 38(4):296-307. PMID: 25434012; PMCID: PMC4315444.
    12. LaRocca TJ, Hearon CM, Henson GD, Seals DR. Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol. 2014 Oct; 58:78-82. PMID: 25034910; PMCID: PMC4252265.
    13. Seals DR, Kaplon RE, Gioscia-Ryan RA, LaRocca TJ. You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda). 2014 Jul; 29(4):250-64. PMID: 24985329; PMCID: PMC4103060.
    14. Gioscia-Ryan RA, LaRocca TJ, Sindler AL, Zigler MC, Murphy MP, Seals DR. Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol. 2014 Jun 15; 592(12):2549-61. PMID: 24665093; PMCID: PMC4080937.
    15. LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR. The autophagy enhancer spermidine reverses arterial aging. Mech Ageing Dev. 2013 Jul-Aug; 134(7-8):314-20. PMID: 23612189; PMCID: PMC3700669.
    16. Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST. CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol. 2012 Aug; 53(2):223-32. PMID: 22668785.
      View in: PubMed
    17. LaRocca TJ, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, Schecter AD, Cheung JY, Sobie EA, Hajjar RJ, Lebeche D. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-?B pathway. Am J Physiol Heart Circ Physiol. 2012 Aug 01; 303(3):H353-67. PMID: 22610174; PMCID: PMC3423163.
    18. LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol. 2012 Jul 15; 590(14):3305-16. PMID: 22570377; PMCID: PMC3459044.
    19. Pierce GL, Donato AJ, LaRocca TJ, Eskurza I, Silver AE, Seals DR. Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell. 2011 Dec; 10(6):1032-7. PMID: 21943306; PMCID: PMC3222334.
    20. Rippe C, Blimline M, Magerko KA, Lawson BR, LaRocca TJ, Donato AJ, Seals DR. MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol. 2012 Jan; 47(1):45-51. PMID: 22037549; PMCID: PMC3245334.
    21. Chen J, Chemaly ER, Liang LF, LaRocca TJ, Yaniz-Galende E, Hajjar RJ. A new model of congestive heart failure in rats. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H994-1003. PMID: 21685270; PMCID: PMC3191108.
    22. LaRocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST. ß2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. J Cardiovasc Pharmacol. 2010 Nov; 56(5):548-59. PMID: 20729750; PMCID: PMC2978286.
    23. Rippe C, Lesniewski L, Connell M, LaRocca T, Donato A, Seals D. Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell. 2010 Jun; 9(3):304-12. PMID: 20121721; PMCID: PMC2894368.
    24. LaRocca TJ, Seals DR, Pierce GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev. 2010 Feb; 131(2):165-7. PMID: 20064545; PMCID: PMC2845985.
    25. Pierce GL, Larocca TJ. Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults? J Physiol. 2008 Jun 01; 586(11):2673-4. PMID: 18388135; PMCID: PMC2536576.
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