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Marc Lee Goalstone

TitleLecturer
InstitutionUniversity of Colorado Denver - Denver Campus
DepartmentCLAS-Biology
Phone303/399-8020

    Collapse Research 
    Collapse research activities and funding
    R01DK068236     (GOALSTONE, MARC LEE)Mar 1, 2005 - Feb 28, 2009
    NIH/NIDDK
    Macrovascular Dysfunction of Diabetes
    Role: Principal Investigator

    I01BX002019     (GOALSTONE, MARC LEE)Apr 1, 2014 - Mar 31, 2018
    VA
    Diabetes: ERK5 and Vascular Inflammation
    Role: Principal Investigator

    IS1BX003574     (GOALSTONE, MARC LEE)May 1, 2016 - Sep 30, 2016
    VA
    ShEEP Request for Flow Cytometer Special Order Laser Upgrade
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Veluthakal R, Arora DK, Goalstone ML, Kowluru RA, Kowluru A. Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic ß-Cells. Cell Physiol Biochem. 2016; 39(6):2110-2120. PMID: 27802439.
      View in: PubMed
    2. Goalstone ML, Pugazhenthi S. Editorial: Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain. Front Endocrinol (Lausanne). 2016; 7:45. PMID: 27242668; PMCID: PMC4873489.
    3. Pott GB, Tsurudome M, Bamfo N, Goalstone ML. ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-a stimulated VCAM-1 expression in rat aorta endothelial cells. J Inflamm (Lond). 2016; 13:6. PMID: 26917991; PMCID: PMC4766666.
    4. Mackesy DZ, Goalstone ML. Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor a-stimulated vascular cell adhesion molecule-1 expression in vascular cells. J Diabetes. 2014 Nov; 6(6):595-602. PMID: 24460840.
      View in: PubMed
    5. Mackesy DZ, Goalstone ML. Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells. J Inflamm (Lond). 2011 Nov 17; 8:34. PMID: 22093181; PMCID: PMC3248376.
    6. Goalstone ML. ERK5: a novel IKKa-kinase in rat hippocampal neurons. Can J Neurol Sci. 2011 Jul; 38(4):639-48. PMID: 21672705.
      View in: PubMed
    7. Goalstone M, Kamath V, Kowluru A. Glucose activates prenyltransferases in pancreatic islet beta-cells. Biochem Biophys Res Commun. 2010 Jan 01; 391(1):895-8. PMID: 19951701; PMCID: PMC2812622.
    8. Sharma G, Goalstone ML. Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1078-83. PMID: 17275785; PMCID: PMC1850970.
    9. Veluthakal R, Kaur H, Goalstone M, Kowluru A. Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells. Diabetes. 2007 Jan; 56(1):204-10. PMID: 17192483.
      View in: PubMed
    10. Sharma G, Goalstone ML. Dominant negative FTase (DNFTalpha) inhibits ERK5, MEF2C and CREB activation in adipogenesis. Mol Cell Endocrinol. 2005 Dec 21; 245(1-2):93-104. PMID: 16356629.
      View in: PubMed
    11. Cornier MA, Donahoo WT, Pereira R, Gurevich I, Westergren R, Enerback S, Eckel PJ, Goalstone ML, Hill JO, Eckel RH, Draznin B. Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res. 2005 Apr; 13(4):703-9. PMID: 15897479.
      View in: PubMed
    12. Wang CC, Goalstone ML, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes. 2004 Nov; 53(11):2735-40. PMID: 15504952.
      View in: PubMed
    13. Finlayson CA, Chappell J, Leitner JW, Goalstone ML, Garrity M, Nawaz S, Ciaraldi TP, Draznin B. Enhanced insulin signaling via Shc in human breast cancer. Metabolism. 2003 Dec; 52(12):1606-11. PMID: 14669164.
      View in: PubMed
    14. Golovchenko I, Yang CH, Goalstone ML, Draznin B. Garlic extract methylallyl thiosulfinate blocks insulin potentiation of platelet-derived growth factor-stimulated migration of vascular smooth muscle cells. Metabolism. 2003 Feb; 52(2):254-9. PMID: 12601642.
      View in: PubMed
    15. Solomon CS, Goalstone ML. Dominant negative alpha-subunit of FTase inhibits effects of insulin and IGF-I in MCF-7 cells. Biochem Biophys Res Commun. 2002 Mar 01; 291(3):458-65. PMID: 11855811.
      View in: PubMed
    16. Montagnani M, Golovchenko I, Kim I, Koh GY, Goalstone ML, Mundhekar AN, Johansen M, Kucik DF, Quon MJ, Draznin B. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem. 2002 Jan 18; 277(3):1794-9. PMID: 11707433.
      View in: PubMed
    17. Goalstone ML, Natarajan R, Standley PR, Walsh MF, Leitner JW, Carel K, Scott S, Nadler J, Sowers JR, Draznin B. Insulin Potentiates Platelet-Derived Growth Factor Action in Vascular Smooth Muscle Cells* * This work was supported by grants from the VA Research Service, the NIH (HL-48920 to R.N., HD-24497-06 to J.S.), PO-1-HL-55798 (to J.N. and R.N.), jointly funded by the NIH and the Juvenile Diabetes Foundation, the American Heart Association, a fellowship support from the American Heart Association (to M.G.), HealthONE Foundation: Diabetes and Endocrine Research and Education Fund, and Foundation for Biomedical Education and Research. Endocrinology. 1998 Oct 01; 139(10):4067-4072. PMID: 28200187.
      View in: PubMed
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