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Ramesh Akkina

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone970/491-1009

    Collapse Research 
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    R01AI042551     (AKKINA, RAMESH)Dec 1, 1997 - Nov 30, 2001
    NIH/NIAID
    HIV PATHOGENESIS AND GENE THERAPY IN SCID-HU MICE
    Role: Principal Investigator

    R21AI050492     (AKKINA, RAMESH)Sep 15, 2001 - Aug 31, 2003
    NIH/NIAID
    Modeling RNA-based HIV gene therapeutics in SCID-hu mice
    Role: Principal Investigator

    R01AI050492     (AKKINA, RAMESH)Jan 1, 2002 - Dec 31, 2007
    NIH/NIAID
    Modeling RNA-based HIV gene therapeutics in SCID-hu mice
    Role: Principal Investigator

    R01AI057066     (AKKINA, RAMESH)Apr 1, 2004 - Mar 31, 2010
    NIH/NIAID
    SiRNA Gene Therapy for HIV/AIDS
    Role: Principal Investigator

    R01AI073255     (AKKINA, RAMESH)Jun 1, 2007 - May 31, 2014
    NIH/NIAID
    Humanized Rag2-/-gammac-/-mice for HIV infection and gene therapy
    Role: Principal Investigator

    R21HL094257     (AKKINA, RAMESH)Sep 19, 2008 - Aug 31, 2012
    NIH/NHLBI
    Human embryonic stem (hES) cells for hematopoietic and HIV/AIDS therapies
    Role: Principal Investigator

    R56AI095101     (AKKINA, RAMESH)Feb 15, 2012 - Jan 31, 2014
    NIH/NIAID
    Efficacy Testing of HIV-Specific Microbicides in Humanized Mice
    Role: Principal Investigator

    R01AI100845     (AKKINA, RAMESH)Jun 1, 2012 - May 31, 2015
    NIH/NIAID
    Modeling Next Generation HIV PrEP in Humanized Mice
    Role: Principal Investigator

    R01AI120021     (AKKINA, RAMESH)Jun 30, 2015 - May 31, 2020
    NIH/NIAID
    An Ultrasensitive In Vivo Latent HIV Viral Outgrowth Assay Using Humanized Mice
    Role: Principal Investigator

    R01AI123234     (AKKINA, RAMESH)Aug 1, 2016 - Jul 31, 2021
    NIH/NIAID
    Modeling the molecular evolution of SIV to HIV using humanized mice
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells. Mol Ther. 2007 Jun; 15(6):1182-1188. PMID: 28182923.
      View in: PubMed
    2. Hu S, Neff CP, Kumar DM, Habu Y, Akkina SR, Seki T, Akkina R. A humanized mouse model for HIV-2 infection and efficacy testing of a single-pill triple-drug combination anti-retroviral therapy. Virology. 2017 Jan 15; 501:115-118. PMID: 27912079.
      View in: PubMed
    3. Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):109-19. PMID: 26670361.
      View in: PubMed
    4. Veselinovic M, Yang KH, Sykes C, Remling-Mulder L, Kashuba AD, Akkina R. Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis. Virology. 2016 Feb; 489:173-8. PMID: 26771889.
      View in: PubMed
    5. Veselinovic M, Charlins P, Akkina R. Modeling HIV-1 Mucosal Transmission and Prevention in Humanized Mice. Methods Mol Biol. 2016; 1354:203-20. PMID: 26714714.
      View in: PubMed
    6. Hu S, Mohan Kumar D, Sax C, Schuler C, Akkina R. Pseudotyping of lentiviral vector with novel vesiculovirus envelope glycoproteins derived from Chandipura and Piry viruses. Virology. 2016 Jan 15; 488:162-8. PMID: 26650691.
      View in: PubMed
    7. Veselinovic M, Yang KH, LeCureux J, Sykes C, Remling-Mulder L, Kashuba AD, Akkina R. HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model. Virology. 2014 Sep; 464-465:253-63. PMID: 25105490.
      View in: PubMed
    8. Akkina R. Humanized Mice for Studying Human Immune Responses and Generating Human Monoclonal Antibodies. Microbiol Spectr. 2014 Apr; 2(2). PMID: 26105817.
      View in: PubMed
    9. Bennett MS, Akkina R. Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice. Viruses. 2013 Dec 12; 5(12):3119-41. PMID: 24351796.
      View in: PubMed
    10. Akkina R. New insights into HIV impact on hematopoiesis. Blood. 2013 Sep 26; 122(13):2144-6. PMID: 24072846.
      View in: PubMed
    11. Taube S, Kolawole AO, Höhne M, Wilkinson JE, Handley SA, Perry JW, Thackray LB, Akkina R, Wobus CE. A mouse model for human norovirus. MBio. 2013 Jul 16; 4(4). PMID: 23860770.
      View in: PubMed
    12. Akkina R. Human immune responses and potential for vaccine assessment in humanized mice. Curr Opin Immunol. 2013 Jun; 25(3):403-9. PMID: 23628166.
      View in: PubMed
    13. Akkina R. New generation humanized mice for virus research: comparative aspects and future prospects. Virology. 2013 Jan 05; 435(1):14-28. PMID: 23217612.
      View in: PubMed
    14. Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y. Identification of novel influenza A virus proteins translated from PA mRNA. J Virol. 2013 Mar; 87(5):2455-62. PMID: 23236060.
      View in: PubMed
    15. Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice. J Immunol. 2013 Jan 01; 190(1):211-9. PMID: 23209326.
      View in: PubMed
    16. Zhou J, Neff CP, Swiderski P, Li H, Smith DD, Aboellail T, Remling-Mulder L, Akkina R, Rossi JJ. Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther. 2013 Jan; 21(1):192-200. PMID: 23164935.
      View in: PubMed
    17. Veselinovic M, Neff CP, Mulder LR, Akkina R. Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model. Virology. 2012 Oct 25; 432(2):505-10. PMID: 22832125.
      View in: PubMed
    18. Nischang M, Gers-Huber G, Audigé A, Akkina R, Speck RF. Modeling HIV infection and therapies in humanized mice. Swiss Med Wkly. 2012 Jul 09; 142:w13618. PMID: 22777836.
      View in: PubMed
    19. Zhou J, Neff CP, Liu X, Zhang J, Li H, Smith DD, Swiderski P, Aboellail T, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi JJ. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther. 2011 Dec; 19(12):2228-38. PMID: 21952167.
      View in: PubMed
    20. Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, Connick E, Folkvord J, Gagliardi K, Kassu A, Akkina SR. Humanized Rag1-/- ?c-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes. PLoS One. 2011; 6(6):e20169. PMID: 21695116.
      View in: PubMed
    21. Evans VA, Lal L, Akkina R, Solomon A, Wright E, Lewin SR, Cameron PU. Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro. Retrovirology. 2011 Jun 03; 8:43. PMID: 21639903.
      View in: PubMed
    22. Neff CP, Kurisu T, Ndolo T, Fox K, Akkina R. A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice. PLoS One. 2011; 6(6):e20209. PMID: 21673796.
      View in: PubMed
    23. Neff CP, Zhou J, Remling L, Kuruvilla J, Zhang J, Li H, Smith DD, Swiderski P, Rossi JJ, Akkina R. An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice. Sci Transl Med. 2011 Jan 19; 3(66):66ra6. PMID: 21248316.
      View in: PubMed
    24. Neff CP, Ndolo T, Tandon A, Habu Y, Akkina R. Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model. PLoS One. 2010 Dec 21; 5(12):e15257. PMID: 21203568.
      View in: PubMed
    25. Kassu A, Marcus RA, D'Souza MB, Kelly-McKnight EA, Golden-Mason L, Akkina R, Fontenot AP, Wilson CC, Palmer BE. Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection. J Immunol. 2010 Sep 01; 185(5):3007-18. PMID: 20656923.
      View in: PubMed
    26. Berges BK, Akkina SR, Remling L, Akkina R. Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year. Virology. 2010 Feb 05; 397(1):100-3. PMID: 19922970.
      View in: PubMed
    27. Kassu A, D'Souza M, O'Connor BP, Kelly-McKnight E, Akkina R, Fontenot AP, Palmer BE. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. Clin Immunol. 2009 Aug; 132(2):234-45. PMID: 19406689.
      View in: PubMed
    28. Zhou J, Swiderski P, Li H, Zhang J, Neff CP, Akkina R, Rossi JJ. Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res. 2009 May; 37(9):3094-109. PMID: 19304999.
      View in: PubMed
    29. Tamhane M, Akkina R. Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance. AIDS Res Ther. 2008 Jul 30; 5:16. PMID: 18667075.
      View in: PubMed
    30. Anderson J, Akkina R. Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue. Hum Gene Ther. 2008 Mar; 19(3):217-28. PMID: 18279037.
      View in: PubMed
    31. Bandi S, Akkina R. Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection. AIDS Res Ther. 2008 Jan 23; 5:1. PMID: 18215326.
      View in: PubMed
    32. Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R. Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice. Virology. 2008 Apr 10; 373(2):342-51. PMID: 18207484.
      View in: PubMed
    33. Kuruvilla JG, Troyer RM, Devi S, Akkina R. Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice. Virology. 2007 Dec 05; 369(1):143-52. PMID: 17707071.
      View in: PubMed
    34. Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells. Mol Ther. 2007 Jun; 15(6):1182-8. PMID: 17406343.
      View in: PubMed
    35. Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R. HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology. 2006 Nov 01; 3:76. PMID: 17078891.
      View in: PubMed
    36. Yam P, Jensen M, Akkina R, Anderson J, Villacres MC, Wu J, Zaia JA, Yee JK. Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. Mol Ther. 2006 Aug; 14(2):236-44. PMID: 16647299.
      View in: PubMed
    37. Anderson JS, Bandi S, Kaufman DS, Akkina R. Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy. Retrovirology. 2006 Apr 19; 3:24. PMID: 16623949.
      View in: PubMed
    38. Anderson J, Akkina R. TRIM5alpharh expression restricts HIV-1 infection in lentiviral vector-transduced CD34+-cell-derived macrophages. Mol Ther. 2005 Oct; 12(4):687-96. PMID: 16081321.
      View in: PubMed
    39. Li MJ, Kim J, Li S, Zaia J, Yee JK, Anderson J, Akkina R, Rossi JJ. Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Mol Ther. 2005 Nov; 12(5):900-9. PMID: 16115802.
      View in: PubMed
    40. Anderson J, Akkina R. CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection. Retrovirology. 2005 Aug 18; 2:53. PMID: 16109172.
      View in: PubMed
    41. Strayer DS, Akkina R, Bunnell BA, Dropulic B, Planelles V, Pomerantz RJ, Rossi JJ, Zaia JA. Current status of gene therapy strategies to treat HIV/AIDS. Mol Ther. 2005 Jun; 11(6):823-42. PMID: 15922953.
      View in: PubMed
    42. Anderson J, Akkina R. HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector. AIDS Res Ther. 2005 Jan 13; 2(1):1. PMID: 15813990.
      View in: PubMed
    43. Banerjea A, Li MJ, Remling L, Rossi J, Akkina R. Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages. AIDS Res Ther. 2004 Dec 17; 1(1):2. PMID: 15813986.
      View in: PubMed
    44. Anderson J, Banerjea A, Planelles V, Akkina R. Potent suppression of HIV type 1 infection by a short hairpin anti-CXCR4 siRNA. AIDS Res Hum Retroviruses. 2003 Aug; 19(8):699-706. PMID: 13678472.
      View in: PubMed
    45. Banerjea A, Li MJ, Bauer G, Remling L, Lee NS, Rossi J, Akkina R. Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages. Mol Ther. 2003 Jul; 8(1):62-71. PMID: 12842429.
      View in: PubMed
    46. Akkina R, Banerjea A, Bai J, Anderson J, Li MJ, Rossi J. siRNAs, ribozymes and RNA decoys in modeling stem cell-based gene therapy for HIV/AIDS. Anticancer Res. 2003 May-Jun; 23(3A):1997-2005. PMID: 12894572.
      View in: PubMed
    47. Anderson J, Banerjea A, Akkina R. Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides. 2003; 13(5):303-12. PMID: 15000821.
      View in: PubMed
    48. Bai J, Banda N, Lee NS, Rossi J, Akkina R. RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model. Mol Ther. 2002 Dec; 6(6):770-82. PMID: 12498773.
      View in: PubMed
    49. Llewellyn ZN, Ou X, Chang GJ, Schmitt B, Salman MD, Akkina RK. Genetic analysis of vesicular stomatitis virus-New Jersey from the 1995 outbreak in the western United States. Am J Vet Res. 2000 Nov; 61(11):1358-63. PMID: 11108179.
      View in: PubMed
    50. Banda NK, Simon GR, Sipple JD, Terrell KL, Archer P, Shpall EJ, Akkina RK, Myers AM, Harrison GS. Depletion of CD34+ CD4+ cells in bone marrow from HIV-1-infected individuals. Biol Blood Marrow Transplant. 1999; 5(3):162-72. PMID: 10392962.
      View in: PubMed
    51. Banda NK, Akkina RK, Terrell K, Shpall EJ, Tomczak J, Campain J, Claman H, Cagle L, Harrison GS. Diphtheria toxin A gene-mediated HIV-1 protection of cord blood-derived T cells in the SCID-hu mouse model. J Hematother. 1998 Aug; 7(4):319-31. PMID: 9735863.
      View in: PubMed
    52. Sullivan DG, Chang GJ, Akkina RK. Genetic characterization of ruminant pestiviruses: sequence analysis of viral genotypes isolated from sheep. Virus Res. 1997 Jan; 47(1):19-29. PMID: 9037733.
      View in: PubMed
    53. Banda NK, Tomczak JA, Shpall EJ, Sipple J, Akkina RK, Steimer KS, Hami L, Curiel TJ, Singer Harrison G. HIV-gp120 induced cell death in hematopoietic progenitor CD34+ cells. Apoptosis. 1997; 2(1):61-8. PMID: 14646565.
      View in: PubMed
    54. Akkina RK, Walton RM, Chen ML, Li QX, Planelles V, Chen IS. High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G. J Virol. 1996 Apr; 70(4):2581-5. PMID: 8642689.
      View in: PubMed
    55. Sullivan DG, Akkina RK. A nested polymerase chain reaction assay to differentiate pestiviruses. Virus Res. 1995 Oct; 38(2-3):231-9. PMID: 8578861.
      View in: PubMed
    56. Akkina RK, Rosenblatt JD, Campbell AG, Chen IS, Zack JA. Modeling human lymphoid precursor cell gene therapy in the SCID-hu mouse. Blood. 1994 Sep 01; 84(5):1393-8. PMID: 7520766.
      View in: PubMed
    57. Sullivan DG, Chang GJ, Trent DW, Akkina RK. Nucleotide sequence analysis of the structural gene coding region of the pestivirus border disease virus. Virus Res. 1994 Sep; 33(3):219-28. PMID: 7985409.
      View in: PubMed
    58. Akkina RK. Pestivirus bovine viral diarrhea virus polypeptides: identification of new precursor proteins and alternative cleavage pathways. Virus Res. 1991 Mar; 19(1):67-81. PMID: 1651034.
      View in: PubMed
    59. Akkina RK, Richardson JC, Aguilera MC, Yang CM. Heterogeneous forms of polymerase proteins exist in influenza A virus-infected cells. Virus Res. 1991 Mar; 19(1):17-30. PMID: 1867008.
      View in: PubMed
    60. Richardson JC, Akkina RK. NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells. Arch Virol. 1991; 116(1-4):69-80. PMID: 1825776.
      View in: PubMed
    61. Akkina RK, Raisch KP. Intracellular virus-induced polypeptides of pestivirus border disease virus. Virus Res. 1990 Apr; 16(1):95-105. PMID: 2161595.
      View in: PubMed
    62. Akkina RK. Antigenic reactivity and electrophoretic migrational heterogeneity of the three polymerase proteins of type A human and animal influenza viruses. Arch Virol. 1990; 111(3-4):187-97. PMID: 2353872.
      View in: PubMed
    63. Akkina RK, Chambers TM, Londo DR, Nayak DP. Intracellular localization of the viral polymerase proteins in cells infected with influenza virus and cells expressing PB1 protein from cloned cDNA. J Virol. 1987 Jul; 61(7):2217-24. PMID: 2438429.
      View in: PubMed
    64. Nayak DP, Chambers TM, Akkina RK. Defective-interfering (DI) RNAs of influenza viruses: origin, structure, expression, and interference. Curr Top Microbiol Immunol. 1985; 114:103-51. PMID: 3888540.
      View in: PubMed
    65. Akkina RK, Chambers TM, Nayak DP. Expression of defective-interfering influenza virus-specific transcripts and polypeptides in infected cells. J Virol. 1984 Aug; 51(2):395-403. PMID: 6205168.
      View in: PubMed
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