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Laura M. Sanchez

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone720/848-6518

    Collapse Research 
    Collapse research activities and funding
    R01GM125943     (MURPHY, BRIAN THACHER)Aug 1, 2018 - Jul 31, 2022
    NIH
    A new paradigm for the creation and mining of microbial libraries for drug discovery
    Role: Co-Principal Investigator

    R01CA240423     (BURDETTE, JOANNA E)May 1, 2020 - Apr 30, 2025
    NIH
    Imaging mass spectrometry methodologies for studying the metabolites of cancer metastasis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ióca LP, Dai Y, Kunakom S, Diaz-Espinosa J, Krunic A, Crnkovic CM, Orjala J, Sanchez LM, Ferreira AG, Berlinck RGS, Eustáquio AS. A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges*. Angew Chem Int Ed Engl. 2021 07 12; 60(29):15891-15898. PMID: 33961724.
      View in: PubMed
    2. Colina JA, Zink KE, Eliadis K, Salehi R, Gargus ES, Wagner SR, Moss KJ, Baligod S, Li K, Kirkpatrick BJ, Woodruff TK, Tsang BK, Sanchez LM, Burdette JE. Fallopian Tube-Derived Tumor Cells Induce Testosterone Secretion from the Ovary, Increasing Epithelial Proliferation and Invasion. Cancers (Basel). 2021 Apr 16; 13(8). PMID: 33923536.
      View in: PubMed
    3. Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. A community resource for paired genomic and metabolomic data mining. Nat Chem Biol. 2021 04; 17(4):363-368. PMID: 33589842.
      View in: PubMed
    4. Zink KE, Ludvik DA, Lazzara PR, Moore TW, Mandel MJ, Sanchez LM. A Small Molecule Coordinates Symbiotic Behaviors in a Host Organ. mBio. 2021 03 09; 12(2). PMID: 33688014.
      View in: PubMed
    5. Shao L, Elujoba-Bridenstine A, Zink KE, Sanchez LM, Cox BJ, Pollok KE, Sinn AL, Bailey BJ, Sims EC, Cooper SH, Broxmeyer HE, Pajcini KV, Tamplin OJ. The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood. 2021 02 11; 137(6):775-787. PMID: 32881992.
      View in: PubMed
    6. Pierce EC, Morin M, Little JC, Liu RB, Tannous J, Keller NP, Pogliano K, Wolfe BE, Sanchez LM, Dutton RJ. Bacterial-fungal interactions revealed by genome-wide analysis of bacterial mutant fitness. Nat Microbiol. 2021 01; 6(1):87-102. PMID: 33139882.
      View in: PubMed
    7. Luu GT, Condren AR, Kahl LJ, Dietrich LEP, Sanchez LM. Evaluation of Data Analysis Platforms and Compatibility with MALDI-TOF Imaging Mass Spectrometry Data Sets. J Am Soc Mass Spectrom. 2020 Jun 03; 31(6):1313-1320. PMID: 32329613.
      View in: PubMed
    8. Condren AR, Costa MS, Sanchez NR, Konkapaka S, Gallik KL, Saxena A, Murphy BT, Sanchez LM. Addition of insoluble fiber to isolation media allows for increased metabolite diversity of lab-cultivable microbes derived from zebrafish gut samples. Gut Microbes. 2020 07 03; 11(4):1064-1076. PMID: 32202200.
      View in: PubMed
    9. Spraker JE, Luu GT, Sanchez LM. Imaging mass spectrometry for natural products discovery: a review of ionization methods. Nat Prod Rep. 2020 02 26; 37(2):150-162. PMID: 31364647.
      View in: PubMed
    10. Clark CM, Murphy BT, Sanchez LM. A Call to Action: the Need for Standardization in Developing Open-Source Mass Spectrometry-Based Methods for Microbial Subspecies Discrimination. mSystems. 2020 Feb 18; 5(1). PMID: 32071161.
      View in: PubMed
    11. Condren AR, Kahl LJ, Boelter G, Kritikos G, Banzhaf M, Dietrich LEP, Sanchez LM. Biofilm Inhibitor Taurolithocholic Acid Alters Colony Morphology, Specialized Metabolism, and Virulence of Pseudomonas aeruginosa. ACS Infect Dis. 2020 04 10; 6(4):603-612. PMID: 31851822.
      View in: PubMed
    12. Galey MM, Young AN, Petukhova VZ, Wang M, Wang J, Salvi A, Russo A, Burdette JE, Sanchez LM. Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment. J Proteome Res. 2020 01 03; 19(1):503-510. PMID: 31738564.
      View in: PubMed
    13. Li F, Hopwood JP, Galey MM, Sanchez LM, Ciszek JW. Chemically transformed monolayers on acene thin films for improved metal/organic interfaces. Chem Commun (Camb). 2019 Nov 19; 55(93):13975-13978. PMID: 31687695.
      View in: PubMed
    14. van Santen JA, Jacob G, Singh AL, Aniebok V, Balunas MJ, Bunsko D, Neto FC, Castaño-Espriu L, Chang C, Clark TN, Cleary Little JL, Delgadillo DA, Dorrestein PC, Duncan KR, Egan JM, Galey MM, Haeckl FPJ, Hua A, Hughes AH, Iskakova D, Khadilkar A, Lee JH, Lee S, LeGrow N, Liu DY, Macho JM, McCaughey CS, Medema MH, Neupane RP, O'Donnell TJ, Paula JS, Sanchez LM, Shaikh AF, Soldatou S, Terlouw BR, Tran TA, Valentine M, van der Hooft JJJ, Vo DA, Wang M, Wilson D, Zink KE, Linington RG. The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. ACS Cent Sci. 2019 Nov 27; 5(11):1824-1833. PMID: 31807684.
      View in: PubMed
    15. Zink KE, Tarnowski DA, Mandel MJ, Sanchez LM. Optimization of a minimal sample preparation protocol for imaging mass spectrometry of unsectioned juvenile invertebrates. J Mass Spectrom. 2020 Apr; 55(4):e4458. PMID: 31693273.
      View in: PubMed
    16. Sanchez LM, Alvarez VA. Advances in Magnetic Noble Metal/Iron-Based Oxide Hybrid Nanoparticles as Biomedical Devices. Bioengineering (Basel). 2019 Aug 28; 6(3). PMID: 31466238.
      View in: PubMed
    17. Costa MS, Clark CM, Ómarsdóttir S, Sanchez LM, Murphy BT. Minimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac. J Nat Prod. 2019 08 23; 82(8):2167-2173. PMID: 31335140.
      View in: PubMed
    18. Grim CM, Luu GT, Sanchez LM. Staring into the void: demystifying microbial metabolomics. FEMS Microbiol Lett. 2019 06 01; 366(11). PMID: 31210257.
      View in: PubMed
    19. Clark CM, Costa MS, Conley E, Li E, Sanchez LM, Murphy BT. Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data. J Vis Exp. 2019 05 15; (147). PMID: 31157770.
      View in: PubMed
    20. Cleary JL, Luu GT, Pierce EC, Dutton RJ, Sanchez LM. BLANKA: an Algorithm for Blank Subtraction in Mass Spectrometry of Complex Biological Samples. J Am Soc Mass Spectrom. 2019 Aug; 30(8):1426-1434. PMID: 30993641.
      View in: PubMed
    21. Zink KE, Dean M, Burdette JE, Sanchez LM. Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry. J Vis Exp. 2019 04 03; (146). PMID: 31009015.
      View in: PubMed
    22. Petukhova VZ, Young AN, Wang J, Wang M, Ladanyi A, Kothari R, Burdette JE, Sanchez LM. Whole Cell MALDI Fingerprinting Is a Robust Tool for Differential Profiling of Two-Component Mammalian Cell Mixtures. J Am Soc Mass Spectrom. 2019 Feb; 30(2):344-354. PMID: 30353292.
      View in: PubMed
    23. Zink KE, Dean M, Burdette JE, Sanchez LM. Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary that Drives Primary Metastasis of Ovarian Cancer. ACS Cent Sci. 2018 Oct 24; 4(10):1360-1370. PMID: 30410974.
      View in: PubMed
    24. Cleary JL, Kolachina S, Wolfe BE, Sanchez LM. Coproporphyrin III Produced by the Bacterium Glutamicibacter arilaitensis Binds Zinc and Is Upregulated by Fungi in Cheese Rinds. mSystems. 2018 Jul-Aug; 3(4). PMID: 30175236.
      View in: PubMed
    25. Puerto D, Reyes V, Lozano C, Buitrago L, Garcia D, Murillo RH, Muñoz N, Hernandez GA, Sanchez L, Wiesner C, Combita AL. Detection and Genotyping of HPV DNA in a Group of Unvaccinated Young Women from Colombia: Baseline Measures Prior to Future Monitoring Program. Cancer Prev Res (Phila). 2018 09; 11(9):581-592. PMID: 29991579.
      View in: PubMed
    26. Spraker JE, Wiemann P, Baccile JA, Venkatesh N, Schumacher J, Schroeder FC, Sanchez LM, Keller NP. Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi. mBio. 2018 05 22; 9(3). PMID: 29789359.
      View in: PubMed
    27. David BP, Dubrovskyi O, Speltz TE, Wolff JJ, Frasor J, Sanchez LM, Moore TW. Using Tumor Explants for Imaging Mass Spectrometry Visualization of Unlabeled Peptides and Small Molecules. ACS Med Chem Lett. 2018 Jul 12; 9(7):768-772. PMID: 30034616.
      View in: PubMed
    28. Clark CM, Costa MS, Sanchez LM, Murphy BT. Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):4981-4986. PMID: 29686101.
      View in: PubMed
    29. Sporer AJ, Beierschmitt C, Bendebury A, Zink KE, Price-Whelan A, Buzzeo MC, Sanchez LM, Dietrich LEP. Pseudomonas aeruginosa PumA acts on an endogenous phenazine to promote self-resistance. Microbiology (Reading). 2018 05; 164(5):790-800. PMID: 29629858.
      View in: PubMed
    30. Galey MM, Sanchez LM. Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts. mSystems. 2018 Mar-Apr; 3(2). PMID: 29556545.
      View in: PubMed
    31. Ochoa JL, Sanchez LM, Koo BM, Doherty JS, Rajendram M, Huang KC, Gross CA, Linington RG. Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile. ACS Infect Dis. 2018 01 12; 4(1):59-67. PMID: 29043783.
      View in: PubMed
    32. Cleary JL, Condren AR, Zink KE, Sanchez LM. Calling all hosts: Bacterial communication in situ. Chem. 2017 Mar 09; 2(3):334-358. PMID: 28948238.
      View in: PubMed
    33. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore BS, Medema MH, Dorrestein PC. Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2017 Jan 23; 2:17010. PMID: 28112718.
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    34. Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein PC. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. mSystems. 2016 Nov-Dec; 1(6). PMID: 28028548.
      View in: PubMed
    35. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore BS, Medema MH, Dorrestein PC. Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2016 10 31; 2:16197. PMID: 27798598.
      View in: PubMed
    36. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. PMID: 27504778.
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    37. Maansson M, Vynne NG, Klitgaard A, Nybo JL, Melchiorsen J, Nguyen DD, Sanchez LM, Ziemert N, Dorrestein PC, Andersen MR, Gram L. An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria. mSystems. 2016 May-Jun; 1(3). PMID: 27822535.
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    38. Sanchez LM, Cheng AT, Warner CJ, Townsley L, Peach KC, Navarro G, Shikuma NJ, Bray WM, Riener RM, Yildiz FH, Linington RG. Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids. PLoS One. 2016; 11(3):e0149603. PMID: 26992172.
      View in: PubMed
    39. Spraker JE, Sanchez LM, Lowe TM, Dorrestein PC, Keller NP. Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues. ISME J. 2016 09; 10(9):2317-30. PMID: 26943626.
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    40. Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick WH, Gutiérrez M, Dorrestein PC. Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chem Biol. 2014 Oct 17; 9(10):2300-8. PMID: 25058318.
      View in: PubMed
    41. Bouslimani A, Sanchez LM, Garg N, Dorrestein PC. Mass spectrometry of natural products: current, emerging and future technologies. Nat Prod Rep. 2014 Jun; 31(6):718-29. PMID: 24801551.
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    42. Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC. Molecular networking as a dereplication strategy. J Nat Prod. 2013 Sep 27; 76(9):1686-99. PMID: 24025162.
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    43. Hsu CC, ElNaggar MS, Peng Y, Fang J, Sanchez LM, Mascuch SJ, Møller KA, Alazzeh EK, Pikula J, Quinn RA, Zeng Y, Wolfe BE, Dutton RJ, Gerwick L, Zhang L, Liu X, Månsson M, Dorrestein PC. Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Anal Chem. 2013 Aug 06; 85(15):7014-8. PMID: 23819546.
      View in: PubMed
    44. Sanchez LM, Dorrestein PC. Analytical chemistry: Virulence caught green-handed. Nat Chem. 2013 Mar; 5(3):155-7. PMID: 23422554.
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    45. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26; 76(4):630-41. PMID: 23445522.
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    46. Sanchez LM, Wong WR, Riener RM, Schulze CJ, Linington RG. Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products. PLoS One. 2012; 7(5):e35398. PMID: 22574119.
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    47. Sanchez LM, Curtis ME, Bracamonte BE, Kurita KL, Navarro G, Sparkman OD, Linington RG. Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry. Org Lett. 2011 Aug 05; 13(15):3770-3. PMID: 21699263.
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    48. Gutierrez-Aranda I, Ramos-Mejia V, Bueno C, Munoz-Lopez M, Real PJ, Mácia A, Sanchez L, Ligero G, Garcia-Parez JL, Menendez P. Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection. Stem Cells. 2010 Sep; 28(9):1568-70. PMID: 20641038.
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    49. Sanchez LM, Lopez D, Vesely BA, Della Togna G, Gerwick WH, Kyle DE, Linington RG. Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. J Med Chem. 2010 May 27; 53(10):4187-97. PMID: 20441198.
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    50. Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P. Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity. J Nat Prod. 2007 Jan; 70(1):95-9. PMID: 17253856.
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    51. Andreu I, Bosca F, Sanchez L, Morera IM, Camps P, Miranda MA. Efficient and selective photogeneration of cholesterol-derived radicals by intramolecular hydrogen abstraction in model dyads. Org Lett. 2006 Sep 28; 8(20):4597-600. PMID: 16986959.
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    52. Garcia-Montero AC, Jara-Acevedo M, Teodosio C, Sanchez ML, Nunez R, Prados A, Aldanondo I, Sanchez L, Dominguez M, Botana LM, Sanchez-Jimenez F, Sotlar K, Almeida J, Escribano L, Orfao A. KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood. 2006 Oct 01; 108(7):2366-72. PMID: 16741248.
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