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Rachel L Zemans

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
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    K08HL103772     (ZEMANS, RACHEL LYNNE)Sep 1, 2010 - Jun 30, 2015
    Role of Beta-catenin in Epithelial Repair in Acute Lung Injury
    Role: Principal Investigator

    R56HL124270     (ZEMANS, RACHEL LYNNE)Sep 1, 2015 - Aug 31, 2016
    Mechanisms of alveolar epithelial repair in lung injury
    Role: Principal Investigator

    R01HL131608     (ZEMANS, RACHEL LYNNE)Apr 1, 2016 - Mar 31, 2021
    Mechanisms of Repair of the Alveolar Epithelium after Lung Injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ravi Kumar S, Paudel S, Ghimire L, Bergeron S, Cai S, Zemans RL, Downey GP, Jeyaseelan S. Emerging Roles of Inflammasomes in Acute Pneumonia. Am J Respir Crit Care Med. 2018 Jan 15; 197(2):160-171. PMID: 28930487.
      View in: PubMed
    2. Jansing NL, McClendon J, Henson PM, Tuder RM, Hyde DM, Zemans RL. Unbiased Quantitation of Alveolar Type II to Alveolar Type I Cell Transdifferentiation during Repair after Lung Injury in Mice. Am J Respir Cell Mol Biol. 2017 11; 57(5):519-526. PMID: 28586241.
      View in: PubMed
    3. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
      View in: PubMed
    4. Zemans RL, Jacobson S, Keene J, Kechris K, Miller BE, Tal-Singer R, Bowler RP. Multiple biomarkers predict disease severity, progression and mortality in COPD. Respir Res. 2017 Jun 13; 18(1):117. PMID: 28610627.
      View in: PubMed
    5. McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug; 187(8):1772-1786. PMID: 28618253.
      View in: PubMed
    6. Zemans RL, Matthay MA. What drives neutrophils to the alveoli in ARDS? Thorax. 2017 01; 72(1):1-3. PMID: 27974631.
      View in: PubMed
    7. Ito Y, Correll K, Zemans RL, Leslie CC, Murphy RC, Mason RJ. Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-a/EGFR signaling. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1178-88. PMID: 26033355; PMCID: PMC4451400.
    8. Zemans RL, Henson PM, Henson JE, Janssen WJ. Conceptual approaches to lung injury and repair. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S9-15. PMID: 25830855; PMCID: PMC4430969.
    9. Carolan BJ, Hughes G, Morrow J, Hersh CP, O'Neal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP. The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. Respir Res. 2014 Oct 12; 15:127. PMID: 25306249; PMCID: PMC4198701.
    10. Baral P, Batra S, Zemans RL, Downey GP, Jeyaseelan S. Divergent functions of Toll-like receptors during bacterial lung infections. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):722-32. PMID: 25033332; PMCID: PMC4299612.
    11. Aschner Y, Zemans RL, Yamashita CM, Downey GP. Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS. Chest. 2014 Oct; 146(4):1081-1091. PMID: 25287998; PMCID: PMC4188143.
    12. Ito Y, Zemans R, Correll K, Yang IV, Ahmad A, Gao B, Mason RJ. Stanniocalcin-1 is induced by hypoxia inducible factor in rat alveolar epithelial cells. Biochem Biophys Res Commun. 2014 Oct 03; 452(4):1091-7. PMID: 25251473; PMCID: PMC4188510.
    13. Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S. Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1461-8. PMID: 24707903; PMCID: PMC4226013.
    14. Long H, O'Connor BP, Zemans RL, Zhou X, Yang IV, Schwartz DA. The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function. PLoS One. 2014; 9(4):e93550. PMID: 24695807; PMCID: PMC3973565.
    15. Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May; 184(5):1489-502. PMID: 24650563; PMCID: PMC4005983.
    16. Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP. Role of ß-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15; 304(6):L415-27. PMID: 23316072; PMCID: PMC3602744.
    17. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644; PMCID: PMC3723751.
    18. Bhatia M, Zemans RL, Jeyaseelan S. Role of chemokines in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 2012 May; 46(5):566-72. PMID: 22323365; PMCID: PMC3361356.
    19. Zemans RL, Stream AR, Musani AI, Dhaliwal G. A 46-year-old man with seizures, brain lesions, and pulmonary infiltrates. Chest. 2012 Jan; 141(1):265-269. PMID: 22215837; PMCID: PMC3251270.
    20. Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47. PMID: 22013192; PMCID: PMC3684246.
    21. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5. PMID: 21880956; PMCID: PMC3179042.
    22. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011 Oct; 179(4):1733-45. PMID: 21871427; PMCID: PMC3181358.
    23. Matthay MA, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011; 6:147-63. PMID: 20936936; PMCID: PMC3108259.
    24. Zemans RL, Arndt PG. Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation. Cell Immunol. 2009; 258(1):90-7. PMID: 19393603; PMCID: PMC2697619.
    25. Suzuki T, Yamashita C, Zemans RL, Briones N, Van Linden A, Downey GP. Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway. Am J Respir Cell Mol Biol. 2009 Dec; 41(6):742-55. PMID: 19307610; PMCID: PMC2784410.
    26. Zemans RL, Briones N, Young SK, Malcolm KC, Refaeli Y, Downey GP, Worthen GS. A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction. J Immunol Methods. 2009 Jan 30; 340(2):102-15. PMID: 19010330; PMCID: PMC2633587.
    27. Cai S, Zemans RL, Young SK, Worthen GS, Jeyaseelan S. Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2009 Jun; 40(6):701-9. PMID: 18988922; PMCID: PMC2689919.
    28. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009 May; 40(5):519-35. PMID: 18978300; PMCID: PMC2677434.
    29. Zemans R, Downey GP. Role of caveolin-1 in regulation of inflammation: different strokes for different folks. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L175-7. PMID: 18055840.
      View in: PubMed
    30. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. PMID: 16143588.
      View in: PubMed
    31. Zemans RL, Matthay MA. Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Crit Care. 2004 Dec; 8(6):469-77. PMID: 15566618; PMCID: PMC1065044.
    32. Zemans RL, Chatterjee K, Matthay MA. Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Am J Med. 2004 Mar 15; 116(6):424-6. PMID: 15006593.
      View in: PubMed
    33. Fang X, Song Y, Zemans R, Hirsch J, Matthay MA. Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L104-10. PMID: 14990396.
      View in: PubMed
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