Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Michael F Wempe

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone3037248982

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mizuno T, Gist KM, Gao Z, Wempe MF, Alten J, Cooper DS, Goldstein SL, Vinks AA. Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. Clin Pharmacokinet. 2019 Jan 03. PMID: 30607889.
      View in: PubMed
    2. Zhao J, Posa DK, Kumar V, Hoetker D, Kumar A, Ganesan S, Riggs DW, Bhatnagar A, Wempe MF, Baba SP. Carnosine protects cardiac myocytes against lipid peroxidation products. Amino Acids. 2018 Nov 17. PMID: 30449006.
      View in: PubMed
    3. Coughlin CR, Swanson MA, Spector E, Meeks NJL, Kronquist KE, Aslamy M, Wempe MF, van Karnebeek CDM, Gospe SM, Aziz VG, Tsai BP, Gao H, Nagy PL, Hyland K, van Dooren SJM, Salomons GS, Van Hove JLK. The genotypic spectrum of ALDH7A1 mutations resulting in pyridoxine dependent epilepsy: a common epileptic encephalopathy. J Inherit Metab Dis. 2018 Jul 24. PMID: 30043187.
      View in: PubMed
    4. Kassel LE, Van Matre ET, Foster CJ, Fish DN, Mueller SW, Sherman DS, Wempe MF, MacLaren R, Neumann RT, Kiser TH. A Randomized Pharmacokinetic and Pharmacodynamic Evaluation of Every 8-Hour and 12-Hour Dosing Strategies of Vancomycin and Cefepime in Neurocritically ill Patients. Pharmacotherapy. 2018 Sep; 38(9):921-934. PMID: 29906310.
      View in: PubMed
    5. Dhar D, Deep G, Kumar S, Wempe MF, Raina K, Agarwal C, Agarwal R. Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells. Mol Carcinog. 2018 Sep; 57(9):1166-1180. PMID: 29727019.
      View in: PubMed
    6. Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018 Jun 01; 128(6):2226-2238. PMID: 29533924.
      View in: PubMed
    7. Gist KM, Cooper DS, Wrona J, Faubel S, Altmann C, Gao Z, Marino BS, Alten J, Hock KM, Mizuno T, Vinks AA, Joy MS, Wempe MF, Bennett MR, Goldstein SL. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Ther Drug Monit. 2018 04; 40(2):186-194. PMID: 29529007.
      View in: PubMed
    8. Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018 02 23; 293(8):2877-2887. PMID: 29326164.
      View in: PubMed
    9. Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H, Kim JK. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov; 21(6):599-607. PMID: 29200902.
      View in: PubMed
    10. Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C. Procyanidin B2 3,3?-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Mol Carcinog. 2018 Jan; 57(1):57-69. PMID: 28876465.
      View in: PubMed
    11. Imbert V, Nebout M, Mary D, Endou H, Wempe MF, Supuran CT, Winum JY, Peyron JF. Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells. Leuk Lymphoma. 2018 02; 59(2):460-468. PMID: 28641473.
      View in: PubMed
    12. Okayama Y, Wakui S, Wempe MF, Sugiyama M, Motohashi M, Mutou T, Takahashi H, Kume E, Ikegami H. In Utero Exposure to Di( n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty. Toxicol Pathol. 2017 06; 45(4):526-535. PMID: 28641505.
      View in: PubMed
    13. Kume E, Mutou T, Kansaku N, Takahashi H, Wempe MF, Ikegami M, Kanai Y, Endou H, Wakui S. Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma. Microscopy (Oxf). 2017 Jun 01; 66(3):198-203. PMID: 28339760.
      View in: PubMed
    14. McHenry AR, Wempe MF, Rice PJ. Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes. Int J Pharm Compd. 2017 May-Jun; 21(3):251-254. PMID: 28557788.
      View in: PubMed
    15. Dosier LBM, Premkumar VJ, Zhu H, Akosman I, Wempe MF, McMahon TJ. Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. Thromb Haemost. 2017 06 28; 117(7):1402-1411. PMID: 28382373.
      View in: PubMed
    16. Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le MT, Wempe MF, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson RJ, Lanaspa MA. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun. 2017 02 13; 8:14181. PMID: 28194018.
      View in: PubMed
    17. Schuetze KB, Stratton MS, Blakeslee WW, Wempe MF, Wagner FF, Holson EB, Kuo YM, Andrews AJ, Gilbert TM, Hooker JM, McKinsey TA. Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther. 2017 04; 361(1):140-150. PMID: 28174211.
      View in: PubMed
    18. Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF. Synthesis of novel Ral inhibitors: An in vitro and in vivo study. Bioorg Med Chem Lett. 2016 12 01; 26(23):5815-5818. PMID: 27825764.
      View in: PubMed
    19. Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):E6669-E6678. PMID: 27791036.
      View in: PubMed
    20. Wempe MF, Oldland A, Stolpman N, Kiser TH. Stability of dronabinol capsules when stored frozen, refrigerated, or at room temperature. Am J Health Syst Pharm. 2016 Jul 15; 73(14):1088-92. PMID: 27385703.
      View in: PubMed
    21. Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P. A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells. ACS Chem Biol. 2016 07 15; 11(7):2066-7. PMID: 27304454.
      View in: PubMed
    22. Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016 08 01; 76(15):4481-92. PMID: 27302165.
      View in: PubMed
    23. Motohashi M, Wempe MF, Mutou T, Okayama Y, Kansaku N, Takahashi H, Ikegami M, Asari M, Wakui S. In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats. J Toxicol Sci. 2016 Apr; 41(2):195-206. PMID: 26961603.
      View in: PubMed
    24. Bao EL, Chystsiakova A, Brahmajothi MV, Sunday ME, Pavlisko EN, Wempe MF, Auten RL. Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung. Pediatr Pulmonol. 2016 10; 51(10):1048-1056. PMID: 26918397.
      View in: PubMed
    25. Castillo-Mancilla JR, Aquilante CL, Wempe MF, Smeaton LM, Firnhaber C, LaRosa AM, Kumarasamy N, Andrade A, Baheti G, Fletcher CV, Campbell TB, Haas DW, MaWhinney S, Anderson PL. Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342). J Antimicrob Chemother. 2016 06; 71(6):1609-18. PMID: 26892777; PMCID: PMC4867099 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    26. Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P. A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells. ACS Chem Biol. 2016 Apr 15; 11(4):921-30. PMID: 26745241.
      View in: PubMed
    27. Motohashi M, Wempe MF, Mutou T, Takahashi H, Kansaku N, Ikegami M, Inomata T, Asari M, Wakui S. Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins. Reprod Toxicol. 2016 Jan; 59:139-46. PMID: 26706031.
      View in: PubMed
    28. Lemon DD, Harrison BC, Horn TR, Stratton MS, Ferguson BS, Wempe MF, McKinsey TA. Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle. FEBS Lett. 2015 Apr 28; 589(10):1080-8. PMID: 25816750; PMCID: PMC4410688.
      View in: PubMed, PubMed Central
    29. Kiser TH, Fish DN, Aquilante CL, Rower JE, Wempe MF, MacLaren R, Teitelbaum I. Evaluation of sulfobutylether-ß-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy. Crit Care. 2015 Feb 03; 19:32. PMID: 25645660; PMCID: PMC4338618.
      View in: PubMed, PubMed Central
    30. Teska BM, Kumar A, Carpenter JF, Wempe MF. Analyzing insulin samples by size-exclusion chromatography: a column degradation study. J Pharm Sci. 2015 Apr; 104(4):1555-60. PMID: 25581527; PMCID: PMC4359628.
      View in: PubMed, PubMed Central
    31. Kumar R, Deep G, Wempe MF, Agarwal R, Agarwal C. Procyanidin B2 3,3?-di-O-gallate inhibits endothelial cells growth and motility by targeting VEGFR2 and integrin signaling pathways. Curr Cancer Drug Targets. 2015; 15(1):14-26. PMID: 25552257; PMCID: PMC4586152.
      View in: PubMed, PubMed Central
    32. Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res. 2015 Mar 15; 21(6):1360-72. PMID: 25547679.
      View in: PubMed
    33. Tilley C, Deep G, Agarwal C, Wempe MF, Biedermann D, Valentová K, Kren V, Agarwal R. Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation. Mol Carcinog. 2016 Jan; 55(1):3-14. PMID: 25492239; PMCID: PMC4461565 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    34. Rosilio C, Nebout M, Imbert V, Griessinger E, Neffati Z, Benadiba J, Hagenbeek T, Spits H, Reverso J, Ambrosetti D, Michiels JF, Bailly-Maitre B, Endou H, Wempe MF, Peyron JF. L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia. Leukemia. 2015 Jun; 29(6):1253-66. PMID: 25482130.
      View in: PubMed
    35. Payton NM, Wempe MF, Xu Y, Anchordoquy TJ. Long-term storage of lyophilized liposomal formulations. J Pharm Sci. 2014 Dec; 103(12):3869-3878. PMID: 25308534; PMCID: PMC4441342.
      View in: PubMed, PubMed Central
    36. Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G. Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo. Mol Carcinog. 2015 Nov; 54(11):1417-29. PMID: 25252179; PMCID: PMC4369479 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    37. Brahmajothi MV, Tinch BT, Wempe MF, Endou H, Auten RL. Hyperoxia inhibits nitric oxide treatment effects in alveolar epithelial cells via effects on L-type amino acid transporter-1. Antioxid Redox Signal. 2014 Nov 01; 21(13):1823-36. PMID: 25089378; PMCID: PMC4202911.
      View in: PubMed, PubMed Central
    38. Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20; 515(7527):443-7. PMID: 25219851; PMCID: PMC4351747.
      View in: PubMed, PubMed Central
    39. Yun DW, Lee SA, Park MG, Kim JS, Yu SK, Park MR, Kim SG, Oh JS, Kim CS, Kim HJ, Kim JS, Chun HS, Kanai Y, Endou H, Wempe MF, Kim DK. JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014; 124(2):208-17. PMID: 24492461.
      View in: PubMed
    40. Hafermann MJ, Kiser TH, Lyda C, Fish DN, Barber GR, Wempe MF, Cleveland JC. Weight-based versus set dosing of vancomycin for coronary artery bypass grafting or aortic valve surgery. J Thorac Cardiovasc Surg. 2014 Jun; 147(6):1925-30. PMID: 24521953.
      View in: PubMed
    41. Wakui S, Motohashi M, Satoh T, Shirai M, Mutou T, Takahashi H, Wempe MF, Endou H, Inomata T, Asari M. Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate. J Toxicol Pathol. 2013 Dec; 26(4):439-46. PMID: 24526819; PMCID: PMC3921929.
      View in: PubMed, PubMed Central
    42. Baker PR, Friederich MW, Swanson MA, Shaikh T, Bhattacharya K, Scharer GH, Aicher J, Creadon-Swindell G, Geiger E, MacLean KN, Lee WT, Deshpande C, Freckmann ML, Shih LY, Wasserstein M, Rasmussen MB, Lund AM, Procopis P, Cameron JM, Robinson BH, Brown GK, Brown RM, Compton AG, Dieckmann CL, Collard R, Coughlin CR, Spector E, Wempe MF, Van Hove JL. Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. Brain. 2014 Feb; 137(Pt 2):366-79. PMID: 24334290; PMCID: PMC3914472.
      View in: PubMed, PubMed Central
    43. Tyagi A, Raina K, Shrestha SP, Miller B, Thompson JA, Wempe MF, Agarwal R, Agarwal C. Procyanidin B2 3,3(?)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-?B, Stat3, and AP1 transcription factors. Nutr Cancer. 2014; 66(4):736-46. PMID: 24191894; PMCID: PMC4079462.
      View in: PubMed, PubMed Central
    44. Wakui S, Shirai M, Motohashi M, Mutou T, Oyama N, Wempe MF, Takahashi H, Inomata T, Ikegami M, Endou H, Asari M. Effects of in utero exposure to di(n-butyl) phthalate for estrogen receptors a, ß, and androgen receptor of Leydig cell on rats. Toxicol Pathol. 2014 Jul; 42(5):877-87. PMID: 24067674.
      View in: PubMed
    45. Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb; 62:73-85. PMID: 24051278; PMCID: PMC3908775.
      View in: PubMed, PubMed Central
    46. Preslaski CR, Mueller SW, Wempe MF, MacLaren R. Stability of dexmedetomidine in polyvinyl chloride bags containing 0.9% sodium chloride injection. Am J Health Syst Pharm. 2013 Aug 01; 70(15):1336-41. PMID: 23867490.
      View in: PubMed
    47. Chiba S, Ikawa T, Takeshita H, Kanno S, Nagai T, Takada M, Mukai T, Wempe MF. Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells. Toxicology. 2013 Aug 09; 310:98-103. PMID: 23770354.
      View in: PubMed
    48. Ferguson BS, Harrison BC, Jeong MY, Reid BG, Wempe MF, Wagner FF, Holson EB, McKinsey TA. Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9806-11. PMID: 23720316; PMCID: PMC3683796.
      View in: PubMed, PubMed Central
    49. Toyoshima J, Kusuhara H, Wempe MF, Endou H, Sugiyama Y. Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203. J Pharm Sci. 2013 Sep; 102(9):3228-38. PMID: 23712732.
      View in: PubMed
    50. Aquilante CL, Wempe MF, Spencer SH, Kosmiski LA, Predhomme JA, Sidhom MS. Influence of CYP2C8*2 on the pharmacokinetics of pioglitazone in healthy African-American volunteers. Pharmacotherapy. 2013 Sep; 33(9):1000-7. PMID: 23712614; PMCID: PMC3760990.
      View in: PubMed, PubMed Central
    51. Payton NM, Wempe MF, Betker JL, Randolph TW, Anchordoquy TJ. Lyophilization of a triply unsaturated phospholipid: effects of trace metal contaminants. Eur J Pharm Biopharm. 2013 Oct; 85(2):306-13. PMID: 23567484; PMCID: PMC3797213.
      View in: PubMed, PubMed Central
    52. Kaur M, Deep G, Jain AK, Raina K, Agarwal C, Wempe MF, Agarwal R. Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells. Carcinogenesis. 2013 Jul; 34(7):1585-92. PMID: 23475945; PMCID: PMC3697895.
      View in: PubMed, PubMed Central
    53. Shirai M, Wakui S, Wempe MF, Mutou T, Oyama N, Motohashi M, Takahashi H, Kansaku N, Asari M, Hano H, Endou H. Male Sprague-Dawley rats exposed to in utero di(n-butyl) phthalate: dose dependent and age-related morphological changes in Leydig cell smooth endoplasmic reticulum. Toxicol Pathol. 2013; 41(7):984-91. PMID: 23416961.
      View in: PubMed
    54. Aquilante CL, Wempe MF, Sidhom MS, Kosmiski LA, Predhomme JA. Effect of ABCB1 polymorphisms and atorvastatin on sitagliptin pharmacokinetics in healthy volunteers. Eur J Clin Pharmacol. 2013 Jul; 69(7):1401-9. PMID: 23407853; PMCID: PMC3676426.
      View in: PubMed, PubMed Central
    55. Wempe MF, Lightner JW, Miller B, Iwen TJ, Rice PJ, Wakui S, Anzai N, Jutabha P, Endou H. Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies. Drug Des Devel Ther. 2012; 6:323-39. PMID: 23152669; PMCID: PMC3496402.
      View in: PubMed, PubMed Central
    56. Wakui S, Takahashi H, Mutou T, Shirai M, Jutabha P, Anzai N, Wempe MF, Kansaku N, Hano H, Inomata T, Endou H. Atypical Leydig cell hyperplasia in adult rats with low T and high LH induced by prenatal Di(n-butyl) phthalate exposure. Toxicol Pathol. 2013; 41(3):480-6. PMID: 22968287.
      View in: PubMed
    57. Jutabha P, Anzai N, Wempe MF, Wakui S, Endou H, Sakurai H. Apical voltage-driven urate efflux transporter NPT4 in renal proximal tubule. Nucleosides Nucleotides Nucleic Acids. 2011 Dec; 30(12):1302-11. PMID: 22132991.
      View in: PubMed
    58. Wempe MF, Quade B, Jutabha P, Iwen T, Frick M, Rice PJ, Wakui S, Endou H. Human uric acid transporter 1 (hURAT1): an inhibitor structure-activity relationship (SAR) study. Nucleosides Nucleotides Nucleic Acids. 2011 Dec; 30(12):1312-23. PMID: 22132992.
      View in: PubMed
    59. Lowman DW, West LJ, Bearden DW, Wempe MF, Power TD, Ensley HE, Haynes K, Williams DL, Kruppa MD. New insights into the structure of (1?3,1?6)-ß-D-glucan side chains in the Candida glabrata cell wall. PLoS One. 2011; 6(11):e27614. PMID: 22096604; PMCID: PMC3214063.
      View in: PubMed, PubMed Central
    60. Shrestha SP, Thompson JA, Wempe MF, Gu M, Agarwal R, Agarwal C. Glucuronidation and methylation of procyanidin dimers b2 and 3,3?-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver. Pharm Res. 2012 Mar; 29(3):856-65. PMID: 22068277; PMCID: PMC3288310.
      View in: PubMed, PubMed Central
    61. Wakui S, Motohashi M, Muto T, Takahashi H, Hano H, Jutabha P, Anzai N, Wempe MF, Endou H. Sex-associated difference in estrogen receptor ß expression in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancers in rats. Comp Med. 2011 Oct; 61(5):412-8. PMID: 22330348; PMCID: PMC3193063.
      View in: PubMed, PubMed Central
    62. Wempe MF, Rice PJ, Lightner JW, Jutabha P, Hayashi M, Anzai N, Wakui S, Kusuhara H, Sugiyama Y, Endou H. Metabolism and pharmacokinetic studies of JPH203, an L-amino acid transporter 1 (LAT1) selective compound. Drug Metab Pharmacokinet. 2012; 27(1):155-61. PMID: 21914964.
      View in: PubMed
    63. Xu L, Wempe MF, Anchordoquy TJ. The effect of cholesterol domains on PEGylated liposomal gene delivery in vitro. Ther Deliv. 2011 Apr; 2(4):451-60. PMID: 22428082.
      View in: PubMed
    64. Wempe MF, Jutabha P, Quade B, Iwen TJ, Frick MM, Ross IR, Rice PJ, Anzai N, Endou H. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem. 2011 Apr 28; 54(8):2701-13. PMID: 21449597; PMCID: PMC3124071.
      View in: PubMed, PubMed Central
    65. Wempe MF, Anderson PL. Atazanavir metabolism according to CYP3A5 status: an in vitro-in vivo assessment. Drug Metab Dispos. 2011 Mar; 39(3):522-7. PMID: 21148251.
      View in: PubMed
    66. Hail N, Chen P, Wempe MF. The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells. Free Radic Biol Med. 2010 Dec 15; 49(12):2001-9. PMID: 20923701; PMCID: PMC3005946.
      View in: PubMed, PubMed Central
    67. Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 05; 285(45):35123-32. PMID: 20810651; PMCID: PMC2966126.
      View in: PubMed, PubMed Central
    68. Collnot EM, Baldes C, Schaefer UF, Edgar KJ, Wempe MF, Lehr CM. Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm. 2010 Jun 07; 7(3):642-51. PMID: 20205474.
      View in: PubMed
    69. Tsuchida H, Anzai N, Shin HJ, Wempe MF, Jutabha P, Enomoto A, Cha SH, Satoh T, Ishida M, Sakurai H, Endou H. Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. Cell Physiol Biochem. 2010; 25(4-5):511-22. PMID: 20332632.
      View in: PubMed
    70. Oda K, Hosoda N, Endo H, Saito K, Tsujihara K, Yamamura M, Sakata T, Anzai N, Wempe MF, Kanai Y, Endou H. L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci. 2010 Jan; 101(1):173-9. PMID: 19900191.
      View in: PubMed
    71. Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H. Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan; 61(1):76-84. PMID: 19631272.
      View in: PubMed
    72. Wempe MF, Lightner JW, Zoeller EL, Rice PJ. Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies. J Cosmet Dermatol. 2009 Mar; 8(1):63-73. PMID: 19250169.
      View in: PubMed
    73. Klein S, Wempe MF, Zoeller T, Buchanan NL, Lambert JL, Ramsey MG, Edgar KJ, Buchanan CM. Improving glyburide solubility and dissolution by complexation with hydroxybutenyl-beta-cyclodextrin. J Pharm Pharmacol. 2009 Jan; 61(1):23-30. PMID: 19126293.
      View in: PubMed
    74. Morimoto E, Kanai Y, Kim DK, Chairoungdua A, Choi HW, Wempe MF, Anzai N, Endou H. Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters. J Pharmacol Sci. 2008 Dec; 108(4):505-16. PMID: 19075510.
      View in: PubMed
    75. Wempe MF, Wright C, Little JL, Lightner JW, Large SE, Caflisch GB, Buchanan CM, Rice PJ, Wacher VJ, Ruble KM, Edgar KJ. Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS. Int J Pharm. 2009 Mar 31; 370(1-2):93-102. PMID: 19100824.
      View in: PubMed
    76. Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, Gordon S, Monteiro MA, Papp-Szabo E, Lowman DW, Power TD, Wempe MF, Williams DL. Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. J Pharmacol Exp Ther. 2008 Apr; 325(1):115-23. PMID: 18171906.
      View in: PubMed
    77. Buchanan CM, Buchanan NL, Edgar KJ, Little JL, Ramsey MG, Ruble KM, Wacher VJ, Wempe MF. Pharmacokinetics of saquinavir after intravenous and oral dosing of saquinavir: hydroxybutenyl-beta-cyclodextrin formulations. Biomacromolecules. 2008 Jan; 9(1):305-13. PMID: 18072746.
      View in: PubMed
    78. Buchanan CM, Buchanan NL, Edgar KJ, Klein S, Little JL, Ramsey MG, Ruble KM, Wacher VJ, Wempe MF. Pharmacokinetics of itraconazole after intravenous and oral dosing of itraconazole-cyclodextrin formulations. J Pharm Sci. 2007 Nov; 96(11):3100-16. PMID: 17712849.
      View in: PubMed
    79. Wempe MF, Wacher VJ, Ruble KM, Ramsey MG, Edgar KJ, Buchanan NL, Buchanan CM. Pharmacokinetics of raloxifene in male Wistar-Hannover rats: influence of complexation with hydroxybutenyl-beta-cyclodextrin. Int J Pharm. 2008 Jan 04; 346(1-2):25-37. PMID: 17644287.
      View in: PubMed
    80. Wempe MF, Buchanan CM, Buchanan NL, Edgar KJ, Hanley GA, Ramsey MG, Skotty JS, Rice PJ. Pharmacokinetics of letrozole in male and female rats: influence of complexation with hydroxybutenyl-beta cyclodextrin. J Pharm Pharmacol. 2007 Jun; 59(6):795-802. PMID: 17637172.
      View in: PubMed
    81. Collnot EM, Baldes C, Wempe MF, Kappl R, Hüttermann J, Hyatt JA, Edgar KJ, Schaefer UF, Lehr CM. Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol Pharm. 2007 May-Jun; 4(3):465-74. PMID: 17367162.
      View in: PubMed
    82. Buchanan CM, Buchanan NL, Edgar KJ, Little JL, Malcolm MO, Ruble KM, Wacher VJ, Wempe MF. Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifen-hydroxybutenyl-beta-cyclodextrin formulations. J Pharm Sci. 2007 Mar; 96(3):644-60. PMID: 17083091.
      View in: PubMed
    83. Buchanan CM, Buchanan NL, Edgar KJ, Lambert JL, Posey-Dowty JD, Ramsey MG, Wempe MF. Solubilization and dissolution of tamoxifen-hydroxybutenyl cyclodextrin complexes. J Pharm Sci. 2006 Oct; 95(10):2246-55. PMID: 16886192.
      View in: PubMed
    84. Little JL, Wempe MF, Buchanan CM. Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 03; 833(2):219-30. PMID: 16497566.
      View in: PubMed
    85. Collnot EM, Baldes C, Wempe MF, Hyatt J, Navarro L, Edgar KJ, Schaefer UF, Lehr CM. Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release. 2006 Mar 10; 111(1-2):35-40. PMID: 16410030.
      View in: PubMed
    86. Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, Anders MW, Endou H. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem. 2002 Sep 27; 277(39):36262-71. PMID: 12089149.
      View in: PubMed
    87. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H. Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr; 61(4):729-37. PMID: 11901210.
      View in: PubMed
    88. Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N. Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. Mol Pharmacol. 2001 Nov; 60(5):1091-9. PMID: 11641438.
      View in: PubMed
    89. Bigeleisen PE, Wempe M. Identification of the precipitate in alkalinized solutions of mepivacaine and bupivacaine at 37 degrees C. J Clin Pharm Ther. 2001 Jun; 26(3):171-3. PMID: 11422599.
      View in: PubMed
    90. Wempe MF, Anderson WB, Tzeng HF, Board PG, Anders MW. Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids. Biochem Biophys Res Commun. 1999 Aug 11; 261(3):779-83. PMID: 10441501.
      View in: PubMed
    91. Wempe M. Rabies in a pronghorn antelope, Antilocapra americana. J Wildl Dis. 1976 Jul; 12(3):347-8. PMID: 16498874.
      View in: PubMed
    Wempe's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (547) concept(s)
    _
    Co-Authors Expand Description
    See all (68) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)