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Cynthia Ju

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-4019

    Collapse Research 
    Collapse research activities and funding
    R21DK068171     (JU, CYNTHIA)Sep 1, 2004 - Jun 30, 2007
    NIH/NIDDK
    Role of 15d-PGJ2 Hepatic Macrophages
    Role: Principal Investigator

    R01ES012914     (JU, CYNTHIA)Jun 6, 2005 - Mar 31, 2011
    NIH/NIEHS
    The immunosuppressive role of hepatic Kupffer cells
    Role: Principal Investigator

    R41AA022260     (JU, CYNTHIA)Sep 1, 2012 - Aug 31, 2014
    NIH/NIAAA
    Human Lactoferrin in Acetaminophen Overdose-Induced Liver Failure
    Role: Principal Investigator

    U01AA021723     (JU, CYNTHIA)Sep 10, 2013 - Aug 31, 2018
    NIH/NIAAA
    Role of Bone Marrow-Derived Myeloid Cells in Alcohol Liver Disease
    Role: Principal Investigator

    R21AA022387     (JU, CYNTHIA)Sep 20, 2013 - Aug 31, 2015
    NIH/NIAAA
    Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Role: Principal Investigator

    R21AA024636     (JU, CYNTHIA)Aug 1, 2016 - Jul 31, 2018
    NIH/NIAAA
    Role of gp91phox in Hepatic MF Programming and Alcohol Liver Disease
    Role: Principal Investigator

    R01DK109574     (JU, CYNTHIA)Sep 21, 2016 - Jun 30, 2020
    NIH/NIDDK
    Hypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. He Y, Feng D, Li M, Gao Y, Ramirez T, Cao H, Kim SJ, Yang Y, Cai Y, Ju C, Wang H, Li J, Gao B. Hepatic mtDNA-TLR9-microRNA-223 forms a negative feedback loop to limit neutrophil over-activation and acetaminophen hepatotoxicity. Hepatology. 2017 Mar 13. PMID: 28295449.
      View in: PubMed
    2. Ju C, Liangpunsakul S. Role of hepatic macrophages in alcoholic liver disease. J Investig Med. 2016 Aug; 64(6):1075-7. PMID: 27382116.
      View in: PubMed
    3. Ju C, Colgan SP, Eltzschig HK. Hypoxia-inducible factors as molecular targets for liver diseases. J Mol Med (Berl). 2016 Jun; 94(6):613-27. PMID: 27094811.
      View in: PubMed
    4. Cai X, Qiu SH, Yin H, Sun ZL, Ju CP, Z├╝gel M, Steinacker JM, Schumann U. Pedometer intervention and weight loss in overweight and obese adults with Type 2 diabetes: a meta-analysis. Diabet Med. 2016 Aug; 33(8):1035-44. PMID: 26926674.
      View in: PubMed
    5. Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol. 2016 May; 13(3):316-27. PMID: 26908374.
      View in: PubMed
    6. You Q, Wu Y, Yao N, Shen G, Zhang Y, Xu L, Li G, Ju C. Interaction of AIM with insulin-like growth factor-binding protein-4. Int J Mol Med. 2015 Sep; 36(3):833-8. PMID: 26135353.
      View in: PubMed
    7. Fritz JM, Tennis MA, Orlicky DJ, Yin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD. Corrigendum: depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Front Immunol. 2015; 6:88. PMID: 25784911.
      View in: PubMed
    8. Mathews S, Feng D, Maricic I, Ju C, Kumar V, Gao B. Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration. Cell Mol Immunol. 2016 Mar; 13(2):206-16. PMID: 25661730.
      View in: PubMed
    9. Ju C, Mandrekar P. Macrophages and Alcohol-Related Liver Inflammation. Alcohol Res. 2015; 37(2):251-62. PMID: 26717583.
      View in: PubMed
    10. Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD. Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Front Immunol. 2014; 5:587. PMID: 25505466.
      View in: PubMed
    11. Moorehead KJ, Burton JR, Everson GT, Zheng JH, Kerr BJ, Bushman LR, Wang M, Ju C, Nydam T, Kiser JJ. Intrahepatic antiviral quantification in a patient undergoing orthotopic cadaveric liver transplantation. J Antimicrob Chemother. 2015 Jan; 70(1):315-7. PMID: 25213274.
      View in: PubMed
    12. Feng D, Wang Y, Wang H, Weng H, Kong X, Martin-Murphy BV, Li Y, Park O, Dooley S, Ju C, Gao B. Acute and chronic effects of IL-22 on acetaminophen-induced liver injury. J Immunol. 2014 Sep 01; 193(5):2512-8. PMID: 25063867.
      View in: PubMed
    13. Wang M, You Q, Lor K, Chen F, Gao B, Ju C. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol. 2014 Oct; 96(4):657-65. PMID: 25030420.
      View in: PubMed
    14. Chang CH, Drechsel DA, Kitson RR, Siegel D, You Q, Backos DS, Ju C, Moody CJ, Ross D. 19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol. 2014 Jun; 85(6):849-57. PMID: 24682466.
      View in: PubMed
    15. Ju C, Roth RA. PKCs: pernicious kinase culprits in acetaminophen pathogenesis. Hepatology. 2014 Apr; 59(4):1229-31. PMID: 24677191.
      View in: PubMed
    16. Martin-Murphy BV, You Q, Wang H, De La Houssaye BA, Reilly TP, Friedman JE, Ju C. Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding. PLoS One. 2014; 9(1):e80949. PMID: 24465369.
      View in: PubMed
    17. Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med. 2013 Sep; 19(9):1132-40. PMID: 23955712.
      View in: PubMed
    18. You Q, Holt M, Yin H, Li G, Hu CJ, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013 Sep 15; 86(6):836-43. PMID: 23876342.
      View in: PubMed
    19. You Q, Cheng L, Li D, Whritenour J, Kawabata TT, Ju C. Development of a screening assay to evaluate the potential of drugs to cause immune-mediated hypersensitivity reactions. J Immunotoxicol. 2014 Apr-Jun; 11(2):110-5. PMID: 23768081.
      View in: PubMed
    20. Martin-Murphy BV, Kominsky DJ, Orlicky DJ, Donohue TM, Ju C. Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury. Hepatology. 2013 Apr; 57(4):1575-84. PMID: 23150232.
      View in: PubMed
    21. Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, Watkins PB, Albassam M, Liu B, Stancic S, Suter L, Bortolini M. Current challenges and controversies in drug-induced liver injury. Drug Saf. 2012 Dec 01; 35(12):1099-117. PMID: 23137150.
      View in: PubMed
    22. Ju C. Damage-associated molecular patterns: their impact on the liver and beyond during acetaminophen overdose. Hepatology. 2012 Nov; 56(5):1599-601. PMID: 22729522.
      View in: PubMed
    23. Ju C, Reilly T. Role of immune reactions in drug-induced liver injury (DILI). Drug Metab Rev. 2012 Feb; 44(1):107-15. PMID: 22235834.
      View in: PubMed
    24. Cheng L, You Q, Yin H, Holt MP, Ju C. Involvement of natural killer T cells in halothane-induced liver injury in mice. Biochem Pharmacol. 2010 Jul 15; 80(2):255-61. PMID: 20359463.
      View in: PubMed
    25. Yin H, Cheng L, Holt M, Hail N, Maclaren R, Ju C. Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology. 2010 Mar; 51(3):1007-16. PMID: 20099297.
      View in: PubMed
    26. You Q, Cheng L, Ju C. Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicol Lett. 2010 May 04; 194(3):79-85. PMID: 20156533.
      View in: PubMed
    27. Holt MP, Yin H, Ju C. Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice. Toxicol Lett. 2010 Apr 15; 194(1-2):34-41. PMID: 20123118.
      View in: PubMed
    28. Yin H, Cheng L, Agarwal C, Agarwal R, Ju C. Lactoferrin protects against concanavalin A-induced liver injury in mice. Liver Int. 2010 Apr; 30(4):623-32. PMID: 20136718.
      View in: PubMed
    29. Adams DH, Ju C, Ramaiah SK, Uetrecht J, Jaeschke H. Mechanisms of immune-mediated liver injury. Toxicol Sci. 2010 Jun; 115(2):307-21. PMID: 20071422.
      View in: PubMed
    30. Holt M, Ju C. Drug-induced liver injury. Handb Exp Pharmacol. 2010; (196):3-27. PMID: 20020257.
      View in: PubMed
    31. Martin-Murphy BV, Holt MP, Ju C. The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol Lett. 2010 Feb 15; 192(3):387-94. PMID: 19931603.
      View in: PubMed
    32. Ju C. The role of haptic macrophages in regulation of idiosyncratic drug reactions. Toxicol Pathol. 2009 Jan; 37(1):12-7. PMID: 19171927.
      View in: PubMed
    33. Cheng L, You Q, Yin H, Holt M, Franklin C, Ju C. Effect of polyI:C cotreatment on halothane-induced liver injury in mice. Hepatology. 2009 Jan; 49(1):215-26. PMID: 19111017.
      View in: PubMed
    34. You Q, Cheng L, Kedl RM, Ju C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology. 2008 Sep; 48(3):978-90. PMID: 18712788.
      View in: PubMed
    35. Holt MP, Cheng L, Ju C. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol. 2008 Dec; 84(6):1410-21. PMID: 18713872.
      View in: PubMed
    36. Cheng L, Stewart BJ, You Q, Petersen DR, Ware JA, Piccotti JR, Kawabata TT, Ju C. Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo. Mol Pharmacol. 2008 Jun; 73(6):1769-75. PMID: 18334600.
      View in: PubMed
    37. Yin H, Cheng L, Langenbach R, Ju C. Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury. Hepatology. 2007 Jan; 45(1):159-69. PMID: 17187424.
      View in: PubMed
    38. You Q, Cheng L, Reilly TP, Wegmann D, Ju C. Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology. 2006 Dec; 44(6):1421-31. PMID: 17133481.
      View in: PubMed
    39. Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci. 2007 Mar; 96(1):2-15. PMID: 17122412.
      View in: PubMed
    40. Holt MP, Ju C. Mechanisms of drug-induced liver injury. AAPS J. 2006 Feb 03; 8(1):E48-54. PMID: 16584133.
      View in: PubMed
    41. Ju C, Pohl LR. Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions. Toxicology. 2005 Apr 15; 209(2):109-12. PMID: 15767021.
      View in: PubMed
    42. Ju C. Immunological mechanisms of drug-induced liver injury. Curr Opin Drug Discov Devel. 2005 Jan; 8(1):38-43. PMID: 15679170.
      View in: PubMed
    43. Ju C, McCoy JP, Chung CJ, Graf ML, Pohl LR. Tolerogenic role of Kupffer cells in allergic reactions. Chem Res Toxicol. 2003 Dec; 16(12):1514-9. PMID: 14680364.
      View in: PubMed
    44. Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, Pohl LR. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem Res Toxicol. 2002 Dec; 15(12):1504-13. PMID: 12482232.
      View in: PubMed
    45. Reilly TP, Ju C. Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions. Curr Opin Allergy Clin Immunol. 2002 Aug; 2(4):307-15. PMID: 12130945.
      View in: PubMed
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