Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John F Carpenter

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-6110
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOP-Administration


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gandhi AV, Pothecary MR, Bain DL, Carpenter JF. Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates. J Pharm Sci. 2017 Aug; 106(8):2178-2186. PMID: 28479353.
      View in: PubMed
    2. Chisholm CF, Soucie KR, Song JS, Strauch P, Torres RM, Carpenter JF, Ragheb JA, Randolph TW. Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models. J Pharm Sci. 2017 Jun; 106(6):1519-1527. PMID: 28216023.
      View in: PubMed
    3. St Clair JB, Detanico T, Aviszus K, Kirchenbaum GA, Christie M, Carpenter JF, Wysocki LJ. Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes. PLoS One. 2017; 12(1):e0170556. PMID: 28114383.
      View in: PubMed
    4. Kiminami H, Krueger AB, Abe Y, Yoshino K, Carpenter JF. Impact of Sterilization Method on Protein Aggregation and Particle Formation in Polymer-Based Syringes. J Pharm Sci. 2017 Apr; 106(4):1001-1007. PMID: 28007562.
      View in: PubMed
    5. Brader ML, Baker EN, Dunn MF, Laue TM, Carpenter JF. Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development. J Pharm Sci. 2017 Feb; 106(2):477-494. PMID: 27889071.
      View in: PubMed
    6. Pardeshi NN, Qi W, Dahl K, Caplan L, Carpenter JF. Microparticles and Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product. J Pharm Sci. 2017 Feb; 106(2):511-520. PMID: 27832839.
      View in: PubMed
    7. Snell JR, Zhou C, Carpenter JF, Randolph TW. Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions. J Pharm Sci. 2016 Oct; 105(10):3057-3063. PMID: 27488901; PMCID: PMC5021584 [Available on 10/01/17].
    8. Mehta SB, Carpenter JF, Randolph TW. Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces. J Pharm Sci. 2016 Aug; 105(8):2338-48. PMID: 27422087.
      View in: PubMed
    9. Zhou C, Qi W, Lewis EN, Randolph TW, Carpenter JF. Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20. J Pharm Sci. 2016 Aug; 105(8):2302-9. PMID: 27290624.
      View in: PubMed
    10. Zhou C, Cleland D, Snell J, Qi W, Randolph TW, Carpenter JF. Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose. J Pharm Sci. 2016 Jul; 105(7):2249-53. PMID: 27287517.
      View in: PubMed
    11. Teska BM, Brake JM, Tronto GS, Carpenter JF. Aggregation and Particle Formation of Therapeutic Proteins in Contact With a Novel Fluoropolymer Surface Versus Siliconized Surfaces: Effects of Agitation in Vials and in Prefilled Syringes. J Pharm Sci. 2016 Jul; 105(7):2053-65. PMID: 27233685.
      View in: PubMed
    12. Jiskoot W, Kijanka G, Randolph TW, Carpenter JF, Koulov AV, Mahler HC, Joubert MK, Jawa V, Narhi LO. Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges. J Pharm Sci. 2016 May; 105(5):1567-1575. PMID: 27044944; PMCID: PMC4846475 [Available on 05/01/17].
    13. Krueger AB, Carnell P, Carpenter JF. Characterization of Factors Affecting Nanoparticle Tracking Analysis Results With Synthetic and Protein Nanoparticles. J Pharm Sci. 2016 Apr; 105(4):1434-43. PMID: 27019960.
      View in: PubMed
    14. Chisholm CF, Baker AE, Soucie KR, Torres RM, Carpenter JF, Randolph TW. Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice. J Pharm Sci. 2016 May; 105(5):1623-1632. PMID: 27020987; PMCID: PMC4846524 [Available on 05/01/17].
    15. Zhou C, Qi W, Lewis EN, Carpenter JF. Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study. J Pharm Sci. 2016 Feb; 105(2):551-558. PMID: 26869418.
      View in: PubMed
    16. Gerhardt A, Mcumber AC, Nguyen BH, Lewus R, Schwartz DK, Carpenter JF, Randolph TW. Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes. J Pharm Sci. 2015 Dec; 104(12):4056-4064. PMID: 26413998; PMCID: PMC4804708 [Available on 12/01/16].
    17. Christie M, Peritt D, Torres RM, Randolph TW, Carpenter JF. The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin. J Pharm Sci. 2015 Dec; 104(12):4041-4055. PMID: 26375484.
      View in: PubMed
    18. Chisholm CF, Nguyen BH, Soucie KR, Torres RM, Carpenter JF, Randolph TW. In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations. J Pharm Sci. 2015 Nov; 104(11):3681-90. PMID: 26190624; PMCID: PMC4604024 [Available on 11/01/16].
    19. Zhou C, Krueger AB, Barnard JG, Qi W, Carpenter JF. Characterization of Nanoparticle Tracking Analysis for Quantification and Sizing of Submicron Particles of Therapeutic Proteins. J Pharm Sci. 2015 Aug; 104(8):2441-50. PMID: 26017684.
      View in: PubMed
    20. Gerhardt A, Nguyen BH, Lewus R, Carpenter JF, Randolph TW. Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes. J Pharm Sci. 2015 May; 104(5):1601-9. PMID: 25740412.
      View in: PubMed
    21. Shomali M, Tanriverdi S, Freitag AJ, Engert J, Winter G, Siedler M, Kaymakcalan Z, Carpenter JF, Randolph TW. Dose levels in particulate-containing formulations impact anti-drug antibody responses to murine monoclonal antibody in mice. J Pharm Sci. 2015 May; 104(5):1610-21. PMID: 25737325.
      View in: PubMed
    22. Mehta SB, Lewus R, Bee JS, Randolph TW, Carpenter JF. Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation. J Pharm Sci. 2015 Apr; 104(4):1282-90. PMID: 25639229.
      View in: PubMed
    23. Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW. Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. J Pharm Sci. 2015 Feb; 104(2):627-39. PMID: 25581103; PMCID: PMC4312196.
    24. Teska BM, Kumar A, Carpenter JF, Wempe MF. Analyzing insulin samples by size-exclusion chromatography: a column degradation study. J Pharm Sci. 2015 Apr; 104(4):1555-60. PMID: 25581527; PMCID: PMC4359628.
    25. Zhou C, Qi W, Lewis EN, Carpenter JF. Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations. Anal Biochem. 2015 Mar 01; 472:7-20. PMID: 25475399.
      View in: PubMed
    26. Volkin DB, Hershenson S, Ho RJ, Uchiyama S, Winter G, Carpenter JF. Two decades of publishing excellence in pharmaceutical biotechnology. J Pharm Sci. 2015 Feb; 104(2):290-300. PMID: 25448882; PMCID: PMC4826475.
    27. Randolph TW, Schiltz E, Sederstrom D, Steinmann D, Mozziconacci O, Schöneich C, Freund E, Ricci MS, Carpenter JF, Lengsfeld CS. Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation. J Pharm Sci. 2015 Feb; 104(2):602-11. PMID: 25418950; PMCID: PMC4312221.
    28. Sung JJ, Pardeshi NN, Mulder AM, Mulligan SK, Quispe J, On K, Carragher B, Potter CS, Carpenter JF, Schneemann A. Transmission electron microscopy as an orthogonal method to characterize protein aggregates. J Pharm Sci. 2015 Feb; 104(2):750-9. PMID: 25231267; PMCID: PMC4376473.
    29. Verhoef JJ, Carpenter JF, Anchordoquy TJ, Schellekens H. Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics. Drug Discov Today. 2014 Dec; 19(12):1945-52. PMID: 25205349.
      View in: PubMed
    30. Freitag AJ, Shomali M, Michalakis S, Biel M, Siedler M, Kaymakcalan Z, Carpenter JF, Randolph TW, Winter G, Engert J. Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice. Pharm Res. 2015 Feb; 32(2):430-44. PMID: 25123991.
      View in: PubMed
    31. Riddell J, Kauffman CA, Smith JA, Assi M, Blue S, Buitrago MI, Deresinski S, Wright PW, Drevets DA, Norris SA, Vikram HR, Carson PJ, Vergidis P, Carpenter J, Seidenfeld SM, Wheat LJ. Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment. Medicine (Baltimore). 2014 Jul; 93(5):186-93. PMID: 25181311; PMCID: PMC4602453.
    32. Teska BM, Alarcón J, Pettis RJ, Randolph TW, Carpenter JF. Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature. J Pharm Sci. 2014 Aug; 103(8):2255-67. PMID: 24909933.
      View in: PubMed
    33. Devineni D, Gonschorek C, Cicerone MT, Xu Y, Carpenter JF, Randolph TW. Storage stability of keratinocyte growth factor-2 in lyophilized formulations: Effects of formulation physical properties and protein fraction at the solid-air interface. Eur J Pharm Biopharm. 2014 Oct; 88(2):332-41. PMID: 24859390.
      View in: PubMed
    34. Liu L, Braun LJ, Wang W, Randolph TW, Carpenter JF. Freezing-induced perturbation of tertiary structure of a monoclonal antibody. J Pharm Sci. 2014 Jul; 103(7):1979-1986. PMID: 24832730; PMCID: PMC4069245.
    35. Mehta SB, Bee JS, Randolph TW, Carpenter JF. Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation. Biochemistry. 2014 May 27; 53(20):3367-77. PMID: 24804773.
      View in: PubMed
    36. Fradkin AH, Mozziconacci O, Schöneich C, Carpenter JF, Randolph TW. UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences. Eur J Pharm Biopharm. 2014 Jul; 87(2):395-402. PMID: 24758742; PMCID: PMC4066668.
    37. Gerhardt A, Mcgraw NR, Schwartz DK, Bee JS, Carpenter JF, Randolph TW. Protein aggregation and particle formation in prefilled glass syringes. J Pharm Sci. 2014 Jun; 103(6):1601-12. PMID: 24729310.
      View in: PubMed
    38. Xu Y, Grobelny P, Von Allmen A, Knudson K, Pikal M, Carpenter JF, Randolph TW. Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples. J Pharm Sci. 2014 May; 103(5):1356-66. PMID: 24623139; PMCID: PMC4049081.
    39. Wang H, Zheng HJ, Wang Z, Bai H, Carpenter JF, Chen S, Fang WJ. Formation of protein sub-visible particles during vacuum degassing of etanercept solutions. Int J Biol Macromol. 2014 May; 66:151-7. PMID: 24513220.
      View in: PubMed
    40. Barnard JG, Kahn D, Cetlin D, Randolph TW, Carpenter JF. Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions. J Pharm Sci. 2014 Mar; 103(3):890-9. PMID: 24549732.
      View in: PubMed
    41. Carpenter JF. Implant-assisted unilateral removable partial dentures. Dent Today. 2014 Jan; 33(1):106, 108-11. PMID: 24660439.
      View in: PubMed
    42. Basu P, Blake-Haskins AW, O'Berry KB, Randolph TW, Carpenter JF. Albinterferon a2b adsorption to silicone oil-water interfaces: effects on protein conformation, aggregation, and subvisible particle formation. J Pharm Sci. 2014 Feb; 103(2):427-36. PMID: 24382812.
      View in: PubMed
    43. Qi W, Zeng Y, Orgel S, Francon A, Kim JH, Randolph TW, Carpenter JF, Middaugh CR. Preformulation study of highly purified inactivated polio vaccine, serotype 3. J Pharm Sci. 2014 Jan; 103(1):140-51. PMID: 24282078.
      View in: PubMed
    44. Christie M, Torres RM, Kedl RM, Randolph TW, Carpenter JF. Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. J Pharm Sci. 2014 Jan; 103(1):128-39. PMID: 25133276; PMCID: PMC4137484.
    45. Shomali M, Freitag A, Engert J, Siedler M, Kaymakcalan Z, Winter G, Carpenter JF, Randolph TW. Antibody responses in mice to particles formed from adsorption of a murine monoclonal antibody onto glass microparticles. J Pharm Sci. 2014 Jan; 103(1):78-89. PMID: 24227137.
      View in: PubMed
    46. Filipe V, Que I, Carpenter JF, Löwik C, Jiskoot W. In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice. Pharm Res. 2014 Jan; 31(1):216-27. PMID: 23949250.
      View in: PubMed
    47. Liu L, Qi W, Schwartz DK, Randolph TW, Carpenter JF. The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study. J Pharm Sci. 2013 Aug; 102(8):2460-70. PMID: 23712900; PMCID: PMC4174554.
    48. Izutsu K, Yomota C, Okuda H, Kawanishi T, Randolph TW, Carpenter JF. Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions. Eur J Pharm Biopharm. 2013 Oct; 85(2):177-83. PMID: 23692695.
      View in: PubMed
    49. Hassett KJ, Cousins MC, Rabia LA, Chadwick CM, O'Hara JM, Nandi P, Brey RN, Mantis NJ, Carpenter JF, Randolph TW. Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization. Eur J Pharm Biopharm. 2013 Oct; 85(2):279-86. PMID: 23583494; PMCID: PMC3797224.
    50. Carpenter JF. Value that industrial collaborations bring to research and education efforts in universities: perspective of a professor working in the field of development of therapeutic proteins. Hum Genomics. 2013 Mar 05; 7:7. PMID: 23496966; PMCID: PMC3632497.
    51. Basu P, Krishnan S, Thirumangalathu R, Randolph TW, Carpenter JF. IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers. J Pharm Sci. 2013 Mar; 102(3):852-65. PMID: 23280943.
      View in: PubMed
    52. Barnard JG, Babcock K, Carpenter JF. Characterization and quantitation of aggregates and particles in interferon-ß products: potential links between product quality attributes and immunogenicity. J Pharm Sci. 2013 Mar; 102(3):915-28. PMID: 23233295.
      View in: PubMed
    53. Gerhardt A, Bonam K, Bee JS, Carpenter JF, Randolph TW. Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces. J Pharm Sci. 2013 Feb; 102(2):429-40. PMID: 23212809.
      View in: PubMed
    54. Chou DK, Krishnamurthy R, Manning MC, Randolph TW, Carpenter JF. Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation. J Pharm Sci. 2013 Feb; 102(2):660-73. PMID: 23203978.
      View in: PubMed
    55. Britt KA, Schwartz DK, Wurth C, Mahler HC, Carpenter JF, Randolph TW. Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions. J Pharm Sci. 2012 Dec; 101(12):4419-32. PMID: 22987313.
      View in: PubMed
    56. Fang WJ, Qi W, Kinzell J, Prestrelski S, Carpenter JF. Effects of excipients on the chemical and physical stability of glucagon during freeze-drying and storage in dried formulations. Pharm Res. 2012 Dec; 29(12):3278-91. PMID: 22766900.
      View in: PubMed
    57. Hni´zda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodi´cek M, Kožich V, Kraus JP. Correction to Conformational Properties of Nine Purified Cystathionine ß-Synthase Mutants. Biochemistry. 2012 Jul 10; 51(27):5540. PMID: 22734603.
      View in: PubMed
    58. Carpenter JF. Journal of Pharmaceutical Sciences. Editorial. J Pharm Sci. 2012 Oct; 101(10):3554. PMID: 22736509.
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    59. Liu L, Randolph TW, Carpenter JF. Particles shed from syringe filters and their effects on agitation-induced protein aggregation. J Pharm Sci. 2012 Aug; 101(8):2952-9. PMID: 22674153.
      View in: PubMed
    60. Chou DK, Krishnamurthy R, Manning MC, Randolph TW, Carpenter JF. Physical stability of albinterferon-a(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation. J Pharm Sci. 2012 Aug; 101(8):2702-19. PMID: 22674119.
      View in: PubMed
    61. Hnízda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodícek M, Kožich V, Kraus JP. Conformational properties of nine purified cystathionine ß-synthase mutants. Biochemistry. 2012 Jun 12; 51(23):4755-63. PMID: 22612060; PMCID: PMC3384745.
    62. Cordes AA, Carpenter JF, Randolph TW. Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses. J Pharm Sci. 2012 Jul; 101(7):2307-15. PMID: 22488299.
      View in: PubMed
    63. Cordes AA, Carpenter JF, Randolph TW. Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate. J Pharm Sci. 2012 Jun; 101(6):2009-16. PMID: 22422106.
      View in: PubMed
    64. Cordes AA, Platt CW, Carpenter JF, Randolph TW. Selective domain stabilization as a strategy to reduce fusion protein aggregation. J Pharm Sci. 2012 Apr; 101(4):1400-9. PMID: 22234888.
      View in: PubMed
    65. Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schöneich C, Winter G, Friess W, Crommelin DJ, Carpenter JF. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci. 2012 Mar; 101(3):946-54. PMID: 22170395.
      View in: PubMed
    66. Barnard JG, Rhyner MN, Carpenter JF. Critical evaluation and guidance for using the Coulter method for counting subvisible particles in protein solutions. J Pharm Sci. 2012 Jan; 101(1):140-53. PMID: 22109687.
      View in: PubMed
    67. Fradkin AH, Carpenter JF, Randolph TW. Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins. J Pharm Sci. 2011 Nov; 100(11):4953-64. PMID: 21721003.
      View in: PubMed
    68. Alford JR, Fowler AC, Wuttke DS, Kerwin BA, Latypov RF, Carpenter JF, Randolph TW. Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. J Pharm Sci. 2011 Oct; 100(10):4215-24. PMID: 21557223.
      View in: PubMed
    69. Ludwig DB, Webb JN, Fernández C, Carpenter JF, Randolph TW. Quaternary conformational stability: the effect of reversible self-association on the fibrillation of two insulin analogs. Biotechnol Bioeng. 2011 Oct; 108(10):2359-70. PMID: 21520027.
      View in: PubMed
    70. Bee JS, Randolph TW, Carpenter JF, Bishop SM, Dimitrova MN. Effects of surfaces and leachables on the stability of biopharmaceuticals. J Pharm Sci. 2011 Oct; 100(10):4158-70. PMID: 21523787.
      View in: PubMed
    71. Liu L, Ammar DA, Ross LA, Mandava N, Kahook MY, Carpenter JF. Silicone oil microdroplets and protein aggregates in repackaged bevacizumab and ranibizumab: effects of long-term storage and product mishandling. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1023-34. PMID: 21051703; PMCID: PMC3053093.
    72. Estey T, Chen Y, Carpenter JF, Vasiliou V. Structural and functional modifications of corneal crystallin ALDH3A1 by UVB light. PLoS One. 2010 Dec 21; 5(12):e15218. PMID: 21203538; PMCID: PMC3006428.
    73. Ludwig DB, Trotter JT, Gabrielson JP, Carpenter JF, Randolph TW. Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations. Anal Biochem. 2011 Mar 15; 410(2):191-9. PMID: 21146492; PMCID: PMC3040987.
    74. Bai S, Manning MC, Randolph TW, Carpenter JF. Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics. J Pharm Sci. 2011 Mar; 100(3):836-48. PMID: 20862672.
      View in: PubMed
    75. Buchanan SS, Pyatt DW, Carpenter JF. Preservation of differentiation and clonogenic potential of human hematopoietic stem and progenitor cells during lyophilization and ambient storage. PLoS One. 2010 Sep 01; 5(9). PMID: 20824143; PMCID: PMC2931707.
    76. Barnard JG, Singh S, Randolph TW, Carpenter JF. Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway. J Pharm Sci. 2011 Feb; 100(2):492-503. PMID: 20803602.
      View in: PubMed
    77. Carpenter J, Cherney B, Lubinecki A, Ma S, Marszal E, Mire-Sluis A, Nikolai T, Novak J, Ragheb J, Simak J. Meeting report on protein particles and immunogenicity of therapeutic proteins: filling in the gaps in risk evaluation and mitigation. Biologicals. 2010 Sep; 38(5):602-11. PMID: 20702108.
      View in: PubMed
    78. Salinas BA, Sathish HA, Shah AU, Carpenter JF, Randolph TW. Buffer-dependent fragmentation of a humanized full-length monoclonal antibody. J Pharm Sci. 2010 Jul; 99(7):2962-74. PMID: 20091831; PMCID: PMC3938388.
    79. Hoehne M, Samuel F, Dong A, Wurth C, Mahler HC, Carpenter JF, Randolph TW. Adsorption of monoclonal antibodies to glass microparticles. J Pharm Sci. 2011 Jan; 100(1):123-32. PMID: 20575075.
      View in: PubMed
    80. Kahook MY, Liu L, Ruzycki P, Mandava N, Carpenter JF, Petrash JM, Ammar DA. High-molecular-weight aggregates in repackaged bevacizumab. Retina. 2010 Jun; 30(6):887-92. PMID: 20458261.
      View in: PubMed
    81. Carpenter JF, Randolph TW, Jiskoot W, Crommelin DJ, Middaugh CR, Winter G. Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. J Pharm Sci. 2010 May; 99(5):2200-8. PMID: 19918982.
      View in: PubMed
    82. Ludwig DB, Carpenter JF, Hamel JB, Randolph TW. Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions. J Pharm Sci. 2010 Apr; 99(4):1721-33. PMID: 19894257.
      View in: PubMed
    83. Majtan T, Liu L, Carpenter JF, Kraus JP. Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes. J Biol Chem. 2010 May 21; 285(21):15866-73. PMID: 20308073; PMCID: PMC2871454.
    84. Serno T, Carpenter JF, Randolph TW, Winter G. Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin. J Pharm Sci. 2010 Mar; 99(3):1193-206. PMID: 19774651.
      View in: PubMed
    85. Bee JS, Davis M, Freund E, Carpenter JF, Randolph TW. Aggregation of a monoclonal antibody induced by adsorption to stainless steel. Biotechnol Bioeng. 2010 Jan 01; 105(1):121-9. PMID: 19725039; PMCID: PMC3926213.
    86. Salinas BA, Sathish HA, Bishop SM, Harn N, Carpenter JF, Randolph TW. Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation. J Pharm Sci. 2010 Jan; 99(1):82-93. PMID: 19475558; PMCID: PMC3927449.
    87. Fast JL, Cordes AA, Carpenter JF, Randolph TW. Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability. Biochemistry. 2009 Dec 15; 48(49):11724-36. PMID: 19899812; PMCID: PMC2835945.
    88. Bee JS, Nelson SA, Freund E, Carpenter JF, Randolph TW. Precipitation of a monoclonal antibody by soluble tungsten. J Pharm Sci. 2009 Sep; 98(9):3290-301. PMID: 19230018; PMCID: PMC2749483.
    89. Fradkin AH, Carpenter JF, Randolph TW. Immunogenicity of aggregates of recombinant human growth hormone in mouse models. J Pharm Sci. 2009 Sep; 98(9):3247-64. PMID: 19569057.
      View in: PubMed
    90. Bee JS, Chiu D, Sawicki S, Stevenson JL, Chatterjee K, Freund E, Carpenter JF, Randolph TW. Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies. J Pharm Sci. 2009 Sep; 98(9):3218-38. PMID: 19492408; PMCID: PMC2749556.
    91. Schwegman JJ, Carpenter JF, Nail SL. Evidence of partial unfolding of proteins at the ice/freeze-concentrate interface by infrared microscopy. J Pharm Sci. 2009 Sep; 98(9):3239-46. PMID: 19544369.
      View in: PubMed
    92. Thirumangalathu R, Krishnan S, Ricci MS, Brems DN, Randolph TW, Carpenter JF. Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution. J Pharm Sci. 2009 Sep; 98(9):3167-81. PMID: 19360857; PMCID: PMC2751612.
    93. Katayama DS, Carpenter JF, Menard KP, Manning MC, Randolph TW. Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study. J Pharm Sci. 2009 Sep; 98(9):2954-69. PMID: 18623211.
      View in: PubMed
    94. Roy S, Mason BD, Schöneich CS, Carpenter JF, Boone TC, Kerwin BA. Light-induced aggregation of type I soluble tumor necrosis factor receptor. J Pharm Sci. 2009 Sep; 98(9):3182-99. PMID: 19384921.
      View in: PubMed
    95. Vessely C, Estey T, Randolph TW, Henderson I, Cooper J, Nayar R, Braun LJ, Carpenter JF. Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. J Pharm Sci. 2009 Sep; 98(9):2970-93. PMID: 18680175; PMCID: PMC2721018.
    96. Estey T, Vessely C, Randolph TW, Henderson I, Braun LJ, Nayar R, Carpenter JF. Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry. J Pharm Sci. 2009 Sep; 98(9):2994-3012. PMID: 18781606; PMCID: PMC2721025.
    97. Bee JS, Stevenson JL, Mehta B, Svitel J, Pollastrini J, Platz R, Freund E, Carpenter JF, Randolph TW. Response of a concentrated monoclonal antibody formulation to high shear. Biotechnol Bioeng. 2009 Aug 01; 103(5):936-43. PMID: 19370772; PMCID: PMC2724069.
    98. Lin JJ, Meyer JD, Carpenter JF, Manning MC. Aggregation of human serum albumin during a thermal viral inactivation step. Int J Biol Macromol. 2009 Aug 01; 45(2):91-6. PMID: 19409925.
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    99. Carpenter JF, Randolph TW, Jiskoot W, Crommelin DJ, Middaugh CR, Winter G, Fan YX, Kirshner S, Verthelyi D, Kozlowski S, Clouse KA, Swann PG, Rosenberg A, Cherney B. Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. J Pharm Sci. 2009 Apr; 98(4):1201-5. PMID: 18704929; PMCID: PMC3928042.
    100. Olsen SN, Andersen KB, Randolph TW, Carpenter JF, Westh P. Role of electrostatic repulsion on colloidal stability of Bacillus halmapalus alpha-amylase. Biochim Biophys Acta. 2009 Jul; 1794(7):1058-65. PMID: 19281873.
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    101. Chen D, Tyagi A, Carpenter J, Perkins S, Sylvester D, Guy M, Kristensen DD, Braun LJ. Characterization of the freeze sensitivity of a hepatitis B vaccine. Hum Vaccin. 2009 Jan-Feb; 5(1):26-32. PMID: 18971625.
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    102. Tyagi AK, Randolph TW, Dong A, Maloney KM, Hitscherich C, Carpenter JF. IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles. J Pharm Sci. 2009 Jan; 98(1):94-104. PMID: 18454482.
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    103. Clausi AL, Morin A, Carpenter JF, Randolph TW. Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine. J Pharm Sci. 2009 Jan; 98(1):114-21. PMID: 18506831; PMCID: PMC2593119.
    104. Roy S, Henderson I, Nayar R, Randolph TW, Carpenter JF. Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations. J Pharm Sci. 2008 Dec; 97(12):5132-46. PMID: 18399536.
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    105. Pikal MJ, Rigsbee D, Roy ML, Galreath D, Kovach KJ, Wang B, Carpenter JF, Cicerone MT. Solid state chemistry of proteins: II. The correlation of storage stability of freeze-dried human growth hormone (hGH) with structure and dynamics in the glassy solid. J Pharm Sci. 2008 Dec; 97(12):5106-21. PMID: 18351639.
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    106. Clausi A, Cummiskey J, Merkley S, Carpenter JF, Braun LJ, Randolph TW. Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine. J Pharm Sci. 2008 Dec; 97(12):5252-62. PMID: 18398901.
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    107. Braun LJ, Tyagi A, Perkins S, Carpenter J, Sylvester D, Guy M, Kristensen D, Chen D. Development of a freeze-stable formulation for vaccines containing aluminum salt adjuvants. Vaccine. 2009 Jan 01; 27(1):72-9. PMID: 18973782.
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    108. Alford JR, Kendrick BS, Carpenter JF, Randolph TW. High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics. J Pharm Sci. 2008 Aug; 97(8):3005-21. PMID: 17924426.
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    109. Alford JR, Kwok SC, Roberts JN, Wuttke DS, Kendrick BS, Carpenter JF, Randolph TW. High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization. J Pharm Sci. 2008 Aug; 97(8):3035-50. PMID: 17973297.
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    110. Cape SP, Villa JA, Huang ET, Yang TH, Carpenter JF, Sievers RE. Preparation of active proteins, vaccines and pharmaceuticals as fine powders using supercritical or near-critical fluids. Pharm Res. 2008 Sep; 25(9):1967-90. PMID: 18581212; PMCID: PMC2515571.
    111. Clausi AL, Merkley SA, Carpenter JF, Randolph TW. Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying. J Pharm Sci. 2008 Jun; 97(6):2049-61. PMID: 17879291.
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    112. Kueltzo LA, Wang W, Randolph TW, Carpenter JF. Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing. J Pharm Sci. 2008 May; 97(5):1801-12. PMID: 17823949.
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    113. Alford JR, Kendrick BS, Carpenter JF, Randolph TW. Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium. Anal Biochem. 2008 Jun 15; 377(2):128-33. PMID: 18395000; PMCID: PMC2518745.
    114. Carpenter JF. Working to improve healthcare for people in developing countries. J Pharm Sci. 2008 Mar; 97(3):1039-40. PMID: 18213681.
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    115. Katayama DS, Carpenter JF, Manning MC, Randolph TW, Setlow P, Menard KP. Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry. J Pharm Sci. 2008 Feb; 97(2):1013-24. PMID: 17724657.
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    116. Vessely C, Estey T, Randolph TW, Henderson I, Nayar R, Carpenter JF. Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants. J Pharm Sci. 2007 Sep; 96(9):2375-89. PMID: 17518359.
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    117. Dotzlaf J, Carpenter J, Luo S, Miles RR, Fisher D, Qian YW, Ehsani M, Wang X, Lin A, McClure DB, Chen VJ, Zuckerman SH. Derivation and characterization of monoclonal antibodies against human folypolyglutamate synthetase. Hybridoma (Larchmt). 2007 Jun; 26(3):155-61. PMID: 17600497.
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    118. Thirumangalathu R, Krishnan S, Bondarenko P, Speed-Ricci M, Randolph TW, Carpenter JF, Brems DN. Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics. Biochemistry. 2007 May 29; 46(21):6213-24. PMID: 17480058.
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    119. Gabrielson JP, Brader ML, Pekar AH, Mathis KB, Winter G, Carpenter JF, Randolph TW. Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity. J Pharm Sci. 2007 Feb; 96(2):268-79. PMID: 17080424.
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    120. Schwegman JJ, Carpenter JF, Nail SL. Infrared microscopy for in situ measurement of protein secondary structure during freezing and freeze-drying. J Pharm Sci. 2007 Jan; 96(1):179-95. PMID: 17031845.
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    121. Estey T, Cantore M, Weston PA, Carpenter JF, Petrash JM, Vasiliou V. Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. J Biol Chem. 2007 Feb 16; 282(7):4382-92. PMID: 17158879.
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    122. Thirumangalathu R, Krishnan S, Brems DN, Randolph TW, Carpenter JF. Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor. J Pharm Sci. 2006 Jul; 95(7):1480-97. PMID: 16729274.
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    123. Estey T, Kang J, Schwendeman SP, Carpenter JF. BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems. J Pharm Sci. 2006 Jul; 95(7):1626-39. PMID: 16729268.
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    124. Roy S, Katayama D, Dong A, Kerwin BA, Randolph TW, Carpenter JF. Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist. Biochemistry. 2006 Mar 28; 45(12):3898-911. PMID: 16548517.
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    125. Dong A, Jones LS, Kerwin BA, Krishnan S, Carpenter JF. Secondary structures of proteins adsorbed onto aluminum hydroxide: infrared spectroscopic analysis of proteins from low solution concentrations. Anal Biochem. 2006 Apr 15; 351(2):282-9. PMID: 16460655.
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    126. Kim YS, Randolph TW, Seefeldt MB, Carpenter JF. High-pressure studies on protein aggregates and amyloid fibrils. Methods Enzymol. 2006; 413:237-53. PMID: 17046400.
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    127. Lee SH, Carpenter JF, Chang BS, Randolph TW, Kim YS. Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Protein Sci. 2006 Feb; 15(2):304-13. PMID: 16385003; PMCID: PMC2242456.
    128. Chi EY, Kendrick BS, Carpenter JF, Randolph TW. Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist. J Pharm Sci. 2005 Dec; 94(12):2735-48. PMID: 16258998.
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    129. Vessely CR, Carpenter JF, Schwartz DK. Calcium-induced changes to the molecular conformation and aggregate structure of beta-casein at the air-water interface. Biomacromolecules. 2005 Nov-Dec; 6(6):3334-44. PMID: 16283763.
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    130. Bai S, Nayar R, Carpenter JF, Manning MC. Noninvasive determination of protein conformation in the solid state using near infrared (NIR) spectroscopy. J Pharm Sci. 2005 Sep; 94(9):2030-8. PMID: 16052558.
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    131. Seefeldt MB, Kim YS, Tolley KP, Seely J, Carpenter JF, Randolph TW. High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies. Protein Sci. 2005 Sep; 14(9):2258-66. PMID: 16081653; PMCID: PMC2253477.
    132. Chou DK, Krishnamurthy R, Randolph TW, Carpenter JF, Manning MC. Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation. J Pharm Sci. 2005 Jun; 94(6):1368-81. PMID: 15858848.
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    133. Roy S, Jung R, Kerwin BA, Randolph TW, Carpenter JF. Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations. J Pharm Sci. 2005 Feb; 94(2):382-96. PMID: 15614819.
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    134. Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci. 2005 Feb; 94(2):256-74. PMID: 15570600.
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    135. Zhang Y, Roy S, Jones LS, Krishnan S, Kerwin BA, Chang BS, Manning MC, Randolph TW, Carpenter JF. Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution. J Pharm Sci. 2004 Dec; 93(12):3076-89. PMID: 15514986.
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    136. Seefeldt MB, Ouyang J, Froland WA, Carpenter JF, Randolph TW. High-pressure refolding of bikunin: efficacy and thermodynamics. Protein Sci. 2004 Oct; 13(10):2639-50. PMID: 15388859; PMCID: PMC2286545.
    137. Bai SJ, Rani M, Suryanarayanan R, Carpenter JF, Nayar R, Manning MC. Quantification of glycine crystallinity by near-infrared (NIR) spectroscopy. J Pharm Sci. 2004 Oct; 93(10):2439-47. PMID: 15349954.
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    138. Buchanan SS, Gross SA, Acker JP, Toner M, Carpenter JF, Pyatt DW. Cryopreservation of stem cells using trehalose: evaluation of the method using a human hematopoietic cell line. Stem Cells Dev. 2004 Jun; 13(3):295-305. PMID: 15186725.
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    139. Meyer JD, Jun Bai S, Rani M, Suryanarayanan R, Nayar R, Carpenter JF, Manning MC. Infrared spectroscopic studies of protein formulations containing glycine. J Pharm Sci. 2004 May; 93(5):1359-66. PMID: 15067711.
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    140. Soenderkaer S, Carpenter JF, van de Weert M, Hansen LL, Flink J, Frokjaer S. Effects of sucrose on rFVIIa aggregation and methionine oxidation. Eur J Pharm Sci. 2004 Apr; 21(5):597-606. PMID: 15066660.
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    141. Garzon-Rodriguez W, Koval RL, Chongprasert S, Krishnan S, Randolph TW, Warne NW, Carpenter JF. Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures. J Pharm Sci. 2004 Mar; 93(3):684-96. PMID: 14762907.
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    142. Meyer JD, Manning MC, Carpenter JF. Effects of potassium bromide disk formation on the infrared spectra of dried model proteins. J Pharm Sci. 2004 Feb; 93(2):496-506. PMID: 14705205.
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    143. Chi EY, Krishnan S, Randolph TW, Carpenter JF. Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm Res. 2003 Sep; 20(9):1325-36. PMID: 14567625.
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    144. Kim YS, Jones LS, Dong A, Kendrick BS, Chang BS, Manning MC, Randolph TW, Carpenter JF. Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins. Protein Sci. 2003 Jun; 12(6):1252-61. PMID: 12761396; PMCID: PMC2323899.
    145. Chi EY, Krishnan S, Kendrick BS, Chang BS, Carpenter JF, Randolph TW. Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor. Protein Sci. 2003 May; 12(5):903-13. PMID: 12717013; PMCID: PMC2323861.
    146. Webb SD, Cleland JL, Carpenter JF, Randolph TW. Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma. J Pharm Sci. 2003 Apr; 92(4):715-29. PMID: 12661058.
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    147. Manzer R, Pappa A, Estey T, Sladek N, Carpenter JF, Vasiliou V. Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1. Chem Biol Interact. 2003 Feb 01; 143-144:45-53. PMID: 12604188.
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    148. Krishnan S, Chi EY, Wood SJ, Kendrick BS, Li C, Garzon-Rodriguez W, Wypych J, Randolph TW, Narhi LO, Biere AL, Citron M, Carpenter JF. Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis. Biochemistry. 2003 Jan 28; 42(3):829-37. PMID: 12534296.
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    149. Kim YS, Randolph TW, Manning MC, Stevens FJ, Carpenter JF. Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation. J Biol Chem. 2003 Mar 21; 278(12):10842-50. PMID: 12529361.
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    150. Garriques LN, Frokjaer S, Carpenter JF, Brange J. The effect of mutations on the structure of insulin fibrils studied by Fourier transform infrared (FTIR) spectroscopy and electron microscopy. J Pharm Sci. 2002 Dec; 91(12):2473-80. PMID: 12434390.
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    151. Nguyen TV, Riggs C, Babovic-Vuksanovic D, Kim YS, Carpenter JF, Burghardt TP, Gregersen N, Vockley J. Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme. Biochemistry. 2002 Sep 17; 41(37):11126-33. PMID: 12220177.
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    152. Pikal-Cleland KA, Cleland JL, Anchordoquy TJ, Carpenter JF. Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems. J Pharm Sci. 2002 Sep; 91(9):1969-79. PMID: 12210044.
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    153. Webb SD, Golledge SL, Cleland JL, Carpenter JF, Randolph TW. Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations. J Pharm Sci. 2002 Jun; 91(6):1474-87. PMID: 12115847.
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    154. Dong A, Malecki JM, Lee L, Carpenter JF, Lee JC. Ligand-induced conformational and structural dynamics changes in Escherichia coli cyclic AMP receptor protein. Biochemistry. 2002 May 28; 41(21):6660-7. PMID: 12022869.
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    155. Kim YS, Randolph TW, Stevens FJ, Carpenter JF. Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies. J Biol Chem. 2002 Jul 26; 277(30):27240-6. PMID: 12023282.
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    156. Krishnan S, Chi EY, Webb JN, Chang BS, Shan D, Goldenberg M, Manning MC, Randolph TW, Carpenter JF. Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition. Biochemistry. 2002 May 21; 41(20):6422-31. PMID: 12009905.
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    157. Fields PA, Kim YS, Carpenter JF, Somero GN. Temperature adaptation in Gillichthys (Teleost: Gobiidae) A(4)-lactate dehydrogenases: identical primary structures produce subtly different conformations. J Exp Biol. 2002 May; 205(Pt 9):1293-303. PMID: 11948206.
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    158. Carpenter JF, Manning MC, Randolph TW. Long-term storage of proteins. Curr Protoc Protein Sci. 2002 May; Chapter 4:Unit 4.6. PMID: 18429236.
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    159. St John RJ, Carpenter JF, Randolph TW. High-pressure refolding of disulfide-cross-linked lysozyme aggregates: thermodynamics and optimization. Biotechnol Prog. 2002 May-Jun; 18(3):565-71. PMID: 12052074.
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    160. Randolph TW, Seefeldt M, Carpenter JF. High hydrostatic pressure as a tool to study protein aggregation and amyloidosis. Biochim Biophys Acta. 2002 Mar 25; 1595(1-2):224-34. PMID: 11983398.
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    161. Webb SD, Cleland JL, Carpenter JF, Randolph TW. A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20. J Pharm Sci. 2002 Feb; 91(2):543-58. PMID: 11835212.
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    162. Carpenter JF, Chang BS, Garzon-Rodriguez W, Randolph TW. Rational design of stable lyophilized protein formulations: theory and practice. Pharm Biotechnol. 2002; 13:109-33. PMID: 11987749.
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    163. Stratton LP, Kelly RM, Rowe J, Shively JE, Smith DD, Carpenter JF, Manning MC. Controlling deamidation rates in a model peptide: effects of temperature, peptide concentration, and additives. J Pharm Sci. 2001 Dec; 90(12):2141-8. PMID: 11745773.
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    164. St John RJ, Carpenter JF, Balny C, Randolph TW. High pressure refolding of recombinant human growth hormone from insoluble aggregates. Structural transformations, kinetic barriers, and energetics. J Biol Chem. 2001 Dec 14; 276(50):46856-63. PMID: 11591710.
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    165. Jones LS, Randolph TW, Kohnert U, Papadimitriou A, Winter G, Hagmann ML, Manning MC, Carpenter JF. The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution. J Pharm Sci. 2001 Oct; 90(10):1466-77. PMID: 11745706.
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    166. Pikal-Cleland KA, Carpenter JF. Lyophilization-induced protein denaturation in phosphate buffer systems: monomeric and tetrameric beta-galactosidase. J Pharm Sci. 2001 Sep; 90(9):1255-68. PMID: 11745778.
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    167. Searles JA, Carpenter JF, Randolph TW. The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf. J Pharm Sci. 2001 Jul; 90(7):860-71. PMID: 11458335.
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    168. Searles JA, Carpenter JF, Randolph TW. Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilization. J Pharm Sci. 2001 Jul; 90(7):872-87. PMID: 11458336.
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    169. Sellers SP, Clark GS, Sievers RE, Carpenter JF. Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO(2)-assisted aerosolization. J Pharm Sci. 2001 Jun; 90(6):785-97. PMID: 11357179.
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    170. Anchordoquy TJ, Izutsu KI, Randolph TW, Carpenter JF. Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying. Arch Biochem Biophys. 2001 Jun 01; 390(1):35-41. PMID: 11368512.
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    171. Webb JN, Webb SD, Cleland JL, Carpenter JF, Randolph TW. Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: high-pressure and cosolute studies on recombinant human IFN-gamma. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7259-64. PMID: 11381145; PMCID: PMC34656.
    172. Cleland JL, Lam X, Kendrick B, Yang J, Yang TH, Overcashier D, Brooks D, Hsu C, Carpenter JF. A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody. J Pharm Sci. 2001 Mar; 90(3):310-21. PMID: 11170024.
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    173. Arakawa T, Prestrelski SJ, Kenney WC, Carpenter JF. Factors affecting short-term and long-term stabilities of proteins. Adv Drug Deliv Rev. 2001 Mar 01; 46(1-3):307-26. PMID: 11259845.
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    174. Kim YS, Cape SP, Chi E, Raffen R, Wilkins-Stevens P, Stevens FJ, Manning MC, Randolph TW, Solomon A, Carpenter JF. Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains. J Biol Chem. 2001 Jan 12; 276(2):1626-33. PMID: 11050093.
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    175. Podrabsky JE, Carpenter JF, Hand SC. Survival of water stress in annual fish embryos: dehydration avoidance and egg envelope amyloid fibers. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R123-31. PMID: 11124142.
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    176. Nielsen L, Frokjaer S, Carpenter JF, Brange J. Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy. J Pharm Sci. 2001 Jan; 90(1):29-37. PMID: 11064376.
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    177. Pikal-Cleland KA, Rodríguez-Hornedo N, Amidon GL, Carpenter JF. Protein denaturation during freezing and thawing in phosphate buffer systems: monomeric and tetrameric beta-galactosidase. Arch Biochem Biophys. 2000 Dec 15; 384(2):398-406. PMID: 11368330.
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    178. DePaz RA, Barnett CC, Dale DA, Carpenter JF, Gaertner AL, Randolph TW. The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin. Arch Biochem Biophys. 2000 Dec 01; 384(1):123-32. PMID: 11147823.
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    179. Yang TH, Cleland JL, Lam X, Meyer JD, Jones LS, Randolph TW, Manning MC, Carpenter JF. Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor. J Pharm Sci. 2000 Nov; 89(11):1480-5. PMID: 11015692.
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    180. Dong A, Meyer JD, Brown JL, Manning MC, Carpenter JF. Comparative fourier transform infrared and circular dichroism spectroscopic analysis of alpha1-proteinase inhibitor and ovalbumin in aqueous solution. Arch Biochem Biophys. 2000 Nov 01; 383(1):148-55. PMID: 11097188.
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    181. Dong A, Randolph TW, Carpenter JF. Entrapping intermediates of thermal aggregation in alpha-helical proteins with low concentration of guanidine hydrochloride. J Biol Chem. 2000 Sep 08; 275(36):27689-93. PMID: 10871628.
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    182. Webb JN, Carpenter JF, Randolph TW. Stability of subtilisin and lysozyme under high hydrostatic pressure. Biotechnol Prog. 2000 Jul-Aug; 16(4):630-6. PMID: 10933838.
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    183. Lin JJ, Meyer JD, Carpenter JF, Manning MC. Stability of human serum albumin during bioprocessing: denaturation and aggregation during processing of albumin paste. Pharm Res. 2000 Apr; 17(4):391-6. PMID: 10870981.
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    184. Allison SD, Manning MC, Randolph TW, Middleton K, Davis A, Carpenter JF. Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran. J Pharm Sci. 2000 Feb; 89(2):199-214. PMID: 10688749.
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    185. Kim Y, Wall JS, Meyer J, Murphy C, Randolph TW, Manning MC, Solomon A, Carpenter JF. Thermodynamic modulation of light chain amyloid fibril formation. J Biol Chem. 2000 Jan 21; 275(3):1570-4. PMID: 10636846.
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    186. St John RJ, Carpenter JF, Randolph TW. High pressure fosters protein refolding from aggregates at high concentrations. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13029-33. PMID: 10557267; PMCID: PMC23894.
    187. Allison SD, Chang B, Randolph TW, Carpenter JF. Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. Arch Biochem Biophys. 1999 May 15; 365(2):289-98. PMID: 10328824.
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    188. Heller MC, Carpenter JF, Randolph TW. Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation. Biotechnol Bioeng. 1999 Apr 20; 63(2):166-74. PMID: 10099593.
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    189. Heller MC, Carpenter JF, Randolph TW. Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization. Arch Biochem Biophys. 1999 Mar 15; 363(2):191-201. PMID: 10068440.
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    190. Kreilgaard L, Frokjaer S, Flink JM, Randolph TW, Carpenter JF. Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid. J Pharm Sci. 1999 Mar; 88(3):281-90. PMID: 10052984.
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    191. Yang TH, Dong A, Meyer J, Johnson OL, Cleland JL, Carpenter JF. Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres. J Pharm Sci. 1999 Feb; 88(2):161-5. PMID: 9950632.
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    192. Heller MC, Carpenter JF, Randolph TW. Conformational stability of lyophilized PEGylated proteins in a phase-separating system. J Pharm Sci. 1999 Jan; 88(1):58-64. PMID: 9874703.
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    193. Carpenter JF, Kendrick BS, Chang BS, Manning MC, Randolph TW. Inhibition of stress-induced aggregation of protein therapeutics. Methods Enzymol. 1999; 309:236-55. PMID: 10507028.
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    194. Kreilgaard L, Frokjaer S, Flink JM, Randolph TW, Carpenter JF. Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid. Arch Biochem Biophys. 1998 Dec 01; 360(1):121-34. PMID: 9826437.
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    195. Bam NB, Cleland JL, Yang J, Manning MC, Carpenter JF, Kelley RF, Randolph TW. Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions. J Pharm Sci. 1998 Dec; 87(12):1554-9. PMID: 10189266.
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    196. Li N, Kendrick BS, Manning MC, Carpenter JF, Duman JG. Secondary structure of antifreeze proteins from overwintering larvae of the beetle Dendroides canadensis. Arch Biochem Biophys. 1998 Dec 01; 360(1):25-32. PMID: 9826425.
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    197. Kreilgaard L, Jones LS, Randolph TW, Frokjaer S, Flink JM, Manning MC, Carpenter JF. Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII. J Pharm Sci. 1998 Dec; 87(12):1597-603. PMID: 10189273.
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    198. Kendrick BS, Carpenter JF, Cleland JL, Randolph TW. A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14142-6. PMID: 9826667; PMCID: PMC24340.
    199. Allison SD, Randolph TW, Manning MC, Middleton K, Davis A, Carpenter JF. Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition. Arch Biochem Biophys. 1998 Oct 01; 358(1):171-81. PMID: 9750178.
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    200. Kendrick BS, Cleland JL, Lam X, Nguyen T, Randolph TW, Manning MC, Carpenter JF. Aggregation of recombinant human interferon gamma: kinetics and structural transitions. J Pharm Sci. 1998 Sep; 87(9):1069-76. PMID: 9724556.
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    201. Anchordoquy TJ, Girouard LG, Carpenter JF, Kroll DJ. Stability of lipid/DNA complexes during agitation and freeze-thawing. J Pharm Sci. 1998 Sep; 87(9):1046-51. PMID: 9724553.
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    202. Dong A, Matsuura J, Manning MC, Carpenter JF. Intermolecular beta-sheet results from trifluoroethanol-induced nonnative alpha-helical structure in beta-sheet predominant proteins: infrared and circular dichroism spectroscopic study. Arch Biochem Biophys. 1998 Jul 15; 355(2):275-81. PMID: 9675038.
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    203. Carpenter JF, Prestrelski SJ, Dong A. Application of infrared spectroscopy to development of stable lyophilized protein formulations. Eur J Pharm Biopharm. 1998 May; 45(3):231-8. PMID: 9653627.
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    204. Crowe JH, Carpenter JF, Crowe LM. The role of vitrification in anhydrobiosis. Annu Rev Physiol. 1998; 60:73-103. PMID: 9558455.
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    205. Anchordoquy TJ, Carpenter JF, Kroll DJ. Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration. Arch Biochem Biophys. 1997 Dec 01; 348(1):199-206. PMID: 9390192.
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    206. Dong A, Kendrick B, Kreilgârd L, Matsuura J, Manning MC, Carpenter JF. Spectroscopic study of secondary structure and thermal denaturation of recombinant human factor XIII in aqueous solution. Arch Biochem Biophys. 1997 Nov 15; 347(2):213-20. PMID: 9367527.
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    207. Kendrick BS, Meyer JD, Matsuura JE, Carpenter JF, Manning MC. Hydrophobic ion pairing as a method for enhancing structure and activity of lyophilized subtilisin BPN' suspended in isooctane. Arch Biochem Biophys. 1997 Nov 01; 347(1):113-8. PMID: 9344471.
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    208. Remmele RL, Stushnoff C, Carpenter JF. Real-time in situ monitoring of lysozyme during lyophilization using infrared spectroscopy: dehydration stress in the presence of sucrose. Pharm Res. 1997 Nov; 14(11):1548-55. PMID: 9434273.
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    209. Kendrick BS, Chang BS, Arakawa T, Peterson B, Randolph TW, Manning MC, Carpenter JF. Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):11917-22. PMID: 9342337; PMCID: PMC23655.
    210. Heller MC, Carpenter JF, Randolph TW. Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteins. Biotechnol Prog. 1997 Sep-Oct; 13(5):590-6. PMID: 9336978.
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    211. Stratton LP, Dong A, Manning MC, Carpenter JF. Drug delivery matrix containing native protein precipitates suspended in a poloxamer gel. J Pharm Sci. 1997 Sep; 86(9):1006-10. PMID: 9294813.
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    212. Carpenter JF, Pikal MJ, Chang BS, Randolph TW. Rational design of stable lyophilized protein formulations: some practical advice. Pharm Res. 1997 Aug; 14(8):969-75. PMID: 9279875.
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    213. Dong A, Kery V, Matsuura J, Manning MC, Kraus JP, Carpenter JF. Secondary structure of recombinant human cystathionine beta-synthase in aqueous solution: effect of ligand binding and proteolytic truncation. Arch Biochem Biophys. 1997 Aug 01; 344(1):125-32. PMID: 9244389.
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    214. Griffin KJ, Dwyer TM, Manning MC, Meyer JD, Carpenter JF, Frerman FE. alphaT244M mutation affects the redox, kinetic, and in vitro folding properties of Paracoccus denitrificans electron transfer flavoprotein. Biochemistry. 1997 Apr 08; 36(14):4194-202. PMID: 9100014.
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    215. Chang BS, Beauvais RM, Arakawa T, Narhi LO, Dong A, Aparisio DI, Carpenter JF. Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution. Biophys J. 1996 Dec; 71(6):3399-406. PMID: 8968609; PMCID: PMC1233827.
    216. Heller MC, Carpenter JF, Randolph TW. Effects of phase separating systems on lyophilized hemoglobin. J Pharm Sci. 1996 Dec; 85(12):1358-62. PMID: 8961153.
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    217. Chang BS, Kendrick BS, Carpenter JF. Surface-induced denaturation of proteins during freezing and its inhibition by surfactants. J Pharm Sci. 1996 Dec; 85(12):1325-30. PMID: 8961147.
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    218. Dong A, Meyer JD, Kendrick BS, Manning MC, Carpenter JF. Effect of secondary structure on the activity of enzymes suspended in organic solvents. Arch Biochem Biophys. 1996 Oct 15; 334(2):406-14. PMID: 8900418.
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    219. Allison SD, Dong A, Carpenter JF. Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration. Biophys J. 1996 Oct; 71(4):2022-32. PMID: 8889176; PMCID: PMC1233668.
    220. Izutsu K, Yoshioka S, Kojima S, Randolph TW, Carpenter JF. Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: phase separation between incompatible polymers. Pharm Res. 1996 Sep; 13(9):1393-400. PMID: 8893281.
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    221. Chao H, Davies PL, Carpenter JF. Effects of antifreeze proteins on red blood cell survival during cryopreservation. J Exp Biol. 1996 Sep; 199(Pt 9):2071-6. PMID: 8831147.
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    222. Anchordoquy TJ, Carpenter JF. Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state. Arch Biochem Biophys. 1996 Aug 15; 332(2):231-8. PMID: 8806730.
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    223. Chang BS, Beauvais RM, Dong A, Carpenter JF. Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation. Arch Biochem Biophys. 1996 Jul 15; 331(2):249-58. PMID: 8660705.
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    224. Dong A, Matsuura J, Allison SD, Chrisman E, Manning MC, Carpenter JF. Infrared and circular dichroism spectroscopic characterization of structural differences between beta-lactoglobulin A and B. Biochemistry. 1996 Feb 06; 35(5):1450-7. PMID: 8634275.
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    225. Chang BS, Reeder G, Carpenter JF. Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist. Pharm Res. 1996 Feb; 13(2):243-9. PMID: 8932444.
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    226. Kendrick BS, Dong A, Allison SD, Manning MC, Carpenter JF. Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states. J Pharm Sci. 1996 Feb; 85(2):155-8. PMID: 8683440.
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    227. Manning MC, Matsuura JE, Kendrick BS, Meyer JD, Dormish JJ, Vrkljan M, Ruth JR, Carpenter JF, Sheftert E. Approaches for increasing the solution stability of proteins. Biotechnol Bioeng. 1995 Dec 05; 48(5):506-12. PMID: 18623515.
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    228. Dong A, Prestrelski SJ, Allison SD, Carpenter JF. Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation. J Pharm Sci. 1995 Apr; 84(4):415-24. PMID: 7629730.
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    229. Vrkljan M, Foster TM, Powers ME, Henkin J, Porter WR, Staack H, Carpenter JF, Manning MC. Thermal stability of low molecular weight urokinase during heat treatment. II. Effect of polymeric additives. Pharm Res. 1994 Jul; 11(7):1004-8. PMID: 7937540.
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    230. Prestrelski SJ, Tedeschi N, Arakawa T, Carpenter JF. Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers. Biophys J. 1993 Aug; 65(2):661-71. PMID: 7693001; PMCID: PMC1225768.
    231. Hansen TN, Carpenter JF. Calorimetric determination of inhibition of ice crystal growth by antifreeze protein in hydroxyethyl starch solutions. Biophys J. 1993 Jun; 64(6):1843-50. PMID: 7690257; PMCID: PMC1262518.
    232. Prestrelski SJ, Arakawa T, Carpenter JF. Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy. Arch Biochem Biophys. 1993 Jun; 303(2):465-73. PMID: 8512329.
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    233. Carpenter JF, Prestrelski SJ, Arakawa T. Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies. Arch Biochem Biophys. 1993 Jun; 303(2):456-64. PMID: 8512328.
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    234. Carpenter JF, Hansen TN. Antifreeze protein modulates cell survival during cryopreservation: mediation through influence on ice crystal growth. Proc Natl Acad Sci U S A. 1992 Oct 01; 89(19):8953-7. PMID: 1409591; PMCID: PMC50042.
    235. Anchordoguy TJ, Carpenter JF, Crowe JH, Crowe LM. Temperature-dependent perturbation of phospholipid bilayers by dimethylsulfoxide. Biochim Biophys Acta. 1992 Feb 17; 1104(1):117-22. PMID: 1550838.
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    236. Carpenter JF, Arakawa T, Crowe JH. Interactions of stabilizing additives with proteins during freeze-thawing and freeze-drying. Dev Biol Stand. 1992; 74:225-38; discussion 238-9. PMID: 1592173.
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    237. Brooks RR, Carpenter JF, Jones SM, Ziegler TC, Pong SF. Canine carrageenin-induced acute paw inflammation model and its response to nonsteroidal antiinflammatory drugs. J Pharmacol Methods. 1991 Jul; 25(4):275-83. PMID: 1909406.
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    238. Carpenter JF, Dawson PE. Quantitation of dimethyl sulfoxide in solutions and tissues by high-performance liquid chromatography. Cryobiology. 1991 Jun; 28(3):210-5. PMID: 1864079.
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    239. Arakawa T, Kita Y, Carpenter JF. Protein--solvent interactions in pharmaceutical formulations. Pharm Res. 1991 Mar; 8(3):285-91. PMID: 2052513.
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    240. Anchordoguy TJ, Carpenter JF, Cecchini CA, Crowe JH, Crowe LM. Effects of protein perturbants on phospholipid bilayers. Arch Biochem Biophys. 1990 Dec; 283(2):356-61. PMID: 2275547.
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    241. Brooks RR, Miller KE, Carpenter JF, Jones SM. Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents. Proc Soc Exp Biol Med. 1989 Jun; 191(2):201-9. PMID: 2726785.
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    242. Carpenter JF, Crowe JH. An infrared spectroscopic study of the interactions of carbohydrates with dried proteins. Biochemistry. 1989 May 02; 28(9):3916-22. PMID: 2526652.
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    243. Anchordoguy T, Carpenter JF, Loomis SH, Crowe JH. Mechanisms of interaction of amino acids with phospholipid bilayers during freezing. Biochim Biophys Acta. 1988 Dec 22; 946(2):299-306. PMID: 3207747.
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    244. Hazen KC, Bourgeois LD, Carpenter JF. Cryoprotection of antibody by organic solutes and organic solute/divalent cation mixtures. Arch Biochem Biophys. 1988 Nov 15; 267(1):363-71. PMID: 3196034.
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    245. Carpenter JF, Martin B, Loomis SH, Crowe JH. Long-term preservation of dried phosphofructokinase by sugars and sugar/zinc mixtures. Cryobiology. 1988 Aug; 25(4):372-6. PMID: 2970370.
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    246. Crowe JH, Crowe LM, Carpenter JF, Rudolph AS, Wistrom CA, Spargo BJ, Anchordoguy TJ. Interactions of sugars with membranes. Biochim Biophys Acta. 1988 Jun 09; 947(2):367-84. PMID: 3285894.
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    247. Carpenter JF, Crowe JH. The mechanism of cryoprotection of proteins by solutes. Cryobiology. 1988 Jun; 25(3):244-55. PMID: 3396389.
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    248. Carpenter JF, Martin B, Crowe LM, Crowe JH. Stabilization of phosphofructokinase during air-drying with sugars and sugar/transition metal mixtures. Cryobiology. 1987 Oct; 24(5):455-64. PMID: 2958239.
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    249. Anchordoguy TJ, Rudolph AS, Carpenter JF, Crowe JH. Modes of interaction of cryoprotectants with membrane phospholipids during freezing. Cryobiology. 1987 Aug; 24(4):324-31. PMID: 3621976.
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    250. Crowe JH, Crowe LM, Carpenter JF, Aurell Wistrom C. Stabilization of dry phospholipid bilayers and proteins by sugars. Biochem J. 1987 Feb 15; 242(1):1-10. PMID: 2954537; PMCID: PMC1147656.
    251. Carpenter JF, Crowe LM, Crowe JH. Stabilization of phosphofructokinase with sugars during freeze-drying: characterization of enhanced protection in the presence of divalent cations. Biochim Biophys Acta. 1987 Jan 20; 923(1):109-15. PMID: 2948571.
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    252. Carpenter JF, Hand SC, Crowe LM, Crowe JH. Cryoprotection of phosphofructokinase with organic solutes: characterization of enhanced protection in the presence of divalent cations. Arch Biochem Biophys. 1986 Nov 01; 250(2):505-12. PMID: 2946263.
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    253. Carpenter JF, Hand SC. Comparison of pH-dependent allostery and dissociation for phosphofructokinases from Artemia embryos and rabbit muscle: nature of the enzymes acylated with diethylpyrocarbonate. Arch Biochem Biophys. 1986 Jul; 248(1):1-9. PMID: 2942107.
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    254. Hand SC, Carpenter JF. pH-Induced Metabolic Transitions in Artemia Embryos Mediated by a Novel Hysteretic Trehalase. Science. 1986 Jun 20; 232(4757):1535-7. PMID: 17773504.
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    255. Carpenter JF, Hand SC. Reversible dissociation and inactivation of phosphofructokinase in the ischemic rat heart. Am J Physiol. 1986 Mar; 250(3 Pt 2):R512-8. PMID: 2937315.
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    256. Hand SC, Carpenter JF. pH-induced hysteretic properties of phosphofructokinase purified from rat myocardium. Am J Physiol. 1986 Mar; 250(3 Pt 2):R505-11. PMID: 2937314.
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    257. Brattain MG, Kimball PM, Durant JR, Pretlow TG, Smith D, Carpenter J, Marks M. Urinary hexosaminidase in patients with lung carcinoma. Cancer. 1979 Dec; 44(6):2267-72. PMID: 228842.
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    258. Ellis KO, Wessels FL, Carpenter JF. Effects of intravenous dantrolene sodium on respiratory and cardiovascular functions. J Pharm Sci. 1976 Sep; 65(9):1359-64. PMID: 966155.
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    259. Ellis KO, Carpenter JF. Mechanism of control of skeletal-muscle contraction by dantrolene sodium. Arch Phys Med Rehabil. 1974 Aug; 55(8):362-9. PMID: 4368898.
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