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David A Siegel

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-3517

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Siegel DA, Li J, Ding H, Singh SD, King JB, Pollack LA. Racial and ethnic differences in survival of pediatric patients with brain and central nervous system cancer in the United States. Pediatr Blood Cancer. 2018 Oct 23; e27501. PMID: 30350913.
      View in: PubMed
    2. Siegel DA, Li J, Henley SJ, Wilson RJ, Lunsford NB, Tai E, Van Dyne EA. Geographic Variation in Pediatric Cancer Incidence - United States, 2003-2014. MMWR Morb Mortal Wkly Rep. 2018 Jun 29; 67(25):707-713. PMID: 29953430.
      View in: PubMed
    3. Siegel DA, Henley SJ, Wike JM, Ryerson AB, Johnson CJ, Rees JR, Pollack LA. Capture of tobacco use among population-based registries: Findings from 10 National Program of Cancer Registries states. Cancer. 2018 Jun 01; 124(11):2381-2389. PMID: 29579317.
      View in: PubMed
    4. Li J, Siegel DA, King JB. Stage-specific incidence rates and trends of prostate cancer by age, race, and ethnicity, United States, 2004-2014. Ann Epidemiol. 2018 May; 28(5):328-330. PMID: 29678312.
      View in: PubMed
    5. Muller-Karger FE, Hestir E, Ade C, Turpie K, Roberts DA, Siegel D, Miller RJ, Humm D, Izenberg N, Keller M, Morgan F, Frouin R, Dekker AG, Gardner R, Goodman J, Schaeffer B, Franz BA, Pahlevan N, Mannino AG, Concha JA, Ackleson SG, Cavanaugh KC, Romanou A, Tzortziou M, Boss ES, Pavlick R, Freeman A, Rousseaux CS, Dunne J, Long MC, Klein E, McKinley GA, Goes J, Letelier R, Kavanaugh M, Roffer M, Bracher A, Arrigo KR, Dierssen H, Zhang X, Davis FW, Best B, Guralnick R, Moisan J, Sosik HM, Kudela R, Mouw CB, Barnard AH, Palacios S, Roesler C, Drakou EG, Appeltans W, Jetz W. Satellite sensor requirements for monitoring essential biodiversity variables of coastal ecosystems. Ecol Appl. 2018 Apr; 28(3):749-760. PMID: 29509310.
      View in: PubMed
    6. Vogl DT, Dingli D, Cornell RF, Huff CA, Jagannath S, Bhutani D, Zonder J, Baz R, Nooka A, Richter J, Cole C, Vij R, Jakubowiak A, Abonour R, Schiller G, Parker TL, Costa LJ, Kaminetzky D, Hoffman JE, Yee AJ, Chari A, Siegel D, Fonseca R, Van Wier S, Ahmann G, Lopez I, Kauffman M, Shacham S, Saint-Martin JR, Picklesimer CD, Choe-Juliak C, Stewart AK. Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma. J Clin Oncol. 2018 Mar 20; 36(9):859-866. PMID: 29381435.
      View in: PubMed
    7. Siegel D, Dehn DD, Bokatzian SS, Quinn K, Backos DS, Di Francesco A, Bernier M, Reisdorph N, de Cabo R, Ross D. Redox modulation of NQO1. PLoS One. 2018; 13(1):e0190717. PMID: 29298345.
      View in: PubMed
    8. Tai EW, Ward KC, Bonaventure A, Siegel DA, Coleman MP. Survival among children diagnosed with acute lymphoblastic leukemia in the United States, by race and age, 2001 to 2009: Findings from the CONCORD-2 study. Cancer. 2017 Dec 15; 123 Suppl 24:5178-5189. PMID: 29205314.
      View in: PubMed
    9. Lamy T, Reed DC, Rassweiler A, Siegel DA, Kui L, Bell TW, Simons RD, Miller RJ. Scale-specific drivers of kelp forest communities. Oecologia. 2018 Jan; 186(1):217-233. PMID: 29101467.
      View in: PubMed
    10. Siegel DA, Henley SJ, Li J, Pollack LA, Van Dyne EA, White A. Rates and Trends of Pediatric Acute Lymphoblastic Leukemia - United States, 2001-2014. MMWR Morb Mortal Wkly Rep. 2017 Sep 15; 66(36):950-954. PMID: 28910269.
      View in: PubMed
    11. Ross D, Siegel D. Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch. Front Physiol. 2017; 8:595. PMID: 28883796.
      View in: PubMed
    12. Siegel DA, Claridy M, Mertens A, George E, Vangile K, Simoneaux SF, Meacham LR, Wasilewski-Masker K. Risk factors and surveillance for reduced bone mineral density in pediatric cancer survivors. Pediatr Blood Cancer. 2017 Sep; 64(9). PMID: 28233475.
      View in: PubMed
    13. Castorani MC, Reed DC, Raimondi PT, Alberto F, Bell TW, Cavanaugh KC, Siegel DA, Simons RD. Fluctuations in population fecundity drive variation in demographic connectivity and metapopulation dynamics. Proc Biol Sci. 2017 01 25; 284(1847). PMID: 28123088.
      View in: PubMed
    14. Siegel DA, Wilson R, Wilkinson EJ, Gargano JW, Watson M, Hernandez BY, Goodman MT, Lynch CF, Unger ER, Saraiya M. Evaluation of the Vulvar Cancer Histology Code Reported by Central Cancer Registries: Importance in Epidemiology. Arch Pathol Lab Med. 2017 Jan; 141(1):139-143. PMID: 27763794.
      View in: PubMed
    15. Di Francesco A, Di Germanio C, Panda AC, Huynh P, Peaden R, Navas-Enamorado I, Bastian P, Lehrmann E, Diaz-Ruiz A, Ross D, Siegel D, Martindale JL, Bernier M, Gorospe M, Abdelmohsen K, de Cabo R. Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation. Free Radic Biol Med. 2016 10; 99:225-233. PMID: 27515817.
      View in: PubMed
    16. Castorani MC, Reed DC, Alberto F, Bell TW, Simons RD, Cavanaugh KC, Siegel DA, Raimondi PT. Connectivity structures local population dynamics: a long-term empirical test in a large metapopulation system. Ecology. 2015 Dec; 96(12):3141-52. PMID: 26909421.
      View in: PubMed
    17. Pondella DJ, Zahn LA, Love MS, Siegel D, Bernstein BB. Modeling fish production for southern California's petroleum platforms. Integr Environ Assess Manag. 2015 Oct; 11(4):584-93. PMID: 26331484.
      View in: PubMed
    18. Johansson ML, Alberto F, Reed DC, Raimondi PT, Coelho NC, Young MA, Drake PT, Edwards CA, Cavanaugh K, Assis J, Ladah LB, Bell TW, Coyer JA, Siegel DA, Serrão EA. Seascape drivers of Macrocystis pyrifera population genetic structure in the northeast Pacific. Mol Ecol. 2015 Oct; 24(19):4866-85. PMID: 26339775.
      View in: PubMed
    19. Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T a-Synuclein Toxicity. Mol Pharmacol. 2015 Dec; 88(6):1045-54. PMID: 26405178; PMCID: PMC4658594 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    20. Rowe S, Siegel D, Benjamin DK. Gaps in Drug Dosing for Obese Children: A Systematic Review of Commonly Prescribed Emergency Care Medications. Clin Ther. 2015 Sep 01; 37(9):1924-32. PMID: 26323523.
      View in: PubMed
    21. Harskamp-van Ginkel MW, Hill KD, Becker KC, Becker K, Testoni D, Cohen-Wolkowiez M, Gonzalez D, Barrett JS, Benjamin DK, Siegel DA, Banks P, Watt KM. Drug Dosing and Pharmacokinetics in Children With Obesity: A Systematic Review. JAMA Pediatr. 2015 Jul; 169(7):678-85. PMID: 25961828.
      View in: PubMed
    22. Blunt CE, Torcuk C, Liu Y, Lewis W, Siegel D, Ross D, Moody CJ. Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8740-5. PMID: 26096359.
      View in: PubMed
    23. Liu L, Siegel DA, Chen W, Liu P, Guo J, Duscher G, Zhao C, Wang H, Wang W, Bai X, McCarty KF, Zhang Z, Gu G. Unusual role of epilayer-substrate interactions in determining orientational relations in van der Waals epitaxy. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16670-5. PMID: 25385622; PMCID: PMC4250159.
      View in: PubMed, PubMed Central
    24. Nadeem S, Sukumaran L, Siegel DA, Jernigan SM, Greenbaum LA. Fever of Unknown Origin (FUO) in a pediatric kidney transplant recipient: Questions and Answers. Pediatr Nephrol. 2015 Dec; 30(12):2109-13. PMID: 25315178.
      View in: PubMed
    25. Siegel DA, King J, Tai E, Buchanan N, Ajani UA, Li J. Cancer incidence rates and trends among children and adolescents in the United States, 2001-2009. Pediatrics. 2014 Oct; 134(4):e945-55. PMID: 25201796; PMCID: PMC4536809.
      View in: PubMed, PubMed Central
    26. Xiong R, Siegel D, Ross D. Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity. Toxicol Appl Pharmacol. 2014 Oct 15; 280(2):285-95. PMID: 25151970; PMCID: PMC4312139.
      View in: PubMed, PubMed Central
    27. Inman M, Visconti A, Yan C, Siegel D, Ross D, Moody CJ. Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells. Org Biomol Chem. 2014 Jul 21; 12(27):4848-61. PMID: 24848343; PMCID: PMC4495957.
      View in: PubMed, PubMed Central
    28. Carvalho C, Siegel D, Inman M, Xiong R, Ross D, Moody CJ. Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation. Org Biomol Chem. 2014 May 07; 12(17):2663-74. PMID: 24608884.
      View in: PubMed
    29. Chang CH, Drechsel DA, Kitson RR, Siegel D, You Q, Backos DS, Ju C, Moody CJ, Ross D. 19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol. 2014 Jun; 85(6):849-57. PMID: 24682466; PMCID: PMC4014664.
      View in: PubMed, PubMed Central
    30. Rassweiler A, Costello C, Hilborn R, Siegel DA. Integrating scientific guidance into marine spatial planning. Proc Biol Sci. 2014 Apr 22; 281(1781):20132252. PMID: 24573841; PMCID: PMC3953828.
      View in: PubMed, PubMed Central
    31. Cavanaugh KC, Siegel DA, Raimondi PT, Alberto F. Patch definition in metapopulation analysis: a graph theory approach to solve the mega-patch problem. Ecology. 2014 Feb; 95(2):316-28. PMID: 24669726.
      View in: PubMed
    32. Liu L, Park J, Siegel DA, McCarty KF, Clark KW, Deng W, Basile L, Idrobo JC, Li AP, Gu G. Heteroepitaxial growth of two-dimensional hexagonal boron nitride templated by graphene edges. Science. 2014 Jan 10; 343(6167):163-7. PMID: 24408431.
      View in: PubMed
    33. Siegel DA. Will you accept the government's friend request? Social networks and privacy concerns. PLoS One. 2013; 8(11):e80682. PMID: 24312236; PMCID: PMC3842270.
      View in: PubMed, PubMed Central
    34. Siegel DA, Chueh WC, El Gabaly F, McCarty KF, de la Figuera J, Blanco-Rey M. Determination of the surface structure of CeO2(111) by low-energy electron diffraction. J Chem Phys. 2013 Sep 21; 139(11):114703. PMID: 24070301.
      View in: PubMed
    35. Cohen-Wolkowiez M, Sampson M, Bloom BT, Arrieta A, Wynn JL, Martz K, Harper B, Kearns GL, Capparelli EV, Siegel D, Benjamin DK, Smith PB. Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants. Pediatr Infect Dis J. 2013 Sep; 32(9):956-61. PMID: 23587979.
      View in: PubMed
    36. Nie S, Starodub E, Monti M, Siegel DA, Vergara L, El Gabaly F, Bartelt NC, de la Figuera J, McCarty KF. Insight into magnetite's redox catalysis from observing surface morphology during oxidation. J Am Chem Soc. 2013 Jul 10; 135(27):10091-8. PMID: 23763580.
      View in: PubMed
    37. Xiong R, Siegel D, Ross D. The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells. Chem Biol Interact. 2013 Jul 05; 204(2):116-24. PMID: 23684743; PMCID: PMC3784407.
      View in: PubMed, PubMed Central
    38. Pasceri R, Siegel D, Ross D, Moody CJ. Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A. J Med Chem. 2013 Apr 25; 56(8):3310-7. PMID: 23521768.
      View in: PubMed
    39. Siegel DA, Regan W, Fedorov AV, Zettl A, Lanzara A. Charge-carrier screening in single-layer graphene. Phys Rev Lett. 2013 Apr 05; 110(14):146802. PMID: 25167021.
      View in: PubMed
    40. Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem. 2013 Apr; 5(4):307-14. PMID: 23511419.
      View in: PubMed
    41. Cavanaugh KC, Kendall BE, Siegel DA, Reed DC, Alberto F, Assis J. Synchrony in dynamics of giant kelp forests is driven by both local recruitment and regional environmental controls. Ecology. 2013 Feb; 94(2):499-509. PMID: 23691668.
      View in: PubMed
    42. Nelson NB, Siegel DA. The global distribution and dynamics of chromophoric dissolved organic matter. Ann Rev Mar Sci. 2013; 5:447-76. PMID: 22809178.
      View in: PubMed
    43. Siegel D, Kepa JK, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells. PLoS One. 2012; 7(9):e44861. PMID: 22984577; PMCID: PMC3439439.
      View in: PubMed, PubMed Central
    44. Rassweiler A, Costello C, Siegel DA. Marine protected areas and the value of spatially optimized fishery management. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11884-9. PMID: 22753469; PMCID: PMC3406815.
      View in: PubMed, PubMed Central
    45. Kostadinov TS, Siegel DA, Maritorena S, Guillocheau N. Optical assessment of particle size and composition in the Santa Barbara Channel, California. Appl Opt. 2012 Jun 01; 51(16):3171-89. PMID: 22695548.
      View in: PubMed
    46. Watson JR, Kendall BE, Siegel DA, Mitarai S. Changing seascapes, stochastic connectivity, and marine metapopulation dynamics. Am Nat. 2012 Jul; 180(1):99-112. PMID: 22673654.
      View in: PubMed
    47. Li Q, Schumacher W, Jablonski D, Siegel D, Uitto J. Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene. Br J Dermatol. 2012 May; 166(5):1107-11. PMID: 22229486; PMCID: PMC3336007.
      View in: PubMed, PubMed Central
    48. Siegel D, Yan C, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012 Apr 15; 83(8):1033-40. PMID: 22209713; PMCID: PMC3482497.
      View in: PubMed, PubMed Central
    49. Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D. Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling. Mol Pharmacol. 2012 Mar; 81(3):401-10. PMID: 22147753; PMCID: PMC3286294.
      View in: PubMed, PubMed Central
    50. Reed DC, Rassweiler A, Carr MH, Cavanaugh KC, Malone DP, Siegel DA. Wave disturbance overwhelms top-down and bottom-up control of primary production in California kelp forests. Ecology. 2011 Nov; 92(11):2108-16. PMID: 22164835.
      View in: PubMed
    51. Watson JR, Siegel DA, Kendall BE, Mitarai S, Rassweiller A, Gaines SD. Identifying critical regions in small-world marine metapopulations. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E907-13. PMID: 21987813; PMCID: PMC3203776.
      View in: PubMed, PubMed Central
    52. Siegel D, Jagannath S, Vesole DH, Borello I, Mazumder A, Mitsiades C, Goddard J, Dunbar J, Normant E, Adams J, Grayzel D, Anderson KC, Richardson P. A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma. Leuk Lymphoma. 2011 Dec; 52(12):2308-15. PMID: 21851215.
      View in: PubMed
    53. Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D. Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry. 2011 Aug 09; 50(31):6678-88. PMID: 21718050; PMCID: PMC3291479.
      View in: PubMed, PubMed Central
    54. Siegel DA, Park CH, Hwang C, Deslippe J, Fedorov AV, Louie SG, Lanzara A. Many-body interactions in quasi-freestanding graphene. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11365-9. PMID: 21709258; PMCID: PMC3136305.
      View in: PubMed, PubMed Central
    55. Watson JR, Hays CG, Raimondi PT, Mitarai S, Dong C, McWilliams JC, Blanchette CA, Caselle JE, Siegel DA. Currents connecting communities: nearshore community similarity and ocean circulation. Ecology. 2011 Jun; 92(6):1193-200. PMID: 21797147.
      View in: PubMed
    56. Alberto F, Raimondi PT, Reed DC, Watson JR, Siegel DA, Mitarai S, Coelho N, Serrão EA. Isolation by oceanographic distance explains genetic structure for Macrocystis pyrifera in the Santa Barbara Channel. Mol Ecol. 2011 Jun; 20(12):2543-54. PMID: 21535280.
      View in: PubMed
    57. Siegel D, Song X, Klontz K, Pastor W, Singh N. Epidemiology of childhood tuberculosis: use and evaluation of the pediatric health information system to assess local and national incidence. Pediatr Infect Dis J. 2011 May; 30(5):428-30. PMID: 21346685.
      View in: PubMed
    58. Dufour M, Yan C, Siegel D, Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Li Y, De Matteis CI, Ross D, Moody CJ. Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition. Chembiochem. 2011 May 16; 12(8):1203-8. PMID: 21506232; PMCID: PMC3880221.
      View in: PubMed, PubMed Central
    59. Siegel DA. Non-disruptive tactics of suppression are superior in countering terrorism, insurgency, and financial panics. PLoS One. 2011 Apr 13; 6(4):e18545. PMID: 21533247; PMCID: PMC3076430.
      View in: PubMed, PubMed Central
    60. Reigan P, Siegel D, Guo W, Ross D. A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins. Mol Pharmacol. 2011 May; 79(5):823-32. PMID: 21285336; PMCID: PMC3082934.
      View in: PubMed, PubMed Central
    61. Siegel D, Shieh B, Yan C, Kepa JK, Ross D. Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells. J Pharmacol Exp Ther. 2011 Mar; 336(3):874-80. PMID: 21156818; PMCID: PMC3061536.
      View in: PubMed, PubMed Central
    62. Ross D, Zhou H, Siegel D. Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function. Chem Biol Interact. 2011 Jun 30; 192(1-2):145-9. PMID: 20970411; PMCID: PMC3155573.
      View in: PubMed, PubMed Central
    63. Selkoe KA, Watson JR, White C, Horin TB, Iacchei M, Mitarai S, Siegel DA, Gaines SD, Toonen RJ. Taking the chaos out of genetic patchiness: seascape genetics reveals ecological and oceanographic drivers of genetic patterns in three temperate reef species. Mol Ecol. 2010 Sep; 19(17):3708-26. PMID: 20723063.
      View in: PubMed
    64. Siegel DA, Franz BA. Oceanography: Century of phytoplankton change. Nature. 2010 Jul 29; 466(7306):569, 571. PMID: 20671698.
      View in: PubMed
    65. Chan KM, Rajab NF, Siegel D, Din LB, Ross D, Inayat-Hussain SH. Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway. Toxicol Sci. 2010 Aug; 116(2):533-48. PMID: 20498002.
      View in: PubMed
    66. Zhou H, Dehn D, Kepa JK, Siegel D, Scott DE, Tan W, Ross D. NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010 Jul; 334(1):260-8. PMID: 20378716; PMCID: PMC2912043.
      View in: PubMed, PubMed Central
    67. Berkley HA, Kendall BE, Mitarai S, Siegel DA. Turbulent dispersal promotes species coexistence. Ecol Lett. 2010 Mar; 13(3):360-71. PMID: 20455921; PMCID: PMC2847191.
      View in: PubMed, PubMed Central
    68. Costello C, Rassweiler A, Siegel D, De Leo G, Micheli F, Rosenberg A. The value of spatial information in MPA network design. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18294-9. PMID: 20176962; PMCID: PMC2972921.
      View in: PubMed, PubMed Central
    69. White C, Selkoe KA, Watson J, Siegel DA, Zacherl DC, Toonen RJ. Ocean currents help explain population genetic structure. Proc Biol Sci. 2010 Jun 07; 277(1688):1685-94. PMID: 20133354; PMCID: PMC2871860.
      View in: PubMed, PubMed Central
    70. Nolan KA, Doncaster JR, Dunstan MS, Scott KA, Frenkel AD, Siegel D, Ross D, Barnes J, Levy C, Leys D, Whitehead RC, Stratford IJ, Bryce RA. Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26; 52(22):7142-56. PMID: 19877692.
      View in: PubMed
    71. Sprinkle M, Siegel D, Hu Y, Hicks J, Tejeda A, Taleb-Ibrahimi A, Le Fèvre P, Bertran F, Vizzini S, Enriquez H, Chiang S, Soukiassian P, Berger C, de Heer WA, Lanzara A, Conrad EH. First direct observation of a nearly ideal graphene band structure. Phys Rev Lett. 2009 Nov 27; 103(22):226803. PMID: 20366119.
      View in: PubMed
    72. Zhou H, Kepa JK, Siegel D, Miura S, Hiraki Y, Ross D. Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells. Mol Pharmacol. 2009 Sep; 76(3):579-87. PMID: 19525446; PMCID: PMC2730389.
      View in: PubMed, PubMed Central
    73. Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, Ross D. Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target. Mol Pharmacol. 2009 Jul; 76(1):163-72. PMID: 19364812; PMCID: PMC2701460.
      View in: PubMed, PubMed Central
    74. Siegel D, Merkel S, Koch M, Emmerling F, Nehls I. 3-{1-[(2,4-Dinitrophenyl)hydrazino]-ethyl-idene}-5-(1-methylpropyl)pyrrolidine-2,4-dione. Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 08; 65(Pt 5):o988-9. PMID: 21584026; PMCID: PMC2977683.
      View in: PubMed, PubMed Central
    75. Guo W, Siegel D, Ross D. Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation. J Pharm Sci. 2008 Dec; 97(12):5147-57. PMID: 18393300; PMCID: PMC2580801.
      View in: PubMed, PubMed Central
    76. Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Mol Pharmacol. 2008 Dec; 74(6):1657-65. PMID: 18794327; PMCID: PMC2612562.
      View in: PubMed, PubMed Central
    77. Zhou SY, Siegel DA, Fedorov AV, Lanzara A. Metal to insulator transition in epitaxial graphene induced by molecular doping. Phys Rev Lett. 2008 Aug 22; 101(8):086402. PMID: 18764644.
      View in: PubMed
    78. Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct; 36(10):2050-7. PMID: 18635747; PMCID: PMC2574845.
      View in: PubMed, PubMed Central
    79. Siegel DA, Mitarai S, Costello CJ, Gaines SD, Kendall BE, Warner RR, Winters KB. The stochastic nature of larval connectivity among nearshore marine populations. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8974-9. PMID: 18577590; PMCID: PMC2449349.
      View in: PubMed, PubMed Central
    80. White C, Kendall BE, Gaines S, Siegel DA, Costello C. Marine reserve effects on fishery profit. Ecol Lett. 2008 Apr; 11(4):370-9. PMID: 18205836; PMCID: PMC2268951.
      View in: PubMed, PubMed Central
    81. Nolan KA, Zhao H, Faulder PF, Frenkel AD, Timson DJ, Siegel D, Ross D, Burke TR, Stratford IJ, Bryce RA. Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity. J Med Chem. 2007 Dec 13; 50(25):6316-25. PMID: 17999461.
      View in: PubMed
    82. Colucci MA, Reigan P, Siegel D, Chilloux A, Ross D, Moody CJ. Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity. J Med Chem. 2007 Nov 15; 50(23):5780-9. PMID: 17944451; PMCID: PMC2536657.
      View in: PubMed, PubMed Central
    83. McGillicuddy DJ, Anderson LA, Bates NR, Bibby T, Buesseler KO, Carlson CA, Davis CS, Ewart C, Falkowski PG, Goldthwait SA, Hansell DA, Jenkins WJ, Johnson R, Kosnyrev VK, Ledwell JR, Li QP, Siegel DA, Steinberg DK. Eddy/wind interactions stimulate extraordinary mid-ocean plankton blooms. Science. 2007 May 18; 316(5827):1021-6. PMID: 17510363.
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    84. Buesseler KO, Lamborg CH, Boyd PW, Lam PJ, Trull TW, Bidigare RR, Bishop JK, Casciotti KL, Dehairs F, Elskens M, Honda M, Karl DM, Siegel DA, Silver MW, Steinberg DK, Valdes J, Van Mooy B, Wilson S. Revisiting carbon flux through the ocean's twilight zone. Science. 2007 Apr 27; 316(5824):567-70. PMID: 17463282.
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    85. Reigan P, Colucci MA, Siegel D, Chilloux A, Moody CJ, Ross D. Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells. Biochemistry. 2007 May 22; 46(20):5941-50. PMID: 17455910.
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    86. Siegel D, Kepa JK, Ross D. Biochemical and genetic analysis of NAD(P)H:quinone oxidoreductase 1 (NQO1). Curr Protoc Toxicol. 2007; Chapter 4:Unit4.22. PMID: 23045144.
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    87. Behrenfeld MJ, O'Malley RT, Siegel DA, McClain CR, Sarmiento JL, Feldman GC, Milligan AJ, Falkowski PG, Letelier RM, Boss ES. Climate-driven trends in contemporary ocean productivity. Nature. 2006 Dec 07; 444(7120):752-5. PMID: 17151666.
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    88. Zafar KS, Inayat-Hussain SH, Siegel D, Bao A, Shieh B, Ross D. Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death. Toxicol Lett. 2006 Oct 25; 166(3):261-7. PMID: 16978807.
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    89. Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins. Mol Pharmacol. 2006 Oct; 70(4):1194-203. PMID: 16825487.
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    90. Dehn DL, Siegel D, Zafar KS, Reigan P, Swann E, Moody CJ, Ross D. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol Cancer Ther. 2006 Jul; 5(7):1702-9. PMID: 16891456.
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    91. Zafar KS, Siegel D, Ross D. A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition. Mol Pharmacol. 2006 Sep; 70(3):1079-86. PMID: 16790533.
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    92. Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition. Cancer Res. 2005 Nov 01; 65(21):10006-15. PMID: 16267026.
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    93. Bironaite D, Siegel D, Moran JL, Weksler BB, Ross D. Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chem Biol Interact. 2004 Oct 15; 149(2-3):177-88. PMID: 15586939.
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    94. van Muiswinkel FL, de Vos RA, Bol JG, Andringa G, Jansen Steur EN, Ross D, Siegel D, Drukarch B. Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra. Neurobiol Aging. 2004 Oct; 25(9):1253-62. PMID: 15312971.
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    95. Bironaite D, Siegel D, Moran JL, Weksler BB, Ross D. Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chem Biol Interact. 2004 Aug 10; 149(1):37-49. PMID: 15356918.
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    96. Siegel D, Gustafson DL, Dehn DL, Han JY, Boonchoong P, Berliner LJ, Ross D. NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol Pharmacol. 2004 May; 65(5):1238-47. PMID: 15102952.
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    97. Ross D, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics. Methods Enzymol. 2004; 382:115-44. PMID: 15047100.
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    98. Sarbia M, Bitzer M, Siegel D, Ross D, Schulz WA, Zotz RB, Kiel S, Geddert H, Kandemir Y, Walter A, Willers R, Gabbert HE. Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract. Int J Cancer. 2003 Nov 10; 107(3):381-6. PMID: 14506737.
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    99. Dehn DL, Siegel D, Swann E, Moody CJ, Ross D. Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol. 2003 Sep; 64(3):714-20. PMID: 12920209.
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    100. Audi SH, Bongard RD, Dawson CA, Siegel D, Roerig DL, Merker MP. Duroquinone reduction during passage through the pulmonary circulation. Am J Physiol Lung Cell Mol Physiol. 2003 Nov; 285(5):L1116-31. PMID: 12882764.
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    101. Richardson PG, Barlogie B, Berenson J, Singhal S, Jagannath S, Irwin D, Rajkumar SV, Srkalovic G, Alsina M, Alexanian R, Siegel D, Orlowski RZ, Kuter D, Limentani SA, Lee S, Hideshima T, Esseltine DL, Kauffman M, Adams J, Schenkein DP, Anderson KC. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003 Jun 26; 348(26):2609-17. PMID: 12826635.
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    102. Zhang J, Schulz WA, Li Y, Wang R, Zotz R, Wen D, Siegel D, Ross D, Gabbert HE, Sarbia M. Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population. Carcinogenesis. 2003 May; 24(5):905-9. PMID: 12771035.
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    103. Gustafson DL, Siegel D, Rastatter JC, Merz AL, Parpal JC, Kepa JK, Ross D, Long ME. Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo. J Pharmacol Exp Ther. 2003 Jun; 305(3):1079-86. PMID: 12649308.
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    104. Anwar A, Dehn D, Siegel D, Kepa JK, Tang LJ, Pietenpol JA, Ross D. Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. J Biol Chem. 2003 Mar 21; 278(12):10368-73. PMID: 12529318.
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    105. Maritorena S, Siegel DA, Peterson AR. Optimization of a semianalytical ocean color model for global-scale applications. Appl Opt. 2002 May 20; 41(15):2705-14. PMID: 12027157.
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    106. Siegel DA, Doney SC, Yoder JA. The North Atlantic spring phytoplankton bloom and Sverdrup's critical depth hypothesis. Science. 2002 Apr 26; 296(5568):730-3. PMID: 11976453.
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    107. Anwar A, Siegel D, Kepa JK, Ross D. Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1. J Biol Chem. 2002 Apr 19; 277(16):14060-7. PMID: 11821413.
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    108. Winski SL, Faig M, Bianchet MA, Siegel D, Swann E, Fung K, Duncan MW, Moody CJ, Amzel LM, Ross D. Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches. Biochemistry. 2001 Dec 18; 40(50):15135-42. PMID: 11735396.
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    109. Siegel D, Ryder J, Ross D. NAD(P)H: quinone oxidoreductase 1 expression in human bone marrow endothelial cells. Toxicol Lett. 2001 Dec 15; 125(1-3):93-8. PMID: 11701227.
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    110. Wilson MW, Schelonka LP, Siegel D, Meininger A, Ross D. Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis. Curr Eye Res. 2001 May; 22(5):348-52. PMID: 11600935.
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    111. Siegel D, Anwar A, Winski SL, Kepa JK, Zolman KL, Ross D. Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1. Mol Pharmacol. 2001 Feb; 59(2):263-8. PMID: 11160862.
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    112. Siegel DA. Oceanography. The Rossby rototiller. Nature. 2001 Feb 01; 409(6820):576-7. PMID: 11214306.
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    113. Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact. 2000 Dec 01; 129(1-2):77-97. PMID: 11154736.
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    114. van Muiswinkel FL, Riemers FM, Peters GJ, LaFleur MV, Siegel D, Jongenelen CA, Drukarch B. L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells. Free Radic Biol Med. 2000 Sep 01; 29(5):442-53. PMID: 11020666.
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    115. Siegel D, Ross D. Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med. 2000 Aug; 29(3-4):246-53. PMID: 11035253.
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    116. Siegel DA, Wang M, Maritorena S, Robinson W. Atmospheric correction of satellite ocean color imagery: the black pixel assumption. Appl Opt. 2000 Jul 20; 39(21):3582-91. PMID: 18349929.
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    117. Schelonka LP, Siegel D, Wilson MW, Meininger A, Ross D. Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1617-22. PMID: 10845577.
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    118. Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem. 2000 Feb 25; 275(8):5416-24. PMID: 10681517.
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    119. Toole DA, Siegel DA, Menzies DW, Neumann MJ, Smith RC. Remote-sensing reflectance determinations in the coastal ocean environment: impact of instrumental characteristics and environmental variability. Appl Opt. 2000 Jan 20; 39(3):456-69. PMID: 18337915.
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    120. Moran JL, Siegel D, Ross D. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):8150-5. PMID: 10393963; PMCID: PMC22203.
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    121. Shiao T, Tran P, Siegel D, Lee J, Vasiliou V. Four amino acid changes are associated with the Aldh3a1 locus polymorphism in mice which may be responsible for corneal sensitivity to ultraviolet light. Pharmacogenetics. 1999 Apr; 9(2):145-53. PMID: 10376761.
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    122. Siegel D, McGuinness SM, Winski SL, Ross D. Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1. Pharmacogenetics. 1999 Feb; 9(1):113-21. PMID: 10208650.
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    123. Beall HD, Winski S, Swann E, Hudnott AR, Cotterill AS, O'Sullivan N, Green SJ, Bien R, Siegel D, Ross D, Moody CJ. Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity. J Med Chem. 1998 Nov 19; 41(24):4755-66. PMID: 9822546.
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    124. Siegel D, Franklin WA, Ross D. Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. Clin Cancer Res. 1998 Sep; 4(9):2065-70. PMID: 9748120.
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    125. Beall HD, Hudnott AR, Winski S, Siegel D, Swann E, Ross D, Moody CJ. Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1. Bioorg Med Chem Lett. 1998 Mar 03; 8(5):545-8. PMID: 9871615.
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    126. Siegel D, Bolton EM, Burr JA, Liebler DC, Ross D. The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant. Mol Pharmacol. 1997 Aug; 52(2):300-5. PMID: 9271353.
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    127. Traver RD, Siegel D, Beall HD, Phillips RM, Gibson NW, Franklin WA, Ross D. Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). Br J Cancer. 1997; 75(1):69-75. PMID: 9000600; PMCID: PMC2222704.
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    128. Ross D, Siegel D, Schattenberg DG, Sun XM, Moran JL. Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ Health Perspect. 1996 Dec; 104 Suppl 6:1177-82. PMID: 9118890.
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    129. Ross D, Traver RD, Siegel D, Kuehl BL, Misra V, Rauth AM. A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity. Br J Cancer. 1996 Sep; 74(6):995-6. PMID: 8826876; PMCID: PMC2074732.
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    130. Moran JL, Siegel D, Sun XM, Ross D. Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells. Mol Pharmacol. 1996 Sep; 50(3):610-5. PMID: 8794901.
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    131. Kuehl BL, Brezden CB, Traver RD, Siegel D, Ross D, Renzing J, Rauth AM. Immortalisation of a human diploid fibroblast cell strain: a DT-diaphorase paradox. Br J Cancer Suppl. 1996 Jul; 27:S19-22. PMID: 8763839; PMCID: PMC2150025.
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    132. Ross D, Beall HD, Siegel D, Traver RD, Gustafson DL. Enzymology of bioreductive drug activation. Br J Cancer Suppl. 1996 Jul; 27:S1-8. PMID: 8763836; PMCID: PMC2150032.
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    133. Beall HD, Liu Y, Siegel D, Bolton EM, Gibson NW, Ross D. Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin. Biochem Pharmacol. 1996 Mar 08; 51(5):645-52. PMID: 8615901.
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    134. Beall HD, Murphy AM, Siegel D, Hargreaves RH, Butler J, Ross D. Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Mol Pharmacol. 1995 Sep; 48(3):499-504. PMID: 7565631.
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    135. Siegel D, Larsen SA, Golden E, Morse S, Fullilove MT, Washington AE. Prevalence, incidence, and correlates of syphilis seroreactivity in multiethnic San Francisco neighborhoods. Ann Epidemiol. 1994 Nov; 4(6):460-5. PMID: 7804501.
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    136. Beall HD, Mulcahy RT, Siegel D, Traver RD, Gibson NW, Ross D. Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases. Cancer Res. 1994 Jun 15; 54(12):3196-201. PMID: 8205540.
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    137. Walkley SU, Thrall MA, Dobrenis K, Huang M, March PA, Siegel DA, Wurzelmann S. Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):2970-4. PMID: 8159689; PMCID: PMC43496.
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    138. Ross D, Beall H, Traver RD, Siegel D, Phillips RM, Gibson NW. Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. Oncol Res. 1994; 6(10-11):493-500. PMID: 7620217.
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    139. Siegel D, Beall H, Kasai M, Arai H, Gibson NW, Ross D. pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin. Mol Pharmacol. 1993 Dec; 44(6):1128-34. PMID: 8264549.
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    140. Bahary N, Siegel DA, Walsh J, Zhang Y, Leopold L, Leibel R, Proenca R, Friedman JM. Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation. Mamm Genome. 1993 Sep; 4(9):511-5. PMID: 7906968.
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    141. Ross D, Siegel D, Beall H, Prakash AS, Mulcahy RT, Gibson NW. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. Cancer Metastasis Rev. 1993 Jun; 12(2):83-101. PMID: 8375023.
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    142. Gibson NW, Hartley JA, Butler J, Siegel D, Ross D. Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity. Mol Pharmacol. 1992 Sep; 42(3):531-6. PMID: 1406604.
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    143. Siegel D, Beall H, Senekowitsch C, Kasai M, Arai H, Gibson NW, Ross D. Bioreductive activation of mitomycin C by DT-diaphorase. Biochemistry. 1992 Sep 01; 31(34):7879-85. PMID: 1510975.
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    144. Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, Bunn PA, Mabry M, Dykes DJ, Harrison SD, et al. Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl. Cancer Res. 1992 Sep 01; 52(17):4752-7. PMID: 1324793.
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    145. Lee CS, Hartley JA, Berardini MD, Butler J, Siegel D, Ross D, Gibson NW. Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase. Biochemistry. 1992 Mar 24; 31(11):3019-25. PMID: 1372518.
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    146. Gibson NW, Siegel D, Ross D. Mitomycin C. Cancer Chemother Biol Response Modif. 1992; 13:59-68. PMID: 1389922.
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    147. Thaete LG, Siegel D, Malkinson AM, Forrest GL, Ross D. NAD(P)H:quinone oxidoreductase (DT-diaphorase) activity and mRNA content in normal and neoplastic mouse lung epithelia. Int J Cancer. 1991 Aug 19; 49(1):145-9. PMID: 1908440.
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    148. Preusch PC, Siegel D, Gibson NW, Ross D. A note on the inhibition of DT-diaphorase by dicoumarol. Free Radic Biol Med. 1991; 11(1):77-80. PMID: 1718826.
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    149. Siegel D, Gibson NW, Preusch PC, Ross D. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res. 1990 Dec 01; 50(23):7483-9. PMID: 1701346.
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    150. Siegel D, Gibson NW, Preusch PC, Ross D. Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res. 1990 Nov 15; 50(22):7293-300. PMID: 2121335.
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    151. Thomas DJ, Sadler A, Subrahmanyam VV, Siegel D, Reasor MJ, Wierda D, Ross D. Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells. Mol Pharmacol. 1990 Feb; 37(2):255-62. PMID: 2154673.
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    152. Ross D, Siegel D, Gibson NW, Pacheco D, Thomas DJ, Reasor M, Wierda D. Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma. Free Radic Res Commun. 1990; 8(4-6):373-81. PMID: 2113030.
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    153. Siegel D, Malkinson AM, Ross D. Butylated hydroxytoluene (BHT)-mediated increases in NAD(P)H-quinone oxidoreductase (QR) in mouse lung: evidence for the alveolar type II cell as a site of QR activity. Toxicol Appl Pharmacol. 1988 Oct; 96(1):68-74. PMID: 3142099.
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