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Zhangguo Chen

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology
Phone303/724-8704

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen Z, Eder MD, Elos MT, Viboolsittiseri SS, Chen X, Wang JH. Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions. J Immunol. 2016 Mar 01; 196(5):2335-47. PMID: 26810227; PMCID: PMC4760233.
    2. Chen Z, Elos MT, Viboolsittiseri SS, Gowan K, Leach SM, Rice M, Eder MD, Jones K, Wang JH. Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity. J Hematol Oncol. 2016 Jan 07; 9:2. PMID: 26740101; PMCID: PMC4704435.
    3. Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 01; 195(11):5461-71. PMID: 26500350; PMCID: PMC4655169 [Available on 12/01/16].
    4. Chen Z, Ranganath S, Viboolsittiseri SS, Eder MD, Chen X, Elos MT, Yuan S, Hansen E, Wang JH. Correction: AID-Initiated DNA Lesions Are Differentially Processed in Distinct B Cell Populations. J Immunol. 2015 Feb 01; 194(3):1383. PMID: 25596302.
      View in: PubMed
    5. Chen Z, Ranganath S, Viboolsittiseri SS, Eder MD, Chen X, Elos MT, Yuan S, Yuan S, Hansen E, Wang JH. AID-initiated DNA lesions are differentially processed in distinct B cell populations. J Immunol. 2014 Dec 01; 193(11):5545-56. PMID: 25339658; PMCID: PMC4239163.
    6. Chen Z, Wang JH. Generation and repair of AID-initiated DNA lesions in B lymphocytes. Front Med. 2014 Jun; 8(2):201-16. PMID: 24748462; PMCID: PMC4039616.
    7. Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity. 2013 Dec 12; 39(6):1095-107. PMID: 24290911; PMCID: PMC3902970.
    8. Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep; 43(9):2473-83. PMID: 23696226; PMCID: PMC3775953.
    9. Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 2012 Nov 16; 37(5):930-46. PMID: 23123061; PMCID: PMC3516394.
    10. Chen Z, Yan CT, Dou Y, Viboolsittiseri SS, Wang JH. The role of a newly identified SET domain-containing protein, SETD3, in oncogenesis. Haematologica. 2013 May; 98(5):739-43. PMID: 23065515; PMCID: PMC3640118.
    11. Chen Z, Viboolsittiseri SS, O'Connor BP, Wang JH. Target DNA sequence directly regulates the frequency of activation-induced deaminase-dependent mutations. J Immunol. 2012 Oct 15; 189(8):3970-82. PMID: 22962683.
      View in: PubMed
    12. Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med. 2011 Dec 19; 208(13):2633-40. PMID: 22143889; PMCID: PMC3244030.
    13. Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9927-32. PMID: 21628593; PMCID: PMC3116387.
    14. Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug; 120(8):2889-99. PMID: 20592474; PMCID: PMC2912200.
    15. Chen Z, Chen L, Blumberg RS. Editorial: CEACAM1: fine-tuned for fine-tuning. J Leukoc Biol. 2009 Aug; 86(2):195-7. PMID: 19643737.
      View in: PubMed
    16. Tang F, Chen Z, Ciszewski C, Setty M, Solus J, Tretiakova M, Ebert E, Han J, Lin A, Guandalini S, Groh V, Spies T, Green P, Jabri B. Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15. J Exp Med. 2009 Mar 16; 206(3):707-19. PMID: 19237603; PMCID: PMC2699120.
    17. Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS. CEACAM1 and the regulation of mucosal inflammation. Mucosal Immunol. 2008 Nov; 1 Suppl 1:S39-42. PMID: 19079227; PMCID: PMC3901578.
    18. Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS. Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules. Eur J Immunol. 2008 Aug; 38(8):2351-9. PMID: 18624350; PMCID: PMC4132950.
    19. Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. J Immunol. 2008 May 01; 180(9):6085-93. PMID: 18424730.
      View in: PubMed
    20. Dupré DJ, Thompson C, Chen Z, Rollin S, Larrivée JF, Le Gouill C, Rola-Pleszczynski M, Stanková J. Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. Cell Signal. 2007 Oct; 19(10):2068-79. PMID: 17609120.
      View in: PubMed
    21. Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity. 2006 Nov; 25(5):769-81. PMID: 17081782.
      View in: PubMed
    22. Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity. 2004 Sep; 21(3):357-66. PMID: 15357947.
      View in: PubMed
    23. Chen Z, Gaudreau R, Le Gouill C, Rola-Pleszczynski M, Stanková J. Agonist-induced internalization of leukotriene B(4) receptor 1 requires G-protein-coupled receptor kinase 2 but not arrestins. Mol Pharmacol. 2004 Sep; 66(3):377-86. PMID: 15322228.
      View in: PubMed
    24. Gaudreau R, Beaulieu ME, Chen Z, Le Gouill C, Lavigne P, Stanková J, Rola-Pleszczynski M. Structural determinants regulating expression of the high affinity leukotriene B4 receptor: involvement of dileucine motifs and alpha-helix VIII. J Biol Chem. 2004 Mar 12; 279(11):10338-45. PMID: 14688279.
      View in: PubMed
    25. Lukashova V, Chen Z, Duhé RJ, Rola-Pleszczynski M, Stanková J. Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. J Immunol. 2003 Oct 01; 171(7):3794-800. PMID: 14500680.
      View in: PubMed
    26. Dupré DJ, Chen Z, Le Gouill C, Thériault C, Parent JL, Rola-Pleszczynski M, Stankova J. Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor. J Biol Chem. 2003 Nov 28; 278(48):48228-35. PMID: 14500726.
      View in: PubMed
    27. Chen Z, Rola-Pleszczynski M, Stankova J. Activation of ERK1/2 by platelet-activating factor receptor is independent of receptor internalisation and G-protein activation. Cell Signal. 2003 Sep; 15(9):843-50. PMID: 12834809.
      View in: PubMed
    28. Perron A, Chen ZG, Gingras D, Dupre DJ, Stankova J, Rola-Pleszczynski M. Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization. J Biol Chem. 2003 Jul 25; 278(30):27956-65. PMID: 12756251.
      View in: PubMed
    29. Chen Z, Dupré DJ, Le Gouill C, Rola-Pleszczynski M, Stanková J. Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif. J Biol Chem. 2002 Mar 01; 277(9):7356-62. PMID: 11729201.
      View in: PubMed
    30. Zhang Z, Tang J, Tikunova S, Johnson JD, Chen Z, Qin N, Dietrich A, Stefani E, Birnbaumer L, Zhu MX. Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3168-73. PMID: 11248050; PMCID: PMC30625.
    31. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem. 2000 Dec 01; 275(48):37559-64. PMID: 10980202.
      View in: PubMed
    32. Boulay G, Brown DM, Qin N, Jiang M, Dietrich A, Zhu MX, Chen Z, Birnbaumer M, Mikoshiba K, Birnbaumer L. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14955-60. PMID: 10611319; PMCID: PMC24754.
    33. Chen Z, Ma D, Zhang Y. [Enhancing immunogenicity of pres antigen of hepatitis B virus by fusing genetically it with interleukin-2]. Zhonghua Yi Xue Za Zhi. 1996 Jan; 76(1):34-7. PMID: 8758461.
      View in: PubMed
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